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19 Results  for Everything (Includes Articles)

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Rapid pharmacokinetic screening for the selection of new drug discovery candidates using a generic isocratic liquid chromatography–atmospheric pressure ionization tandem mass spectrometry method

Colwell, Lawrence F ; Tamvakopoulos, Constantin S ; Wang, Pei Ran ; Pivnichny, James V ; Shih, Thomas L

Journal of Chromatography B, 2002, Vol.772(1), pp.89-98 [Peer Reviewed Journal]

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Autooxidation of simvastatin

Smith, George B ; Dimichele, Lisa ; Colwell, Lawrence F ; Dezeny, George C ; Douglas, Alan W ; Reamer, Robert A ; Verhoeven, Thomas R

Tetrahedron, 1993, Vol.49(21), pp.4447-4462 [Peer Reviewed Journal]

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Characterization of resistance to non-obligate chain-terminating ribonucleoside analogs that inhibit hepatitis C virus replication in vitro

Migliaccio, Giovanni ; Tomassini, Joanne E ; Carroll, Steven S ; Tomei, Licia ; Altamura, Sergio ; Bhat, Balkrishen ; Bartholomew, Linda ; Bosserman, Michele R ; Ceccacci, Alessandra ; Colwell, Lawrence F ; Cortese, Riccardo ; De Francesco, Raffaele ; Eldrup, Anne B ; Getty, Krista L ; Hou, Xiaoli S ; Lafemina, Robert L ; Ludmerer, Steven W ; Maccoss, Malcolm ; Mcmasters, Daniel R ; Stahlhut, Mark W ; Olsen, David B ; Hazuda, Daria J ; Flores, Osvaldo A

The Journal of biological chemistry, 05 December 2003, Vol.278(49), pp.49164-70 [Peer Reviewed Journal]

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Structure-activity relationship of heterobase-modified 2'-C-methyl ribonucleosides as inhibitors of hepatitis C virus RNA replication

Eldrup, Anne B ; Prhavc, Marija ; Brooks, Jennifer ; Bhat, Balkrishen ; Prakash, Thazha P ; Song, Quanlai ; Bera, Sanjib ; Bhat, Neelima ; Dande, Prasad ; Cook, P Dan ; Bennett, C Frank ; Carroll, Steven S ; Ball, Richard G ; Bosserman, Michele ; Burlein, Christine ; Colwell, Lawrence F ; Fay, John F ; Flores, Osvaldo A ; Getty, Krista ; Lafemina, Robert L ; Leone, Joseph ; Maccoss, Malcolm ; Mcmasters, Daniel R ; Tomassini, Joanne E ; Von Langen, Derek ; Wolanski, Bohdan ; Olsen, David B

Journal of medicinal chemistry, 07 October 2004, Vol.47(21), pp.5284-97 [Peer Reviewed Journal]

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A 7-deaza-adenosine analog is a potent and selective inhibitor of hepatitis C virus replication with excellent pharmacokinetic properties

Olsen, David B ; Eldrup, Anne B ; Bartholomew, Linda ; Bhat, Balkrishen ; Bosserman, Michele R ; Ceccacci, Alessandra ; Colwell, Lawrence F ; Fay, John F ; Flores, Osvaldo A ; Getty, Krista L ; Grobler, Jay A ; Lafemina, Robert L ; Markel, Eric J ; Migliaccio, Giovanni ; Prhavc, Marija ; Stahlhut, Mark W ; Tomassini, Joanne E ; Maccoss, Malcolm ; Hazuda, Daria J ; Carroll

Antimicrobial agents and chemotherapy, October 2004, Vol.48(10), pp.3944-53 [Peer Reviewed Journal]

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Discovery of a Potent, Orally Bioavailable β 3 Adrenergic Receptor Agonist, ( R )- N -[4-[2-[[2-Hydroxy-2-(3-pyridinyl)ethyl]amino]ethyl]phenyl]-4-[4-[4-(trifluoromethyl)phenyl]thiazol-2-yl]benzenesulfonamide
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Discovery of a Potent, Orally Bioavailable β 3 Adrenergic Receptor Agonist, ( R )- N -[4-[2-[[2-Hydroxy-2-(3-pyridinyl)ethyl]amino]ethyl]phenyl]-4-[4-[4-(trifluoromethyl)phenyl]thiazol-2-yl]benzenesulfonamide

Mathvink, Robert J. ; Tolman, J. Samuel ; Chitty, Dawn ; Candelore, Mari R. ; Cascieri, Margaret A. ; Colwell, Lawrence F. ; Deng, Liping ; Feeney, William P. ; Forrest, Michael J. ; Hom, Gary J. ; Macintyre, D. Euan ; Miller, Randall R. ; Stearns, Ralph A. ; Tota, Laurie ; Wyvratt, Matthew J. ; Fisher, Michael H. ; Weber, Ann E.

Journal of Medicinal Chemistry, 10/2000, Vol.43(21), pp.3832-3836 [Peer Reviewed Journal]

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Control of rat tail skin temperature regulation by estrogen receptor-beta selective ligand

Opas, Evan E ; Scafonas, Angela ; Nantermet, Pascale V ; Wilkening, Robert R ; Birzin, Elizabeth T ; Wilkinson, Hilary ; Colwell, Lawrence F ; Schaeffer, James M ; Towler, Dwight A ; Rodan, Gideon A ; Schmidt, Azriel

Maturitas, 2009, Vol.64(1), pp.46-51 [Peer Reviewed Journal]

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Erratum to “Triazolo-tetrahydrofluorenones as selective estrogen receptor beta agonists” [Bioorg. Med. Chem. Lett. 16 (2006) 4652–4656]

Parker, Dann L ; Meng, Dongfang ; Ratcliffe, Ronald W ; Wilkening, Robert R ; Sperbeck, Donald M ; Greenlee, Mark L ; Colwell, Lawrence F ; Lambert, Sherrie ; Birzin, Elizabeth T ; Frisch, Katalin ; Rohrer, Susan P ; Nilsson, Stefan ; Thorsell, Ann-Gerd ; Hammond, Milton L

Bioorganic & Medicinal Chemistry Letters, 2006, Vol.16(20), pp.5472-5472 [Peer Reviewed Journal]

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Triazolo-tetrahydrofluorenones as selective estrogen receptor beta agonists

Parker, Dann L ; Meng, Dongfang ; Ratcliffe, Ronald W ; Wilkening, Robert R ; Sperbeck, Donald M ; Greenlee, Mark L ; Colwell, Lawrence F ; Lambert, Sherrie ; Birzin, Elizabeth T ; Frisch, Katalin ; Rohrer, Susan P ; Nilsson, Stefan ; Thorsell, Ann-Gerd ; Hammond, Milton L

Bioorganic & Medicinal Chemistry Letters, 2006, Vol.16(17), pp.4652-4656 [Peer Reviewed Journal]

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Discovery of potent and selective β-homophenylalanine based dipeptidyl peptidase IV inhibitors

Xu, Jinyou ; Ok, Hyun O ; Gonzalez, Edward J ; Colwell, Lawrence F ; Habulihaz, Bahanu ; He, Huaibing ; Leiting, Barbara ; Lyons, Kathryn A ; Marsilio, Frank ; Patel, Reshma A ; Wu, Joseph K ; Thornberry, Nancy A ; Weber, Ann E ; Parmee, Emma R

Bioorganic & Medicinal Chemistry Letters, 2004, Vol.14(18), pp.4759-4762 [Peer Reviewed Journal]

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Substituted piperazines as novel dipeptidyl peptidase IV inhibitors

Brockunier, Linda L ; He, Jiafang ; Colwell, Lawrence F ; Habulihaz, Bahanu ; He, Huaibing ; Leiting, Barbara ; Lyons, Kathryn A ; Marsilio, Frank ; Patel, Reshma A ; Teffera, Yohannes ; Wu, Joseph K ; Thornberry, Nancy A ; Weber, Ann E ; Parmee, Emma R

Bioorganic & Medicinal Chemistry Letters, 2004, Vol.14(18), pp.4763-4766 [Peer Reviewed Journal]

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Potent and selective proline derived dipeptidyl peptidase IV inhibitors

Edmondson, Scott D ; Mastracchio, Anthony ; Beconi, Maria ; Colwell, Lawrence F ; Habulihaz, Bahanu ; He, Huaibing ; Kumar, Sanjeev ; Leiting, Barbara ; Lyons, Kathryn A ; Mao, Ann ; Marsilio, Frank ; Patel, Reshma A ; Wu, Joseph K ; Zhu, Lan ; Thornberry, Nancy A ; Weber, Ann E ; Parmee, Emma R

Bioorganic & Medicinal Chemistry Letters, 18 October 2004, Vol.14(20), pp.5151-5155 [Peer Reviewed Journal]

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3-pyridylethanolamines: Potent and selective human β 3 adrenergic receptor agonists

Naylor, Elizabeth M ; Colandrea, Vincent J ; Candelore, Mari R ; Cascieri, Margaret A ; Colwell, Lawrence F ; Deng, Liping ; Feeney, William P ; Forrest, Michael J ; Hom, Gary J ; Euan Macintyre, D ; Strader, Catherine D ; Tota, Laurie ; Wang, Pei-Ran ; Wyvratt, Matthew J ; Fisher, Michael H ; Weber, Ann E

Bioorganic & Medicinal Chemistry Letters, 1998, Vol.8(21), pp.3087-3092 [Peer Reviewed Journal]

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Discovery of an orally bioavailable alkyl oxadiazole β 3 adrenergic receptor agonist

Feng, Danqing D ; Biftu, Tesfaye ; Candelore, Mari R ; Cascieri, Margaret A ; Colwell, Lawrence F ; Deng, Liping ; Feeney, William P ; Forrest, Michael J ; Hom, Gary J ; Macintyre, D.Euan ; Miller, Randall R ; Stearns, Ralph A ; Strader, Catherine D ; Tota, Laurie ; Wyvratt, Matthew J ; Fisher, Michael H ; Weber, Ann E

Bioorganic & Medicinal Chemistry Letters, 2000, Vol.10(13), pp.1427-1429 [Peer Reviewed Journal]

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Potent, selective 3-pyridylethanolamine β 3 adrenergic receptor agonists possessing a thiazole benzenesulfonamide pharmacophore

Mathvink, Robert J ; Tolman, J.Samuel ; Chitty, Dawn ; Candelore, Mari R ; Cascieri, Margaret A ; Colwell, Lawrence F ; Deng, Liping ; Feeney, William P ; Forrest, Michael J ; Hom, Gary J ; Macintyre, D.Euan ; Tota, Laurie ; Wyvratt, Matthew J ; Fisher, Michael H ; Weber, Ann E

Bioorganic & Medicinal Chemistry Letters, 2000, Vol.10(17), pp.1971-1973 [Peer Reviewed Journal]

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Human β 3-adrenergic receptor agonists containing 1,2,3-triazole-substituted benzenesulfonamides

Brockunier, Linda L ; Parmee, Emma R ; Ok, Hyun O ; Candelore, Mari R ; Cascieri, Margaret A ; Colwell, Lawrence F ; Deng, Liping ; Feeney, William P ; Forrest, Michael J ; Hom, Gary J ; Macintyre, D.Euan ; Tota, Laurie ; Wyvratt, Matthew J ; Fisher, Michael H ; Weber, Ann E

Bioorganic & Medicinal Chemistry Letters, 2000, Vol.10(18), pp.2111-2114 [Peer Reviewed Journal]

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Human β3 andrenergic receptor agonists containing imidazolidinone and imidazolone benzenesulfonamides

Naylor, Elizabeth M ; Parmee, Emma R ; Colandrea, Vincent J ; Perkins, Leroy ; Brockunier, Linda ; Candelore, Mari R ; Cascieri, Margaret A ; Colwell, Lawrence F ; Deng, Liping ; Feeney, William P ; Forrest, Michael J ; Hom, Gary J ; Macintyre, D.Euan ; Strader, Catherine D ; Tota, Laurie ; Wang, Pei-Ran ; Wyvratt, Matthew J ; Fisher, Michael H ; Weber, Ann E

Bioorganic & Medicinal Chemistry Letters, 1999, Vol.9(5), pp.755-758 [Peer Reviewed Journal]

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Synthesis and SAR of benzyl and phenoxymethylene oxadiazole benzenesulfonamides as selective β 3 adrenergic receptor agonist antiobesity agents

Biftu, Tesfaye ; Feng, Dennis D ; Liang, Gui-Bai ; Kuo, Howard ; Qian, Xiaoxia ; Naylor, Elizabeth M ; Colandrea, Vincent J ; Candelore, Mari R ; Cascieri, Margaret A ; Colwell, Lawrence F ; Forrest, Michael J ; Hom, Gary J ; Macintyre, D.Euan ; Stearns, Ralph A ; Strader, Catherine D ; Wyvratt, Matthew J ; Fisher, Michael H ; Weber, Ann E

Bioorganic & Medicinal Chemistry Letters, 2000, Vol.10(13), pp.1431-1434 [Peer Reviewed Journal]

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L-770,644: A potent and selective human β3 adrenergic receptor agonist with improved oral bioavailability

Shih, Thomas L ; Candelore, Mari R ; Cascieri, Margaret A ; Chiu, Shuet-Hing L ; Colwell, Lawrence F ; Deng, Liping ; Feeney, William P ; Forrest, Michael J ; Hom, Gary J ; Macintyre, D.Euan ; Miller, Randall R ; Stearns, Ralph A ; Strader, Catherine D ; Tota, Laurie ; Wyvratt, Matthew J ; Fisher, Michael H ; Weber, Ann E

Bioorganic & Medicinal Chemistry Letters, 1999, Vol.9(9), pp.1251-1254 [Peer Reviewed Journal]

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