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Binding of [ 125I]Bolton Hunter conjugated eledoisin to rat brain cortex membranes - Evidence for two classes of tachykinin receptors in the mammalian central nervous system

Cascieri, Margaret A ; Liang, Tehming

Life Sciences, 1984, Vol.35(2), pp.179-184 [Peer Reviewed Journal]

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The potential for novel anti-inflammatory therapies for coronary artery disease

Cascieri, Margaret A

Nature reviews. Drug discovery, February 2002, Vol.1(2), pp.122-30 [Peer Reviewed Journal]

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Discovery of 3-piperidinyl-1-cyclopentanecarboxamide as a novel scaffold for highly potent CC chemokine receptor 2 antagonists

Yang, Lihu ; Butora, Gabor ; Jiao, Richard X ; Pasternak, Alex ; Zhou, Changyou ; Parsons, William H ; Mills, Sander G ; Vicario, Pasquale P ; Ayala, Julia M ; Cascieri, Margaret A ; Maccoss, Malcolm

Journal of medicinal chemistry, 31 May 2007, Vol.50(11), pp.2609-11 [Peer Reviewed Journal]

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Visualization of rat brain receptors for the neuropeptide, substance P

Rothman, Richard B ; Herkenham, Miles ; Pert, Candace B ; Liang, Tehming ; Cascieri, Margaret A

Brain Research, 1984, Vol.309(1), pp.47-54 [Peer Reviewed Journal]

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Synthesis of Potent Cyclic Hexapeptide NK-1 Antagonists. Use of a Minilibrary in Transforming a Peptidal Somatostatin Receptor Ligand into an NK-1 Receptor Ligand via a Polyvalent Peptidomimetic
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Synthesis of Potent Cyclic Hexapeptide NK-1 Antagonists. Use of a Minilibrary in Transforming a Peptidal Somatostatin Receptor Ligand into an NK-1 Receptor Ligand via a Polyvalent Peptidomimetic

Hirschmann, Ralph ; Yao, Wenqing ; Cascieri, Margaret A. ; Strader, Catherine D. ; Maechler, Laurie ; Cichy-Knight, Maria A. ; Hynes,, John ; van Rijn, Rachel D. ; Sprengeler, Paul A. ; Smith, Amos B.

Journal of Medicinal Chemistry, 01/1996, Vol.39(13), pp.2441-2448 [Peer Reviewed Journal]

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Synthesis of a Substance P Antagonist with a Somatostatin Scaffold:  Factors Affecting Agonism/Antagonism at GPCRs and the Role of Pseudosymmetry
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Synthesis of a Substance P Antagonist with a Somatostatin Scaffold:  Factors Affecting Agonism/Antagonism at GPCRs and the Role of Pseudosymmetry

Liu, Josephine ; Underwood, Dennis J. ; Cascieri, Margaret A. ; Rohrer, Susan P. ; Cantin, Louis-David ; Chicchi, Gary ; Smith, Amos B. ; Hirschmann, Ralph

Journal of Medicinal Chemistry, 10/2000, Vol.43(21), pp.3827-3831 [Peer Reviewed Journal]

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An Orally Active, Water-Soluble Neurokinin-1 Receptor Antagonist Suitable for Both Intravenous and Oral Clinical Administration
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An Orally Active, Water-Soluble Neurokinin-1 Receptor Antagonist Suitable for Both Intravenous and Oral Clinical Administration

Harrison, Timothy ; Owens, Andrew P. ; Williams, Brian J. ; Swain, Christopher J. ; Williams, Angela ; Carlson, Emma J. ; Rycroft, Wayne ; Tattersall, F. David ; Cascieri, Margaret A. ; Chicchi, Gary G. ; Sadowski, Sharon ; Rupniak, Nadia M. J. ; Hargreaves, Richard J.

Journal of Medicinal Chemistry, 11/2001, Vol.44(24), pp.4296-4299 [Peer Reviewed Journal]

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A comparative autoradiographic study of the distributions of substance P and eledoisin binding sites in rat brain

Danks, Janine A ; Rothman, Richard B ; Cascieri, Margaret A ; Chicchi, Gary G ; Liang, Tehming ; Herkenham, Miles

Brain Research, 1986, Vol.385(2), pp.273-281 [Peer Reviewed Journal]

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4,4-Disubstituted Piperidine High-Affinity NK 1 Antagonists:  Structure−Activity Relationships and in Vivo Activity
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4,4-Disubstituted Piperidine High-Affinity NK 1 Antagonists:  Structure−Activity Relationships and in Vivo Activity

Stevenson, Graeme I. ; Huscroft, Ian ; Macleod, Angus M. ; Swain, Christopher J. ; Cascieri, Margaret A. ; Chicchi, Gary G. ; Graham, Michael I. ; Harrison, Timothy ; Kelleher, Fintan J. ; Kurtz, Marc ; Ladduwahetty, Tamara ; Merchant, Kevin J. ; Metzger, Joseph M. ; Macintyre, D. E. ; Sadowski, Sharon ; Sohal, Balbinder ; Owens, Andrew P.

Journal of Medicinal Chemistry, 11/1998, Vol.41(23), pp.4623-4635 [Peer Reviewed Journal]

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10
2( S )-((3,5-Bis(trifluoromethyl)benzyl)oxy)-3( S )-phenyl-4-((3-oxo-1,2,4-triazol- 5-yl)methyl)morpholine ( 1 ):  A Potent, Orally Active, Morpholine-Based Human Neurokinin-1 Receptor Antagonist
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2( S )-((3,5-Bis(trifluoromethyl)benzyl)oxy)-3( S )-phenyl-4-((3-oxo-1,2,4-triazol- 5-yl)methyl)morpholine ( 1 ):  A Potent, Orally Active, Morpholine-Based Human Neurokinin-1 Receptor Antagonist

Hale, Jeffrey J. ; Mills, Sander G. ; Maccoss, Malcolm ; Shah, Shrenik K. ; Qi, Hongbo ; Mathre, David J. ; Cascieri, Margaret A. ; Sadowski, Sharon ; Strader, Catherine D. ; Macintyre, D. Euan ; Metzger, Joseph M.

Journal of Medicinal Chemistry, 01/1996, Vol.39(9), pp.1760-1762 [Peer Reviewed Journal]

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11
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CCR5 antagonists: 3-(pyrrolidin-1-yl)propionic acid analogues with potent anti-HIV activity

Lynch, Christopher L ; Hale, Jeffrey J ; Budhu, Richard J ; Gentry, Amy L ; Finke, Paul E ; Caldwell, Charles G ; Mills, Sander G ; Maccoss, Malcolm ; Shen, Dong-Ming ; Chapman, Kevin T ; Malkowitz, Lorraine ; Springer, Martin S ; Gould, Sandra L ; Demartino, Julie A ; Siciliano, Salvatore J ; Cascieri, Margaret A ; Carella, Anthony ; Carver, Gwen ; Holmes, Karen ; Schleif, William A ; Danzeisen, Renee ; Hazuda, Daria ; Kessler, Joseph ; Lineberger, Janet ; Miller, Michael ; Emini, Emilio

Organic letters, 10 July 2003, Vol.5(14), pp.2473-5 [Peer Reviewed Journal]

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12
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Molecular cloning and characterization of a new receptor for galanin

Howard, Andrew D ; Tan, Carina ; Shiao, Lin-Lin ; Palyha, Oksana C ; Mckee, Karen Kulju ; Weinberg, David H ; Feighner, Scott D ; Cascieri, Margaret A ; Smith, Roy G ; Van Der Ploeg, Lex H.T ; Sullivan, Kathleen A

FEBS Letters, 1997, Vol.405(3), pp.285-290 [Peer Reviewed Journal]

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13
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The CXCR4 agonist ligand stromal derived factor-1 maintains high affinity for receptors in both G α i-coupled and uncoupled states

Di Salvo, Jerry ; Koch, Greg E ; Johnson, Kristine E ; Blake, Allan D ; Daugherty, Bruce L ; Demartino, Julie A ; Sirotina-Meisher, Anna ; Liu, Yong ; Springer, Martin S ; Cascieri, Margaret A ; Sullivan, Kathleen A

European Journal of Pharmacology, 2000, Vol.409(2), pp.143-154 [Peer Reviewed Journal]

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14
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Desensitization of β 3-adrenergic receptor- stimulated adenylyl cyclase activity and lipolysis in rats

Vicario, Pasquale P ; Candelore, Mari R ; Schaeffer, Marie-Therese ; Kelly, Linda ; Thompson, G.Marie ; Brady, Edward J ; Saperstein, Richard ; Macintyre, D.Euan ; Tota, Laurie M ; Cascieri, Margaret A

Life Sciences, 1998, Vol.62(7), pp.627-638 [Peer Reviewed Journal]

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15
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3-Amino-1-alkyl-cyclopentane carboxamides as small molecule antagonists of the human and murine CC chemokine receptor 2

Butora, Gabor ; Jiao, Richard ; Parsons, William H ; Vicario, Pasquale P ; Jin, Hong ; Ayala, Julia M ; Cascieri, Margaret A ; Yang, Lihu

Bioorganic & Medicinal Chemistry Letters, 2007, Vol.17(13), pp.3636-3641 [Peer Reviewed Journal]

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16
Structural Optimization Affording 2-( R )-(1-( R )-3,5-Bis(trifluoromethyl)phenylethoxy)-3-( S )-(4-fluoro)phenyl-4- (3-oxo-1,2,4-triazol-5-yl)methylmorpholine, a Potent, Orally Active, Long-Acting Morpholine Acetal Human NK-1 Receptor Antagonist
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Structural Optimization Affording 2-( R )-(1-( R )-3,5-Bis(trifluoromethyl)phenylethoxy)-3-( S )-(4-fluoro)phenyl-4- (3-oxo-1,2,4-triazol-5-yl)methylmorpholine, a Potent, Orally Active, Long-Acting Morpholine Acetal Human NK-1 Receptor Antagonist

Hale, Jeffrey J. ; Mills, Sander G. ; Maccoss, Malcolm ; Finke, Paul E. ; Cascieri, Margaret A. ; Sadowski, Sharon ; Ber, Elzbieta ; Chicchi, Gary G. ; Kurtz, Marc ; Metzger, Joseph ; Eiermann, George ; Tsou, Nancy N. ; Tattersall, F. David ; Rupniak, Nadia M. J. ; Williams, Angela R. ; Rycroft, Wayne ; Hargreaves, Richard ; Macintyre, D. Euan

Journal of Medicinal Chemistry, 11/1998, Vol.41(23), pp.4607-4614 [Peer Reviewed Journal]

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17
Discovery of a Potent, Orally Bioavailable β 3 Adrenergic Receptor Agonist, ( R )- N -[4-[2-[[2-Hydroxy-2-(3-pyridinyl)ethyl]amino]ethyl]phenyl]-4-[4-[4-(trifluoromethyl)phenyl]thiazol-2-yl]benzenesulfonamide
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Discovery of a Potent, Orally Bioavailable β 3 Adrenergic Receptor Agonist, ( R )- N -[4-[2-[[2-Hydroxy-2-(3-pyridinyl)ethyl]amino]ethyl]phenyl]-4-[4-[4-(trifluoromethyl)phenyl]thiazol-2-yl]benzenesulfonamide

Mathvink, Robert J. ; Tolman, J. Samuel ; Chitty, Dawn ; Candelore, Mari R. ; Cascieri, Margaret A. ; Colwell, Lawrence F. ; Deng, Liping ; Feeney, William P. ; Forrest, Michael J. ; Hom, Gary J. ; Macintyre, D. Euan ; Miller, Randall R. ; Stearns, Ralph A. ; Tota, Laurie ; Wyvratt, Matthew J. ; Fisher, Michael H. ; Weber, Ann E.

Journal of Medicinal Chemistry, 10/2000, Vol.43(21), pp.3832-3836 [Peer Reviewed Journal]

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18
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Specific binding of an immunoreactive and biologically active 125I-labeled N(1)acylated substance P derivative to parotid cells

Liang, Tehming ; Cascieri, Margaret A

Biochemical and Biophysical Research Communications, 1980, Vol.96(4), pp.1793-1799 [Peer Reviewed Journal]

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19
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L-tryptophan urea amides as [formula omitted] dual antagonists

Qi, Hongbo ; Shah, Shrenik K ; Cascieri, Margaret A ; Sadowski, Sharon J ; Maccoss, Malcolm

Bioorganic & Medicinal Chemistry Letters, 1998, Vol.8(16), pp.2259-2262 [Peer Reviewed Journal]

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20
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L-750355, a human ß3-adrenoceptor agonist; in vitro pharmacology and profile of activity in vivo in the rhesus monkey

Forrest, Michael J ; Hom, Gary ; Bach, Tom ; Candelore, Mari Rios ; Cascieri, Margaret A ; Strader, Catherine ; Tota, Laurie ; Fisher, Michael H ; Szumiloski, John ; Ok, Hyun O ; Weber, Ann E ; Wyvratt, Matthew ; Vicario, Pasquale ; Marko, Olga ; Deng, Liping ; Cioffe, Christine ; Hegarty-Friscino, Bonnie ; Macintyre, Euan

European Journal of Pharmacology, 2000, Vol.407(1), pp.175-181 [Peer Reviewed Journal]

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21
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Alpha-aminothiazole-gamma-aminobutanoic amides as potent, small molecule CCR2 receptor antagonists

Zhou, Changyou ; Guo, Liangqin ; Parsons, William H ; Mills, Sander G ; Maccoss, Malcolm ; Vicario, Pasquale P ; Zweerink, Hans ; Cascieri, Margaret A ; Springer, Martin S ; Yang, Lihu

Bioorganic & medicinal chemistry letters, 15 January 2007, Vol.17(2), pp.309-14 [Peer Reviewed Journal]

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α-Aminothiazole-γ-aminobutanoic amides as potent, small molecule CCR2 receptor antagonists

Zhou, Changyou ; Guo, Liangqin ; Parsons, William H ; Mills, Sander G ; Maccoss, Malcolm ; Vicario, Pasquale P ; Zweerink, Hans ; Cascieri, Margaret A ; Springer, Martin S ; Yang, Lihu

Bioorganic & Medicinal Chemistry Letters, 2007, Vol.17(2), pp.309-314 [Peer Reviewed Journal]

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23
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Pharmacological Characterization and Tissue Distribution of the Human and Rat GALR1 Receptors

Sullivan, Kathleen A ; Shiao, Lin-Lin ; Cascieri, Margaret A

Biochemical and Biophysical Research Communications, 28 April 1997, Vol.233(3), pp.823-828 [Peer Reviewed Journal]

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24
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4-Amino-2-alkyl-butyramides as small molecule CCR2 antagonists with favorable pharmacokinetic properties

Butora, Gabor ; Morriello, Gregori J ; Kothandaraman, Shankaran ; Guiadeen, Deodialsingh ; Pasternak, Alexander ; Parsons, William H ; Maccoss, Malcolm ; Vicario, Pasquale P ; Cascieri, Margaret A ; Yang, Lihu

Bioorganic & Medicinal Chemistry Letters, 15 September 2006, Vol.16(18), pp.4715-4722 [Peer Reviewed Journal]

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25
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Identification, localization and receptor characterization of novel mammalian substance P-like peptides

Kurtz, Marc M ; Wang, Ruiping ; Clements, Michelle K ; Cascieri, Margaret A ; Austin, Christopher P ; Cunningham, Barry R ; Chicchi, Gary G ; Liu, Qingyun

Gene, 21 August 2002, Vol.296(1-2), pp.205-212 [Peer Reviewed Journal]

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26
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Expression and characterization of the chemokine receptor CCR2B from rhesus monkey

Jin, Hong ; Vicario, Pasquale P ; Zweerink, Hans ; Goyal, Shefali ; Hanlon, William A ; Dorn, Conrad P ; Mills, Sander G ; Demartino, Julie A ; Cascieri, Margaret A ; Struthers, Mary

Biochemical Pharmacology, 2003, Vol.66(2), pp.321-330 [Peer Reviewed Journal]

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27
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Design, synthesis, and structure–activity relationship of novel CCR2 antagonists

Kothandaraman, Shankaran ; Donnely, Karla L ; Butora, Gabor ; Jiao, Richard ; Pasternak, Alexander ; Morriello, Gregori J ; Goble, Stephen D ; Zhou, Changyou ; Mills, Sander G ; Maccoss, Malcolm ; Vicario, Pasquale P ; Ayala, Julia M ; Demartino, Julie A ; Struthers, Mary ; Cascieri, Margaret A ; Yang, Lihu

Bioorganic & Medicinal Chemistry Letters, 2009, Vol.19(6), pp.1830-1834 [Peer Reviewed Journal]

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28
Phosphorylated Morpholine Acetal Human Neurokinin-1 Receptor Antagonists as Water-Soluble Prodrugs
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Phosphorylated Morpholine Acetal Human Neurokinin-1 Receptor Antagonists as Water-Soluble Prodrugs

Hale, Jeffrey J. ; Mills, Sander G. ; Maccoss, Malcolm ; Dorn, Conrad P. ; Finke, Paul E. ; Budhu, Richard J. ; Reamer, Robert A. ; Huskey, Su-Er W. ; Luffer-Atlas, Debra ; Dean, Brian J. ; Mcgowan, Erin M. ; Feeney, William P. ; Chiu, Shuet-Hing Lee ; Cascieri, Margaret A. ; Chicchi, Gary G. ; Kurtz, Marc M. ; Sadowski, Sharon ; Ber, Elzbieta ; Tattersall, F. David ; Rupniak, Nadia M. J. ; Williams, Angela R. ; Rycroft, Wayne ; Hargreaves, Richard ; Metzger, Joseph M. ; Macintyre, D. Euan

Journal of Medicinal Chemistry, 03/2000, Vol.43(6), pp.1234-1241 [Peer Reviewed Journal]

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29
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1,2,4-Triacylpiperidine substance p antagonists: Separation of affinities for the NK-1 receptor and the L-type calcium channel

Mills, Sander G ; Maccoss, Malcolm ; Cascieri, Margaret A ; Sadowski, Sharon ; Patel, Smita ; Chapman, Kerry L ; Hutson, Peter H

Bioorganic & Medicinal Chemistry Letters, 1995, Vol.5(6), pp.599-604 [Peer Reviewed Journal]

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30
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Cyclopentane-based human NK1 antagonists. Part 1: Discovery and initial SAR

Finke, Paul E ; Meurer, Laura C ; Levorse, Dorothy A ; Mills, Sander G ; Maccoss, Malcolm ; Sadowski, Sharon ; Cascieri, Margaret A ; Tsao, Kwei-Lan ; Chicchi, Gary G ; Metzger, Joseph M ; Macintyre, D. Euan

Bioorganic & Medicinal Chemistry Letters, 2006, Vol.16(17), pp.4497-4503 [Peer Reviewed Journal]

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31
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Human β3 adrenergic receptor agonists containing cyanoguanidine and nitroethylenediamine moieties

Brockunier, Linda L ; Candelore, Mari R ; Cascieri, Margaret A ; Liu, Yong ; Tota, Laurie ; Wyvratt, Matthew J ; Fisher, Michael H ; Weber, Ann E ; Parmee, Emma R

Bioorganic & Medicinal Chemistry Letters, 02 February 2001, Vol.11(3), pp.379-382 [Peer Reviewed Journal]

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32
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Substituted Imidazoles as Glucagon Receptor Antagonists

Chang, Linda L ; Sidler, Kelly L ; Cascieri, Margaret A ; de Laszlo, Stephen ; Koch, Greg ; Li, Bing ; Maccoss, Malcolm ; Mantlo, Nathan ; O'Keefe, Stephen ; Pang, Margaret ; Rolando, Anna ; Hagmann, William K

Bioorganic & Medicinal Chemistry Letters, 2001, Vol.11(18), pp.2549-2553 [Peer Reviewed Journal]

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33
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Spirocyclic NK 1 antagonists II: [4.5]-spiroethers

Williams, Brian J ; Cascieri, Margaret A ; Chicchi, Gary G ; Harrison, Timothy ; Owens, Andrew P ; Owen, Simon N ; Rupniak, Nadia M.J ; Tattersall, David F ; Williams, Angela ; Swain, Christopher J

Bioorganic & Medicinal Chemistry Letters, 2002, Vol.12(19), pp.2719-2722 [Peer Reviewed Journal]

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34
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(Thr-59)-insulin-like growth factor I stimulates 2-deoxyglucose transport in BC3H1 myocytes through the insulin-like growth factor receptor, not the insulin receptor

Cascieri, Margaret A ; Chicchi, Gary G ; Hayes, Nancy S ; Strader, Catherine D

BBA - Molecular Cell Research, 1986, Vol.886(3), pp.491-499 [Peer Reviewed Journal]

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35
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Substance P stimulation of amylase release by isolated parotid cells and inhibition of substance P induction of salivation by vasoactive peptides

Liang, Tehming ; Cascieri, Margaret A

Molecular and Cellular Endocrinology, 1979, Vol.15(3), pp.151-162 [Peer Reviewed Journal]

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