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11 Results  for Everything (Includes Articles)

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Functional analysis of sites within PCSK9 responsible for hypercholesterolemia

Pandit, Shilpa ; Wisniewski, Doug ; Santoro, Joseph C ; Ha, Sookhee ; Ramakrishnan, Vijayalakshmi ; Cubbon, Rose M ; Cummings, Richard T ; Wright, Samuel D ; Sparrow, Carl P ; Sitlani, Ayesha ; Fisher, Timothy S

Journal of lipid research, June 2008, Vol.49(6), pp.1333-43 [Peer Reviewed Journal]

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Design, synthesis, and biological evaluation of aminopyrazine derivatives as inhibitors of mitogen-activated protein kinase-activated protein kinase 2 (MK-2)

Lin, Songnian ; Malkani, Sunita ; Lombardo, Matthew ; Yang, Lihu ; Mills, Sander G ; Chapman, Kevin ; Thompson, James E ; Zhang, Wen Xiao ; Wang, Ruixiu ; Cubbon, Rose M ; O’neill, Edward A ; Hale, Jeffrey J

Bioorganic & Medicinal Chemistry Letters, 15 November 2015, Vol.25(22), pp.5402-5408 [Peer Reviewed Journal]

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Effects of pH and low density lipoprotein (LDL) on PCSK9-dependent LDL receptor regulation

Fisher, Timothy S ; Lo Surdo, Paola ; Pandit, Shilpa ; Mattu, Marco ; Santoro, Joseph C ; Wisniewski, Doug ; Cummings, Richard T ; Calzetta, Alessandra ; Cubbon, Rose M ; Fischer, Paul A ; Tarachandani, Anil ; De Francesco, Raffaele ; Wright, Samuel D ; Sparrow, Carl P ; Carfi, Andrea ; Sitlani, Ayesha

The Journal of biological chemistry, 13 July 2007, Vol.282(28), pp.20502-12 [Peer Reviewed Journal]

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Structural and biochemical characterization of the wild type PCSK9-EGF(AB) complex and natural familial hypercholesterolemia mutants

Bottomley, Matthew J ; Cirillo, Agostino ; Orsatti, Laura ; Ruggeri, Lionello ; Fisher, Timothy S ; Santoro, Joseph C ; Cummings, Richard T ; Cubbon, Rose M ; Lo Surdo, Paola ; Calzetta, Alessandra ; Noto, Alessia ; Baysarowich, Jennifer ; Mattu, Marco ; Talamo, Fabio ; De Francesco, Raffaele ; Sparrow, Carl P ; Sitlani, Ayesha ; Carfí, Andrea

The Journal of biological chemistry, 09 January 2009, Vol.284(2), pp.1313-23 [Peer Reviewed Journal]

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A PCSK9-binding antibody that structurally mimics the EGF(A) domain of LDL-receptor reduces LDL cholesterol in vivo

Ni, Yan G ; Di Marco, Stefania ; Condra, Jon H ; Peterson, Laurence B ; Wang, Weirong ; Wang, Fubao ; Pandit, Shilpa ; Hammond, Holly A ; Rosa, Ray ; Cummings, Richard T ; Wood, Dana D ; Liu, Xiaomei ; Bottomley, Matthew J ; Shen, Xun ; Cubbon, Rose M ; Wang, Sheng-Ping ; Johns, Douglas G ; Volpari, Cinzia ; Hamuro, Lora ; Chin, Jayne ; Huang, Lingyi ; Zhao, Jing Zhang ; Vitelli, Salvatore ; Haytko, Peter ; Wisniewski, Douglas ; Mitnaul, Lyndon J ; Sparrow, Carl P ; Hubbard, Brian ; Carfí, Andrea ; Sitlani, Ayesha

Journal of lipid research, January 2011, Vol.52(1), pp.78-86 [Peer Reviewed Journal]

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A proprotein convertase subtilisin-like/kexin type 9 (PCSK9) C-terminal domain antibody antigen-binding fragment inhibits PCSK9 internalization and restores low density lipoprotein uptake

Ni, Yan G ; Condra, Jon H ; Orsatti, Laura ; Shen, Xun ; Di Marco, Stefania ; Pandit, Shilpa ; Bottomley, Matthew J ; Ruggeri, Lionello ; Cummings, Richard T ; Cubbon, Rose M ; Santoro, Joseph C ; Ehrhardt, Anka ; Lewis, Dale ; Fisher, Timothy S ; Ha, Sookhee ; Njimoluh, Leila ; Wood, Dana D ; Hammond, Holly A ; Wisniewski, Douglas ; Volpari, Cinzia ; Noto, Alessia ; Lo Surdo, Paola ; Hubbard, Brian ; Carfí, Andrea ; Sitlani, Ayesha

The Journal of biological chemistry, 23 April 2010, Vol.285(17), pp.12882-91 [Peer Reviewed Journal]

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Novel 1-(2-aminopyrazin-3-yl)methyl-2-thioureas as potent inhibitors of mitogen-activated protein kinase-activated protein kinase 2 (MK-2)

Lin, Songnian ; Lombardo, Matthew ; Malkani, Sunita ; Hale, Jeffrey J ; Mills, Sander G ; Chapman, Kevin ; Thompson, James E ; Zhang, Wen Xiao ; Wang, Ruixiu ; Cubbon, Rose M ; O’neill, Edward A ; Luell, Silvi ; Carballo-Jane, Ester ; Yang, Lihu

Bioorganic & Medicinal Chemistry Letters, 2009, Vol.19(12), pp.3238-3242 [Peer Reviewed Journal]

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Photochemical preparation of a pyridone containing tetracycle: A jak protein kinase inhibitor

Thompson, James E ; Cubbon, Rose M ; Cummings, Richard T ; Wicker, Linda S ; Frankshun, Robert ; Cunningham, Barry R ; Cameron, Patricia M ; Meinke, Peter T ; Liverton, Nigel ; Weng, Youmin ; Demartino, Julie A

Bioorganic & Medicinal Chemistry Letters, 22 April 2002, Vol.12(8), pp.1219-1223 [Peer Reviewed Journal]

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Tetrapeptide derived inhibitors of complexation of a class II MHC: the peptide backbone is not inviolate

Jones, A.Brian ; Acton, John J ; Rivetna, Meheryar N ; Cummings, Richard T ; Cubbon, Rose M ; Nichols, Elizabeth A ; Schwartz, Cheryl D ; Wicker, Linda S ; Hermes, Jeffrey D

Bioorganic & Medicinal Chemistry Letters, 1999, Vol.9(14), pp.2109-2114 [Peer Reviewed Journal]

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DIFFERENTIAL GLYCOSYLATION OF INTERLEUKIN 2, THE MOLECULAR BASIS FOR THE NOD Idd3 TYPE 1 DIABETES GENE?

Podolin, Patricia L ; Wilusz, Mary Beth ; Cubbon, Rose M ; Pajvani, Utpal ; Lord, Christopher J ; Todd, John A ; Peterson, Laurence B ; Wicker, Linda S ; Lyons, Paul A

Cytokine, May 2000, Vol.12(5), pp.477-482 [Peer Reviewed Journal]

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p38 MAP kinase inhibitors: Metabolically stabilized piperidine-substituted quinolinones and naphthyridinones

Bao, Jianming ; Hunt, Julianne A ; Miao, Shouwu ; Rupprecht, Kathleen M ; Stelmach, John E ; Liu, Luping ; Ruzek, Rowena D ; Sinclair, Peter J ; Pivnichny, James V ; Hop, Cornelis E.C.A ; Kumar, Sanjeev ; Zaller, Dennis M ; Shoop, Wesley L ; O’neill, Edward A ; O’keefe, Stephen J ; Thompson, Chris M ; Cubbon, Rose M ; Wang, Ruixiu ; Zhang, Wen Xiao ; Thompson, James E ; Doherty, James B

Bioorganic & Medicinal Chemistry Letters, 2006, Vol.16(1), pp.64-68 [Peer Reviewed Journal]

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