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28 Results  for Everything (Includes Articles)

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1
The interleukin-1β converting enzyme family of cysteine proteases
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The interleukin-1β converting enzyme family of cysteine proteases

Miller, Douglas K. ; Myerson, Joseph ; Becker, Joseph W.

Journal of Cellular Biochemistry, 01/1997, Vol.64(1), pp.2-10 [Peer Reviewed Journal]

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2
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Isolation, enzyme-bound structure, and activity of platensimycin A 1 from Streptomyces platensis

Singh, Sheo B ; Jayasuriya, Hiranthi ; Herath, Kithsiri B ; Zhang, Chaowei ; Ondeyka, John G ; Zink, Deborah L ; Ha, Sookhee ; Parthasarathy, Gopalakrishnan ; Becker, Joseph W ; Wang, Jun ; Soisson, Stephen M

Tetrahedron Letters, 2009, Vol.50(37), pp.5182-5185 [Peer Reviewed Journal]

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3
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Mouse and human granzyme B have distinct tetrapeptide specificities and abilities to recruit the bid pathway

Casciola-Rosen, Livia ; Garcia-Calvo, Margarita ; Bull, Herbert G ; Becker, Joseph W ; Hines, Tonie ; Thornberry, Nancy A ; Rosen, Antony

The Journal of biological chemistry, 16 February 2007, Vol.282(7), pp.4545-52 [Peer Reviewed Journal]

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4
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Functional characterization and crystal structure of the C215D mutant of protein-tyrosine phosphatase-1B

Romsicki, Yolanda ; Scapin, Giovanna ; Beaulieu-Audy, Veronique ; Patel, Sangita ; Becker, Joseph W ; Kennedy, Brian P ; Asante-Appiah, Ernest

The Journal of biological chemistry, 01 August 2003, Vol.278(31), pp.29009-15 [Peer Reviewed Journal]

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5
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Conformation-assisted inhibition of protein-tyrosine phosphatase-1B elicits inhibitor selectivity over T-cell protein-tyrosine phosphatase

Asante-Appiah, Ernest ; Patel, Sangita ; Desponts, Caroline ; Taylor, Jillian M ; Lau, Cheuk ; Dufresne, Claude ; Therien, Michel ; Friesen, Rick ; Becker, Joseph W ; Leblanc, Yves ; Kennedy, Brian P ; Scapin, Giovanna

The Journal of biological chemistry, 24 March 2006, Vol.281(12), pp.8010-5 [Peer Reviewed Journal]

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6
32-Indolyl Ether Derivatives of Ascomycin:  Three-Dimensional Structures of Complexes with FK506-Binding Protein
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32-Indolyl Ether Derivatives of Ascomycin:  Three-Dimensional Structures of Complexes with FK506-Binding Protein

Becker, Joseph W. ; Rotonda, Jennifer ; Cryan, John G. ; Martin, Mary ; Parsons, William H. ; Sinclair, Peter J. ; Wiederrecht, Greg ; Wong, Frederick

Journal of Medicinal Chemistry, 07/1999, Vol.42(15), pp.2798-2804 [Peer Reviewed Journal]

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7
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Crystal structure of human phosphodiesterase 3B: atomic basis for substrate and inhibitor specificity

Scapin, Giovanna ; Patel, Sangita B ; Chung, Christine ; Varnerin, Jeffrey P ; Edmondson, Scott D ; Mastracchio, Anthony ; Parmee, Emma R ; Singh, Suresh B ; Becker, Joseph W ; Van Der Ploeg, Lex H T ; Tota, Michael R

Biochemistry, 25 May 2004, Vol.43(20), pp.6091-100 [Peer Reviewed Journal]

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8
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The structure of PTP-1B in complex with a peptide inhibitor reveals an alternative binding mode for bisphosphonates

Asante-Appiah, Ernest ; Patel, Sangita ; Dufresne, Claude ; Roy, Patrick ; Wang, Qingping ; Patel, Vira ; Friesen, Richard W ; Ramachandran, Chidambaram ; Becker, Joseph W ; Leblanc, Yves ; Kennedy, Brian P ; Scapin, Giovanna

Biochemistry, 23 July 2002, Vol.41(29), pp.9043-51 [Peer Reviewed Journal]

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9
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The three‐dimensional structure of MAP kinase p38β: different features of the ATP‐binding site in p38β compared with p38α

Patel, Sangita B. ; Cameron, Patricia M. ; O' Keefe, Stephen J. ; Frantz‐Wattley, Betsy ; Thompson, Jed ; O' Neill, Edward A. ; Tennis, Trevor ; Liu, Luping ; Becker, Joseph W. ; Scapin, Giovanna

Acta Crystallographica Section D, 01 August 2009, Vol.65(8), pp.777-785 [Peer Reviewed Journal]

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10
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Isolation, enzyme-bound structure and antibacterial activity of platencin A 1 from Streptomyces platensis

Singh, Sheo B ; Ondeyka, John G ; Herath, Kithsiri B ; Zhang, Chaowei ; Jayasuriya, Hiranthi ; Zink, Deborah L ; Parthasarathy, Gopalakrishnan ; Becker, Joseph W ; Wang, Jun ; Soisson, Stephen M

Bioorganic & Medicinal Chemistry Letters, 2009, Vol.19(16), pp.4756-4759 [Peer Reviewed Journal]

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11
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Surface‐entropy reduction approaches to manipulate crystal forms of β‐ketoacyl acyl carrier protein synthase II from Streptococcus pneumoniae

Parthasarathy, Gopalakrishnan ; Cummings, Richard ; Becker, Joseph W. ; Soisson, Stephen M.

Acta Crystallographica Section D, 01 February 2008, Vol.64(2), pp.141-148 [Peer Reviewed Journal]

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12
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Surface-entropy reduction approaches to manipulate crystal forms of beta-ketoacyl acyl carrier protein synthase II from Streptococcus pneumoniae

Parthasarathy, Gopalakrishnan ; Cummings, Richard ; Becker, Joseph W ; Soisson, Stephen M

Acta crystallographica. Section D, Biological crystallography, February 2008, Vol.64(Pt 2), pp.141-8 [Peer Reviewed Journal]

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13
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The structural basis for the selectivity of benzotriazole inhibitors of PTP1B

Scapin, Giovanna ; Patel, Sangita B ; Becker, Joseph W ; Wang, Qingping ; Desponts, Caroline ; Waddleton, Deena ; Skorey, Kathryn ; Cromlish, Wanda ; Bayly, Christopher ; Therien, Michel ; Gauthier, Jacques Yves ; Li, Chun Sing ; Lau, Cheuk K ; Ramachandran, Chidambaram ; Kennedy, Brian P ; Asante-Appiah, Ernest

Biochemistry, 07 October 2003, Vol.42(39), pp.11451-9 [Peer Reviewed Journal]

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14
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Design and synthesis of alpha-aryloxyphenylacetic acid derivatives: a novel class of PPARalpha/gamma dual agonists with potent antihyperglycemic and lipid modulating activity

Shi, Guo Q ; Dropinski, James F ; Mckeever, Brian M ; Xu, Shihua ; Becker, Joseph W ; Berger, Joel P ; Macnaul, Karen L ; Elbrecht, Alex ; Zhou, Gaochao ; Doebber, Thomas W ; Wang, Peiran ; Chao, Yu-Sheng ; Forrest, Mike ; Heck, James V ; Moller, David E ; Jones, A Brian

Journal of medicinal chemistry, 30 June 2005, Vol.48(13), pp.4457-68 [Peer Reviewed Journal]

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15
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Reducing the peptidyl features of caspase-3 inhibitors: a structural analysis

Becker, Joseph W ; Rotonda, Jennifer ; Soisson, Stephen M ; Aspiotis, Renee ; Bayly, Christopher ; Francoeur, Sébastien ; Gallant, Michel ; Garcia-Calvo, Marga ; Giroux, Andre ; Grimm, Erich ; Han, Yongxin ; Mckay, Dan ; Nicholson, Donald W ; Peterson, Erin ; Renaud, Johanne ; Roy, Sophie ; Thornberry, Nancy ; Zamboni, Robert

Journal of medicinal chemistry, 06 May 2004, Vol.47(10), pp.2466-74 [Peer Reviewed Journal]

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16
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Crystallization and preliminary X‐ray diffraction analysis of the catalytic domain of recombinant human phosphodiesterase 3B

Patel, Sangita B. ; Varnerin, Jeffrey P. ; Tota, Michael R. ; Edmondson, Scott D. ; Parmee, Emma R. ; Becker, Joseph W. ; Scapin, Giovanna

Acta Crystallographica Section D, January 2004, Vol.60(1), pp.169-171 [Peer Reviewed Journal]

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17
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Lattice stabilization and enhanced diffraction in human p38α crystals by protein engineering

Patel, Sangita B ; Cameron, Patricia M ; Frantz-Wattley, Betsy ; O'Neill, Edward ; Becker, Joseph W ; Scapin, Giovanna

BBA - Proteins and Proteomics, 2004, Vol.1696(1), pp.67-73 [Peer Reviewed Journal]

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18
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Identification of a potent synthetic FXR agonist with an unexpected mode of binding and activation

Soisson, Stephen M ; Parthasarathy, Gopalakrishnan ; Adams, Alan D ; Sahoo, Soumya ; Sitlani, Ayesha ; Sparrow, Carl ; Cui, Jisong ; Becker, Joseph W

Proceedings of the National Academy of Sciences of the United States of America, 08 April 2008, Vol.105(14), pp.5337-42 [Peer Reviewed Journal]

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19
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Favin, a crystalline lectin from Vicia faba

Wang, John L ; Becker, Joseph W ; Reeke, George N ; Edelman, Gerald M

Journal of Molecular Biology, 1974, Vol.88(1), pp.259,IN37,261-260,IN38,262 [Peer Reviewed Journal]

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20
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RELATIONSHIPS BETWEEN THE STRUCTURE AND ACTIVITIES OF CONCANAVALIN A*

Reeke, George N. ; Becker, Joseph W. ; Cunningham, Bruce A. ; Gunther, Gary R. ; Wang, John L. ; Edelman, Gerald M.

Annals of the New York Academy of Sciences, June 1974, Vol.234(1), pp.369-382 [Peer Reviewed Journal]

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21
Inhibition of Stromelysin-1 (MMP-3) by P 1 ‘-Biphenylylethyl Carboxyalkyl Dipeptides
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Inhibition of Stromelysin-1 (MMP-3) by P 1 ‘-Biphenylylethyl Carboxyalkyl Dipeptides

Esser, Craig K. ; Bugianesi, Robert L. ; Caldwell, Charles G. ; Chapman, Kevin T. ; Durette, Philippe L. ; Girotra, Narindar N. ; Kopka, Ihor E. ; Lanza, Thomas J. ; Levorse, Dorothy A. ; Maccoss, Malcolm ; Owens, Karen A. ; Ponpipom, Mitree M. ; Simeone, Joseph P. ; Harrison, Richard K. ; Niedzwiecki, Lisa ; Becker, Joseph W. ; Marcy, Alice I. ; Axel, Melinda G. ; Christen, Amy J. ; Mcdonnell, Joseph ; Moore, Vernon L. ; Olszewski, Julie M. ; Saphos, Cheryl ; Visco, Denise M. ; Shen, Frank ; Colletti, Adria ; Krieter, Philip A. ; Hagmann, William K.

Journal of Medicinal Chemistry, 03/1997, Vol.40(6), pp.1026-1040 [Peer Reviewed Journal]

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22
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The differential interactions of peroxisome proliferator-activated receptor gamma ligands with Tyr473 is a physical basis for their unique biological activities

Einstein, Monica ; Akiyama, Taro E ; Castriota, Gino A ; Wang, Chuanlin F ; Mckeever, Brian ; Mosley, Ralph T ; Becker, Joseph W ; Moller, David E ; Meinke, Peter T ; Wood, Harold B ; Berger, Joel P

Molecular pharmacology, January 2008, Vol.73(1), pp.62-74 [Peer Reviewed Journal]

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23
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Expression, purification and crystallization of human 5‐lipoxygenase‐activating protein with leukotriene‐biosynthesis inhibitors

Xu, Shihua ; Mckeever, Brian M. ; Wisniewski, Douglas ; Miller, Douglas K. ; Spencer, Robert H. ; Chu, Lin ; Ujjainwalla, Feroze ; Yamin, Ting‐Ting ; Evans, Jilly F. ; Becker, Joseph W. ; Ferguson, Andrew D.

Acta Crystallographica Section F, December 2007, Vol.63(12), pp.1054-1057 [Peer Reviewed Journal]

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24
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Crystal structure of inhibitor-bound human 5-lipoxygenase-activating protein

Ferguson, Andrew D ; Mckeever, Brian M ; Xu, Shihua ; Wisniewski, Douglas ; Miller, Douglas K ; Yamin, Ting-Ting ; Spencer, Robert H ; Chu, Lin ; Ujjainwalla, Feroze ; Cunningham, Barry R ; Evans, Jilly F ; Becker, Joseph W

Science (New York, N.Y.), 27 July 2007, Vol.317(5837), pp.510-2 [Peer Reviewed Journal]

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25
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Stromelysin‐1: Three‐dimensional structure of the inhibited catalytic domain and of the C‐truncated proenzyme

Becker, Joseph W. ; Marcy, Alice I. ; Rokosz, Laura L. ; Axel, Melinda G. ; Burbaum, Jonathan J. ; Fitzgerald, Paula M. D. ; Cameron, Patricia M. ; Esser, Craig K. ; Hagmann, William K. ; Hermes, Jeffrey D. ; Springer, James P.

Protein Science, October 1995, Vol.4(10), pp.1966-1976 [Peer Reviewed Journal]

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26
Stromelysin-1: Three-dimensional structure of the inhibited catalytic domain and of the C-truncated proenzyme
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Stromelysin-1: Three-dimensional structure of the inhibited catalytic domain and of the C-truncated proenzyme

Becker, Joseph W. ; Marcy, Alice I. ; Rokosz, Laura L. ; Axel, Melinda G. ; Burbaum, Jonathan J. ; Fitzgerald, Paula M.D. ; Cameron, Patricia M. ; Esser, Craig K. ; Hagmann, William K. ; Hermes, Jeffrey D. ; Springer, James P.

Protein Science, 10/1995, Vol.4(10), pp.1966-1976 [Peer Reviewed Journal]

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27
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Discovery of novel aspartyl ketone dipeptides as potent and selective caspase-3 inhibitors

Han, Yongxin ; Giroux, André ; Grimm, Erich L ; Aspiotis, Renée ; Francoeur, Sébastien ; Bayly, Christopher I ; Mckay, Daniel J ; Roy, Sophie ; Xanthoudakis, Steve ; Vaillancourt, John P ; Rasper, Dita M ; Tam, John ; Tawa, Paul ; Thornberry, Nancy A ; Paterson, Erin P ; Garcia-Calvo, Margarita ; Becker, Joseph W

Bioorganic & Medicinal Chemistry Letters, 2004, Vol.14(3), pp.805-808 [Peer Reviewed Journal]

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28
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Platensimycin is a selective FabF inhibitor with potent antibiotic properties

Wang, Jun ; Soisson, Stephen M ; Young, Katherine ; Shoop, Wesley ; Kodali, Srinivas ; Galgoci, Andrew ; Painter, Ronald ; Parthasarathy, Gopalakrishnan ; Tang, Yui S ; Cummings, Richard ; Ha, Sookhee ; Dorso, Karen ; Motyl, Mary ; Jayasuriya, Hiranthi ; Ondeyka, John ; Herath, Kithsiri ; Zhang, Chaowei ; Hernandez, Lorraine ; Allocco, John ; Basilio

Nature, 18 May 2006, Vol.441(7091), pp.358-61 [Peer Reviewed Journal]

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