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31 Results  for Everything (Includes Articles)

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Engineering Glucose Responsiveness Into Insulin

Kaarsholm, Niels C ; Lin, Songnian ; Yan, Lin ; Kelly, Theresa ; Van Heek, Margaret ; Mu, James ; Wu, Margaret ; Dai, Ge ; Cui, Yan ; Zhu, Yonghua ; Carballo-Jane, Ester ; Reddy, Vijay ; Zafian, Peter ; Huo, Pei ; Shi, Shuai ; Antochshuk, Valentyn ; Ogawa, Aimie ; Liu, Franklin ; Souza, Sandra C ; Seghezzi, Wolfgang ; Duffy, Joseph L ; Erion, Mark ; Nargund, Ravi P ; Kelley, David E

Diabetes, February 2018, Vol.67(2), pp.299-308 [Peer Reviewed Journal]

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Measurement of catecholamines in rat and mini-pig plasma and urine by liquid chromatography–tandem mass spectrometry coupled with solid phase extraction

He, Huaibing ; Carballo-Jane, Ester ; Tong, Xinchun ; Cohen, Lucinda H

Journal of Chromatography B, 01 August 2015, Vol.997, pp.154-161 [Peer Reviewed Journal]

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(1aR,5aR)1a,3,5,5a-Tetrahydro-1H-2,3-diaza-cyclopropaapentalene-4-carboxylic acid (MK-1903): a potent GPR109a agonist that lowers free fatty acids in humans

Boatman, P Douglas ; Lauring, Brett ; Schrader, Thomas O ; Kasem, Michelle ; Johnson, Benjamin R ; Skinner, Philip ; Jung, Jae-Kyu ; Xu, Jerry ; Cherrier, Martin C ; Webb, Peter J ; Semple, Graeme ; Sage, Carleton R ; Knudsen, Jens ; Chen, Ruoping ; Luo, Wen-Lin ; Caro, Luzelena ; Cote, Josee ; Lai, Eseng ; Wagner, John ; Taggart, Andrew K ; Carballo-Jane, Ester ; Hammond, Milton ; Colletti, Steven L ; Tata, James R ; Connolly, Daniel T ; Waters, M Gerard ; Richman, Jeremy G

Journal of medicinal chemistry, 26 April 2012, Vol.55(8), pp.3644-66 [Peer Reviewed Journal]

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Pharmacological inhibition of diacylglycerol acyltransferase 1 reduces body weight and modulates gut peptide release—Potential insight into mechanism of action

Liu, Jinqi ; Gorski, Judith N. ; Gold, Stephen J. ; Chen, Dunlu ; Chen, Shirley ; Forrest, Gail ; Itoh, Yoshiki ; Marsh, Donald J. ; Mclaren, David G. ; Shen, Zhu ; Sonatore, Lisa ; CarballoJane, Ester ; Craw, Stephanie ; Guan, Xiaoming ; Karanam, Bindhu ; Sakaki, Junichi ; Szeto, Daphne ; Tong, Xinchun ; Xiao, Jianying ; Yoshimoto, Ryo ; Yu, Hong ; Roddy, Thomas P. ; Balkovec, James ; Pinto, Shirly

Obesity, July 2013, Vol.21(7), pp.1406-1415 [Peer Reviewed Journal]

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ApoA-I mimetic peptides promote pre-β HDL formation in vivo causing remodeling of HDL and triglyceride accumulation at higher dose

Carballo-Jane, Ester ; Chen, Zhu ; O’neill, Edward ; Wang, Jun ; Burton, Charlotte ; Chang, Ching H ; Chen, Xun ; Eveland, Suzanne ; Frantz-Wattley, Betsy ; Gagen, Karen ; Hubbard, Brian ; Ichetovkin, Marina ; Luell, Silvi ; Meurer, Roger ; Song, Xuelei ; Strack, Alison ; Langella, Annunziata ; Cianetti, Simona ; Rech, Francesca ; Capitò, Elena ; Bufali, Simone ; Veneziano, Maria ; Verdirame, Maria ; Bonelli, Fabio ; Monteagudo, Edith ; Pessi, Antonello ; Ingenito, Raffaele ; Bianchi, Elisabetta

Bioorganic & Medicinal Chemistry, 2010, Vol.18(24), pp.8669-8678 [Peer Reviewed Journal]

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Discovery of a biaryl cyclohexene carboxylic acid (MK-6892): a potent and selective high affinity niacin receptor full agonist with reduced flushing profiles in animals as a preclinical candidate

Shen, Hong C ; Ding, Fa-Xiang ; Raghavan, Subharekha ; Deng, Qiaolin ; Luell, Silvi ; Forrest, Michael J ; Carballo-Jane, Ester ; Wilsie, Larissa C ; Krsmanovic, Mihajlo L ; Taggart, Andrew K ; Wu, Kenneth K ; Wu, Tsuei-Ju ; Cheng, Kang ; Ren, Ning ; Cai, Tian-Quan ; Chen, Qing ; Wang, Junying ; Wolff, Michael S ; Tong, Xinchun ; Holt, Tom G ; Waters, M Gerard ; Hammond, Milton L ; Tata, James R ; Colletti, Steven L

Journal of medicinal chemistry, 25 March 2010, Vol.53(6), pp.2666-70 [Peer Reviewed Journal]

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Altered lipoprotein metabolism in P2Y 13 knockout mice

Blom, Daniël ; Yamin, Ting-Ting ; Champy, Marie-France ; Selloum, Mohammed ; Bedu, Elodie ; Carballo-Jane, Ester ; Gerckens, Lynn ; Luell, Silvi ; Meurer, Roger ; Chin, Jayne ; Mudgett, John ; Puig, Oscar

BBA - Molecular and Cell Biology of Lipids, 2010, Vol.1801(12), pp.1349-1360 [Peer Reviewed Journal]

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Reconstituted HDL Elicits Marked Changes in Plasma Lipids Following Single-Dose Injection in C57Bl/6 Mice

Chen, Zhu ; O'Neill, Edward A ; Meurer, Roger D ; Gagen, Karen ; Luell, Silvi ; Wang, Sheng-Ping ; Ichetovkin, Marina ; Frantz-Wattley, Betsy ; Eveland, Suzanne ; Strack, Alison M ; Fisher, Timothy S ; Johns, Douglas G ; Sparrow, Carl P ; Wright, Samuel D ; Hubbard, Brian K ; Carballo-Jane, Ester

Journal of Cardiovascular Pharmacology and Therapeutics, September 2012, Vol.17(3), pp.315-323 [Peer Reviewed Journal]

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Chemical genetics define the roles of p38alpha and p38beta in acute and chronic inflammation

O'Keefe, Stephen J ; Mudgett, John S ; Cupo, Susan ; Parsons, Janey N ; Chartrain, Nicole A ; Fitzgerald, Catherine ; Chen, Shiow-Ling ; Lowitz, Karen ; Rasa, Cordelia ; Visco, Denise ; Luell, Silvi ; Carballo-Jane, Ester ; Owens, Karen ; Zaller, Dennis M

The Journal of biological chemistry, 30 November 2007, Vol.282(48), pp.34663-71 [Peer Reviewed Journal]

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Erratum. Engineering Glucose Responsiveness Into Insulin. Diabetes 2018;67:299-308

Kaarsholm, Niels C ; Lin, Songnian ; Yan, Lin ; Kelly, Theresa ; Van Heek, Margaret ; Mu, James ; Wu, Margaret ; Dai, Ge ; Cui, Yan ; Zhu, Yonghua ; Carballo-Jane, Ester ; Reddy, Vijay ; Zafian, Peter ; Huo, Pei ; Shi, Shuai ; Antochshuk, Valentyn ; Ogawa, Aimie ; Liu, Franklin ; Souza, Sandra C ; Seghezzi, Wolfgang ; Duffy, Joseph L ; Erion, Mark ; Nargund, Ravi P ; Kelley, David E

Diabetes, May 2018, Vol.67(5), pp.1030 [Peer Reviewed Journal]

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Nicotinic acid and DP1 blockade: studies in mouse models of atherosclerosis

Strack, Alison M ; Carballo-Jane, Ester ; Wang, Sheng-Ping ; Xue, Jiyan ; Ping, Xiaoli ; Mcnamara, Lesley Ann ; Thankappan, Anil ; Price, Olga ; Wolff, Michael ; Wu, T J ; Kawka, Douglas ; Mariano, Michele ; Burton, Charlotte ; Chang, Ching H ; Chen, Jing ; Menke, John ; Luell, Silvi ; Zycband, Emanuel I ; Tong, Xinchun ; Raubertas, Richard ; Sparrow, Carl P ; Hubbard, Brian ; Woods, John ; O'Neill, Gary ; Waters, M Gerard ; Sitlani, Ayesha

Journal of lipid research, January 2013, Vol.54(1), pp.177-88 [Peer Reviewed Journal]

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12
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GPR109a agonists. Part 2: Pyrazole-acids as agonists of the human orphan G-protein coupled receptor GPR109a

Imbriglio, Jason E ; Chang, Sookhee ; Liang, Rui ; Raghavan, Subharekha ; Schmidt, Darby ; Smenton, Abby ; Tria, Scott ; Schrader, Thomas O ; Jung, Jae-Kyu ; Esser, Craig ; Holt, Tom G ; Wolff, Michael S ; Taggart, Andrew K.P ; Cheng, Kang ; Carballo-Jane, Ester ; Waters, M. Gerard ; Tata, James R ; Colletti, Steven L

Bioorganic & Medicinal Chemistry Letters, 01 August 2010, Vol.20(15), pp.4472-4474 [Peer Reviewed Journal]

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13
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Potent tricyclic pyrazole tetrazole agonists of the nicotinic acid receptor (GPR109a)

Boatman, P. Douglas ; Schrader, Thomas O ; Kasem, Michelle ; Johnson, Benjamin R ; Skinner, Philip J ; Jung, Jae-Kyu ; Xu, Jerry ; Cherrier, Martin C ; Webb, Peter J ; Semple, Graeme ; Sage, Carleton R ; Knudsen, Jens ; Chen, Ruoping ; Taggart, Andrew K ; Carballo-Jane, Ester ; Richman, Jeremy G

Bioorganic & Medicinal Chemistry Letters, 2010, Vol.20(9), pp.2797-2800 [Peer Reviewed Journal]

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14
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Anthranilic acid replacements in a niacin receptor agonist

Schmidt, Darby ; Smenton, Abigail ; Raghavan, Subharekha ; Shen, Hong ; Ding, Fa-Xiang ; Carballo-Jane, Ester ; Luell, Silvi ; Ciecko, Tanya ; Holt, Tom G ; Wolff, Michael ; Taggart, Andrew ; Wilsie, Larissa ; Krsmanovic, Mihajlo ; Ren, Ning ; Blom, Daniel ; Cheng, Kang ; Mccann, Peggy E ; Waters, M.Gerard ; Tata, James ; Colletti, Steven

Bioorganic & Medicinal Chemistry Letters, 01 June 2010, Vol.20(11), pp.3426-3430 [Peer Reviewed Journal]

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15
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Discovery of novel tricyclic full agonists for the G-protein-coupled niacin receptor 109A with minimized flushing in rats

Shen, Hong C ; Ding, Fa-Xiang ; Deng, Qiaolin ; Wilsie, Larissa C ; Krsmanovic, Mihajlo L ; Taggart, Andrew K ; Carballo-Jane, Ester ; Ren, Ning ; Cai, Tian-Quan ; Wu, Tsuei-Ju ; Wu, Kenneth K ; Cheng, Kang ; Chen, Qing ; Wolff, Michael S ; Tong, Xinchun ; Holt, Tom G ; Waters, M Gerard ; Hammond, Milton L ; Tata, James R ; Colletti, Steven L

Journal of medicinal chemistry, 23 April 2009, Vol.52(8), pp.2587-602 [Peer Reviewed Journal]

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16
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Discovery of betamethasone 17α-carbamates as dissociated glucocorticoid receptor modulators in the rat

Ali, Amjad ; Balkovec, James M ; Greenlee, Mark ; Hammond, Milton L ; Rouen, Greg ; Taylor, Gayle ; Einstein, Monica ; Ge, Lan ; Harris, Georgianna ; Kelly, Terri M ; Mazur, Paul ; Pandit, Shilpa ; Santoro, Joseph ; Sitlani, Ayesha ; Wang, Chuanlin ; Williamson, Joann ; Forrest, Michael J ; Carballo-Jane, Ester ; Luell, Silvi ; Lowitz, Karen ; Visco, Denise

Bioorganic & Medicinal Chemistry, 2008, Vol.16(16), pp.7535-7542 [Peer Reviewed Journal]

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17
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3-(1H-tetrazol-5-yl)-1,4,5,6-tetrahydro-cyclopentapyrazole (MK-0354): a partial agonist of the nicotinic acid receptor, G-protein coupled receptor 109a, with antilipolytic but no vasodilatory activity in mice

Semple, Graeme ; Skinner, Philip J ; Gharbaoui, Tawfik ; Shin, Young-Jun ; Jung, Jae-Kyu ; Cherrier, Martin C ; Webb, Peter J ; Tamura, Susan Y ; Boatman, P Douglas ; Sage, Carleton R ; Schrader, Thomas O ; Chen, Ruoping ; Colletti, Steven L ; Tata, James R ; Waters, M Gerard ; Cheng, Kang ; Taggart, Andrew K ; Cai, Tian-Quan ; Carballo-Jane, Ester ; Behan, Dominic P ; Connolly, Daniel T ; Richman, Jeremy G

Journal of medicinal chemistry, 28 August 2008, Vol.51(16), pp.5101-8 [Peer Reviewed Journal]

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18
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Discovery of biaryl anthranilides as full agonists for the high affinity niacin receptor

Shen, Hong C ; Ding, Fa-Xiang ; Luell, Silvi ; Forrest, Michael J ; Carballo-Jane, Ester ; Wu, Kenneth K ; Wu, Tsuei-Ju ; Cheng, Kang ; Wilsie, Larissa C ; Krsmanovic, Mihajlo L ; Taggart, Andrew K ; Ren, Ning ; Cai, Tian-Quan ; Deng, Qiaolin ; Chen, Qing ; Wang, Junying ; Wolff, Michael S ; Tong, Xinchun ; Holt, Tom G ; Waters, M Gerard ; Hammond, Milton L ; Tata, James R ; Colletti, Steven L

Journal of medicinal chemistry, 13 December 2007, Vol.50(25), pp.6303-6 [Peer Reviewed Journal]

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19
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Novel N-arylpyrazolo3,2-c-based ligands for the glucocorticoid receptor: receptor binding and in vivo activity

Ali, Amjad ; Thompson, Christopher F ; Balkovec, James M ; Graham, Donald W ; Hammond, Milton L ; Quraishi, Nazia ; Tata, James R ; Einstein, Monica ; Ge, Lan ; Harris, Georgianna ; Kelly, Terri M ; Mazur, Paul ; Pandit, Shilpa ; Santoro, Joseph ; Sitlani, Ayesha ; Wang, Chuanlin ; Williamson, Joanne ; Miller, Douglas K ; Thompson, Chris M ; Zaller, Dennis M ; Forrest, Michael J ; Carballo-Jane, Ester ; Luell, Silvi

Journal of medicinal chemistry, 06 May 2004, Vol.47(10), pp.2441-52 [Peer Reviewed Journal]

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20
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Plasma lipid profiling across species for the identification of optimal animal models of human dyslipidemia

Yin, Wu ; Carballo-Jane, Ester ; Mclaren, David G ; Mendoza, Vivienne H ; Gagen, Karen ; Geoghagen, Neil S ; Mcnamara, Lesley Ann ; Gorski, Judith N ; Eiermann, George J ; Petrov, Aleksandr ; Wolff, Michael ; Tong, Xinchun ; Wilsie, Larissa C ; Akiyama, Taro E ; Chen, Jing ; Thankappan, Anil ; Xue, Jiyan ; Ping, Xiaoli ; Andrews, Genevieve ; Wickham, L Alexandra ; Gai, Cesaire L ; Trinh, Tu ; Kulick, Alison A ; Donnelly, Marcie J ; Voronin, Gregory O ; Rosa, Ray ; Cumiskey, Anne-Marie ; Bekkari, Kavitha ; Mitnaul, Lyndon J ; Puig, Oscar ; Chen, Fabian ; Raubertas, Richard ; Wong, Peggy H ; Hansen, Barbara C ; Koblan, Ken S ; Roddy, Thomas P ; Hubbard, Brian K ; Strack, Alison M

Journal of lipid research, January 2012, Vol.53(1), pp.51-65 [Peer Reviewed Journal]

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21
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Skeletal muscle: a dual system to measure glucocorticoid-dependent transactivation and transrepression of gene regulation

Carballo-Jane, Ester ; Pandit, Shilpa ; Santoro, Joseph C ; Freund, Concetta ; Luell, Silvi ; Harris, Georgianna ; Forrest, Michael J ; Sitlani, Ayesha

Journal of Steroid Biochemistry and Molecular Biology, 2004, Vol.88(2), pp.191-201 [Peer Reviewed Journal]

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22
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Novel 1-(2-aminopyrazin-3-yl)methyl-2-thioureas as potent inhibitors of mitogen-activated protein kinase-activated protein kinase 2 (MK-2)

Lin, Songnian ; Lombardo, Matthew ; Malkani, Sunita ; Hale, Jeffrey J ; Mills, Sander G ; Chapman, Kevin ; Thompson, James E ; Zhang, Wen Xiao ; Wang, Ruixiu ; Cubbon, Rose M ; O’neill, Edward A ; Luell, Silvi ; Carballo-Jane, Ester ; Yang, Lihu

Bioorganic & Medicinal Chemistry Letters, 2009, Vol.19(12), pp.3238-3242 [Peer Reviewed Journal]

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23
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GPR109a agonists. Part 1: 5-Alkyl and 5-aryl-pyrazole–tetrazoles as agonists of the human orphan G-protein coupled receptor GPR109a

Imbriglio, Jason E ; Chang, Sookhee ; Liang, Rui ; Raghavan, Subharekha ; Schmidt, Darby ; Smenton, Abby ; Tria, Scott ; Schrader, Thomas O ; Jung, Jae-Kyu ; Esser, Craig ; Taggart, Andrew K.P ; Cheng, Kang ; Carballo-Jane, Ester ; Gerard Waters, M ; Tata, James R ; Colletti, Steven L

Bioorganic & Medicinal Chemistry Letters, 2009, Vol.19(8), pp.2121-2124 [Peer Reviewed Journal]

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24
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Pyrazole acids as niacin receptor agonists for the treatment of dyslipidemia

Schmidt, Darby ; Smenton, Abigail ; Raghavan, Subharekha ; Carballo-Jane, Ester ; Lubell, Silvi ; Ciecko, Tanya ; Holt, Tom G ; Wolff, Michael ; Taggart, Andrew ; Wilsie, Larissa ; Krsmanovic, Mihajlo ; Ren, Ning ; Blom, Daniel ; Cheng, Kang ; Mccann, Peggy E ; Gerard Waters, M ; Tata, James ; Colletti, Steven

Bioorganic & Medicinal Chemistry Letters, 2009, Vol.19(16), pp.4768-4772 [Peer Reviewed Journal]

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25
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Molecular modeling aided design of nicotinic acid receptor GPR109A agonists

Deng, Qiaolin ; Frie, Jessica L ; Marley, Daria M ; Beresis, Richard T ; Ren, Ning ; Cai, Tian-Quan ; Taggart, Andrew K.P ; Cheng, Kang ; Carballo-Jane, Ester ; Wang, Junying ; Tong, Xinchun ; Waters, M. Gerard ; Tata, James R ; Colletti, Steven L

Bioorganic & Medicinal Chemistry Letters, 2008, Vol.18(18), pp.4963-4967 [Peer Reviewed Journal]

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p38 MAP kinase inhibitors. Part 5: Discovery of an orally bio-available and highly efficacious compound based on the 7-amino-naphthyridone scaffold

Natarajan, Swaminathan R ; Liu, Luping ; Levorse, Mark ; Thompson, James E ; O’neill, Edward A ; O’keefe, Stephen J ; Vora, Kalpit A ; Cvetovich, Raymond ; Chung, John Y ; Carballo-Jane, Ester ; Visco, Denise M

Bioorganic & Medicinal Chemistry Letters, 2006, Vol.16(20), pp.5468-5471 [Peer Reviewed Journal]

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27
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Discovery of orally bioavailable and novel urea agonists of the high affinity niacin receptor GPR109A

Shen, Hong C ; Szymonifka, Michael J ; Kharbanda, Divya ; Deng, Qiaolin ; Carballo-Jane, Ester ; Wu, Kenneth K ; Wu, Tsuei-Ju ; Cheng, Kang ; Ren, Ning ; Cai, Tian-Quan ; Taggart, Andrew K ; Wang, Junying ; Tong, Xinchun ; Waters, M. Gerard ; Hammond, Milton L ; Tata, James R ; Colletti, Steven L

Bioorganic & Medicinal Chemistry Letters, 2007, Vol.17(24), pp.6723-6728 [Peer Reviewed Journal]

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28
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Comparison of rat and dog models of vasodilatation and lipolysis for the calculation of a therapeutic index for GPR109A agonists

Carballo-Jane, Ester ; Gerckens, Lynn S ; Luell, Silvi ; Parlapiano, Allison S ; Wolff, Michael ; Colletti, Steven L ; Tata, James R ; Taggart, Andrew K.P ; Waters, M. Gerard ; Richman, Jeremy G ; Mccann, Margaret E ; Forrest, Michael J

Journal of Pharmacological and Toxicological Methods, 2007, Vol.56(3), pp.308-316 [Peer Reviewed Journal]

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29
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Novel glucocorticoids containing a 6,5-bicyclic core fused to a pyrazole ring: Synthesis, in vitro profile, molecular modeling studies, and in vivo experiments

Thompson, Christopher F ; Quraishi, Nazia ; Ali, Amjad ; Mosley, Ralph T ; Tata, James R ; Hammond, Milton L ; Balkovec, James M ; Einstein, Monica ; Ge, Lan ; Harris, Georgianna ; Kelly, Terri M ; Mazur, Paul ; Pandit, Shilpa ; Santoro, Joseph ; Sitlani, Ayesha ; Wang, Chuanlin ; Williamson, Joanne ; Miller, Douglas K ; Yamin, Ting-Ting D ; Thompson, Chris M ; O’neill, Edward A ; Zaller, Dennis ; Forrest, Michael J ; Carballo-Jane, Ester ; Luell, Silvi

Bioorganic & Medicinal Chemistry Letters, 2007, Vol.17(12), pp.3354-3361 [Peer Reviewed Journal]

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30
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Novel heterocyclic glucocorticoids: in vitro profile and in vivo efficacy

Thompson, Christopher F ; Quraishi, Nazia ; Ali, Amjad ; Tata, James R ; Hammond, Milton L ; Balkovec, James M ; Einstein, Monica ; Ge, Lan ; Harris, Georgianna ; Kelly, Theresa M ; Mazur, Paul ; Pandit, Shilpa ; Santoro, Joseph ; Sitlani, Ayesha ; Wang, Chuanlin ; Williamson, Joanne ; Miller, Douglas K ; Yamin, Ting-Ting D ; Thompson, Chris M ; O’neill, Edward A ; Zaller, Dennis ; Forrest, Michael J ; Carballo-Jane, Ester ; Luell, Silvi

Bioorganic & Medicinal Chemistry Letters, 2005, Vol.15(8), pp.2163-2167 [Peer Reviewed Journal]

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31
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Novel ketal ligands for the glucocorticoid receptor: in vitro and in vivo activity

Smith, Cameron J ; Ali, Amjad ; Balkovec, James M ; Graham, Donald W ; Hammond, Milton L ; Patel, Gool F ; Rouen, Gregory P ; Smith, Scott K ; Tata, James R ; Einstein, Monica ; Ge, Lan ; Harris, Georgianna S ; Kelly, Theresa M ; Mazur, Paul ; Thompson, Chris M ; Wang, Chuanlin F ; Williamson, Joanne M ; Miller, Douglas K ; Pandit, Shilpa ; Santoro, Joseph C ; Sitlani, Ayesha ; Yamin, Ting-Ting D ; O’neill, Edward A ; Zaller, Dennis M ; Carballo-Jane, Ester ; Forrest, Michael J ; Luell, Silvi

Bioorganic & Medicinal Chemistry Letters, 2005, Vol.15(11), pp.2926-2931 [Peer Reviewed Journal]

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