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Characterization of the selective mGluR1 antagonist, JNJ16259685, in rodent models of movement and coordination

Hodgson, Robert A ; Hyde, Lynn A ; Guthrie, Donald H ; Cohen-Williams, Mary E ; Leach, Prescott T ; Kazdoba, Tatiana M ; Bleickardt, Carina J ; Lu, Sherry X ; Parker, Eric M ; Varty, Geoffrey B

Pharmacology, Biochemistry and Behavior, April 2011, Vol.98(2), pp.181-187 [Peer Reviewed Journal]

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Cyclic hydroxyamidines as amide isosteres: discovery of oxadiazolines and oxadiazines as potent and highly efficacious γ-secretase modulators in vivo

Sun, Zhong-Yue ; Asberom, Theodros ; Bara, Thomas ; Bennett, Chad ; Burnett, Duane ; Chu, Inhou ; Clader, John ; Cohen-Williams, Mary ; Cole, David ; Czarniecki, Michael ; Durkin, James ; Gallo, Gioconda ; Greenlee, William ; Josien, Hubert ; Huang, Xianhai ; Hyde, Lynn ; Jones, Nicholas ; Kazakevich, Irina ; Li, Hongmei ; Liu, Xiaoxiang ; Lee, Julie ; Maccoss, Malcolm ; Mandal, Mihir B ; Mccracken, Troy ; Nomeir, Amin ; Mazzola, Robert ; Palani, Anandan ; Parker, Eric M ; Pissarnitski, Dmitri A ; Qin, Jun ; Song, Lixin ; Terracina, Giuseppe ; Vicarel, Monica ; Voigt, Johannes ; Xu, Ruo ; Zhang, Lili ; Zhang, Qi ; Zhao, Zhiqiang ; Zhu, Xiaohong ; Zhu, Zhaoning

Journal of medicinal chemistry, 12 January 2012, Vol.55(1), pp.489-502 [Peer Reviewed Journal]

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Potent and selective adenosine A 2A receptor antagonists: [1,2,4]-triazolo[4,3- c]pyrimidin-3-ones

Harris, Joel M ; Neustadt, Bernard R ; Zhang, Hongtao ; Lachowicz, Jean ; Cohen-Williams, Mary ; Varty, Geoff ; Hao, Jinsong ; Stamford, Andrew W

Bioorganic & Medicinal Chemistry Letters, 2011, Vol.21(8), pp.2497-2501 [Peer Reviewed Journal]

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The antipsychotic drug, fluphenazine, effectively reverses mechanical allodynia in rat models of neuropathic pain

Dong, Xiao-Wei ; Jia, Yuping ; Lu, Sherry ; Zhou, Xiaoping ; Cohen-Williams, Mary ; Hodgson, Robert ; Li, Huiqing ; Priestley, Tony

Psychopharmacology, 2008, Vol.195(4), pp.559-568 [Peer Reviewed Journal]

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The effect of caffeine to increase reaction time in the rat during a test of attention is mediated through antagonism of adenosine A 2A receptors

Higgins, Guy A ; Grzelak, Michael E ; Pond, Annamarie J ; Cohen-Williams, Mary E ; Hodgson, Robert A ; Varty, Geoffrey B

Behavioural Brain Research, 2007, Vol.185(1), pp.32-42 [Peer Reviewed Journal]

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The Discovery of Pyridone and Pyridazone Heterocycles as γ-Secretase Modulators

Huang, Xianhai ; Aslanian, Robert ; Zhou, Wei ; Zhu, Xiaohong ; Qin, Jun ; Greenlee, William ; Zhu, Zhaoning ; Zhang, Lili ; Hyde, Lynn ; Chu, Inhou ; Cohen-Williams, Mary ; Palani, Anandan

ACS medicinal chemistry letters, 08 July 2010, Vol.1(4), pp.184-7 [Peer Reviewed Journal]

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The discovery of fused oxadiazepines as gamma secretase modulators for treatment of Alzheimer’s disease

Li, Hongmei ; Qin, Jun ; Dhondi, Pawan ; Zhou, Wei ; Vicarel, Monica ; Bara, Thomas ; Cole, David ; Josien, Hubert ; Pissarnitski, Dmitri ; Zhu, Zhaoning ; Palani, Anandan ; Aslanian, Robert ; Clader, John ; Czarniecki, Michael ; Greenlee, William ; Cohen-Williams, Mary ; Hyde, Lynn ; Song, Lixin ; Zhang, Lili ; Chu, Inhou ; Huang, Xianhai

Bioorganic & Medicinal Chemistry Letters, 15 January 2013, Vol.23(2), pp.466-471 [Peer Reviewed Journal]

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Discovery of a Potent Pyrazolopyridine Series of γ-Secretase Modulators

Qin, Jun ; Zhou, Wei ; Huang, Xianhai ; Dhondi, Pawan ; Palani, Anandan ; Aslanian, Robert ; Zhu, Zhaoning ; Greenlee, William ; Cohen-Williams, Mary ; Jones, Nicholas ; Hyde, Lynn ; Zhang, Lili

ACS medicinal chemistry letters, 09 June 2011, Vol.2(6), pp.471-6 [Peer Reviewed Journal]

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Design and synthesis of water soluble β-aminosulfone analogues of SCH 900229 as γ-secretase inhibitors

Wu, Wen-Lian ; Burnett, Duane A ; Clader, John ; Greenlee, William J ; Jiang, Qin ; Hyde, Lynn A ; Del Vecchio, Robert A ; Cohen-Williams, Mary E ; Song, Lixin ; Lee, Julie ; Terracina, Giuseppe ; Zhang, Qi ; Nomeir, Amin ; Parker, Eric M ; Zhang, Lili

Bioorganic & Medicinal Chemistry Letters, 01 December 2016, Vol.26(23), pp.5836-5841 [Peer Reviewed Journal]

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Discovery of fused 5,6-bicyclic heterocycles as γ-secretase modulators

Qin, Jun ; Dhondi, Pawan ; Huang, Xianhai ; Mandal, Mihirbaran ; Zhao, Zhiqiang ; Pissarnitski, Dmitri ; Zhou, Wei ; Aslanian, Robert ; Zhu, Zhaoning ; Greenlee, William ; Clader, John ; Zhang, Lili ; Cohen-Williams, Mary ; Jones, Nicholas ; Hyde, Lynn ; Palani, Anandan

Bioorganic & Medicinal Chemistry Letters, 2011, Vol.21(2), pp.664-669 [Peer Reviewed Journal]

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11
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In Vivo Characterization of a Novel -Secretase Inhibitor SCH 697466 in Rodents and Investigation of Strategies for Managing Notch-Related Side Effects

Hyde, Lynn A ; Zhang, Qi ; Del Vecchio, Robert A ; Leach, Prescott T ; Cohen-Williams, Mary E ; Chen, Lei ; Wong, Gwendolyn T ; McHugh, Nansie A ; Chen, Joseph ; Higgins, Guy A ; Asberom, Theodros ; Li, Wei ; Pissarnitski, Dmitri ; Levitan, Diane ; Nomeir, Amin A ; Clader, John W ; Zhang, Lili ; Parker, Eric M Toyn, Jeremy

International Journal of Alzheimer's Disease, 2013, Vol.2013, 14 pages [Peer Reviewed Journal]

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12
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Melanin-concentrating hormone-1 receptor antagonism decreases feeding by reducing meal size

Kowalski, Timothy J ; Farley, Constance ; Cohen-Williams, Mary E ; Varty, Geoffrey ; Spar, Brian D

European Journal of Pharmacology, 2004, Vol.497(1), pp.41-47 [Peer Reviewed Journal]

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13
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Comparison of apomorphine, amphetamine and dizocilpine disruptions of prepulse inhibition in inbred and outbred mice strains

Varty, Geoffrey B ; Walters, Nafesa ; Cohen-Williams, Mary ; Carey, Galen J

European Journal of Pharmacology, 2001, Vol.424(1), pp.27-36 [Peer Reviewed Journal]

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14
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Cholinergic improvement of a naturally-occurring memory deficit in the young rat

Smith, Richard D ; Kistler, Michael K ; Cohen-Williams, Mary ; Coffin, Vicki L

Brain Research, 1996, Vol.707(1), pp.13-21 [Peer Reviewed Journal]

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15
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Structure activity relationship studies of tricyclic bispyran sulfone γ-secretase inhibitors

Wu, Wen-Lian ; Asberom, Theodros ; Bara, Thomas ; Bennett, Chad ; Burnett, Duane A ; Clader, John ; Domalski, Martin ; Greenlee, William J ; Josien, Hubert ; Mcbriar, Mark ; Rajagopalan, Murali ; Vicarel, Monica ; Xu, Ruo ; Hyde, Lynn A ; Del Vecchio, Robert A ; Cohen-Williams, Mary E ; Song, Lixin ; Lee, Julie ; Terracina, Giuseppe ; Zhang, Qi ; Nomeir, Amin ; Parker, Eric M ; Zhang, Lili

Bioorganic & Medicinal Chemistry Letters, 01 February 2013, Vol.23(3), pp.844-849 [Peer Reviewed Journal]

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16
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Synthesis and SAR Studies of Fused Oxadiazines as γ-Secretase Modulators for Treatment of Alzheimer's Disease

Huang, Xianhai ; Zhou, Wei ; Liu, Xiaoxiang ; Li, Hongmei ; Sun, George ; Mandal, Mihirbaran ; Vicarel, Monica ; Zhu, Xiaohong ; Bennett, Chad ; Mccraken, Troy ; Pissarnitski, Dmitri ; Zhao, Zhiqiang ; Cole, David ; Gallo, Gioconda ; Zhu, Zhaoning ; Palani, Anandan ; Aslanian, Robert ; Clader, John ; Czarniecki, Michael ; Greenlee, William ; Burnett, Duane ; Cohen-Williams, Mary ; Hyde, Lynn ; Song, Lixin ; Zhang, Lili ; Chu, Inhou ; Buevich, Alexei

ACS medicinal chemistry letters, 08 November 2012, Vol.3(11), pp.931-5 [Peer Reviewed Journal]

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17
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Discovery of SCH 900229, a Potent Presenilin 1 Selective γ-Secretase Inhibitor for the Treatment of Alzheimer's Disease

Wu, Wen-Lian ; Domalski, Martin ; Burnett, Duane A ; Josien, Hubert ; Bara, Thomas ; Rajagopalan, Murali ; Xu, Ruo ; Clader, John ; Greenlee, William J ; Brunskill, Andrew ; Hyde, Lynn A ; Del Vecchio, Robert A ; Cohen-Williams, Mary E ; Song, Lixin ; Lee, Julie ; Terracina, Giuseppe ; Zhang, Qi ; Nomeir, Amin ; Parker, Eric M ; Zhang, Lili

ACS medicinal chemistry letters, 08 November 2012, Vol.3(11), pp.892-6 [Peer Reviewed Journal]

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18
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Iminoheterocycles as γ-secretase modulators

Caldwell, John P ; Bennett, Chad E ; Mccracken, Troy M ; Mazzola, Robert D ; Bara, Thomas ; Buevich, Alexei ; Burnett, Duane A ; Chu, Inhou ; Cohen-Williams, Mary ; Josein, Hubert ; Hyde, Lynn ; Lee, Julie ; Mckittrick, Brian ; Song, Lixin ; Terracina, Giuseppe ; Voigt, Johannes ; Zhang, Lili ; Zhu, Zhaoning

Bioorganic & Medicinal Chemistry Letters, 2010, Vol.20(18), pp.5380-5384 [Peer Reviewed Journal]

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19
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Facilitation of acetylcholine release and improvement in cognition by a selective M 2 muscarinic antagonist, SCH 72788

Lachowicz, Jean E ; Duffy, Ruth A ; Ruperto, Vilma ; Kozlowski, Joseph ; Zhou, Guowei ; Clader, John ; Billard, William ; Binch, Herbert ; Crosby, Gordon ; Cohen-Williams, Mary ; Strader, Catherine D ; Coffin, Victoria

Life Sciences, 2001, Vol.68(22), pp.2585-2592 [Peer Reviewed Journal]

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20
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Improving the oral efficacy of CNS drug candidates: discovery of highly orally efficacious piperidinyl piperidine M2 muscarinic receptor antagonists

Wang, Yuguang ; Chackalamannil, Samuel ; Hu, Zhiyong ; Greenlee, William J ; Clader, John ; Boyle, Craig D ; Kaminski, James J ; Billard, William ; Binch, Herbert ; Crosby, Gordon ; Ruperto, Vilma ; Duffy, Ruth A ; Cohen-Williams, Mary ; Coffin, Vicki L ; Cox, Kathleen A ; Grotz, Diane E ; Lachowicz, Jean E

Journal of medicinal chemistry, 05 December 2002, Vol.45(25), pp.5415-8 [Peer Reviewed Journal]

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21
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SCH 57790, a selective muscarinic M 2 receptor antagonist, releases acetylcholine and produces cognitive enhancement in laboratory animals

Carey, Galen J ; Billard, William ; Binch, Herbert ; Cohen-Williams, Mary ; Crosby, Gordon ; Grzelak, Michael ; Guzik, Henry ; Kozlowski, Joseph A ; Lowe, Derek B ; Pond, Annamarie J ; Tedesco, Richard P ; Watkins, Robert W ; Coffin, Vicki L

European Journal of Pharmacology, 2001, Vol.431(2), pp.189-200 [Peer Reviewed Journal]

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22
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The gerbil elevated plus-maze I: behavioral characterization and pharmacological validation

Varty, Geoffrey B ; Morgan, Cynthia A ; Cohen-Williams, Mary E ; Coffin, Vicki L ; Carey, Galen J

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, September 2002, Vol.27(3), pp.357-70 [Peer Reviewed Journal]

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23
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CCDC 957887: Experimental Crystal Structure Determination

Wu, Wen-Lian ; Domalski, Martin ; Burnett, Duane A. ; Josien, Hubert ; Bara, Thomas ; Rajagopalan, Murali ; Xu, Ruo ; Clader, John ; Greenlee, William J. ; Brunskill, Andrew ; Hyde, Lynn A. ; Del Vecchio, Robert A. ; Cohen-Williams, Mary E. ; Song, Lixin ; Lee, Julie ; Terracina, Giuseppe ; Zhang, Qi ; Nomeir, Amin ; Parker, Eric M. ; Zhang, Lili

2013

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24
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2-(2-Furanyl)-7-phenyl[1,2,4]triazolo[1,5- c]pyrimidin-5-amine analogs: Highly potent, orally active, adenosine A 2A antagonists. Part 1

Matasi, Julius J ; Caldwell, John P ; Zhang, Hongtao ; Fawzi, Ahmad ; Cohen-Williams, Mary E ; Varty, Geoffrey B ; Tulshian, Deen B

Bioorganic & Medicinal Chemistry Letters, 2005, Vol.15(16), pp.3670-3674 [Peer Reviewed Journal]

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25
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2-(2-Furanyl)-7-phenyl[1,2,4]triazolo[1,5- c]pyrimidin-5-amine analogs as adenosine A 2A antagonists: The successful reduction of hERG activity. Part 2

Matasi, Julius J ; Caldwell, John P ; Zhang, Hongtao ; Fawzi, Ahmad ; Higgins, Guy A ; Cohen-Williams, Mary E ; Varty, Geoffrey B ; Tulshian, Deen B

Bioorganic & Medicinal Chemistry Letters, 2005, Vol.15(16), pp.3675-3678 [Peer Reviewed Journal]

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26
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The gerbil elevated plus-maze II: anxiolytic-like effects of selective neurokinin NK1 receptor antagonists

Varty, Geoffrey B ; Cohen-Williams, Mary E ; Morgan, Cynthia A ; Pylak, Ursula ; Duffy, Ruth A ; Lachowicz, Jean E ; Carey, Galen J ; Coffin, Vicki L

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, September 2002, Vol.27(3), pp.371-9 [Peer Reviewed Journal]

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27
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Potent and selective adenosine A 2A receptor antagonists: 1,2,4-Triazolo[1,5- c]pyrimidines

Neustadt, Bernard R ; Liu, Hong ; Hao, Jinsong ; Greenlee, William J ; Stamford, Andrew W ; Foster, Carolyn ; Arik, Leyla ; Lachowicz, Jean ; Zhang, Hongtao ; Bertorelli, Rosalia ; Fredduzzi, Silva ; Varty, Geoffrey ; Cohen-Williams, Mary ; Ng, Kwokei

Bioorganic & Medicinal Chemistry Letters, 2009, Vol.19(3), pp.967-971 [Peer Reviewed Journal]

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28
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Design, synthesis, and evaluation of fused heterocyclic analogs of SCH 58261 as adenosine A 2A receptor antagonists

Shah, Unmesh ; Lankin, Claire M ; Boyle, Craig D ; Chackalamannil, Samuel ; Greenlee, William J ; Neustadt, Bernard R ; Cohen-Williams, Mary E ; Higgins, Guy A ; Ng, Kwokei ; Varty, Geoffrey B ; Zhang, Hongtao ; Lachowicz, Jean E

Bioorganic & Medicinal Chemistry Letters, 2008, Vol.18(14), pp.4204-4209 [Peer Reviewed Journal]

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29
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Characterization of the potent and highly selective A2A receptor antagonists preladenant and SCH 412348 7-2-4-2,4-difluorophenyl-1-piperazinylethyl-2-(2-furanyl)-7H-pyrazolo4,3-e1,2,4triazolo1,5-cpyrimidin-5-amine in rodent models of movement disorders and depression

Hodgson, Robert A ; Bertorelli, Rosalia ; Varty, Geoffrey B ; Lachowicz, Jean E ; Forlani, Angelo ; Fredduzzi, Silva ; Cohen-Williams, Mary E ; Higgins, Guy A ; Impagnatiello, Francesco ; Nicolussi, Elisa ; Parra, Leonard E ; Foster, Carolyn ; Zhai, Ying ; Neustadt, Bernie R ; Stamford, Andrew W ; Parker, Eric M ; Reggiani, Angelo ; Hunter, John C

The Journal of pharmacology and experimental therapeutics, July 2009, Vol.330(1), pp.294-303 [Peer Reviewed Journal]

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30
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The anxiolytic-like effects of the novel, orally active nociceptin opioid receptor agonist 8-bis(2-methylphenyl)methyl-3-phenyl-8-azabicyclo3.2.1octan-3-ol (SCH 221510)

Varty, Geoffrey B ; Lu, Sherry X ; Morgan, Cynthia A ; Cohen-Williams, Mary E ; Hodgson, Robert A ; Smith-Torhan, April ; Zhang, Hongtao ; Fawzi, Ahmad B ; Graziano, Michael P ; Ho, Ginny D ; Matasi, Julius ; Tulshian, Deen ; Coffin, Vicki L ; Carey, Galen J

The Journal of pharmacology and experimental therapeutics, August 2008, Vol.326(2), pp.672-82 [Peer Reviewed Journal]

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31
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Benzylidene ketal derivatives as M 2 muscarinic receptor antagonists

Boyle, Craig D ; Chackalamannil, Samuel ; Chen, Lian-Yong ; Dugar, Sundeep ; Pushpavanam, Pradeep ; Billard, William ; Binch, Herbert ; Crosby, Gordon ; Cohen-Williams, Mary ; Coffin, Vicki L ; Duffy, Ruth A ; Ruperto, Vilma ; Lachowicz, Jean E

Bioorganic & Medicinal Chemistry Letters, 2000, Vol.10(24), pp.2727-2730 [Peer Reviewed Journal]

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32
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Metabolic stabilization of benzylidene ketal M 2 muscarinic receptor antagonists via halonaphthoic acid substitution

Boyle, Craig D ; Chackalamannil, Samuel ; Clader, John W ; Greenlee, William J ; Josien, Hubert B ; Kaminski, James J ; Kozlowski, Joseph A ; Mccombie, Stuart W ; Nazareno, Dennis V ; Tagat, Jayaram R ; Wang, Yuguang ; Zhou, Guowei ; Billard, William ; Binch, Herbert ; Crosby, Gordon ; Cohen-Williams, Mary ; Coffin, Vicki L ; Cox, Kathleen A ; Grotz, Diane E ; Duffy, Ruth A ; Ruperto, Vilma ; Lachowicz, Jean E

Bioorganic & Medicinal Chemistry Letters, 2001, Vol.11(17), pp.2311-2314 [Peer Reviewed Journal]

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