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Differential effects of oxyntomodulin and GLP-1 on glucose metabolism

Du, Xiaobing ; Kosinski, Jennifer R ; Lao, Julie ; Shen, Xiaolan ; Petrov, Aleksandr ; Chicchi, Gary G ; Eiermann, George J ; Pocai, Alessandro

American journal of physiology. Endocrinology and metabolism, 15 July 2012, Vol.303(2), pp.E265-71 [Peer Reviewed Journal]

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3-Substituted 3-(4-aryloxyaryl)-propanoic acids as GPR40 agonists

Walsh, Shawn P ; Severino, Alexandra ; Zhou, Changyou ; He, Jiafang ; Liang, Gui-Bai ; Tan, Carina P ; Cao, Jin ; Eiermann, George J ; Xu, Ling ; Salituro, Gino ; Howard, Andrew D ; Mills, Sander G ; Yang, Lihu

Bioorganic & Medicinal Chemistry Letters, 2011, Vol.21(11), pp.3390-3394 [Peer Reviewed Journal]

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A comparative study of the binding properties, dipeptidyl peptidase‐4 (DPP‐4) inhibitory activity and glucose‐lowering efficacy of the DPP‐4 inhibitors alogliptin, linagliptin, saxagliptin, sitagliptin and vildagliptin in mice

Berger, Joel P. ; Sinharoy, Ranabir ; Pocai, Alessandro ; Kelly, Theresa M. ; Scapin, Giovanna ; Gao, Ying‐Duo ; Pryor, Kelly Ann D. ; Wu, Joseph K. ; Eiermann, George J. ; Xu, Shiyao S. ; Zhang, Xiaoping ; Tatosian, Daniel A. ; Weber, Ann E. ; Thornberry, Nancy A. ; Carr, Richard D.

Endocrinology, Diabetes & Metabolism, January 2018, Vol.1(1), pp.n/a-n/a [Peer Reviewed Journal]

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Inhibition of DPP-4 with sitagliptin improves glycemic control and restores islet cell mass and function in a rodent model of type 2 diabetes

Mu, James ; Petrov, Aleksandr ; Eiermann, George J ; Woods, John ; Zhou, Yun-Ping ; Li, Zhihua ; Zycband, Emanuel ; Feng, Yue ; Zhu, Lan ; Roy, Ranabir Sinha ; Howard, Andrew D ; Li, Cai ; Thornberry, Nancy A ; Zhang, Bei B

European Journal of Pharmacology, 2009, Vol.623(1), pp.148-154 [Peer Reviewed Journal]

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Discovery of orally active hepatoselective glucokinase activators for treatment of Type II Diabetes Mellitus

Xu, Jiayi ; Lin, Songnian ; Myers, Robert W ; Trujillo, Maria E ; Pachanski, Michele J ; Malkani, Sunita ; Chen, Hsuan-Shen ; Chen, Zhesheng ; Campbell, Brian ; Eiermann, George J ; Elowe, Nadine ; Farrer, Brian T ; Feng, Wen ; Fu, Qinghong ; Kats-Kagan, Roman ; Kavana, Michael ; Mcmasters, Daniel R ; Mitra, Kaushik ; Tong, Xinchun ; Xu, Libo ; Zhang, Fengqi ; Zhang, Rui ; Addona, George H ; Berger, Joel P ; Zhang, Bei ; Parmee, Emma R

Bioorganic & Medicinal Chemistry Letters, 01 May 2017, Vol.27(9), pp.2063-2068 [Peer Reviewed Journal]

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Quantifying rates of glucose production in vivo following an intraperitoneal tracer bolus

Wang, Sheng-Ping ; Zhou, Dan ; Yao, Zuliang ; Satapati, Santhosh ; Chen, Ying ; Daurio, Natalie A ; Petrov, Aleksandr ; Shen, Xiaolan ; Metzger, Daniel ; Yin, Wu ; Nawrocki, Andrea R ; Eiermann, George J ; Hwa, Joyce ; Fancourt, Craig ; Miller, Corin ; Herath, Kithsiri ; Roddy, Thomas P ; Slipetz, Deborah ; Erion, Mark D ; Previs, Stephen F ; Kelley, David E

American journal of physiology. Endocrinology and metabolism, 01 December 2016, Vol.311(6), pp.E911-E921 [Peer Reviewed Journal]

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Novel, highly potent systemic glucokinase activators for the treatment of Type 2 Diabetes Mellitus

Xu, Jiayi ; Lin, Songnian ; Myers, Robert W ; Addona, George ; Berger, Joel P ; Campbell, Brian ; Chen, Hsuan-Shen ; Chen, Zhesheng ; Eiermann, George J ; Elowe, Nadine H ; Farrer, Brian T ; Feng, Wen ; Fu, Qinghong ; Kats-Kagan, Roman ; Kavana, Michael ; Malkani, Sunita ; Mcmasters, Daniel R ; Mitra, Kaushik ; Pachanski, Michele J ; Tong, Xinchun ; Trujillo, Maria E ; Xu, Libo ; Zhang, Bei ; Zhang, Fengqi ; Zhang, Rui ; Parmee, Emma R

Bioorganic & Medicinal Chemistry Letters, 01 May 2017, Vol.27(9), pp.2069-2073 [Peer Reviewed Journal]

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Stimulation of Glucose-Dependent Insulin Secretion by a Potent, Selective sst3 Antagonist

Pasternak, Alexander ; Feng, Zhe ; De Jesus, Reynalda ; Ye, Zhixiong ; He, Shuwen ; Dobbelaar, Peter ; Bradley, Scott A ; Chicchi, Gary G ; Tsao, Kwei-Lan ; Trusca, Dorina ; Eiermann, George J ; Li, Cai ; Feng, Yue ; Wu, Margaret ; Shao, Qing ; Zhang, Bei B ; Nargund, Ravi ; Mills, Sander G ; Howard, Andrew D ; Yang, Lihu ; Zhou, Yun-Ping

ACS medicinal chemistry letters, 12 April 2012, Vol.3(4), pp.289-93 [Peer Reviewed Journal]

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Diamine Derivatives as Novel Small-Molecule, Potent, and Subtype-Selective Somatostatin SST3 Receptor Agonists

Li, Derun ; Wu, Zhicai ; Yu, Yang ; Ball, Richard G ; Guo, Liangqin ; Sherer, Edward ; He, Shuwen ; Hong, Qingmei ; Lai, Zhong ; Qi, Hongbo ; Truong, Quang ; Yang, David X ; Chicchi, Gary G ; Tsao, Kwei-Lan ; Trusca, Dorina ; Trujillo, Maria ; Pachanski, Michele ; Eiermann, George J ; Howard, Andrew D ; Zhou, Yun-Ping ; Zhang, Bei B ; Nargund, Ravi P ; Hagmann, William K

ACS medicinal chemistry letters, 12 June 2014, Vol.5(6), pp.690-5 [Peer Reviewed Journal]

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10
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Discovery of 5-aryloxy-2,4-thiazolidinediones as potent GPR40 agonists

Zhou, Changyou ; Tang, Cheng ; Chang, Eric ; Ge, Min ; Lin, Songnian ; Cline, Eric ; Tan, Carina P ; Feng, Yue ; Zhou, Yun-Ping ; Eiermann, George J ; Petrov, Aleksandr ; Salituro, Gino ; Meinke, Peter ; Mosley, Ralph ; Akiyama, Taro E ; Einstein, Monica ; Kumar, Sanjeev ; Berger, Joel ; Howard, Andrew D ; Thornberry, Nancy ; Mills, Sander G ; Yang, Lihu

Bioorganic & Medicinal Chemistry Letters, 2010, Vol.20(3), pp.1298-1301 [Peer Reviewed Journal]

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11
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Discovery of potent and selective dipeptidyl peptidase IV inhibitors derived from beta-aminoamides bearing subsituted triazolopiperazines

Kim, Dooseop ; Kowalchick, Jennifer E ; Brockunier, Linda L ; Parmee, Emma R ; Eiermann, George J ; Fisher, Michael H ; He, Huaibing ; Leiting, Barbara ; Lyons, Kathryn ; Scapin, Giovanna ; Patel, Sangita B ; Petrov, Aleksandr ; Pryor, Kellyann D ; Roy, Ranabir Sinha ; Wu, Joseph K ; Zhang, Xiaoping ; Wyvratt, Matthew J ; Zhang, Bei B ; Zhu, Lan ; Thornberry, Nancy A ; Weber, Ann E

Journal of medicinal chemistry, 14 February 2008, Vol.51(3), pp.589-602 [Peer Reviewed Journal]

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12
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Selective small-molecule agonists of G protein-coupled receptor 40 promote glucose-dependent insulin secretion and reduce blood glucose in mice

Tan, Carina P ; Feng, Yue ; Zhou, Yun-Ping ; Eiermann, George J ; Petrov, Aleksandr ; Zhou, Changyou ; Lin, Songnian ; Salituro, Gino ; Meinke, Peter ; Mosley, Ralph ; Akiyama, Taro E ; Einstein, Monica ; Kumar, Sanjeev ; Berger, Joel P ; Mills, Sander G ; Thornberry, Nancy A ; Yang, Lihu ; Howard, Andrew D

Diabetes, August 2008, Vol.57(8), pp.2211-9 [Peer Reviewed Journal]

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13
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Investigation of Cardiovascular Effects of Tetrahydro-β-carboline sstr3 antagonists

He, Shuwen ; Lai, Zhong ; Ye, Zhixiong ; Dobbelaar, Peter H ; Shah, Shrenik K ; Truong, Quang ; Du, Wu ; Guo, Liangqin ; Liu, Jian ; Jian, Tianying ; Qi, Hongbo ; Bakshi, Raman K ; Hong, Qingmei ; Dellureficio, James ; Reibarkh, Mikhail ; Samuel, Koppara ; Reddy, Vijay B ; Mitelman, Stan ; Tong, Sharon X ; Chicchi, Gary G ; Tsao, Kwei-Lan ; Trusca, Dorina ; Wu, Margaret ; Shao, Qing ; Trujillo, Maria E ; Fernandez, Guillermo ; Nelson, Donald ; Bunting, Patricia ; Kerr, Janet ; Fitzgerald, Patrick ; Morissette, Pierre ; Volksdorf, Sylvia ; Eiermann, George J ; Li, Cai ; Zhang, Bei ; Howard, Andrew D ; Zhou, Yun-Ping ; Nargund, Ravi P ; Hagmann, William K

ACS medicinal chemistry letters, 10 July 2014, Vol.5(7), pp.748-53 [Peer Reviewed Journal]

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14
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Discovery and Optimization of a Novel Triazole Series of GPR142 Agonists for the Treatment of Type 2 Diabetes

Guo, Liangqin ; Parker, Dann L ; Zang, Yi ; Sweis, Ramzi F ; Liu, Weiguo ; Sherer, Edward C ; Buist, Nicole ; Terebetski, Jenna ; Kelly, Terri ; Bugianesi, Randal ; Priest, Birgit T ; Dingley, Karen H ; Li, Xiaofang ; Mitelman, Stan ; Salituro, Gino ; Trujillo, Maria E ; Pachanski, Michele ; Kirkland, Melissa ; Powles, Mary Ann ; Eiermann, George J ; Feng, Yue ; Shang, Jin ; Howard, Andrew D ; Ujjainwalla, Feroze ; Sinz, Christopher J ; Debenham, John S ; Edmondson, Scott D ; Nargund, Ravi P ; Hagmann, William K ; Li, Derun

ACS medicinal chemistry letters, 08 December 2016, Vol.7(12), pp.1107-1111 [Peer Reviewed Journal]

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15
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SAR exploration at the C-3 position of tetrahydro-β-carboline sstr3 antagonists

He, Shuwen ; Dobbelaar, Peter H ; Guo, Liangqin ; Ye, Zhixiong ; Liu, Jian ; Jian, Tianying ; Truong, Quang ; Shah, Shrenik K ; Du, Wu ; Qi, Hongbo ; Bakshi, Raman K ; Hong, Qingmei ; Dellureficio, James D ; Sherer, Edward ; Pasternak, Alexander ; Feng, Zhe ; Reibarkh, Mikhail ; Lin, Melissa ; Samuel, Koppara ; Reddy, Vijay B ; Mitelman, Stan ; Tong, Sharon X ; Chicchi, Gary G ; Tsao, Kwei-Lan ; Trusca, Dorina ; Wu, Margaret ; Shao, Qing ; Trujillo, Maria E ; Fernandez, Guillermo ; Nelson, Donald ; Bunting, Patricia ; Kerr, Janet ; Fitzgerald, Patrick ; Morissette, Pierre ; Volksdorf, Sylvia ; Eiermann, George J ; Li, Cai ; Zhang, Bei B ; Howard, Andrew D ; Zhou, Yun-Ping ; Nargund, Ravi P ; Hagmann, William K

Bioorganic & Medicinal Chemistry Letters, 15 March 2016, Vol.26(6), pp.1529-1535 [Peer Reviewed Journal]

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16
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(2S,3S)-3-Amino-4-(3,3-difluoropyrrolidin-1-yl)-N,N-dimethyl-4-oxo-2-(4-1,2,4triazolo1,5-a-pyridin-6-ylphenyl)butanamide: a selective alpha-amino amide dipeptidyl peptidase IV inhibitor for the treatment of type 2 diabetes

Edmondson, Scott D ; Mastracchio, Anthony ; Mathvink, Robert J ; He, Jiafang ; Harper, Bart ; Park, You-Jung ; Beconi, Maria ; Di Salvo, Jerry ; Eiermann, George J ; He, Huaibing ; Leiting, Barbara ; Leone, Joseph F ; Levorse, Dorothy A ; Lyons, Kathryn ; Patel, Reshma A ; Patel, Sangita B ; Petrov, Aleksandr ; Scapin, Giovanna ; Shang, Jackie ; Roy, Ranabir Sinha ; Smith, Aaron ; Wu, Joseph K ; Xu, Shiyao ; Zhu, Bing ; Thornberry, Nancy A ; Weber, Ann E

Journal of medicinal chemistry, 15 June 2006, Vol.49(12), pp.3614-27 [Peer Reviewed Journal]

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17
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(2R)-4-oxo-4-3-(trifluoromethyl)-5,6-dihydro1,2,4triazolo4,3-apyrazin-7(8H)-yl-1-(2,4,5-trifluorophenyl)butan-2-amine: a potent, orally active dipeptidyl peptidase IV inhibitor for the treatment of type 2 diabetes

Kim, Dooseop ; Wang, Liping ; Beconi, Maria ; Eiermann, George J ; Fisher, Michael H ; He, Huaibing ; Hickey, Gerard J ; Kowalchick, Jennifer E ; Leiting, Barbara ; Lyons, Kathryn ; Marsilio, Frank ; Mccann, Margaret E ; Patel, Reshma A ; Petrov, Aleksandr ; Scapin, Giovanna ; Patel, Sangita B ; Roy, Ranabir Sinha ; Wu, Joseph K ; Wyvratt, Matthew J ; Zhang, Bei B ; Zhu, Lan ; Thornberry, Nancy A ; Weber, Ann E

Journal of medicinal chemistry, 13 January 2005, Vol.48(1), pp.141-51 [Peer Reviewed Journal]

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18
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Discovery of MK-1421, a Potent, Selective sstr3 Antagonist, as a Development Candidate for Type 2 Diabetes

Shah, Shrenik K ; He, Shuwen ; Guo, Liangqin ; Truong, Quang ; Qi, Hongbo ; Du, Wu ; Lai, Zhong ; Liu, Jian ; Jian, Tianying ; Hong, Qingmei ; Dobbelaar, Peter ; Ye, Zhixiong ; Sherer, Edward ; Feng, Zhe ; Yu, Yang ; Wong, Frederick ; Samuel, Koppara ; Madiera, Maria ; Karanam, Bindhu V ; Reddy, Vijay B ; Mitelman, Stan ; Tong, Sharon X ; Chicchi, Gary G ; Tsao, Kwei-Lan ; Trusca, Dorina ; Feng, Yue ; Wu, Margaret ; Shao, Qing ; Trujillo, Maria E ; Eiermann, George J ; Li, Cai ; Pachanski, Michele ; Fernandez, Guillermo ; Nelson, Donald ; Bunting, Patricia ; Morissette, Pierre ; Volksdorf, Sylvia ; Kerr, Janet ; Zhang, Bei B ; Howard, Andrew D ; Zhou, Yun-Ping ; Pasternak, Alexander ; Nargund, Ravi P ; Hagmann, William K

ACS medicinal chemistry letters, 14 May 2015, Vol.6(5), pp.513-7 [Peer Reviewed Journal]

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19
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The Discovery of MK-4256, a Potent SSTR3 Antagonist as a Potential Treatment of Type 2 Diabetes

He, Shuwen ; Ye, Zhixiong ; Truong, Quang ; Shah, Shrenik ; Du, Wu ; Guo, Liangqin ; Dobbelaar, Peter H ; Lai, Zhong ; Liu, Jian ; Jian, Tianying ; Qi, Hongbo ; Bakshi, Raman K ; Hong, Qingmei ; Dellureficio, James ; Pasternak, Alexander ; Feng, Zhe ; Dejesus, Reynalda ; Yang, Lihu ; Reibarkh, Mikhail ; Bradley, Scott A ; Holmes, Mark A ; Ball, Richard G ; Ruck, Rebecca T ; Huffman, Mark A ; Wong, Frederick ; Samuel, Koppara ; Reddy, Vijay B ; Mitelman, Stan ; Tong, Sharon X ; Chicchi, Gary G ; Tsao, Kwei-Lan ; Trusca, Dorina ; Wu, Margaret ; Shao, Qing ; Trujillo, Maria E ; Eiermann, George J ; Li, Cai ; Zhang, Bei B ; Howard, Andrew D ; Zhou, Yun-Ping ; Nargund, Ravi P ; Hagmann, William K

ACS medicinal chemistry letters, 14 June 2012, Vol.3(6), pp.484-9 [Peer Reviewed Journal]

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20
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Plasma lipid profiling across species for the identification of optimal animal models of human dyslipidemia

Yin, Wu ; Carballo-Jane, Ester ; Mclaren, David G ; Mendoza, Vivienne H ; Gagen, Karen ; Geoghagen, Neil S ; Mcnamara, Lesley Ann ; Gorski, Judith N ; Eiermann, George J ; Petrov, Aleksandr ; Wolff, Michael ; Tong, Xinchun ; Wilsie, Larissa C ; Akiyama, Taro E ; Chen, Jing ; Thankappan, Anil ; Xue, Jiyan ; Ping, Xiaoli ; Andrews, Genevieve ; Wickham, L Alexandra ; Gai, Cesaire L ; Trinh, Tu ; Kulick, Alison A ; Donnelly, Marcie J ; Voronin, Gregory O ; Rosa, Ray ; Cumiskey, Anne-Marie ; Bekkari, Kavitha ; Mitnaul, Lyndon J ; Puig, Oscar ; Chen, Fabian ; Raubertas, Richard ; Wong, Peggy H ; Hansen, Barbara C ; Koblan, Ken S ; Roddy, Thomas P ; Hubbard, Brian K ; Strack, Alison M

Journal of lipid research, January 2012, Vol.53(1), pp.51-65 [Peer Reviewed Journal]

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21
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Dipeptidyl peptidase IV inhibition for the treatment of type 2 diabetes: potential importance of selectivity over dipeptidyl peptidases 8 and 9

Lankas, George R ; Leiting, Barbara ; Roy, Ranabir Sinha ; Eiermann, George J ; Beconi, Maria G ; Biftu, Tesfaye ; Chan, Chi-Chung ; Edmondson, Scott ; Feeney, William P ; He, Huaibing ; Ippolito, Dawn E ; Kim, Dooseop ; Lyons, Kathryn A ; Ok, Hyun O ; Patel, Reshma A ; Petrov, Aleksandr N ; Pryor, Kelly Ann ; Qian, Xiaoxia ; Reigle, Leah ; Woods, Andrea ; Wu, Joseph K ; Zaller, Dennis ; Zhang, Xiaoping ; Zhu, Lan ; Weber, Ann E ; Thornberry, Nancy A

Diabetes, October 2005, Vol.54(10), pp.2988-94 [Peer Reviewed Journal]

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22
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Aminopiperidine-fused imidazoles as dipeptidyl peptidase-IV inhibitors

Edmondson, Scott D ; Mastracchio, Anthony ; Cox, Jason M ; Eiermann, George J ; He, Huaibing ; Lyons, Kathryn A ; Patel, Reshma A ; Patel, Sangita B ; Petrov, Aleksandr ; Scapin, Giovanna ; Wu, Joseph K ; Xu, Shiyao ; Zhu, Bing ; Thornberry, Nancy A ; Roy, Ranabir Sinha ; Weber, Ann E

Bioorganic & Medicinal Chemistry Letters, 01 August 2009, Vol.19(15), pp.4097-4101 [Peer Reviewed Journal]

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23
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Design, synthesis, and biological evaluation of triazolopiperazine-based β-amino amides as potent, orally active dipeptidyl peptidase IV (DPP-4) inhibitors

Kowalchick, Jennifer E ; Leiting, Barbara ; Pryor, Kellyann D ; Marsilio, Frank ; Wu, Joseph K ; He, Huaibing ; Lyons, Kathryn A ; Eiermann, George J ; Petrov, Aleksandr ; Scapin, Giovanna ; Patel, Reshma A ; Thornberry, Nancy A ; Weber, Ann E ; Kim, Dooseop

Bioorganic & Medicinal Chemistry Letters, 2007, Vol.17(21), pp.5934-5939 [Peer Reviewed Journal]

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24
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Triazolopiperazine-amides as dipeptidyl peptidase IV inhibitors: Close analogs of JANUVIA™ (sitagliptin phosphate)

Kim, Dooseop ; Kowalchick, Jennifer E ; Edmondson, Scott D ; Mastracchio, Anthony ; Xu, Jinyou ; Eiermann, George J ; Leiting, Barbara ; Wu, Joseph K ; Pryor, Kellyann D ; Patel, Reshma A ; He, Huaibing ; Lyons, Kathryn A ; Thornberry, Nancy A ; Weber, Ann E

Bioorganic & Medicinal Chemistry Letters, 2007, Vol.17(12), pp.3373-3377 [Peer Reviewed Journal]

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25
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4-Aminophenylalanine and 4-aminocyclohexylalanine derivatives as potent, selective, and orally bioavailable inhibitors of dipeptidyl peptidase IV

Duffy, Joseph L ; Kirk, Brian A ; Wang, Liping ; Eiermann, George J ; He, Huaibing ; Leiting, Barbara ; Lyons, Kathryn A ; Patel, Reshma A ; Patel, Sangita B ; Petrov, Alexsandr ; Scapin, Giovanna ; Wu, Joseph K ; Thornberry, Nancy A ; Weber, Ann E

Bioorganic & Medicinal Chemistry Letters, 2007, Vol.17(10), pp.2879-2885 [Peer Reviewed Journal]

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26
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4-Arylcyclohexylalanine analogs as potent, selective, and orally active inhibitors of dipeptidyl peptidase IV

Kaelin, David E ; Smenton, Abigail L ; Eiermann, George J ; He, Huaibing ; Leiting, Barbara ; Lyons, Kathryn A ; Patel, Reshma A ; Patel, Sangita B ; Petrov, Alexsandr ; Scapin, Giovanna ; Wu, Joseph K ; Thornberry, Nancy A ; Weber, Ann E ; Duffy, Joseph L

Bioorganic & Medicinal Chemistry Letters, 2007, Vol.17(21), pp.5806-5811 [Peer Reviewed Journal]

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27
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Discovery of potent, selective, and orally bioavailable pyridone-based dipeptidyl peptidase-4 inhibitors

Xu, Jinyou ; Wei, Lan ; Mathvink, Robert ; Edmondson, Scott D ; Mastracchio, Anthony ; Eiermann, George J ; He, Huaibing ; Leone, Joseph F ; Leiting, Barbara ; Lyons, Kathryn A ; Marsilio, Frank ; Patel, Reshma A ; Petrov, Aleksandr ; Wu, Joseph K ; Thornberry, Nancy A ; Weber, Ann E

Bioorganic & Medicinal Chemistry Letters, 2006, Vol.16(5), pp.1346-1349 [Peer Reviewed Journal]

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28
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Discovery of potent, selective, and orally bioavailable oxadiazole-based dipeptidyl peptidase IV inhibitors

Xu, Jinyou ; Wei, Lan ; Mathvink, Robert J ; Edmondson, Scott D ; Eiermann, George J ; He, Huaibing ; Leone, Joseph F ; Leiting, Barbara ; Lyons, Kathryn A ; Marsilio, Frank ; Patel, Reshma A ; Patel, Sangita B ; Petrov, Aleksandr ; Scapin, Giovanna ; Wu, Joseph K ; Thornberry, Nancy A ; Weber, Ann E

Bioorganic & Medicinal Chemistry Letters, 2006, Vol.16(20), pp.5373-5377 [Peer Reviewed Journal]

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29
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Discovery of potent and selective orally bioavailable β-substituted phenylalanine derived dipeptidyl peptidase IV inhibitors

Edmondson, Scott D ; Mastracchio, Anthony ; Duffy, Joseph L ; Eiermann, George J ; He, Huaibing ; Ita, Ida ; Leiting, Barbara ; Leone, Joseph F ; Lyons, Kathryn A ; Makarewicz, Amanda M ; Patel, Reshma A ; Petrov, Aleksandr ; Wu, Joseph K ; Thornberry, Nancy A ; Weber, Ann E

Bioorganic & Medicinal Chemistry Letters, 2005, Vol.15(12), pp.3048-3052 [Peer Reviewed Journal]

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30
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Fluoropyrrolidine amides as dipeptidyl peptidase IV inhibitors

Caldwell, Charles G ; Chen, Ping ; He, Jiafang ; Parmee, Emma R ; Leiting, Barbara ; Marsilio, Frank ; Patel, Reshma A ; Wu, Joseph K ; Eiermann, George J ; Petrov, Aleksandr ; He, Huaibing ; Lyons, Kathryn A ; Thornberry, Nancy A ; Weber, Ann E

Bioorganic & Medicinal Chemistry Letters, 08 March 2004, Vol.14(5), pp.1265-1268 [Peer Reviewed Journal]

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