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DPP-4 inhibition as a therapeutic strategy to ameliorate diabetic metabolic memory

Guo, Xin ; Zhang, Bo-Fang ; Chen, Jing ; Jiang, Hong

International Journal of Cardiology, 15 November 2017, Vol.247, pp.40-40 [Peer Reviewed Journal]

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A concise and efficient synthesis of vildagliptin

Castaldi, Michele ; Baratella, Marco ; Menegotto, Ivan G ; Castaldi, Graziano ; Giovenzana, Giovanni B

Tetrahedron Letters, 30 August 2017, Vol.58(35), pp.3426-3428 [Peer Reviewed Journal]

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Discovery and preclinical profile of teneligliptin (3-[(2S,4S)-4-[4-(3-methyl-1-phenyl-1H-pyrazol-5-yl)piperazin-1-yl]pyrrolidin-2-ylcarbonyl]thiazolidine): A highly potent, selective, long-lasting and orally active dipeptidyl peptidase IV inhibitor for the treatment of type 2 diabetes

Yoshida, Tomohiro ; Akahoshi, Fumihiko ; Sakashita, Hiroshi ; Kitajima, Hiroshi ; Nakamura, Mitsuharu ; Sonda, Shuji ; Takeuchi, Masahiro ; Tanaka, Yoshihito ; Ueda, Naoko ; Sekiguchi, Sumie ; Ishige, Takayuki ; Shima, Kyoko ; Nabeno, Mika ; Abe, Yuji ; Anabuki, Jun ; Soejima, Aki ; Yoshida, Kumiko ; Takashina, Yoko ; Ishii, Shinichi ; Kiuchi, Satoko

Bioorganic & Medicinal Chemistry, 01 October 2012, Vol.20(19), pp.5705-5719 [Peer Reviewed Journal]

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Fused bicyclic heteroarylpiperazine-substituted l-prolylthiazolidines as highly potent DPP-4 inhibitors lacking the electrophilic nitrile group

Yoshida, Tomohiro ; Akahoshi, Fumihiko ; Sakashita, Hiroshi ; Sonda, Shuji ; Takeuchi, Masahiro ; Tanaka, Yoshihito ; Nabeno, Mika ; Kishida, Hiroyuki ; Miyaguchi, Ikuko ; Hayashi, Yoshiharu

Bioorganic & Medicinal Chemistry, 15 August 2012, Vol.20(16), pp.5033-5041 [Peer Reviewed Journal]

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Stromal cell–derived factor-1 is upregulated by dipeptidyl peptidase-4 inhibition and has protective roles in progressive diabetic nephropathy

Takashima, Satoru ; Fujita, Hiroki ; Fujishima, Hiromi ; Shimizu, Tatsunori ; Sato, Takehiro ; Morii, Tsukasa ; Tsukiyama, Katsushi ; Narita, Takuma ; Takahashi, Takamune ; Drucker, Daniel J ; Seino, Yutaka ; Yamada, Yuichiro

Kidney International, October 2016, Vol.90(4), pp.783-796 [Peer Reviewed Journal]

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The potential for renoprotection with incretin-based drugs

Tanaka, Tetsuhiro ; Higashijima, Yoshiki ; Wada, Takehiko ; Nangaku, Masaomi

Kidney International, October 2014, Vol.86(4), pp.701-711 [Peer Reviewed Journal]

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Serum levels of pigment epithelium-derived factor (PEDF) are inversely associated with circulating levels of dipeptidyl peptidase-4 (DPP-4) in humans

Tahara, Nobuhiro ; Yamagishi, Sho-Ichi ; Matsui, Takanori ; Nishino, Yuri ; Honda, Akihiro ; Tahara, Atsuko ; Igata, Sachiyo ; Fukumoto, Yoshihiro

International Journal of Cardiology, 01 April 2015, Vol.184, pp.14-16 [Peer Reviewed Journal]

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Dipeptidyl peptidase-4 inhibitors and the ischemic heart: Additional benefits beyond glycemic control

Chattipakorn, Nipon ; Apaijai, Nattayaporn ; Chattipakorn, Siriporn C

International Journal of Cardiology, 01 January 2016, Vol.202, pp.415-416 [Peer Reviewed Journal]

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The dipeptidyl peptidase-4 inhibitor-sitagliptin modulates calcium dysregulation, inflammation, and PPARs in hypertensive cardiomyocytes

Lee, T-I ; Kao, Y-H ; Chen, Y-C ; Huang, J-H ; Hsu, M-I ; Chen, Y-J

International Journal of Cardiology, 15 October 2013, Vol.168(6), pp.5390-5395 [Peer Reviewed Journal]

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Identification of 3-aminomethyl-1,2-dihydro-4-phenyl-1-isoquinolones: A new class of potent, selective, and orally active non-peptide dipeptidyl peptidase IV inhibitors that form a unique interaction with Lys554

Banno, Yoshihiro ; Miyamoto, Yasufumi ; Sasaki, Mitsuru ; Oi, Satoru ; Asakawa, Tomoko ; Kataoka, Osamu ; Takeuchi, Koji ; Suzuki, Nobuhiro ; Ikedo, Koji ; Kosaka, Takuo ; Tsubotani, Shigetoshi ; Tani, Akiyoshi ; Funami, Miyuki ; Tawada, Michiko ; Yamamoto, Yoshio ; Aertgeerts, Kathleen ; Yano, Jason ; Maezaki, Hironobu

Bioorganic & Medicinal Chemistry, 15 August 2011, Vol.19(16), pp.4953-4970 [Peer Reviewed Journal]

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Dipeptidyl Peptidase-4 Inhibitors Have Protective Effect on Cognitive Impairment in Aged Diabetic Patients With Mild Cognitive Impairment

Rizzo, Maria Rosaria ; Barbieri, Michelangela ; Boccardi, Virginia ; Angellotti, Edith ; Marfella, Raffaele ; Paolisso, Giuseppe

Journals of Gerontology Series A: Biomedical Sciences and Medical Sciences, 2014, Vol. 69(9), pp.1122-1131 [Peer Reviewed Journal]

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Evidence for neural contribution to islet effects of DPP-4 inhibition in mice

Ahlkvist, Linda ; Omar, Bilal ; Pacini, Giovanni ; Ahrén, Bo

European Journal of Pharmacology, 05 June 2016, Vol.780, pp.46-52 [Peer Reviewed Journal]

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Separation of alogliptin enantiomers in cyclodextrin‐modified capillary electrophoresis: A validated method

Fejős, Ida ; Urbancsok, Zsuzsanna ; Zhou, Wei ; Sohajda, Tamás ; Hu, Wenhui ; Szente, Lajos ; Béni, Szabolcs

ELECTROPHORESIS, October 2014, Vol.35(19), pp.2885-2891 [Peer Reviewed Journal]

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Development and validation of a cyclodextrin‐modified capillary electrophoresis method for the enantiomeric separation of vildagliptin enantiomers

Kazsoki, Adrienn ; Fejős, Ida ; Sohajda, Tamás ; Zhou, Wei ; Hu, Wenhui ; Szente, Lajos ; Béni, Szabolcs

ELECTROPHORESIS, May 2016, Vol.37(10), pp.1318-1325 [Peer Reviewed Journal]

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Efficacy of vildagliptin versus sulfonylureas as add-on therapy to metformin: comparison of results from randomised controlled and observational studies

Ahrén, Bo ; Mathieu, Chantal ; Bader, Giovanni ; Schweizer, Anja ; Foley, James

Diabetologia, 2014, Vol.57(7), pp.1304-1307 [Peer Reviewed Journal]

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Risk of pancreatitis in patients treated with incretin-based therapies

Meier, Juris ; Nauck, Michael

Diabetologia, 2014, Vol.57(7), pp.1320-1324 [Peer Reviewed Journal]

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17
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Cardioprotective effect of dipeptidyl peptidase-4 inhibitor during ischemia–reperfusion injury

Chinda, Kroekkiat ; Palee, Siripong ; Surinkaew, Sirirat ; Phornphutkul, Mattabhorn ; Chattipakorn, Siriporn ; Chattipakorn, Nipon

International Journal of Cardiology, 31 July 2013, Vol.167(2), pp.451-457 [Peer Reviewed Journal]

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18
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Cardiovascular effects of dipeptidyl peptidase-4 inhibitors in diabetic patients: A meta-analysis

Savarese, Gianluigi ; Perrone-Filardi, Pasquale ; D'Amore, Carmen ; Vitale, Cristiana ; Trimarco, Bruno ; Pani, Luca ; Rosano, Giuseppe M.C

International Journal of Cardiology, 15 February 2015, Vol.181, pp.239-244 [Peer Reviewed Journal]

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19
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Effects of dipeptidyl peptidase-4 (DPP-4) inhibition on angiogenesis and hypoxic injury in type 2 diabetes

Fiordaliso, Fabio ; Maggioni, Serena ; Balconi, Giovanna ; Schiarea, Silvia ; Corbelli, Alessandro ; De Luigi, Ada ; Figliuzzi, Marina ; Antoniou, Xenia ; Chiabrando, Chiara ; Masson, Serge ; Cervo, Luigi ; Latini, Roberto

Life Sciences, 01 June 2016, Vol.154, pp.87-95 [Peer Reviewed Journal]

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20
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Alogliptin, a dipeptidylpeptidase-4 inhibitor, for patients with diabetes mellitus type 2, induces tolerance to focal cerebral ischemia in non-diabetic, normal mice

Yang, Dong ; Nakajo, Yukako ; Iihara, Koji ; Kataoka, Hiroharu ; Yanamoto, Hiroji

Brain Research, 23 June 2013, Vol.1517, pp.104-113 [Peer Reviewed Journal]

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21
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Neuroprotective effect of selective DPP-4 inhibitor in experimental vascular dementia

Jain, Swati ; Sharma, Bhupesh

Physiology & Behavior, 01 December 2015, Vol.152, pp.182-193 [Peer Reviewed Journal]

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22
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Dipeptidyl peptidase- IV inhibitor alogliptin improves stress-induced insulin resistance and prothrombotic state in a murine model

Yisireyili, Maimaiti ; Takeshita, Kyosuke ; Hayashi, Motoharu ; Wu, Hongxian ; Uchida, Yasuhiro ; Yamamoto, Koji ; Kikuchi, Ryosuke ; Hao, Chang-Ning ; Nakayama, Takayuki ; Cheng, Xian Wu ; Matsushita, Tadashi ; Nakamura, Shigeo ; Murohara, Toyoaki

Psychoneuroendocrinology, November 2016, Vol.73, pp.186-195 [Peer Reviewed Journal]

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23
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Design and synthesis of 3-pyridylacetamide derivatives as dipeptidyl peptidase IV (DPP-4) inhibitors targeting a bidentate interaction with Arg125

Miyamoto, Yasufumi ; Banno, Yoshihiro ; Yamashita, Tohru ; Fujimoto, Tatsuhiko ; Oi, Satoru ; Moritoh, Yusuke ; Asakawa, Tomoko ; Kataoka, Osamu ; Takeuchi, Koji ; Suzuki, Nobuhiro ; Ikedo, Koji ; Kosaka, Takuo ; Tsubotani, Shigetoshi ; Tani, Akiyoshi ; Funami, Miyuki ; Amano, Michiko ; Yamamoto, Yoshio ; Aertgeerts, Kathleen ; Yano, Jason ; Maezaki, Hironobu

Bioorganic & Medicinal Chemistry, 01 January 2011, Vol.19(1), pp.172-185 [Peer Reviewed Journal]

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24
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(R)-3-Amino-1-((3aS,7aS)-octahydro-1H-indol-1-yl)-4-(2,4,5-trifluorophenyl)butan-1-one derivatives as potent inhibitors of dipeptidyl peptidase-4: Design, synthesis, biological evaluation, and molecular modeling

Wang, Sinan ; Su, Mingbo ; Wang, Jiang ; Li, Zeng ; Zhang, Lei ; Ji, Xun ; Li, Jingya ; Li, Jia ; Liu, Hong

Bioorganic & Medicinal Chemistry, 01 December 2014, Vol.22(23), pp.6684-6693 [Peer Reviewed Journal]

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25
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Effect of addition of either sitagliptin or pioglitazone in patients with uncontrolled type 2 diabetes mellitus on metformin: A randomized controlled trial

Chawla, Shalini ; Kaushik, Nitin ; Singh, Narinder ; Ghosh, Raktim ; Saxena, Alpana

Journal of Pharmacology and Pharmacotherapeutics, 2013, Vol.4(1), p.27-32 [Peer Reviewed Journal]

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26
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Efficacy and tolerability of vildagliptin in type 2 diabetic patients on hemodialysis

Kume, Shinji ; Uzu, Takashi ; Takagi, Chieko ; Kondo, Morihiro ; Okabe, Tomoko ; Araki, Shin‐Ichi ; Isshiki, Keiji ; Takeda, Naoko ; Kondo, Keiko ; Haneda, Masakazu ; Koya, Daisuke ; Nishio, Yoshihiko ; Kashiwagi, Atsunori ; Maegawa, Hiroshi

Journal of Diabetes Investigation, June 2012, Vol.3(3), pp.298-301 [Peer Reviewed Journal]

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27
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The dipeptidyl peptidase inhibitor linagliptin and the angiotensin II receptor blocker telmisartan show renal benefit by different pathways in rats with 5/6 nephrectomy

Tsuprykov, Oleg ; Ando, Ryotaro ; Reichetzeder, Christoph ; Von Websky, Karoline ; Antonenko, Viktoriia ; Sharkovska, Yuliya ; Chaykovska, Lyubov ; Rahnenführer, Jan ; Hasan, Ahmed A ; Tammen, Harald ; Alter, Markus ; Klein, Thomas ; Ueda, Seiji ; Yamagishi, Sho-Ichi ; Okuda, Seiya ; Hocher, Berthold

Kidney International, May 2016, Vol.89(5), pp.1049-1061 [Peer Reviewed Journal]

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28
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Enhanced beta cell function and anti-inflammatory effect after chronic treatment with the dipeptidyl peptidase-4 inhibitor vildagliptin in an advanced-aged diet-induced obesity mouse model

Omar, B. ; Vikman, J. ; Winzell, M. ; Voss, U. ; Ekblad, E. ; Foley, J. ; Ahrén, B.

Diabetologia, 2013, Vol.56(8), pp.1752-1760 [Peer Reviewed Journal]

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29
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Chronic treatment with a glucagon receptor antagonist lowers glucose and moderately raises circulating glucagon and glucagon-like peptide 1 without severe alpha cell hypertrophy in diet-induced obese mice

Mu, J. ; Jiang, G. ; Brady, E. ; Dallas-Yang, Q. ; Liu, F. ; Woods, J. ; Zycband, E. ; Wright, M. ; Li, Z. ; Lu, K. ; Zhu, L. ; Shen, X. ; SinhaRoy, R. ; Candelore, M. ; Qureshi, S. ; Shen, D-M. ; Zhang, F. ; Parmee, E. ; Zhang, B.

Diabetologia, 2011, Vol.54(9), pp.2381-2391 [Peer Reviewed Journal]

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30
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Influence of TCF7L2 gene variants on the therapeutic response to the dipeptidylpeptidase-4 inhibitor linagliptin

Zimdahl, Heike ; Ittrich, Carina ; Graefe-Mody, Ulrike ; Boehm, Bernhard ; Mark, Michael ; Woerle, Hans-Juergen ; Dugi, Klaus

Diabetologia, 2014, Vol.57(9), pp.1869-1875 [Peer Reviewed Journal]

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31
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The efficacy and effectiveness of drugs for diabetes: how do clinical trials and the real world compare?

Pratley, Richard

Diabetologia, 2014, Vol.57(7), pp.1273-1275 [Peer Reviewed Journal]

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32
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DPP-4 inhibition contributes to the prevention of hypoglycaemia through a GIP–glucagon counterregulatory axis in mice

Malmgren, Siri ; Ahrén, Bo

Diabetologia, 2015, Vol.58(5), pp.1091-1099 [Peer Reviewed Journal]

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33
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Metformin and the gastrointestinal tract

McCreight, Laura ; Bailey, Clifford ; Pearson, Ewan

Diabetologia, 2016, Vol.59(3), pp.426-435 [Peer Reviewed Journal]

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34
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The importance of Pharmacovigilance for the drug safety: Focus on cardiovascular profile of incretin-based therapy

Sportiello, Liberata ; Rafaniello, Concetta ; Scavone, Cristina ; Vitale, Cristiana ; Rossi, Francesco ; Capuano, Annalisa

International Journal of Cardiology, 01 January 2016, Vol.202, pp.731-735 [Peer Reviewed Journal]

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35
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Tolerability of Dipeptidyl Peptidase-4 Inhibitors: A Review

Richard, Kathleen R ; Shelburne, Jamie S ; Kirk, Julienne K

Clinical Therapeutics, 2011, Vol.33(11), pp.1609-1629 [Peer Reviewed Journal]

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36
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Cardiometabolic Effects of a New Class of Antidiabetic Agents

Desouza, Cyrus V ; Gupta, Namita ; Patel, Anery

Clinical Therapeutics, 01 June 2015, Vol.37(6), pp.1178-1194 [Peer Reviewed Journal]

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37
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Efficacy and Safety of Linagliptin in Subjects With Long-standing Type 2 Diabetes Mellitus (>10 Years): Evidence From Pooled Data of Randomized, Double-blind, Placebo-controlled, Phase III Trials

Lajara, Rosemarie ; Aguilar, Richard ; Hehnke, Uwe ; Woerle, Hans-Juergen ; Von Eynatten, Maximilian

Clinical Therapeutics, 01 November 2014, Vol.36(11), pp.1595-1605 [Peer Reviewed Journal]

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A Randomized, Open-Label, Crossover Study to Evaluate the Pharmacokinetics of Empagliflozin and Linagliptin After Coadministration in Healthy Male Volunteers

Friedrich, Christian ; Metzmann, Katrin ; Rose, Peter ; Mattheus, Michaela ; Pinnetti, Sabine ; Woerle, Hans J

Clinical Therapeutics, January 2013, Vol.35(1), pp.A33-A42 [Peer Reviewed Journal]

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