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9 Results  for Everything (Includes Articles)

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Antidiabetic and antisteatotic effects of the selective fatty acid synthase (FAS) inhibitor platensimycin in mouse models of diabetes

Wu, Margaret ; Singh, Sheo B ; Wang, Jun ; Chung, Christine C ; Salituro, Gino ; Karanam, Bindhu V ; Lee, Sang Ho ; Powles, Maryann ; Ellsworth, Kenneth P ; Lassman, Michael E ; Miller, Corey ; Myers, Robert W ; Tota, Michael R ; Zhang, Bei B ; Li, Cai

Proceedings of the National Academy of Sciences of the United States of America, 29 March 2011, Vol.108(13), pp.5378-83 [Peer Reviewed Journal]

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Potent DGAT1 Inhibitors in the Benzimidazole Class with a Pyridyl-oxy-cyclohexanecarboxylic Acid Moiety

He, Shuwen ; Hong, Qingmei ; Lai, Zhong ; Wu, Zhicai ; Yu, Yang ; Kim, David W ; Ting, Pauline C ; Kuethe, Jeffrey T ; Yang, Ginger X ; Jian, Tianying ; Liu, Jian ; Guiadeen, Deodial ; Krikorian, Arto D ; Sperbeck, Donald M ; Sonatore, Lisa M ; Wiltsie, Judyann ; Chung, Christine C ; Gibson, Jack T ; Lisnock, Jeanmarie ; Murphy, Beth A ; Gorski, Judith N ; Liu, Jinqi ; Chen, Dunlu ; Chen, Xiaoli ; Wolff, Michael ; Tong, Sharon X ; Madeira, Maria ; Karanam, Bindhu V ; Shen, Dong-Ming ; Balkovec, James M ; Pinto, Shirly ; Nargund, Ravi P ; Devita, Robert J

ACS medicinal chemistry letters, 08 August 2013, Vol.4(8), pp.773-8 [Peer Reviewed Journal]

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Discovery of a Potent and Selective DGAT1 Inhibitor with a Piperidinyl-oxy-cyclohexanecarboxylic Acid Moiety

He, Shuwen ; Hong, Qingmei ; Lai, Zhong ; Yang, David X ; Ting, Pauline C ; Kuethe, Jeffrey T ; Cernak, Timothy A ; Dykstra, Kevin D ; Sperbeck, Donald M ; Wu, Zhicai ; Yu, Yang ; Yang, Ginger X ; Jian, Tianying ; Liu, Jian ; Guiadeen, Deodial ; Krikorian, Arto D ; Sonatore, Lisa M ; Wiltsie, Judyann ; Liu, Jinqi ; Gorski, Judith N ; Chung, Christine C ; Gibson, Jack T ; Lisnock, Jeanmarie ; Xiao, Jianying ; Wolff, Michael ; Tong, Sharon X ; Madeira, Maria ; Karanam, Bindhu V ; Shen, Dong-Ming ; Balkovec, James M ; Pinto, Shirly ; Nargund, Ravi P ; Devita, Robert J

ACS medicinal chemistry letters, 09 October 2014, Vol.5(10), pp.1082-7 [Peer Reviewed Journal]

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Discovery and optimization of novel 4-[(aminocarbonyl)amino]- N-[4-(2-aminoethyl)phenyl]benzenesulfonamide ghrelin receptor antagonists

Pasternak, Alexander ; Goble, Stephen D ; Dejesus, Reynalda K ; Hreniuk, Donna L ; Chung, Christine C ; Tota, Michael R ; Mazur, Paul ; Feighner, Scott D ; Howard, Andrew D ; Mills, Sander G ; Yang, Lihu

Bioorganic & Medicinal Chemistry Letters, 2009, Vol.19(21), pp.6237-6240 [Peer Reviewed Journal]

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Expression, refolding, and purification of recombinant human phosphodiesterase 3B: definition of the N-terminus of the catalytic core

Varnerin, Jeffrey P ; Chung, Christine C ; Patel, Sangita B ; Scapin, Giovanna ; Parmee, Emma R ; Morin, Nancy R ; Macneil, Douglas J ; Cully, Doris F ; Van Der Ploeg, Lex H.T ; Tota, Michael R

Protein Expression and Purification, 2004, Vol.35(2), pp.225-236 [Peer Reviewed Journal]

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3-Aryl-4-hydroxyquinolin-2(1 H)-one derivatives as type I fatty acid synthase inhibitors

Rivkin, Alexey ; Kim, Yoona R ; Goulet, Mark T ; Bays, Nathan ; Hill, Armetta D ; Kariv, Ilona ; Krauss, Stefan ; Ginanni, Nicole ; Strack, Peter R ; Kohl, Nancy E ; Chung, Christine C ; Varnerin, Jeffrey P ; Goudreau, Paul N ; Chang, Amy ; Tota, Michael R ; Munoz, Benito

Bioorganic & Medicinal Chemistry Letters, 2006, Vol.16(17), pp.4620-4623 [Peer Reviewed Journal]

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Benzyl vinylogous amide substituted aryldihydropyridazinones and aryldimethylpyrazolones as potent and selective PDE3B inhibitors

Edmondson, Scott D ; Mastracchio, Anthony ; He, Jiafang ; Chung, Christine C ; Forrest, Michael J ; Hofsess, Scott ; Macintyre, Euan ; Metzger, Joseph ; O'Connor, Naphtali ; Patel, Kajal ; Tong, Xinchun ; Tota, Michael R ; Van Der Ploeg, Lex H.T ; Varnerin, Jeff P ; Fisher, Michael H ; Wyvratt, Matthew J ; Weber, Ann E ; Parmee, Emma R

Bioorganic & Medicinal Chemistry Letters, 2003, Vol.13(22), pp.3983-3987 [Peer Reviewed Journal]

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Accelerating the discovery of DGAT1 inhibitors through the application of parallel medicinal chemistry (PMC)

Yu, Yang ; Wu, Zhicai ; Shi, Zhi-Cai ; He, Shuwen ; Lai, Zhong ; Cernak, Timothy A ; Vachal, Petr ; Liu, Min ; Liu, Jian ; Hong, Qingmei ; Jian, Tianying ; Guiadeen, Deodial ; Krikorian, Arto ; Sperbeck, Donald M ; Verras, Andreas ; Sonatore, Lisa M ; Murphy, Beth A ; Wiltsie, Judyann ; Chung, Christine C ; Gorski, Judith N ; Liu, Jinqi ; Xiao, Jianying ; Wolff, Michael ; Tong, Sharon X ; Madeira, Maria ; Karanam, Bindhu V ; Shen, Dong-Ming ; Balkovec, James M ; De Vita, Robert J ; Pinto, Shirly ; Nargund, Ravi P

Bioorganic & Medicinal Chemistry Letters, 01 June 2019, Vol.29(11), pp.1380-1385 [Peer Reviewed Journal]

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Benzimidazole-based DGAT1 inhibitors with a [3.1.0] bicyclohexane carboxylic acid moiety

He, Shuwen ; Lai, Zhong ; Hong, Qingmei ; Shang, Jackie ; Reibarkh, Mikhail ; Kuethe, Jeffrey T ; Liu, Jian ; Guiadeen, Deodial ; Krikorian, Arto D ; Cernak, Timothy A ; Dykstra, Kevin D ; Sperbeck, Donald M ; Wu, Zhicai ; Yu, Yang ; Yang, Ginger X ; Jian, Tianying ; Verras, Andreas ; Sonatore, Lisa M ; Wiltsie, Judyann ; Chung, Christine C ; Murphy, Beth A ; Gorski, Judith N ; Liu, Jinqi ; Xiao, Jianying ; Wolff, Michael ; Tong, Sharon X ; Madeira, Maria ; Karanam, Bindhu V ; Shen, Dong-Ming ; Balkovec, James M ; Pinto, Shirly ; Nargund, Ravi P ; Devita, Robert J

Bioorganic & Medicinal Chemistry Letters, 15 May 2019, Vol.29(10), pp.1182-1186 [Peer Reviewed Journal]

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