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1
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Structural insights into the mechanism for recognizing substrate of the cytochrome P450 enzyme TxtE

Yu, Feng ; Li, Minjun ; Xu, Chunyan ; Wang, Zhijun ; Zhou, Huan ; Yang, Min ; Chen, Yaxing ; Tang, Lin ; He, Jianhua

PloS one, 2013, Vol.8(11), pp.e81526 [Peer Reviewed Journal]

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Newly identified CYP2C93 is a functional enzyme in rhesus monkey, but not in cynomolgus monkey

Uno, Yasuhiro ; Uehara, Shotaro ; Kohara, Sakae ; Iwasaki, Kazuhide ; Nagata, Ryoichi ; Fukuzaki, Koichiro ; Utoh, Masahiro ; Murayama, Norie ; Yamazaki, Hiroshi

PloS one, 08 February 2011, Vol.6(2), pp.e16923 [Peer Reviewed Journal]

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3
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Water oxidation by a cytochrome p450: mechanism and function of the reaction

Prasad, Brinda ; Mah, Derrick J ; Lewis, Andrew R ; Plettner, Erika

PloS one, 2013, Vol.8(4), pp.e61897 [Peer Reviewed Journal]

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4
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Kinetic isotope effects implicate two electrophilic oxidants in cytochrome p450-catalyzed hydroxylations

Newcomb, Martin ; Aebisher, David ; Shen, Runnan ; Chandrasena, R Esala P ; Hollenberg, Paul F ; Coon, Minor J

Journal of the American Chemical Society, 21 May 2003, Vol.125(20), pp.6064-5 [Peer Reviewed Journal]

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Oxygen economy of cytochrome P450: what is the origin of the mixed functionality as a dehydrogenase-oxidase enzyme compared with its normal function?

Kumar, Devesh ; De Visser, Samuël P ; Shaik, Sason

Journal of the American Chemical Society, 28 April 2004, Vol.126(16), pp.5072-3 [Peer Reviewed Journal]

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6
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What factors affect the regioselectivity of oxidation by cytochrome p450? A DFT study of allylic hydroxylation and double bond epoxidation in a model reaction

De Visser, Sam P ; Ogliaro, François ; Sharma, Pankaz K ; Shaik, Sason

Journal of the American Chemical Society, 02 October 2002, Vol.124(39), pp.11809-26 [Peer Reviewed Journal]

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7
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Computational explanation for bioactivation mechanism of targeted anticancer agents mediated by cytochrome P450s: A case of Erlotinib

Ai, Chun-Zhi ; Liu, Yong ; Li, Wei ; Chen, De-Meng ; Zhu, Xin-Xing ; Yan, Ya-Wei ; Chen, Du-Chu ; Jiang, Yi-Zhou

PloS one, 2017, Vol.12(6), pp.e0179333 [Peer Reviewed Journal]

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8
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Formation of cyclopropanone during cytochrome P450-catalyzed N-dealkylation of a cyclopropylamine

Shaffer, Christopher L ; Harriman, Shawn ; Koen, Yakov M ; Hanzlik, Robert P

Journal of the American Chemical Society, 17 July 2002, Vol.124(28), pp.8268-74 [Peer Reviewed Journal]

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9
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CYP2J2 overexpression protects against arrhythmia susceptibility in cardiac hypertrophy

Westphal, Christina ; Spallek, Bastian ; Konkel, Anne ; Marko, Lajos ; Qadri, Fatimunnisa ; Degraff, Laura M ; Schubert, Carola ; Bradbury, J Alyce ; Regitz-Zagrosek, Vera ; Falck, John R ; Zeldin, Darryl C ; Müller, Dominik N ; Schunck, Wolf-Hagen ; Fischer, Robert

PloS one, 2013, Vol.8(8), pp.e73490 [Peer Reviewed Journal]

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10
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Exploring the electron transfer pathway in the oxidation of avermectin by CYP107Z13 in Streptomyces ahygroscopicus ZB01

Li, Mei ; Zhang, Yujie ; Zhang, Lin ; Yang, Xiaoyan ; Jiang, Xiliang

PloS one, 2014, Vol.9(6), pp.e98916 [Peer Reviewed Journal]

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11
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Important role of CYP2J2 in protein kinase inhibitor degradation: a possible role in intratumor drug disposition and resistance

Narjoz, Céline ; Favre, Amélie ; Mcmullen, Justin ; Kiehl, Philippe ; Montemurro, Michael ; Figg, William D ; Beaune, Philippe ; De Waziers, Isabelle ; Rochat, Bertrand

PloS one, 2014, Vol.9(5), pp.e95532 [Peer Reviewed Journal]

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12
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Novel cytochrome P450, cyp6a17, is required for temperature preference behavior in Drosophila

Kang, Jongkyun ; Kim, Jaeseob ; Choi, Kwang-Wook

PloS one, 2011, Vol.6(12), pp.e29800 [Peer Reviewed Journal]

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13
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What is the active species of cytochrome P450 during camphor hydroxylation? QM/MM studies of different electronic states of compound I and of reduced and oxidized iron-oxo intermediates

Altun, Ahmet ; Shaik, Sason ; Thiel, Walter

Journal of the American Chemical Society, 25 July 2007, Vol.129(29), pp.8978-87 [Peer Reviewed Journal]

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14
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Genetics. SNP-ing drugs to size

Gura, T

Science (New York, N.Y.), 27 July 2001, Vol.293(5530), pp.595 [Peer Reviewed Journal]

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15
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Cytochrome P450-dependent metabolism of caffeine in Drosophila melanogaster

Coelho, Alexandra ; Fraichard, Stephane ; Le Goff, Gaëlle ; Faure, Philippe ; Artur, Yves ; Ferveur, Jean-François ; Heydel, Jean-Marie

PloS one, 2015, Vol.10(2), pp.e0117328 [Peer Reviewed Journal]

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16
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Microsomal P450-catalyzed N-dealkylation of N,N-dialkylanilines: evidence for a C(alpha)-H abstraction mechanism

Bhakta, Mehul N ; Wimalasena, Kandatege

Journal of the American Chemical Society, 06 March 2002, Vol.124(9), pp.1844-5 [Peer Reviewed Journal]

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17
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CYP5122A1, a novel cytochrome P450 is essential for survival of Leishmania donovani

Verma, Smriti ; Mehta, Ashish ; Shaha, Chandrima

PloS one, 2011, Vol.6(9), pp.e25273 [Peer Reviewed Journal]

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18
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Enzymatic N-dealkylation of an N-cyclopropylamine: an unusual fate for the cyclopropyl group

Shaffer, C L ; Morton, M D ; Hanzlik, R P

Journal of the American Chemical Society, 17 January 2001, Vol.123(2), pp.349-50 [Peer Reviewed Journal]

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19
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Ribosomal protein S29 regulates metabolic insecticide resistance through binding and degradation of CYP6N3

Yu, Jing ; Hu, Shengli ; Ma, Kai ; Sun, Linchun ; Hu, Hongxia ; Zou, Feifei ; Guo, Qin ; Lei, Zhentao ; Zhou, Dan ; Sun, Yan ; Zhang, Donghui ; Ma, Lei ; Shen, Bo ; Zhu, Changliang

PloS one, 2014, Vol.9(4), pp.e94611 [Peer Reviewed Journal]

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20
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Searching the cytochrome p450 enzymes for the metabolism of meranzin hydrate: a prospective antidepressant originating from Chaihu-Shugan-San

Huang, Xi ; Guo, Ying ; Huang, Wei-Hua ; Zhang, Wei ; Tan, Zhi-Rong ; Peng, Jing-Bo ; Wang, Yi-Cheng ; Hu, Dong-Li ; Ouyang, Dong-Sheng ; Xiao, Jian ; Wang, Yang ; Luo, Min ; Chen, Yao

PloS one, 2014, Vol.9(11), pp.e113819 [Peer Reviewed Journal]

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21
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Enhanced electron transfer and lauric acid hydroxylation by site-directed mutagenesis of CYP119

Koo, Laura S ; Immoos, Chad E ; Cohen, Michael S ; Farmer, Patrick J ; Ortiz De Montellano, Paul R

Journal of the American Chemical Society, 22 May 2002, Vol.124(20), pp.5684-91 [Peer Reviewed Journal]

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22
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Thermodynamic and kinetic studies on the binding of nitric oxide to a new enzyme mimic of cytochrome p450

Franke, Alicja ; Hessenauer-Ilicheva, Natalya ; Meyer, Dominik ; Stochel, Grazyna ; Woggon, Wolf-D ; Van Eldik, Rudi

Journal of the American Chemical Society, 18 October 2006, Vol.128(41), pp.13611-24 [Peer Reviewed Journal]

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23
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Nonenzymatic oxidative steps accompanying action of the cytochrome P450 enzymes StaP and RebP in the biosynthesis of staurosporine and rebeccamycin

Howard-Jones, Annaleise R ; Walsh, Christopher T

Journal of the American Chemical Society, 12 September 2007, Vol.129(36), pp.11016-7 [Peer Reviewed Journal]

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24
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Combination of Plant Metabolic Modules Yields Synthetic Synergies

Rajabi, Fatemeh ; Heene, Ernst ; Maisch, Jan ; Nick, Peter

PloS one, 2017, Vol.12(1), pp.e0169778 [Peer Reviewed Journal]

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25
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Vascular endothelial overexpression of human CYP2J2 (Tie2-CYP2J2 Tr) modulates cardiac oxylipin profiles and enhances coronary reactive hyperemia in mice

Hanif, Ahmad ; Edin, Matthew L ; Zeldin, Darryl C ; Morisseau, Christophe ; Falck, John R ; Nayeem, Mohammed A

PloS one, 2017, Vol.12(3), pp.e0174137 [Peer Reviewed Journal]

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26
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Metabolizing enzyme toxicology assay chip (MetaChip) for high-throughput microscale toxicity analyses

Lee, Moo-Yeal ; Park, Chan Beum ; Dordick, Jonathan S ; Clark, Douglas S

Proceedings of the National Academy of Sciences of the United States of America, 25 January 2005, Vol.102(4), pp.983-7 [Peer Reviewed Journal]

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27
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Low-temperature rapid-scan detection of reactive intermediates in epoxidation reactions catalyzed by a new enzyme mimic of cytochrome p450

Hessenauer-Ilicheva, Natalya ; Franke, Alicja ; Meyer, Dominik ; Woggon, Wolf-D ; Van Eldik, Rudi

Journal of the American Chemical Society, 17 October 2007, Vol.129(41), pp.12473-9 [Peer Reviewed Journal]

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28
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Defective Cytochrome P450-Catalysed Drug Metabolism in Niemann-Pick Type C Disease

Nicoli, Elena-Raluca ; Al Eisa, Nada ; Cluzeau, Celine V M ; Wassif, Christopher A ; Gray, James ; Burkert, Kathryn R ; Smith, David A ; Morris, Lauren ; Cologna, Stephanie M ; Peer, Cody J ; Sissung, Tristan M ; Uscatu, Constantin-Daniel ; Figg, William D ; Pavan, William J ; Vite, Charles H ; Porter, Forbes D ; Platt, Frances M

PloS one, 2016, Vol.11(3), pp.e0152007 [Peer Reviewed Journal]

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29
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Cytochrome P450 CYP1B1 interacts with 8-methoxypsoralen (8-MOP) and influences psoralen-ultraviolet A (PUVA) sensitivity

Deeni, Yusuf Y ; Ibbotson, Sally H ; Woods, Julie A ; Wolf, C Roland ; Smith, Gillian

PloS one, 2013, Vol.8(9), pp.e75494 [Peer Reviewed Journal]

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30
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Enzymes. Picking a winner

Sheldon, R

Nature, 17 June 1999, Vol.399(6737), pp.636-7 [Peer Reviewed Journal]

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31
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Formation of the aureothin tetrahydrofuran ring by a bifunctional cytochrome p450 monooxygenase

He, Jing ; Müller, Markus ; Hertweck, Christian

Journal of the American Chemical Society, 29 December 2004, Vol.126(51), pp.16742-3 [Peer Reviewed Journal]

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32
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Purification of an allene oxide synthase and identification of the enzyme as a cytochrome P-450

Song, W C ; Brash, A R

Science (New York, N.Y.), 16 August 1991, Vol.253(5021), pp.781-4 [Peer Reviewed Journal]

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33
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Involvement of cytochrome P450 in pentachlorophenol transformation in a white rot fungus Phanerochaete chrysosporium

Ning, Daliang ; Wang, Hui

PloS one, 2012, Vol.7(9), pp.e45887 [Peer Reviewed Journal]

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34
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Role of the cytochrome P450 NocL in nocardicin A biosynthesis

Kelly, Wendy L ; Townsend, Craig A

Journal of the American Chemical Society, 17 July 2002, Vol.124(28), pp.8186-7 [Peer Reviewed Journal]

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35
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Endogenous epoxygenases are modulators of monocyte/macrophage activity

Bystrom, Jonas ; Wray, Jessica A ; Sugden, Mary C ; Holness, Mark J ; Swales, Karen E ; Warner, Timothy D ; Edin, Matthew L ; Zeldin, Darryl C ; Gilroy, Derek W ; Bishop-Bailey, David

PloS one, 2011, Vol.6(10), pp.e26591 [Peer Reviewed Journal]

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36
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Multiple active intermediates in oxidation reaction catalyzed by synthetic heme-thiolate complex relevant to cytochrome p450

Suzuki, Noriyuki ; Higuchi, Tsunehiko ; Nagano, Tetsuo

Journal of the American Chemical Society, 14 August 2002, Vol.124(32), pp.9622-8 [Peer Reviewed Journal]

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