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21 Results  for Everything (Includes Articles)

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1
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Discovery of Pyrophosphate Diesters as Tunable, Soluble, and Bioorthogonal Linkers for Site-Specific Antibody-Drug Conjugates

Kern, Jeffrey C ; Cancilla, Mark ; Dooney, Deborah ; Kwasnjuk, Kristen ; Zhang, Rena ; Beaumont, Maribel ; Figueroa, Isabel ; Hsieh, Suchun ; Liang, Linda ; Tomazela, Daniela ; Zhang, Jeffrey ; Brandish, Philip E ; Palmieri, Anthony ; Stivers, Peter ; Cheng, Mangeng ; Feng, Guo ; Geda, Prasanthi ; Shah, Sanjiv ; Beck, Andrew ; Bresson

Journal of the American Chemical Society, 03 February 2016, Vol.138(4), pp.1430-45 [Peer Reviewed Journal]

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Correction to Inhibition of Soluble Guanylate Cyclase by ODQ
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Correction to Inhibition of Soluble Guanylate Cyclase by ODQ

Zhao, Yunde ; Brandish, Philip E. ; Di Valentin, Marilena ; Schelvis, Johannes P. M. ; Babcock, Gerald T. ; Marletta, Michael A.

Biochemistry, 11/27/2012, Vol.51(47), pp.9593-9593 [Peer Reviewed Journal]

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Discovery of selective glucocorticoid receptor modulator MK-5932

Bungard, Christopher J ; Hartman, George D ; Manikowski, Jesse J ; Perkins, James J ; Bai, Chang ; Brandish, Philip E ; Euler, Danielle H ; Hershey, James C ; Schmidt, Azriel ; Fang, Yulin ; Norcross, Ryan T ; Rushmore, Tom H ; Thompson, Charles D ; Meissner, Robert S

Bioorganic & Medicinal Chemistry, 15 December 2011, Vol.19(24), pp.7374-7386 [Peer Reviewed Journal]

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4
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Pharmacological Inhibition of O-GlcNAcase Does Not Increase Sensitivity of Glucocorticoid Receptor-Mediated Transrepression

Stivers, Peter J ; Harmonay, Lauren ; Hicks, Alexandra ; Mehmet, Huseyin ; Morris, Melody ; Robinson, Gain M ; Strack, Peter R ; Savage, Mary J ; Zaller, Dennis M ; Zwierzynski, Izabela ; Brandish, Philip E

PloS one, 2015, Vol.10(12), pp.e0145151 [Peer Reviewed Journal]

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5
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Revisiting the kinetics of nitric oxide (NO) binding to soluble guanylate cyclase: the simple NO-binding model is incorrect

Ballou, David P ; Zhao, Yunde ; Brandish, Philip E ; Marletta, Michael A

Proceedings of the National Academy of Sciences of the United States of America, 17 September 2002, Vol.99(19), pp.12097-101 [Peer Reviewed Journal]

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The preclinical efficacy, selectivity and pharmacologic profile of MK-5932, an insulin-sparing selective glucocorticoid receptor modulator

Brandish, Philip E ; Anderson, Kenneth ; Baltus, Gretchen A ; Bai, Chang ; Bungard, Christopher J ; Bunting, Patricia ; Byford, Alan ; Chiu, Chi-Sung ; Cicmil, Milenko ; Corcoran, Halea ; Euler, Danielle ; Fisher, John E ; Gambone, Carlo ; Hasbun-Manning, Martha ; Kuklin, Nelly ; Landis, Elizabeth ; Lifsted, Traci Q ; Mcelwee-Witmer, Sheila ; Mcintosh, Ian S ; Meissner, Robert S

European Journal of Pharmacology, 05 February 2014, Vol.724, pp.102-111 [Peer Reviewed Journal]

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7
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N-desmethylclozapine, an allosteric agonist at muscarinic 1 receptor, potentiates N-methyl-D-aspartate receptor activity

Sur, Cyrille ; Mallorga, Pierre J ; Wittmann, Marion ; Jacobson, Marlene A ; Pascarella, Danette ; Williams, Jacinta B ; Brandish, Philip E ; Pettibone, Douglas J ; Scolnick, Edward M ; Conn, P Jeffrey

Proceedings of the National Academy of Sciences of the United States of America, 11 November 2003, Vol.100(23), pp.13674-9 [Peer Reviewed Journal]

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8
Regeneration of the Ferrous Heme of Soluble Guanylate Cyclase from the Nitric Oxide Complex:  Acceleration by Thiols and Oxyhemoglobin †
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Regeneration of the Ferrous Heme of Soluble Guanylate Cyclase from the Nitric Oxide Complex:  Acceleration by Thiols and Oxyhemoglobin †

Brandish, Philip E. ; Buechler, Wolfgang ; Marletta, Michael A.

Biochemistry, 12/1998, Vol.37(48), pp.16898-16907 [Peer Reviewed Journal]

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9
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Phospho-N-acetyl-muramyl-pentapeptide translocase from Escherichia coli: catalytic role of conserved aspartic acid residues

Lloyd, Adrian J ; Brandish, Philip E ; Gilbey, Andrea M ; Bugg, Timothy D H

Journal of bacteriology, March 2004, Vol.186(6), pp.1747-57 [Peer Reviewed Journal]

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10
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Novel Phosphate Modified Cathepsin B Linkers: Improving Aqueous Solubility and Enhancing Payload Scope of ADCs

Kern, Jeffrey C ; Dooney, Deborah ; Zhang, Rena ; Liang, Linda ; Brandish, Philip E ; Cheng, Mangeng ; Feng, Guo ; Beck, Andrew ; Bresson, Damien ; Firdos, Juhi ; Gately, Dennis ; Knudsen, Nick ; Manibusan, Anthony ; Sun, Ying ; Garbaccio, Robert M

Bioconjugate chemistry, 21 September 2016, Vol.27(9), pp.2081-8 [Peer Reviewed Journal]

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11
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Scintillation proximity assay of inositol phosphates in cell extracts: High-throughput measurement of G-protein-coupled receptor activation

Brandish, Philip E ; Hill, Lorraine A ; Zheng, Wei ; Scolnick, Edward M

Analytical Biochemistry, 2003, Vol.313(2), pp.311-318 [Peer Reviewed Journal]

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12
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Development of Anti-CD74 Antibody-Drug Conjugates to Target Glucocorticoids to Immune Cells

Brandish, Philip E ; Palmieri, Anthony ; Antonenko, Svetlana ; Beaumont, Maribel ; Benso, Lia ; Cancilla, Mark ; Cheng, Mangeng ; Fayadat-Dilman, Laurence ; Feng, Guo ; Figueroa, Isabel ; Firdos, Juhi ; Garbaccio, Robert ; Garvin-Queen, Laura ; Gately, Dennis ; Geda, Prasanthi ; Haines, Christopher ; Hseih, Suchun ; Hodges, Douglas ; Kern, Jeffrey ; Knudsen

Bioconjugate chemistry, 18 July 2018, Vol.29(7), pp.2357-2369 [Peer Reviewed Journal]

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13
Interaction of Soluble Guanylate Cyclase with YC-1:  Kinetic and Resonance Raman Studies †
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Interaction of Soluble Guanylate Cyclase with YC-1:  Kinetic and Resonance Raman Studies †

Denninger, John W. ; Schelvis, Johannes P. M. ; Brandish, Philip E. ; Zhao, Yunde ; Babcock, Gerald T. ; Marletta, Michael A.

Biochemistry, 04/2000, Vol.39(14), pp.4191-4198 [Peer Reviewed Journal]

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14
Inhibition of Soluble Guanylate Cyclase by ODQ †
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Inhibition of Soluble Guanylate Cyclase by ODQ †

Zhao, Yunde ; Brandish, Philip E. ; Divalentin, Marilena ; Schelvis, Johannes P. M. ; Babcock, Gerald T. ; Marletta, Michael A.

Biochemistry, 09/2000, Vol.39(35), pp.10848-10854 [Peer Reviewed Journal]

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15
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Discovery of novel BTK inhibitors with carboxylic acids

Gao, Xiaolei ; Wang, James ; Liu, Jian ; Guiadeen, Deodial ; Krikorian, Arto ; Boga, Sobhana Babu ; Alhassan, Abdul-Basit ; Selyutin, Oleg ; Yu, Wensheng ; Yu, Younong ; Anand, Rajan ; Liu, Shilan ; Yang, Chundao ; Wu, Hao ; Cai, Jiaqiang ; Cooper, Alan ; Zhu, Hugh ; Maloney, Kevin ; Gao, Ying-Duo ; Fischmann

Bioorganic & medicinal chemistry letters, 15 March 2017, Vol.27(6), pp.1471-1477 [Peer Reviewed Journal]

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16
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Discovery of 3-morpholino-imidazole1,5-apyrazine BTK inhibitors for rheumatoid arthritis

Boga, Sobhana Babu ; Alhassan, Abdul-Basit ; Liu, Jian ; Guiadeen, Deodial ; Krikorian, Arto ; Gao, Xiaolei ; Wang, James ; Yu, Younong ; Anand, Rajan ; Liu, Shilan ; Yang, Chundao ; Wu, Hao ; Cai, Jiaqiang ; Zhu, Hugh ; Desai, Jagdish ; Maloney, Kevin ; Gao, Ying-Duo ; Fischmann, Thierry O ; Presland, Jeremy ; Mansueto

Bioorganic & medicinal chemistry letters, 15 August 2017, Vol.27(16), pp.3939-3943 [Peer Reviewed Journal]

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17
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Development of a simplified assay for determination of the antimineralocorticoid activity of compounds dosed in rats

Brandish, Philip E ; Chen, Hongxing ; Szczerba, Peter ; Hershey, James C

Journal of Pharmacological and Toxicological Methods, 2008, Vol.57(2), pp.155-160 [Peer Reviewed Journal]

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18
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Regulation of Gene Expression by Lithium and Depletion of Inositol in Slices of Adult Rat Cortex

Brandish, Philip E ; Su, Ming ; Holder, Daniel J ; Hodor, Paul ; Szumiloski, John ; Kleinhanz, Robert R ; Forbes, Jaime E ; Mcwhorter, Mollie E ; Duenwald, Sven J ; Parrish, Mark L ; Na, Sang ; Liu, Yuan ; Phillips, Robert L ; Renger, John J ; Sankaranarayanan, Sethu ; Simon, Adam J ; Scolnick, Edward M

Neuron, 2005, Vol.45(6), pp.861-872 [Peer Reviewed Journal]

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19
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Discovery of 8-Amino-imidazo[1,5- a ]pyrazines as Reversible BTK Inhibitors for the Treatment of Rheumatoid Arthritis

Liu, Jian ; Guiadeen, Deodial ; Krikorian, Arto ; Gao, Xiaolei ; Wang, James ; Boga, Sobhana Babu ; Alhassan, Abdul-Basit ; Yu, Younong ; Vaccaro, Henry ; Liu, Shilan ; Yang, Chundao ; Wu, Hao ; Cooper, Alan ; de Man, Jos ; Kaptein, Allard ; Maloney, Kevin ; Hornak, Viktor ; Gao, Ying-Duo ; Fischmann, Thierry O ; Raaijmakers, Hans ; Vu-Pham, Diep ; Presland, Jeremy ; Mansueto, My ; Xu, Zangwei ; Leccese, Erica ; Zhang-Hoover, Jie ; Knemeyer, Ian ; Garlisi, Charles G ; Bays, Nathan ; Stivers, Peter ; Brandish, Philip E ; Hicks, Alexandra ; Kim, Ronald ; Kozlowski, Joseph A Argonne National Lab. (Anl), Argonne, Il (United States). Advanced Photon Source (APS) (Corporate Author)

ACS Medicinal Chemistry Letters, 11 February 2016, Vol.7(2) [Peer Reviewed Journal]

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20
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High-Throughput Cell-Based Screening Using Scintillation Proximity Assay for the Discovery of Inositol Phosphatase Inhibitors

Zheng, Wei ; Brandish, Philip E ; Kolodin, D. Garrett ; Scolnick, Edward M ; Strulovici, Berta

Journal of Biomolecular Screening, March 2004, Vol.9(2), pp.132-140 [Peer Reviewed Journal]

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21
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A Cell-Based Ultra-High-Throughput Screening Assay for Identifying Inhibitors of D-Amino Acid Oxidase

Brandish, Philip E ; Chiu, Chi-Sung ; Schneeweis, Jonathan ; Brandon, Nicholas J ; Leech, Clare L ; Kornienko, Oleg ; Scolnick, Edward M ; Strulovici, Berta ; Zheng, Wei

Journal of Biomolecular Screening, August 2006, Vol.11(5), pp.481-487 [Peer Reviewed Journal]

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