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1
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Carbon‐14 labeling of a trifluoromethoxy group: synthesis of a substance P antagonist

Raab, Conrad E. ; Dean, Dennis C. ; Melillo, David G.

Journal of Labelled Compounds and Radiopharmaceuticals, 30 October 2001, Vol.44(12), pp.815-829 [Peer Reviewed Journal]

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A Photoactivatable Prenylated Cysteine Designed to Study Isoprenoid Recognition
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A Photoactivatable Prenylated Cysteine Designed to Study Isoprenoid Recognition

Kale, Tamara A. ; Raab, Conrad ; Yu, Nathan ; Dean, Dennis C. ; Distefano, Mark D.

Journal of the American Chemical Society, 05/2001, Vol.123(19), pp.4373-4381 [Peer Reviewed Journal]

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3
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Efficient utilization of [ 14C]carbon dioxide as a phosgene equivalent for labeled synthesis

Dean, Dennis C ; Wallace, Michael A ; Marks, Tina M ; Melillo, David G

Tetrahedron Letters, 1997, Vol.38(6), pp.919-922 [Peer Reviewed Journal]

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Pharmacokinetics, metabolism, and excretion of anacetrapib, a novel inhibitor of the cholesteryl ester transfer protein, in rats and rhesus monkeys

Tan, Eugene Y ; Hartmann, Georgy ; Chen, Qing ; Pereira, Antonio ; Bradley, Scott ; Doss, George ; Zhang, Andy Shiqiang ; Ho, Jonathan Z ; Braun, Matthew P ; Dean, Dennis C ; Tang, Wei ; Kumar, Sanjeev

Drug metabolism and disposition: the biological fate of chemicals, March 2010, Vol.38(3), pp.459-73 [Peer Reviewed Journal]

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5
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Formation of functionalized cyclic ethers by intramolecular nitrile oxide cycloadditions

Padwa, Albert ; Chiacchio, Ugo ; Dean, Dennis C ; Schoffstall, Allen M ; Hassner, Alfred ; Murthy, K.S.K

Tetrahedron Letters, 1988, Vol.29(33), pp.4169-4172 [Peer Reviewed Journal]

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6
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Azomethine ylide generation via the dipole cascade

Padwa, Albert ; Dean, Dennis C ; Hertzog, Donald L ; Nadler, William R ; Zhi, Lin

Tetrahedron, 1992, Vol.48(36), pp.7565-7580 [Peer Reviewed Journal]

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7
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Transport of the dipeptidyl peptidase-4 inhibitor sitagliptin by human organic anion transporter 3, organic anion transporting polypeptide 4C1, and multidrug resistance P-glycoprotein

Chu, Xiao-Yan ; Bleasby, Kelly ; Yabut, Jocelyn ; Cai, Xiaoxin ; Chan, Grace Hoyee ; Hafey, Michael J ; Xu, Shiyao ; Bergman, Arthur J ; Braun, Matthew P ; Dean, Dennis C ; Evers, Raymond

The Journal of pharmacology and experimental therapeutics, May 2007, Vol.321(2), pp.673-83 [Peer Reviewed Journal]

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8
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A nonpeptide oxytocin receptor antagonist radioligand highly selective for human receptors

Lemaire, Wei ; O'Brien, Julie A ; Burno, Maryann ; Chaudhary, Ashok G ; Dean, Dennis C ; Williams, Peter D ; Freidinger, Roger M ; Pettibone, Douglas J ; Williams, David L

European Journal of Pharmacology, 2002, Vol.450(1), pp.19-28 [Peer Reviewed Journal]

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9
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Metabolism and excretion of anacetrapib, a novel inhibitor of the cholesteryl ester transfer protein, in humans

Kumar, Sanjeev ; Tan, Eugene Y ; Hartmann, Georgy ; Biddle, Zachary ; Bergman, Arthur J ; Dru, James ; Ho, Jonathan Z ; Jones, Allen N ; Staskiewicz, Steve J ; Braun, Matthew P ; Karanam, Bindhu ; Dean, Dennis C ; Gendrano, Isaias Noel ; Graves, Mark W ; Wagner, John A ; Krishna, Rajesh

Drug metabolism and disposition: the biological fate of chemicals, March 2010, Vol.38(3), pp.474-83 [Peer Reviewed Journal]

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10
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Comparative assessment of the ligand and metal ion binding properties of integrins alpha9beta1 and alpha4beta1

Pepinsky, R Blake ; Mumford, Richard A ; Chen, Ling Ling ; Leone, Diane ; Amo, Suzanne E ; Riper, Gail Van ; Whitty, Adrian ; Dolinski, Brian ; Lobb, Roy R ; Dean, Dennis C ; Chang, Linda L ; Raab, Conrad E ; Si, Qian ; Hagmann, William K ; Lingham, Russell B

Biochemistry, 04 June 2002, Vol.41(22), pp.7125-41 [Peer Reviewed Journal]

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11
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Ivermectin and nodulisporic acid receptors in Drosophila melanogaster contain both gamma-aminobutyric acid-gated Rdl and glutamate-gated GluCl alpha chloride channel subunits

Ludmerer, Steven W ; Warren, Vivien A ; Williams, Brande S ; Zheng, Yingcong ; Hunt, David C ; Ayer, Michelle B ; Wallace, Michael A ; Chaudhary, Ashok G ; Egan, Marjorie A ; Meinke, Peter T ; Dean, Dennis C ; Garcia, Maria L ; Cully, Doris F ; Smith, Mchardy M

Biochemistry, 21 May 2002, Vol.41(20), pp.6548-60 [Peer Reviewed Journal]

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12
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The target of ezetimibe is Niemann-Pick C1-Like 1 (NPC1L1)

Garcia-Calvo, Margarita ; Lisnock, Jeanmarie ; Bull, Herbert G ; Hawes, Brian E ; Burnett, Duane A ; Braun, Matthew P ; Crona, James H ; Davis, Harry R ; Dean, Dennis C ; Detmers, Patricia A ; Graziano, Michael P ; Hughes, Meredith ; Macintyre, D Euan ; Ogawa, Anthony ; O'Neill, Kim A ; Iyer, Sai Prasad N ; Shevell, Diane E ; Smith, Marsha M ; Tang

Proceedings of the National Academy of Sciences of the United States of America, 07 June 2005, Vol.102(23), pp.8132-7 [Peer Reviewed Journal]

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13
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The syntheses of [ 14 C] and [ 13 C 2 , 15 N 3 ]aprepitant

Elmore, Charles S. ; Dean, Dennis C. ; Zhang, Yong ; Mellilo, David G.

Journal of Labelled Compounds and Radiopharmaceuticals, 30 October 2004, Vol.47(12), pp.837-846 [Peer Reviewed Journal]

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14
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Synthesis of [3,5‐dichlorobenzenesulfonamide‐U‐ 14 C)] labeled VLA‐4 antagonists

Yu, Nathan X. ; Raab, Conrad E. ; Dean, Dennis C. ; Lin, Linus S. ; Melillo, David G.

Journal of Labelled Compounds and Radiopharmaceuticals, February 2004, Vol.47(2), pp.115-125 [Peer Reviewed Journal]

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15
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Synthesis of two non‐peptidyl GnRH receptor antagonists via [ 14 C]carbonylation

Elmore, Charles S. ; Dean, Dennis C. ; Devita, Robert J. ; Melillo, David G.

Journal of Labelled Compounds and Radiopharmaceuticals, September 2003, Vol.46(10), pp.993-1000 [Peer Reviewed Journal]

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16
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The changing environment of graduate and postdoctoral training in drug metabolism: viewpoints from academia, industry, and government

Stevens, Jeffrey C ; Dean, Dennis C ; Preusch, Peter C ; Correia, Maria Almira

Drug metabolism and disposition: the biological fate of chemicals, April 2003, Vol.31(4), pp.360-6 [Peer Reviewed Journal]

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17
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Synthesis of high specific activity 35S‐labelled N‐methanesulfonyl farnesylcysteine and a photoactive analog

Kale, Tamara A. ; Raab, Conrad ; Yu, Nathan ; Aquino, Evelyn ; Dean, Dennis C. ; Distefano, Mark D.

Journal of Labelled Compounds and Radiopharmaceuticals, January 2003, Vol.46(1), pp.29-54 [Peer Reviewed Journal]

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18
Development of a High Specific Activity Sulfur-35-Labeled Sulfonamide Radioligand That Allowed the Identification of a New Growth Hormone Secretagogue Receptor
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Development of a High Specific Activity Sulfur-35-Labeled Sulfonamide Radioligand That Allowed the Identification of a New Growth Hormone Secretagogue Receptor

Dean, Dennis C. ; Nargund, Ravi P. ; Pong, Sheng-Shung ; Chaung, Lee-Yuh P. ; Griffin, Patrick ; Melillo, David G. ; Ellsworth, Robert L. ; Van Der Ploeg, Lex H. T. ; Patchett, Arthur A. ; Smith, Roy G.

Journal of Medicinal Chemistry, 01/1996, Vol.39(9), pp.1767-1770 [Peer Reviewed Journal]

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19
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Suzuki cross‐coupling for the incorporation of labeled methyl groups onto aryl halides. A synthesis of [ 14 C]tosyl chloride and its use in the synthesis of [ 14 C]L‐738,167

Braun, Matthew P. ; Dean, Dennis C. ; Melillo, David G.

Journal of Labelled Compounds and Radiopharmaceuticals, May 1999, Vol.42(5), pp.469-476 [Peer Reviewed Journal]

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20
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A convenient method for [ 14 C] carbonylation reactions

Elmore, Charles S. ; Dean, Dennis C. ; Melillo, David G.

Journal of Labelled Compounds and Radiopharmaceuticals, 15 October 2000, Vol.43(11), pp.1135-1144 [Peer Reviewed Journal]

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21
Suzuki cross-coupling for the incorporation of labeled methyl groups onto aryl halides. A synthesis of [14C]tosyl chloride and its use in the synthesis of [14C]L-738,167
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Suzuki cross-coupling for the incorporation of labeled methyl groups onto aryl halides. A synthesis of [14C]tosyl chloride and its use in the synthesis of [14C]L-738,167

Braun, Matthew P. ; Dean, Dennis C. ; Melillo, David G.

Journal of Labelled Compounds and Radiopharmaceuticals, 05/1999, Vol.42(5), pp.469-476 [Peer Reviewed Journal]

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22
Suzuki cross‐coupling for the incorporation of labeled methyl groups onto aryl halides. A synthesis of [14C]tosyl chloride and its use in the synthesis of [14C]L‐738,167
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Suzuki cross‐coupling for the incorporation of labeled methyl groups onto aryl halides. A synthesis of [14C]tosyl chloride and its use in the synthesis of [14C]L‐738,167

Braun, Matthew P. ; Dean, Dennis C. ; Melillo, David G.

Journal of Labelled Compounds and Radiopharmaceuticals, 5/1999, Vol.42(5), pp.469-476 [Peer Reviewed Journal]

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23
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Synthesis of [ 35 S]aryl sulfonyl chlorides from [ 35 S]elemental sulfur

Wallace, Michael A. ; Raab, Conrad E. ; Dean, Dennis C. ; Melillo, David G.

Journal of Labelled Compounds and Radiopharmaceuticals, 30 March 2005, Vol.48(4), pp.275-283 [Peer Reviewed Journal]

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24
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Simultaneous determination of a novel KDR kinase inhibitor and its N-oxide metabolite in human plasma using 96-well solid-phase extraction and liquid chromatography/tandem mass spectrometry

Xu, Yang ; Du, Lihong ; Soli, Eric D ; Braun, Matthew P ; Dean, Dennis C ; Musson, Donald G

Journal of Chromatography B, 2005, Vol.817(2), pp.287-296 [Peer Reviewed Journal]

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25
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Use of fluorous and solid‐phase electrophiles as scavengers for excess amine in the preparation of sulfur‐35 labelled radioligands

Zhang, Andy Shiqiang ; Elmore, Charles S. ; Egan, Marjorie A. ; Melillo, David G. ; Dean, Dennis C.

Journal of Labelled Compounds and Radiopharmaceuticals, 15 March 2005, Vol.48(3), pp.203-208 [Peer Reviewed Journal]

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26
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Synthesis of 13 C‐Labeled Pyrazinone Thrombin Inhibitors and Elucidation of Metabolic Activation Pathways

Ho, Jonathan Z. ; Braun, Matthew P. ; Subramanian, Raju ; Gao, Ying‐Duo ; Dean, DennisC. ; Melillo, David G.

Helvetica Chimica Acta, March 2004, Vol.87(3), pp.674-681 [Peer Reviewed Journal]

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27
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Pharmacological characterization and radioligand binding properties of a high-affinity, nonpeptide, bradykinin B 1 receptor antagonist

Ransom, Richard W ; Harrell, Charles M ; Reiss, Duane R ; Murphy, Kathryn L ; Chang, Raymond S.L ; Hess, J. Fred ; Miller, Patricia J ; O'Malley, Stacey S ; Hey, Pat J ; Kunapuli, Priya ; Su, Dai-Shi ; Markowitz, M. Kristine ; Wallace, Michael A ; Raab, Conrad E ; Jones, Allen N ; Dean, Dennis C ; Pettibone, Douglas J ; Freidinger, Roger M ; Bock, Mark G

European Journal of Pharmacology, 2004, Vol.499(1), pp.77-84 [Peer Reviewed Journal]

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28
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Synthesis of [C 2 H 3 ]methotrexate and [C 2 H 3 ]7‐hydroxymethotrexate

Elmore, Charles S. ; Dean, Dennis C. ; Zhang, Yong ; Gibson, Carter ; Jenkins, Herb ; Jones, Allen N. ; Melillo, David G.

Journal of Labelled Compounds and Radiopharmaceuticals, January 2002, Vol.45(1), pp.29-36 [Peer Reviewed Journal]

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29
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Multiple strategies for the preparation of a sulfur-35 labeled NPC1L1 radioligand

Simeone, Joseph P ; Braun, Matthew P ; Leone, Joseph F ; Lin, Peter ; Devita, Robert J ; Garcia-Calvo, Margarita ; Bull, Herb G ; Lisnock, Jeanmarie ; Dean, Dennis C

Bioorganic & Medicinal Chemistry Letters, 2009, Vol.19(17), pp.5033-5036 [Peer Reviewed Journal]

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30
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A small molecule alpha4beta1/alpha4beta7 antagonist differentiates between the low-affinity states of alpha4beta1 and alpha4beta7: characterization of divalent cation dependence

Egger, Linda A ; Cao, Jin ; Mccallum, Christine ; Kidambi, Usha ; Van Riper, Gail ; Mccauley, Ermengilda ; Mumford, Richard A ; Lanza, Thomas J ; Lin, Linus S ; De Laszlo, Stephen E ; Young, David N ; Yang, Ginger ; Dean, Dennis C ; Raab, Conrad E ; Wallace, Mike A ; Jones, Allen N ; Hagmann, William K ; Schmidt, John A ; Pepinsky, R Blake ; Scott

The Journal of pharmacology and experimental therapeutics, September 2003, Vol.306(3), pp.903-13 [Peer Reviewed Journal]

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31
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Identification of potent agonists of photoreceptor-specific nuclear receptor (NR2E3) and preparation of a radioligand

Wolkenberg, Scott E ; Zhao, Zhijian ; Kapitskaya, Marianna ; Webber, Andrea L ; Petrukhin, Konstantin ; Tang, Yui Sing ; Dean, Dennis C ; Hartman, George D ; Lindsley, Craig W

Bioorganic & Medicinal Chemistry Letters, 2006, Vol.16(19), pp.5001-5004 [Peer Reviewed Journal]

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32
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Synthesis of the first sulfur-35-labeled hERG radioligand

Raab, Conrad E ; Butcher, John W ; Connolly, Thomas M ; Karczewski, Jerzy ; Yu, Nathan X ; Staskiewicz, Steven J ; Liverton, Nigel ; Dean, Dennis C ; Melillo, David G

Bioorganic & Medicinal Chemistry Letters, 15 March 2006, Vol.16(6), pp.1692-1695 [Peer Reviewed Journal]

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33
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Validation of (-)-N-3-benzyl-phenobarbital as a selective inhibitor of CYP2C19 in human liver microsomes

Cai, Xiaoxin ; Wang, Regina W ; Edom, Richard W ; Evans, David C ; Shou, Magang ; Rodrigues, A David ; Liu, Wensheng ; Dean, Dennis C ; Baillie, Thomas A

Drug metabolism and disposition: the biological fate of chemicals, June 2004, Vol.32(6), pp.584-6 [Peer Reviewed Journal]

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34
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The Potential for CYP2D6 Inhibition Screening Using a Novel Scintillation Proximity Assay-Based Approach

Delaporte, Enock ; Slaughter, Donald E ; Egan, Marjorie A ; Gatto, Gregory J ; Santos, Albie ; Shelley, Joanne ; Price, Elizabeth ; Howells, Leighton ; Dean, Dennis C ; Rodrigues, A. David

Journal of Biomolecular Screening, August 2001, Vol.6(4), pp.225-231 [Peer Reviewed Journal]

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35
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In vitro metabolic activation of lumiracoxib in rat and human liver preparations

Li, Ying ; Slatter, J Greg ; Zhang, Zhoupeng ; Li, Yan ; Doss, George A ; Braun, Matthew P ; Stearns, Ralph A ; Dean, Dennis C ; Baillie, Thomas A ; Tang, Wei

Drug metabolism and disposition: the biological fate of chemicals, February 2008, Vol.36(2), pp.469-73 [Peer Reviewed Journal]

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36
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Use of Dibutyl[ 14 C]formamide as a Formylating Reagent in the Vilsmeier – Haack Reaction and Synthesis of a 14 C‐Labeled Novel Phosphodiesterase‐4 (PDE‐4) Inhibitor

Ho, Jonathan Z. ; Elmore, Charles S. ; Wallace, Michael A. ; Yao, Dan ; Braun, Matthew P. ; Dean, DennisC. ; Melillo, David G. ; Chen, Cheng‐Yi

Helvetica Chimica Acta, May 2005, Vol.88(5), pp.1040-1047 [Peer Reviewed Journal]

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37
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