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Torcetrapib and coronary events

Cohn, Lawrence J

The New England journal of medicine, 24 April 2008, Vol.358(17), pp.1863; author reply 1863-4 [Peer Reviewed Journal]

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Good news for 'good' cholesterol

Katsnelson, Alla

Nature, Nov 18, 2010, Vol.468(7322), p.354 [Peer Reviewed Journal]

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Cholesteryl ester transfer protein inhibitors in the treatment of dyslipidemia: a systematic review and meta-analysis

Li, Chuanwei ; Zhang, Wen ; Zhou, Faying ; Chen, Caiyu ; Zhou, Liang ; Li, Yafei ; Liu, Ling ; Pei, Fang ; Luo, Hao ; Hu, Zhangxue ; Cai, Jing ; Zeng, Chunyu

PloS one, 2013, Vol.8(10), pp.e77049 [Peer Reviewed Journal]

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Dissociating HDL cholesterol from cardiovascular risk

Hausenloy, Derek ; Opie, Lionel ; Yellon, Derek

The Lancet, Jul 31-Aug 6, 2010, Vol.376(9738), pp.305-6 [Peer Reviewed Journal]

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Biphenyl-substituted oxazolidinones as cholesteryl ester transfer protein inhibitors: modifications of the oxazolidinone ring leading to the discovery of anacetrapib

Smith, Cameron J ; Ali, Amjad ; Hammond, Milton L ; Li, Hong ; Lu, Zhijian ; Napolitano, Joann ; Taylor, Gayle E ; Thompson, Christopher F ; Anderson, Matt S ; Chen, Ying ; Eveland, Suzanne S ; Guo, Qiu ; Hyland, Sheryl A ; Milot, Denise P ; Sparrow, Carl P ; Wright, Samuel D ; Cumiskey, Anne-Marie ; Latham, Melanie ; Peterson, Laurence B ; Rosa

Journal of medicinal chemistry, 14 July 2011, Vol.54(13), pp.4880-95 [Peer Reviewed Journal]

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Quinoline-3-carboxamide derivatives as potential cholesteryl ester transfer protein inhibitors

Li, Wen-Yan ; Xiong, Xu-Qiong ; Zhao, Dong-Mei ; Shi, Yu-Fang ; Yang, Zhi-Heng ; Yu, Chao ; Fan, Pei-Wei ; Cheng, Mao-Sheng ; Shen, Jing-Kang

Molecules (Basel, Switzerland), 09 May 2012, Vol.17(5), pp.5497-507 [Peer Reviewed Journal]

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Tetrazole and ester substituted tetrahydoquinoxalines as potent cholesteryl ester transfer protein inhibitors

Eary, C Todd ; Jones, Zachary S ; Groneberg, Robert D ; Burgess, Laurence E ; Mareska, David A ; Drew, Mark D ; Blake, James F ; Laird, Ellen R ; Balachari, Devan ; O'Sullivan, Michael ; Allen, Andrew ; Marsh, Vivienne

Bioorganic & medicinal chemistry letters, 01 May 2007, Vol.17(9), pp.2608-13 [Peer Reviewed Journal]

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How anacetrapib inhibits the activity of the cholesteryl ester transfer protein? Perspective through atomistic simulations

Äijänen, Tarja ; Koivuniemi, Artturi ; Javanainen, Matti ; Rissanen, Sami ; Rog, Tomasz ; Vattulainen, Ilpo

PLoS computational biology, November 2014, Vol.10(11), pp.e1003987 [Peer Reviewed Journal]

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9
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Design, synthesis and structure-activity-relationship of 1,5-tetrahydronaphthyridines as CETP inhibitors

Fernandez, Maria-Carmen ; Escribano, Ana ; Mateo, Ana I ; Parthasarathy, Saravanan ; Martin De La Nava, Eva M ; Wang, Xiaodong ; Cockerham, Sandra L ; Beyer, Thomas P ; Schmidt, Robert J ; Cao, Guoqing ; Zhang, Youyan ; Jones, Timothy M ; Borel, Anthony ; Sweetana, Stephanie A ; Cannady, Ellen A ; Stephenson, Gregory ; Frank, Scott ; Mantlo, Nathan B

Bioorganic & medicinal chemistry letters, 01 May 2012, Vol.22(9), pp.3056-62 [Peer Reviewed Journal]

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2D Quantitative structure-activity relationship studies on a series of cholesteryl ester transfer protein inhibitors

Castilho, Marcelo S ; Guido, Rafael V C ; Andricopulo, Adriano D

Bioorganic & medicinal chemistry, 15 September 2007, Vol.15(18), pp.6242-52 [Peer Reviewed Journal]

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CETP inhibitors boost 'good' cholesterol to no avail

Sheridan, Cormac

Nature biotechnology, January 2016, Vol.34(1), pp.5-6 [Peer Reviewed Journal]

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12
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SAR studies on the central phenyl ring of substituted biphenyl oxazolidinone-potent CETP inhibitors

Lu, Zhijian ; Chen, Yi-Heng ; Napolitano, Joann B ; Taylor, Gayle ; Ali, Amjad ; Hammond, Milton L ; Deng, Qiaolin ; Tan, Eugene ; Tong, Xinchun ; Xu, Suoyu S ; Latham, Melanie J ; Peterson, Laurence B ; Anderson, Matt S ; Eveland, Suzanne S ; Guo, Qiu ; Hyland, Sheryl A ; Milot, Denise P ; Chen, Ying ; Sparrow, Carl P ; Wright

Bioorganic & medicinal chemistry letters, 01 January 2012, Vol.22(1), pp.199-203 [Peer Reviewed Journal]

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Facile entry to an efficient and practical enantioselective synthesis of a polycyclic cholesteryl ester transfer protein inhibitor

Han, Zhengxu S ; Xu, Yibo ; Fandrick, Daniel R ; Rodriguez, Sonia ; Li, Zhibin ; Qu, Bo ; Gonnella, Nina C ; Sanyal, Sanjit ; Reeves, Jonathan T ; Ma, Shengli ; Grinberg, Nelu ; Haddad, Nizar ; Krishnamurthy, Dhileep ; Song, Jinhua J ; Yee, Nathan K ; Pfrengle, Waldemar ; Ostermeier, Markus ; Schnaubelt, Jürgen ; Leuter

Organic letters, 15 August 2014, Vol.16(16), pp.4142-5 [Peer Reviewed Journal]

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Future of cholesteryl ester transfer protein (CETP) inhibitors: a pharmacological perspective

Mohammadpour, Amir Hooshang ; Akhlaghi, Fatemeh

Clinical pharmacokinetics, August 2013, Vol.52(8), pp.615-26 [Peer Reviewed Journal]

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Refocusing on use of cholesteryl ester transfer protein inhibitors

Kastelein, John J P

The American journal of cardiology, 03 December 2007, Vol.100(11 A), pp.n47-52 [Peer Reviewed Journal]

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16
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Cholesteryl ester transfer protein antagonism by drugs--a poor choice

Sirtori, Cesare R ; Mombelli, Giuliana

Clinical chemistry, October 2010, Vol.56(10), pp.1550-3 [Peer Reviewed Journal]

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17
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Changes in lipoprotein subfraction concentration and composition in healthy individuals treated with the CETP inhibitor anacetrapib

Krauss, Ronald M ; Wojnooski, Kathleen ; Orr, Joseph ; Geaney, J Casey ; Pinto, Cathy Anne ; Liu, Yang ; Wagner, John A ; Luk, Julie Mabalot ; Johnson-Levonas, Amy O ; Anderson, Matt S ; Dansky, Hayes M

Journal of lipid research, March 2012, Vol.53(3), pp.540-7 [Peer Reviewed Journal]

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18
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2-(4-carbonylphenyl)benzoxazole inhibitors of CETP: scaffold design and advancement in HDLc-raising efficacy

Sweis, Ramzi F ; Hunt, Julianne A ; Kallashi, Florida ; Hammond, Milton L ; Chen, Ying ; Eveland, Suzanne S ; Guo, Qiu ; Hyland, Sheryl A ; Milot, Denise P ; Cumiskey, Anne-Marie ; Latham, Melanie ; Rosa, Raymond ; Peterson, Larry ; Sparrow, Carl P ; Wright, Samuel D ; Anderson, Matt S ; Sinclair, Peter J

Bioorganic & medicinal chemistry letters, 15 March 2011, Vol.21(6), pp.1890-5 [Peer Reviewed Journal]

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19
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Update on CETP inhibition

Davidson, Michael H

Journal of clinical lipidology, 2010, Vol.4(5), pp.394-8 [Peer Reviewed Journal]

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20
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Diphenylpyridylethanamine (DPPE)-based aminoheterocycles as cholesteryl ester transfer protein inhibitors

Wang, Yufeng ; Yang, Wu ; Finlay, Heather J ; Harikrishnan, Lalgudi S ; Jiang, Ji ; Kamau, Muthoni G ; Van Kirk, Katy ; Nirschl, David S ; Taylor, David S ; Chen, Alice Ye A ; Yin, Xiaohong ; Sleph, Paul G ; Yang, Richard Z ; Huang, Christine S ; Adam, Leonard P ; Lawrence, R Michael ; Wexler, Ruth R ; Salvati, Mark E

Bioorganic & medicinal chemistry letters, 01 February 2014, Vol.24(3), pp.860-4 [Peer Reviewed Journal]

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21
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Identification of a potent and metabolically stable series of fluorinated diphenylpyridylethanamine-based cholesteryl ester transfer protein inhibitors

Miller, Michael M ; Liu, Yalei ; Jiang, Ji ; Johnson, James A ; Kamau, Muthoni ; Nirschl, David S ; Wang, Yufeng ; Harikrishnan, Lalgudi ; Taylor, David S ; Chen, Alice Ye A ; Yin, Xiaohong ; Seethala, Ramakrishna ; Peterson, Tara L ; Zvyaga, Tatyana ; Zhang, Jun ; Huang, Christine S ; Wexler, Ruth R ; Poss, Michael A ; Lawrence, R Michael ; Adam, Leonard P ; Salvati, Mark E

Bioorganic & medicinal chemistry letters, 15 October 2012, Vol.22(20), pp.6503-8 [Peer Reviewed Journal]

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22
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Prediction of a potentially effective dose in humans for BAY 60-5521, a potent inhibitor of cholesteryl ester transfer protein (CETP) by allometric species scaling and combined pharmacodynamic and physiologically-based pharmacokinetic modelling

Weber, Olaf ; Willmann, Stefan ; Bischoff, Hilmar ; Li, Volkhart ; Vakalopoulos, Alexandros ; Lustig, Klemens ; Hafner, Frank-Thorsten ; Heinig, Roland ; Schmeck, Carsten ; Buehner, Klaus

British journal of clinical pharmacology, February 2012, Vol.73(2), pp.219-31 [Peer Reviewed Journal]

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23
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Disposition into Adipose Tissue Determines Accumulation and Elimination Kinetics of the Cholesteryl Ester Transfer Protein Inhibitor Anacetrapib in Mice

Hartmann, Georgy ; Kumar, Sanjeev ; Johns, Douglas ; Gheyas, Ferdous ; Gutstein, David ; Shen, Xiaolan ; Burton, Aimee ; Lederman, Harmony ; Lutz, Ryan ; Jackson, Tonya ; Chavez-Eng, Cynthia ; Mitra, Kaushik

Drug metabolism and disposition: the biological fate of chemicals, March 2016, Vol.44(3), pp.428-34 [Peer Reviewed Journal]

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24
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Discovery of new cholesteryl ester transfer protein inhibitors via ligand-based pharmacophore modeling and QSAR analysis followed by synthetic exploration

Abu Khalaf, Reema ; Abu Sheikha, Ghassan ; Bustanji, Yasser ; Taha, Mutasem O

European journal of medicinal chemistry, April 2010, Vol.45(4), pp.1598-617 [Peer Reviewed Journal]

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25
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Off-Target Vascular Effects of Cholesteryl Ester Transfer Protein Inhibitors Involve Redox-Sensitive and Signal Transducer and Activator of Transcription 3-Dependent Pathways

Rios, Francisco J ; Lopes, Rheure A ; Neves, Karla B ; Camargo, Livia L ; Montezano, Augusto C ; Touyz, Rhian M

The Journal of pharmacology and experimental therapeutics, May 2016, Vol.357(2), pp.415-22 [Peer Reviewed Journal]

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26
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Discovery of a Novel Piperidine-Based Inhibitor of Cholesteryl Ester Transfer Protein (CETP) That Retains Activity in Hypertriglyceridemic Plasma

Yamada, Ken ; Brousseau, Margaret ; Honma, Wataru ; Iimura, Akiko ; Imase, Hidetomo ; Iwaki, Yuki ; Kawanami, Toshio ; Lasala, Daniel ; Liang, Guiqing ; Mitani, Hironobu ; Nonomura, Kazuhiko ; Ohmori, Osamu ; Pan, Meihui ; Rigel, Dean F ; Umemura, Ichiro ; Yasoshima, Kayo ; Zhu, Guoming ; Mogi, Muneto

Journal of medicinal chemistry, 26 October 2017, Vol.60(20), pp.8466-8481 [Peer Reviewed Journal]

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27
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Lack of a meaningful effect of anacetrapib on the pharmacokinetics and pharmacodynamics of warfarin in healthy subjects

Krishna, Rajesh ; Stypinski, Daria ; Ali, Melissa ; Garg, Amit ; Cote, Josee ; Maes, Andrea ; Degroot, Bruce ; Liu, Yang ; Li, Susie ; Connolly, Sandra M ; Wagner, John A ; Stoch, S Aubrey

British journal of clinical pharmacology, July 2012, Vol.74(1), pp.116-24 [Peer Reviewed Journal]

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28
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Evacetrapib is a novel, potent, and selective inhibitor of cholesteryl ester transfer protein that elevates HDL cholesterol without inducing aldosterone or increasing blood pressure

Cao, Guoqing ; Beyer, Thomas P ; Zhang, Youyan ; Schmidt, Robert J ; Chen, Yan Q ; Cockerham, Sandra L ; Zimmerman, Karen M ; Karathanasis, Sotirios K ; Cannady, Ellen A ; Fields, Todd ; Mantlo, Nathan B

Journal of lipid research, December 2011, Vol.52(12), pp.2169-76 [Peer Reviewed Journal]

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29
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Anacetrapib: hope for CETP inhibitors?

Gurfinkel, Ronen ; Joy, Tisha R

Cardiovascular therapeutics, October 2011, Vol.29(5), pp.327-39 [Peer Reviewed Journal]

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30
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Evacetrapib at a supratherapeutic steady state concentration does not prolong QT in a thorough QT/QTc study in healthy participants

Suico, Jeffrey G ; Friedrich, Stuart ; Krueger, Kathryn A ; Zhang, Wei

Journal of cardiovascular pharmacology and therapeutics, May 2014, Vol.19(3), pp.283-9 [Peer Reviewed Journal]

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31
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Triphenylethanamine Derivatives as Cholesteryl Ester Transfer Protein Inhibitors: Discovery of N-(1R)-1-(3-Cyclopropoxy-4-fluorophenyl)-1-3-fluoro-5-(1,1,2,2-tetrafluoroethoxy)phenyl-2-phenylethyl-4-fluoro-3-(trifluoromethyl)benzamide (BMS-795311)

Qiao, Jennifer X ; Wang, Tammy C ; Adam, Leonard P ; Chen, Alice Ye A ; Taylor, David S ; Yang, Richard Z ; Zhuang, Shaobin ; Sleph, Paul G ; Li, Julia P ; Li, Danshi ; Yin, Xiaohong ; Chang, Ming ; Chen, Xue-Qing ; Shen, Hong ; Li, Jianqing ; Smith, Daniel ; Wu, Dauh-Rurng ; Leith, Leslie ; Harikrishnan, Lalgudi S ; Kamau

Journal of medicinal chemistry, 25 November 2015, Vol.58(22), pp.9010-26 [Peer Reviewed Journal]

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32
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Anacetrapib

Anonymous

American Journal of Cardiovascular Drugs, Aug 2010, Vol.10(4), pp.267-70 [Peer Reviewed Journal]

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33
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Cholesteryl ester transfer protein and its inhibitors

Shrestha, Sudichhya ; Wu, Ben J ; Guiney, Liam ; Barter, Philip J ; Rye, Kerry-Anne

Journal of lipid research, May 2018, Vol.59(5), pp.772-783 [Peer Reviewed Journal]

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34
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Cholesteryl ester-transfer protein inhibitors stimulate aldosterone biosynthesis in adipocytes through Nox-dependent processes

Rios, Francisco J ; Neves, Karla B ; Nguyen Dinh Cat, Aurelie ; Even, Sarah ; Palacios, Roberto ; Montezano, Augusto C ; Touyz, Rhian M

The Journal of pharmacology and experimental therapeutics, April 2015, Vol.353(1), pp.27-34 [Peer Reviewed Journal]

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35
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On- and off-target pharmacology of torcetrapib: current understanding and implications for the structure activity relationships (SAR), discovery and development of cholesteryl ester-transfer protein (CETP) inhibitors

Johns, Douglas G ; Duffy, Joseph ; Fisher, Timothy ; Hubbard, Brian K ; Forrest, Michael J

Drugs, 05 March 2012, Vol.72(4), pp.491-507 [Peer Reviewed Journal]

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36
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Chromanol derivatives--a novel class of CETP inhibitors

Vakalopoulos, Alexandros ; Schmeck, Carsten ; Thutewohl, Michael ; Li, Volkhart ; Bischoff, Hilmar ; Lustig, Klemens ; Weber, Olaf ; Paulsen, Holger ; Elias, Harry

Bioorganic & medicinal chemistry letters, 01 January 2011, Vol.21(1), pp.488-91 [Peer Reviewed Journal]

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