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1
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Characterization of the substance P receptor in rat brain cortex membranes and the inhibition of radioligand binding by guanine nucleotides

Cascieri, M A ; Liang, T

The Journal of biological chemistry, 25 April 1983, Vol.258(8), pp.5158-64 [Peer Reviewed Journal]

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2
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Amino-aromatic interaction between histidine 197 of the neurokinin-1 receptor and CP 96345

Fong, T M ; Cascieri, M A ; Yu, H ; Bansal, A ; Swain, C ; Strader, C D

Nature, 25 March 1993, Vol.362(6418), pp.350-3 [Peer Reviewed Journal]

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3
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Binding of 125IBolton Hunter conjugated eledoisin to rat brain cortex membranes--evidence for two classes of tachykinin receptors in the mammalian central nervous system

Cascieri, M A ; Liang, T

Life sciences, 09 July 1984, Vol.35(2), pp.179-84 [Peer Reviewed Journal]

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4
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Substance P receptor on parotid cell membranes

Liang, T ; Cascieri, M A

The Journal of neuroscience : the official journal of the Society for Neuroscience, October 1981, Vol.1(10), pp.1133-41 [Peer Reviewed Journal]

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5
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Structural determinants for binary and ternary complex formation between insulin-like growth factor-I (IGF-I) and IGF binding protein-3

Baxter, R C ; Bayne, M L ; Cascieri, M A

The Journal of biological chemistry, 05 January 1992, Vol.267(1), pp.60-5 [Peer Reviewed Journal]

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6
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Demonstration of two distinct tachykinin receptors in rat brain cortex

Cascieri, M A ; Chicchi, G G ; Liang, T

The Journal of biological chemistry, 10 February 1985, Vol.260(3), pp.1501-7 [Peer Reviewed Journal]

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7
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Alterations in receptor activation and divalent cation activation of agonist binding by deletion of intracellular domains of the glucagon receptor

Chicchi, G G ; Graziano, M P ; Koch, G ; Hey, P ; Sullivan, K ; Vicario, P P ; Cascieri, M A

The Journal of biological chemistry, 21 March 1997, Vol.272(12), pp.7765-9 [Peer Reviewed Journal]

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8
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Expression of a synthetic gene encoding human insulin-like growth factor I in cultured mouse fibroblasts

Bayne, M L ; Cascieri, M A ; Kelder, B ; Applebaum, J ; Chicchi, G ; Shapiro, J A ; Pasleau, F ; Kopchick, J J

Proceedings of the National Academy of Sciences of the United States of America, May 1987, Vol.84(9), pp.2638-42 [Peer Reviewed Journal]

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9
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Discrete alterations of the insulin-like growth factor I molecule which alter its affinity for insulin-like growth factor-binding proteins result in changes in bioactivity

Clemmons, D R ; Cascieri, M A ; Camacho-Hubner, C ; Mccusker, R H ; Bayne, M L

The Journal of biological chemistry, 25 July 1990, Vol.265(21), pp.12210-6 [Peer Reviewed Journal]

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10
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The roles of tyrosines 24, 31, and 60 in the high affinity binding of insulin-like growth factor-I to the type 1 insulin-like growth factor receptor

Bayne, M L ; Applebaum, J ; Chicchi, G G ; Miller, R E ; Cascieri, M A

The Journal of biological chemistry, 15 September 1990, Vol.265(26), pp.15648-52 [Peer Reviewed Journal]

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11
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Characterization of a novel, non-peptidyl antagonist of the human glucagon receptor

Cascieri, M A ; Koch, G E ; Ber, E ; Sadowski, S J ; Louizides, D ; De Laszlo, S E ; Hacker, C ; Hagmann, W K ; Maccoss, M ; Chicchi, G G ; Vicario, P P

The Journal of biological chemistry, 26 March 1999, Vol.274(13), pp.8694-7 [Peer Reviewed Journal]

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12
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The role of histidine 265 in antagonist binding to the neurokinin-1 receptor

Fong, T M ; Yu, H ; Cascieri, M A ; Underwood, D ; Swain, C J ; Strader, C D

The Journal of biological chemistry, 28 January 1994, Vol.269(4), pp.2728-32 [Peer Reviewed Journal]

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13
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Interaction of glutamine 165 in the fourth transmembrane segment of the human neurokinin-1 receptor with quinuclidine antagonists

Fong, T M ; Yu, H ; Cascieri, M A ; Underwood, D ; Swain, C J ; Strader, C D

The Journal of biological chemistry, 27 May 1994, Vol.269(21), pp.14957-61 [Peer Reviewed Journal]

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14
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Receptor for motilin identified in the human gastrointestinal system

Feighner, S D ; Tan, C P ; Mckee, K K ; Palyha, O C ; Hreniuk, D L ; Pong, S S ; Austin, C P ; Figueroa, D ; Macneil, D ; Cascieri, M A ; Nargund, R ; Bakshi, R ; Abramovitz, M ; Stocco, R ; Kargman, S ; O'Neill, G ; Van Der Ploeg, L H ; Evans, J ; Patchett

Science (New York, N.Y.), 25 June 1999, Vol.284(5423), pp.2184-8 [Peer Reviewed Journal]

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15
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Distinct mechanism for antidepressant activity by blockade of central substance P receptors

Kramer, M S ; Cutler, N ; Feighner, J ; Shrivastava, R ; Carman, J ; Sramek, J J ; Reines, S A ; Liu, G ; Snavely, D ; Wyatt-Knowles, E ; Hale, J J ; Mills, S G ; Maccoss, M ; Swain, C J ; Harrison, T ; Hill, R G ; Hefti, F ; Scolnick, E M ; Cascieri, M A ; Chicchi

Science (New York, N.Y.), 11 September 1998, Vol.281(5383), pp.1640-5 [Peer Reviewed Journal]

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16
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Visualization of rat brain receptors for the neuropeptide, substance P

Rothman, R B ; Herkenham, M ; Pert, C B ; Liang, T ; Cascieri, M A

Brain research, 20 August 1984, Vol.309(1), pp.47-54 [Peer Reviewed Journal]

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17
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Structural analogs of human insulin-like growth factor I with reduced affinity for serum binding proteins and the type 2 insulin-like growth factor receptor

Bayne, M L ; Applebaum, J ; Chicchi, G G ; Hayes, N S ; Green, B G ; Cascieri, M A

The Journal of biological chemistry, 05 May 1988, Vol.263(13), pp.6233-9 [Peer Reviewed Journal]

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18
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Purification and characterization of a unique, potent inhibitor of apamin binding from Leiurus quinquestriatus hebraeus venom

Chicchi, G G ; Gimenez-Gallego, G ; Ber, E ; Garcia, M L ; Winquist, R ; Cascieri, M A

The Journal of biological chemistry, 25 July 1988, Vol.263(21), pp.10192-7 [Peer Reviewed Journal]

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19
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Structural analogs of human insulin-like growth factor (IGF) I with altered affinity for type 2 IGF receptors

Cascieri, M A ; Chicchi, G G ; Applebaum, J ; Green, B G ; Hayes, N S ; Bayne, M L

The Journal of biological chemistry, 05 February 1989, Vol.264(4), pp.2199-202 [Peer Reviewed Journal]

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20
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Cloning and expression of a novel neuropeptide Y receptor

Weinberg, D H ; Sirinathsinghji, D J ; Tan, C P ; Shiao, L L ; Morin, N ; Rigby, M R ; Heavens, R H ; Rapoport, D R ; Bayne, M L ; Cascieri, M A ; Strader, C D ; Linemeyer, D L ; Macneil, D J

The Journal of biological chemistry, 12 July 1996, Vol.271(28), pp.16435-8 [Peer Reviewed Journal]

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21
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Endogenous insulin-like growth factor (IGF) binding proteins cause IGF-1 resistance in cultured fibroblasts from a patient with short stature

Tollefsen, S E ; Heath-Monnig, E ; Cascieri, M A ; Bayne, M L ; Daughaday, W H

The Journal of clinical investigation, April 1991, Vol.87(4), pp.1241-50 [Peer Reviewed Journal]

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22
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Synthesis of potent cyclic hexapeptide NK-1 antagonists. Use of a minilibrary in transforming a peptidal somatostatin receptor ligand into an NK-1 receptor ligand via a polyvalent peptidomimetic

Hirschmann, R ; Yao, W ; Cascieri, M A ; Strader, C D ; Maechler, L ; Cichy-Knight, M A ; Hynes, J ; Van Rijn, R D ; Sprengeler, P A ; Smith, A B

Journal of medicinal chemistry, 21 June 1996, Vol.39(13), pp.2441-8 [Peer Reviewed Journal]

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23
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Synthesis of a substance P antagonist with a somatostatin scaffold: factors affecting agonism/antagonism at GPCRs and the role of pseudosymmetry

Liu, J ; Underwood, D J ; Cascieri, M A ; Rohrer, S P ; Cantin, L D ; Chicchi, G ; Smith, A B ; Hirschmann, R

Journal of medicinal chemistry, 19 October 2000, Vol.43(21), pp.3827-31 [Peer Reviewed Journal]

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24
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Potent and selective human beta(3)-adrenergic receptor antagonists

Candelore, M R ; Deng, L ; Tota, L ; Guan, X M ; Amend, A ; Liu, Y ; Newbold, R ; Cascieri, M A ; Weber, A E

The Journal of pharmacology and experimental therapeutics, August 1999, Vol.290(2), pp.649-55 [Peer Reviewed Journal]

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25
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Characterization of the interaction of N-acyl-L-tryptophan benzyl ester neurokinin antagonists with the human neurokinin-1 receptor

Cascieri, M A ; Macleod, A M ; Underwood, D ; Shiao, L L ; Ber, E ; Sadowski, S ; Yu, H ; Merchant, K J ; Swain, C J ; Strader, C D

The Journal of biological chemistry, 04 March 1994, Vol.269(9), pp.6587-91 [Peer Reviewed Journal]

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26
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An orally active, water-soluble neurokinin-1 receptor antagonist suitable for both intravenous and oral clinical administration

Harrison, T ; Owens, A P ; Williams, B J ; Swain, C J ; Williams, A ; Carlson, E J ; Rycroft, W ; Tattersall, F D ; Cascieri, M A ; Chicchi, G G ; Sadowski, S ; Rupniak, N M ; Hargreaves, R J

Journal of medicinal chemistry, 22 November 2001, Vol.44(24), pp.4296-9 [Peer Reviewed Journal]

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27
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The C region of human insulin-like growth factor (IGF) I is required for high affinity binding to the type 1 IGF receptor

Bayne, M L ; Applebaum, J ; Underwood, D ; Chicchi, G G ; Green, B G ; Hayes, N S ; Cascieri, M A

The Journal of biological chemistry, 05 July 1989, Vol.264(19), pp.11004-8 [Peer Reviewed Journal]

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28
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A comparative autoradiographic study of the distributions of substance P and eledoisin binding sites in rat brain

Danks, J A ; Rothman, R B ; Cascieri, M A ; Chicchi, G G ; Liang, T ; Herkenham, M

Brain research, 22 October 1986, Vol.385(2), pp.273-81 [Peer Reviewed Journal]

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29
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Effect of charybdotoxin and leiurotoxin I on potassium currents in bullfrog sympathetic ganglion and hippocampal neurons

Goh, J W ; Kelly, M E ; Pennefather, P S ; Chicchi, G G ; Cascieri, M A ; Garcia, M L ; Kaczorowski, G J

Brain research, 18 September 1992, Vol.591(1), pp.165-70 [Peer Reviewed Journal]

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30
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Beta(3)-adrenoceptor agonist-induced increases in lipolysis, metabolic rate, facial flushing, and reflex tachycardia in anesthetized rhesus monkeys

Hom, G J ; Forrest, M J ; Bach, T J ; Brady, E ; Candelore, M R ; Cascieri, M A ; Fletcher, D J ; Fisher, M H ; Iliff, S A ; Mathvink, R ; Metzger, J ; Pecore, V ; Saperstein, R ; Shih, T ; Weber, A E ; Wyvratt, M ; Zafian, P ; Macintyre, D E

The Journal of pharmacology and experimental therapeutics, April 2001, Vol.297(1), pp.299-307 [Peer Reviewed Journal]

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31
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4,4-Disubstituted piperidine high-affinity NK1 antagonists: structure-activity relationships and in vivo activity

Stevenson, G I ; Huscroft, I ; Macleod, A M ; Swain, C J ; Cascieri, M A ; Chicchi, G G ; Graham, M I ; Harrison, T ; Kelleher, F J ; Kurtz, M ; Ladduwahetty, T ; Merchant, K J ; Metzger, J M ; Macintyre, D E ; Sadowski, S ; Sohal, B ; Owens, A P

Journal of medicinal chemistry, 05 November 1998, Vol.41(23), pp.4623-35 [Peer Reviewed Journal]

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32
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Structural optimization affording 2-(R)-(1-(R)-3, 5-bis(trifluoromethyl)phenylethoxy)-3-(S)-(4-fluoro)phenyl-4- (3-oxo-1,2,4-triazol-5-yl)methylmorpholine, a potent, orally active, long-acting morpholine acetal human NK-1 receptor antagonist

Hale, J J ; Mills, S G ; Maccoss, M ; Finke, P E ; Cascieri, M A ; Sadowski, S ; Ber, E ; Chicchi, G G ; Kurtz, M ; Metzger, J ; Eiermann, G ; Tsou, N N ; Tattersall, F D ; Rupniak, N M ; Williams, A R ; Rycroft, W ; Hargreaves, R ; Macintyre, D E

Journal of medicinal chemistry, 05 November 1998, Vol.41(23), pp.4607-14 [Peer Reviewed Journal]

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33
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2(S)-((3,5-bis(trifluoromethyl)benzyl)-oxy)-3(S)-phenyl-4- ((3-oxo-1,2,4-triazol-5-yl)methyl)morpholine (1): a potent, orally active, morpholine-based human neurokinin-1 receptor antagonist

Hale, J J ; Mills, S G ; Maccoss, M ; Shah, S K ; Qi, H ; Mathre, D J ; Cascieri, M A ; Sadowski, S ; Strader, C D ; Macintyre, D E ; Metzger, J M

Journal of medicinal chemistry, 26 April 1996, Vol.39(9), pp.1760-2 [Peer Reviewed Journal]

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34
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Molecular cloning and characterization of a new receptor for galanin

Howard, A D ; Tan, C ; Shiao, L L ; Palyha, O C ; Mckee, K K ; Weinberg, D H ; Feighner, S D ; Cascieri, M A ; Smith, R G ; Van Der Ploeg, L H ; Sullivan, K A

FEBS letters, 01 April 1997, Vol.405(3), pp.285-90 [Peer Reviewed Journal]

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35
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The CXCR4 agonist ligand stromal derived factor-1 maintains high affinity for receptors in both Galpha(i)-coupled and uncoupled states

Di Salvo, J ; Koch, G E ; Johnson, K E ; Blake, A D ; Daugherty, B L ; Demartino, J A ; Sirotina-Meisher, A ; Liu, Y ; Springer, M S ; Cascieri, M A ; Sullivan, K A

European journal of pharmacology, 08 December 2000, Vol.409(2), pp.143-54 [Peer Reviewed Journal]

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36
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Desensitization of beta3-adrenergic receptor-stimulated adenylyl cyclase activity and lipolysis in rats

Vicario, P P ; Candelore, M R ; Schaeffer, M T ; Kelly, L ; Thompson, G M ; Brady, E J ; Saperstein, R ; Macintyre, D E ; Tota, L M ; Cascieri, M A

Life sciences, 1998, Vol.62(7), pp.627-38 [Peer Reviewed Journal]

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37
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Discovery of a potent, orally bioavailable beta(3) adrenergic receptor agonist, (R)-N-4-2-2-hydroxy-2-(3-pyridinyl)ethylaminoethylphenyl-4-4 -4-(trifluoromethyl)phenylthiazol-2-ylbenzenesulfonamide

Mathvink, R J ; Tolman, J S ; Chitty, D ; Candelore, M R ; Cascieri, M A ; Colwell, L F ; Deng, L ; Feeney, W P ; Forrest, M J ; Hom, G J ; Macintyre, D E ; Miller, R R ; Stearns, R A ; Tota, L ; Wyvratt, M J ; Fisher, M H ; Weber, A E

Journal of medicinal chemistry, 19 October 2000, Vol.43(21), pp.3832-6 [Peer Reviewed Journal]

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38
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N-heteroaryl-2-phenyl-3-(benzyloxy)piperidines: a novel class of potent orally active human NK1 antagonists

Ladduwahetty, T ; Baker, R ; Cascieri, M A ; Chambers, M S ; Haworth, K ; Keown, L E ; Macintyre, D E ; Metzger, J M ; Owen, S ; Rycroft, W ; Sadowski, S ; Seward, E M ; Shepheard, S L ; Swain, C J ; Tattersall, F D ; Watt, A P ; Williamson, D W ; Hargreaves, R J

Journal of medicinal chemistry, 19 July 1996, Vol.39(15), pp.2907-14 [Peer Reviewed Journal]

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39
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Specific binding of an immunoreactive and biologically active 125I-labeled N(1)acylated substance P derivative to parotid cells

Liang, T ; Cascieri, M A

Biochemical and biophysical research communications, 31 October 1980, Vol.96(4), pp.1793-9 [Peer Reviewed Journal]

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