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Enantioselective Synthesis of Hemiaminals via Pd-Catalyzed C-N Coupling with Chiral Bisphosphine Mono-oxides

Li, Hongming ; Belyk, Kevin M ; Yin, Jingjun ; Chen, Qinghao ; Hyde, Alan ; Ji, Yining ; Oliver, Steven ; Tudge, Matthew T ; Campeau, Louis-Charles ; Campos, Kevin R

Journal of the American Chemical Society, 04 November 2015, Vol.137(43), pp.13728-31 [Peer Reviewed Journal]

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Synthesis of α-hydroxyacetophenones

Mclaughlin, Mark ; Belyk, Kevin M ; Qian, Gang ; Reamer, Robert A ; Chen, Cheng-Yi

The Journal of organic chemistry, 01 June 2012, Vol.77(11), pp.5144-8 [Peer Reviewed Journal]

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Discovery and Application of Doubly Quaternized Cinchona‐Alkaloid‐Based Phase‐Transfer Catalysts

Xiang, Bangping ; Belyk, Kevin M. ; Reamer, Robert A. ; Yasuda, Nobuyoshi

Angewandte Chemie International Edition, 04 August 2014, Vol.53(32), pp.8375-8378 [Peer Reviewed Journal]

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Correction to Synthesis of Vaniprevir (MK-7009): Lactamization To Prepare a 22-Membered Macrocycle
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Correction to Synthesis of Vaniprevir (MK-7009): Lactamization To Prepare a 22-Membered Macrocycle

Song, Zhiguo J. ; Tellers, David M. ; Journet, Michel ; Kuethe, Jeffrey T. ; Lieberman, David ; Humphrey, Guy ; Zhang, Fei ; Peng, Zhihui ; Waters, Marjorie S. ; Zewge, Daniel ; Nolting, Andrew ; Zhao, Dalian ; Reamer, Robert A. ; Dormer, Peter G. ; Belyk, Kevin M. ; Davies, Ian W. ; Devine, Paul N. ; Tschaen, David M.

The Journal of Organic Chemistry, 11/18/2011, Vol.76(22), pp.9553-9553 [Peer Reviewed Journal]

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Synthesis of vaniprevir (MK-7009): lactamization to prepare a 20-membered corrected macrocycle

Song, Zhiguo J ; Tellers, David M ; Journet, Michel ; Kuethe, Jeffrey T ; Lieberman, David ; Humphrey, Guy ; Zhang, Fei ; Peng, Zhihui ; Waters, Marjorie S ; Zewge, Daniel ; Nolting, Andrew ; Zhao, Dalian ; Reamer, Robert A ; Dormer, Peter G ; Belyk, Kevin M ; Davies, Ian W ; Devine, Paul N ; Tschaen, David M

The Journal of organic chemistry, 07 October 2011, Vol.76(19), pp.7804-15 [Peer Reviewed Journal]

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Enantioselective Synthesis of 4'-Ethynyl-2-fluoro-2'-deoxyadenosine (EFdA) via Enzymatic Desymmetrization

Mclaughlin, Mark ; Kong, Jongrock ; Belyk, Kevin M ; Chen, Billy ; Gibson, Andrew W ; Keen, Stephen P ; Lieberman, David R ; Milczek, Erika M ; Moore, Jeffrey C ; Murray, David ; Peng, Feng ; Qi, Ji ; Reamer, Robert A ; Song, Zhiguo J ; Tan, Lushi ; Wang, Lin ; Williams, Michael J

Organic letters, 17 February 2017, Vol.19(4), pp.926-929 [Peer Reviewed Journal]

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Discovery and Application of Doubly Quaternized Cinchona‐Alkaloid‐Based Phase‐Transfer Catalysts

Xiang, Bangping ; Belyk, Kevin M. ; Reamer, Robert A. ; Yasuda, Nobuyoshi

Angewandte Chemie, 04 August 2014, Vol.126(32), pp.8515-8518 [Peer Reviewed Journal]

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A rapid catalytic asymmetric synthesis of 1,3,4-trisubstituted pyrrolidines

Belyk, Kevin M ; Beguin, Charlotte D ; Palucki, Michael ; Grinberg, Nelu ; Dasilva, Jimmy ; Askin, David ; Yasuda, Nobuyoshi

Tetrahedron Letters, 2004, Vol.45(16), pp.3265-3268 [Peer Reviewed Journal]

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9
Practical Synthesis of 1,6-Anhydro-2,4-dideoxy-β- d -glycero- hexopyranos-3-ulose from Levoglucosan
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Practical Synthesis of 1,6-Anhydro-2,4-dideoxy-β- d -glycero- hexopyranos-3-ulose from Levoglucosan

Belyk, Kevin M. ; Leonard,, William R. ; Bender, Dean R. ; Hughes, David L.

The Journal of Organic Chemistry, 04/2000, Vol.65(8), pp.2588-2590 [Peer Reviewed Journal]

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10
Enantioselective Synthesis of (1 R ,2 S )-1-Amino-2-vinylcyclopropanecarboxylic Acid Ethyl Ester (Vinyl-ACCA-OEt) by Asymmetric Phase-Transfer Catalyzed Cyclopropanation of ( E )- N -Phenylmethyleneglycine Ethyl Ester
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Enantioselective Synthesis of (1 R ,2 S )-1-Amino-2-vinylcyclopropanecarboxylic Acid Ethyl Ester (Vinyl-ACCA-OEt) by Asymmetric Phase-Transfer Catalyzed Cyclopropanation of ( E )- N -Phenylmethyleneglycine Ethyl Ester

Belyk, Kevin M. ; Xiang, Bangping ; Bulger, Paul G. ; Leonard, William R. ; Balsells, Jaume ; Yin, Jingjun ; Chen, Cheng-Yi

Organic Process Research & Development, 05/21/2010, Vol.14(3), pp.692-700 [Peer Reviewed Journal]

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Determination of the relative and absolute configuration of the dimethylmyristoyl side chain of pneumocandin B0 by asymmetric synthesis

Leonard, William R ; Belyk, Kevin M ; Bender, Dean R ; Conlon, David A ; Hughes, David L ; Reider, Paul J

Organic letters, 28 November 2002, Vol.4(24), pp.4201-4 [Peer Reviewed Journal]

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Synthesis of the antifungal beta-1,3-glucan synthase inhibitor CANCIDAS (caspofungin acetate) from pneumocandin B0

Leonard, William R ; Belyk, Kevin M ; Conlon, David A ; Bender, Dean R ; Dimichele, Lisa M ; Liu, Ji ; Hughes, David L

The Journal of organic chemistry, 30 March 2007, Vol.72(7), pp.2335-43 [Peer Reviewed Journal]

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13
Asymmetric Synthesis of Letermovir Using a Novel Phase-Transfer-Catalyzed Aza-Michael Reaction
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Asymmetric Synthesis of Letermovir Using a Novel Phase-Transfer-Catalyzed Aza-Michael Reaction

Humphrey, Guy R. ; Dalby, Stephen M. ; Andreani, Teresa ; Xiang, Bangping ; Luzung, Michael R. ; Song, Zhiguo Jake ; Shevlin, Michael ; Christensen, Melodie ; Belyk, Kevin M. ; Tschaen, David M.

Organic Process Research & Development, 06/17/2016, Vol.20(6), pp.1097-1103 [Peer Reviewed Journal]

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14
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A rational pre-catalyst design for bis-phosphine mono-oxide palladium catalyzed reactions

Ji, Yining ; Li, Hongming ; Hyde, Alan M ; Chen, Qinghao ; Belyk, Kevin M ; Lexa, Katrina W ; Yin, Jingjun ; Sherer, Edward C ; Williamson, R Thomas ; Brunskill, Andrew ; Ren, Sumei ; Campeau, Louis-Charles ; Davies, Ian W ; Ruck, Rebecca T

Chemical science, 01 April 2017, Vol.8(4), pp.2841-2851 [Peer Reviewed Journal]

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15
Development of a Second-Generation, Highly Efficient Manufacturing Route for the HIV Integrase Inhibitor Raltegravir Potassium
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Development of a Second-Generation, Highly Efficient Manufacturing Route for the HIV Integrase Inhibitor Raltegravir Potassium

Humphrey, Guy R. ; Pye, Philip J. ; Zhong, Yong-Li ; Angelaud, Remy ; Askin, David ; Belyk, Kevin M. ; Maligres, Peter E. ; Mancheno, Danny E. ; Miller, Ross A. ; Reamer, Robert A. ; Weissman, Steven A.

Organic Process Research & Development, 01/21/2011, Vol.15(1), pp.73-83 [Peer Reviewed Journal]

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16
Process Development of C–N Cross-Coupling and Enantioselective Biocatalytic Reactions for the Asymmetric Synthesis of Niraparib
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Process Development of C–N Cross-Coupling and Enantioselective Biocatalytic Reactions for the Asymmetric Synthesis of Niraparib

Chung, Cheol K. ; Bulger, Paul G. ; Kosjek, Birgit ; Belyk, Kevin M. ; Rivera, Nelo ; Scott, Mark E. ; Humphrey, Guy R. ; Limanto, John ; Bachert, Donald C. ; Emerson, Khateeta M.

Organic Process Research & Development, 01/17/2014, Vol.18(1), pp.215-227 [Peer Reviewed Journal]

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17
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Discovery of MK-4409, a Novel Oxazole FAAH Inhibitor for the Treatment of Inflammatory and Neuropathic Pain

Chobanian, Harry R ; Guo, Yan ; Liu, Ping ; Chioda, Marc D ; Fung, Selena ; Lanza, Thomas J ; Chang, Linda ; Bakshi, Raman K ; Dellureficio, James P ; Hong, Qingmei ; Mclaughlin, Mark ; Belyk, Kevin M ; Krska, Shane W ; Makarewicz, Amanda K ; Martel, Elliot J ; Leone, Joseph F ; Frey, Lisa ; Karanam, Bindhu ; Madeira, Maria ; Alvaro

ACS medicinal chemistry letters, 12 June 2014, Vol.5(6), pp.717-21 [Peer Reviewed Journal]

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18
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CCDC 1404559: Experimental Crystal Structure Determination

Li, Hongming ; Belyk, Kevin M. ; Yin, Jingjun ; Chen, Qinghao ; Hyde, Alan ; Ji, Yining ; Oliver, Steven ; Tudge, Matthew T. ; Campeau, Louis-Charles ; Campos, Kevin R.

2015

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19
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CCDC 1404558: Experimental Crystal Structure Determination

Li, Hongming ; Belyk, Kevin M. ; Yin, Jingjun ; Chen, Qinghao ; Hyde, Alan ; Ji, Yining ; Oliver, Steven ; Tudge, Matthew T. ; Campeau, Louis-Charles ; Campos, Kevin R.

2015

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20
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Research Dataset
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CCDC 1404561: Experimental Crystal Structure Determination

Li, Hongming ; Belyk, Kevin M. ; Yin, Jingjun ; Chen, Qinghao ; Hyde, Alan ; Ji, Yining ; Oliver, Steven ; Tudge, Matthew T. ; Campeau, Louis-Charles ; Campos, Kevin R.

2015

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21
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Research Dataset
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CCDC 1404557: Experimental Crystal Structure Determination

Li, Hongming ; Belyk, Kevin M. ; Yin, Jingjun ; Chen, Qinghao ; Hyde, Alan ; Ji, Yining ; Oliver, Steven ; Tudge, Matthew T. ; Campeau, Louis-Charles ; Campos, Kevin R.

2015

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22
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Research Dataset
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CCDC 1512975: Experimental Crystal Structure Determination

Ji, Yining ; Li, Hongming ; Hyde, Alan M. ; Chen, Qinghao ; Belyk, Kevin M. ; Lexa, Katrina W. ; Yin, Jingjun ; Sherer, Edward C. ; Williamson, R. Thomas ; Brunskill, Andrew ; Ren, Sumei ; Campeau, Louis-Charles ; Davies, Ian W. ; Ruck, Rebecca T.

2017

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23
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Research Dataset
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CCDC 1512974: Experimental Crystal Structure Determination

Ji, Yining ; Li, Hongming ; Hyde, Alan M. ; Chen, Qinghao ; Belyk, Kevin M. ; Lexa, Katrina W. ; Yin, Jingjun ; Sherer, Edward C. ; Williamson, R. Thomas ; Brunskill, Andrew ; Ren, Sumei ; Campeau, Louis-Charles ; Davies, Ian W. ; Ruck, Rebecca T.

2017

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24
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Research Dataset
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CCDC 1512973: Experimental Crystal Structure Determination

Ji, Yining ; Li, Hongming ; Hyde, Alan M. ; Chen, Qinghao ; Belyk, Kevin M. ; Lexa, Katrina W. ; Yin, Jingjun ; Sherer, Edward C. ; Williamson, R. Thomas ; Brunskill, Andrew ; Ren, Sumei ; Campeau, Louis-Charles ; Davies, Ian W. ; Ruck, Rebecca T.

2017

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25
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Research Dataset
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CCDC 1499865: Experimental Crystal Structure Determination

McLaughlin, Mark ; Kong, Jongrock ; Belyk, Kevin M. ; Chen, Billy ; Gibson, Andrew W. ; Keen, Stephen P. ; Lieberman, David R. ; Milczek, Erika M. ; Moore, Jeffrey C. ; Murray, David ; Peng, Feng ; Qi, Ji ; Reamer, Robert A. ; Song, Zhiguo J. ; Tan, Lushi ; Wang, Lin ; Williams, Michael J.

2017

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26
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Research Dataset
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CCDC 1499851: Experimental Crystal Structure Determination

McLaughlin, Mark ; Kong, Jongrock ; Belyk, Kevin M. ; Chen, Billy ; Gibson, Andrew W. ; Keen, Stephen P. ; Lieberman, David R. ; Milczek, Erika M. ; Moore, Jeffrey C. ; Murray, David ; Peng, Feng ; Qi, Ji ; Reamer, Robert A. ; Song, Zhiguo J. ; Tan, Lushi ; Wang, Lin ; Williams, Michael J.

2017

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