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16 Results  for Everything (Includes Articles)

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The Discovery of 3-((4-Chloro-3-methoxyphenyl)amino)-1-((3R,4S)-4-cyanotetrahydro-2H-pyran-3-yl)-1H-pyrazole-4-carboxamide, a Highly Ligand Efficient and Efficacious Janus Kinase 1 Selective Inhibitor with Favorable Pharmacokinetic Properties

Siu, Tony ; Brubaker, Jason ; Fuller, Peter ; Torres, Luis ; Zeng, Hongbo ; Close, Joshua ; Mampreian, Dawn M ; Shi, Feng ; Liu, Duan ; Fradera, Xavier ; Johnson, Kevin ; Bays, Nathan ; Kadic, Elma ; He, Fang ; Goldenblatt, Peter ; Shaffer, Lynsey ; Patel, Sangita B ; Lesburg, Charles A ; Alpert, Carla ; Dorosh

Journal of medicinal chemistry, 14 December 2017, Vol.60(23), pp.9676-9690 [Peer Reviewed Journal]

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2
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Conference Proceeding
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MATLAB-Graphical User Interface to study partial shading of PV array characteristics

Bays, Nathan ; Clifton, Jared ; Hatipoglu, Kenan

IEEE SOUTHEASTCON 2014, March 2014, pp.1-4

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Endoplasmic Reticulum Degradation Requires Lumen to Cytosol Signaling
Transmembrane Control of Hrd1p by Hrd3p

Gardner, Richard G ; Swarbrick, Gwendolyn M ; Bays, Nathan W ; Cronin, Stephen R ; Wilhovsky, Sharon ; Seelig, Linda ; Kim, Christine ; Hampton, Randolph Y

The Journal of Cell Biology, 2000, Vol.151(1), p.69-82 [Peer Reviewed Journal]

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Triazoloamides as potent γ-secretase modulators with reduced hERG liability

Fischer, Christian ; Zultanski, Susan L ; Zhou, Hua ; Methot, Joey L ; Shah, Sanjiv ; Nuthall, Hugh ; Hughes, Bethany L ; Smotrov, Nadja ; Hill, Armetta ; Szewczak, Alexander A ; Moxham, Christopher M ; Bays, Nathan ; Middleton, Richard E ; Munoz, Benito ; Shearman, Mark S

Bioorganic & Medicinal Chemistry Letters, 01 May 2012, Vol.22(9), pp.3140-3146 [Peer Reviewed Journal]

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Article
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Yeast as a budding technology in target validation

Bays, Nathan ; Margolis, Jonathan

Drug Discovery Today: Technologies, 2004, Vol.1(2), pp.157-162 [Peer Reviewed Journal]

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Discovery of novel triazolobenzazepinones as γ-secretase modulators with central Aβ42 lowering in rodents and rhesus monkeys

Fischer, Christian ; Zultanski, Susan L ; Zhou, Hua ; Methot, Joey L ; Shah, Sanjiv ; Hayashi, Ikuo ; Hughes, Bethany L ; Moxham, Christopher M ; Bays, Nathan W ; Smotrov, Nadya ; Hill, Armetta D ; Pan, Bo-Sheng ; Wu, Zhenhua ; Moy, Lily Y ; Tanga, Flobert ; Kenific, Candia ; Cruz, Jonathan C ; Walker, Deborah ; Bouthillette, Melanie ; Nikov, George N

Bioorganic & Medicinal Chemistry Letters, 01 September 2015, Vol.25(17), pp.3488-3494 [Peer Reviewed Journal]

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7
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A Simplified Scintillation Proximity Assay for Fatty Acid Synthase Activity: Development and Comparison with Other FAS Activity Assays

Bays, Nathan W ; Hill, Armetta D ; Kariv, Ilona

Journal of Biomolecular Screening, July 2009, Vol.14(6), pp.636-642 [Peer Reviewed Journal]

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8
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Article
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Control of cell growth and survival by enzymes of the fatty acid synthesis pathway in HCT-116 colon cancer cells

Zhan, Yanai ; Ginanni, Nicole ; Tota, Michael R ; Wu, Margaret ; Bays, Nathan W ; Richon, Victoria M ; Kohl, Nancy E ; Bachman, Eric S ; Strack, Peter R ; Krauss, Stefan

Clinical cancer research : an official journal of the American Association for Cancer Research, 15 September 2008, Vol.14(18), pp.5735-42 [Peer Reviewed Journal]

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9
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Article
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Discovery of novel BTK inhibitors with carboxylic acids

Gao, Xiaolei ; Wang, James ; Liu, Jian ; Guiadeen, Deodial ; Krikorian, Arto ; Boga, Sobhana Babu ; Alhassan, Abdul-Basit ; Selyutin, Oleg ; Yu, Wensheng ; Yu, Younong ; Anand, Rajan ; Liu, Shilan ; Yang, Chundao ; Wu, Hao ; Cai, Jiaqiang ; Cooper, Alan ; Zhu, Hugh ; Maloney, Kevin ; Gao, Ying-Duo ; Fischmann

Bioorganic & medicinal chemistry letters, 15 March 2017, Vol.27(6), pp.1471-1477 [Peer Reviewed Journal]

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Evaluation of JAK3 Biology in Autoimmune Disease Using a Highly Selective, Irreversible JAK3 Inhibitor

Elwood, Fiona ; Witter, David J ; Piesvaux, Jennifer ; Kraybill, Brian ; Bays, Nathan ; Alpert, Carla ; Goldenblatt, Peter ; Qu, Yujie ; Ivanovska, Irena ; Lee, Hyun-Hee ; Chiu, Chi-Sung ; Tang, Hao ; Scott, Mark E ; Deshmukh, Sujal V ; Zielstorff, Mark ; Byford, Alan ; Chakravarthy, Kalyan ; Dorosh, Lauren ; Rivkin, Alexey ; Klappenbach

The Journal of pharmacology and experimental therapeutics, May 2017, Vol.361(2), pp.229-244 [Peer Reviewed Journal]

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11
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Article
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Discovery of 3-morpholino-imidazole1,5-apyrazine BTK inhibitors for rheumatoid arthritis

Boga, Sobhana Babu ; Alhassan, Abdul-Basit ; Liu, Jian ; Guiadeen, Deodial ; Krikorian, Arto ; Gao, Xiaolei ; Wang, James ; Yu, Younong ; Anand, Rajan ; Liu, Shilan ; Yang, Chundao ; Wu, Hao ; Cai, Jiaqiang ; Zhu, Hugh ; Desai, Jagdish ; Maloney, Kevin ; Gao, Ying-Duo ; Fischmann, Thierry O ; Presland, Jeremy ; Mansueto

Bioorganic & medicinal chemistry letters, 15 August 2017, Vol.27(16), pp.3939-3943 [Peer Reviewed Journal]

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12
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Triazoles as γ-secretase modulators

Fischer, Christian ; Zultanski, Susan L ; Zhou, Hua ; Methot, Joey L ; Brown, W Colby ; Mampreian, Dawn M ; Schell, Adam J ; Shah, Sanjiv ; Nuthall, Hugh ; Hughes, Bethany L ; Smotrov, Nadja ; Kenific, Candia M ; Cruz, Jonathan C ; Walker, Deborah ; Bouthillette, Melanie ; Nikov, George N ; Savage, Dan F ; Jeliazkova-Mecheva, Valentina V ; Diaz, Damaris ; Szewczak

Bioorganic & medicinal chemistry letters, 01 July 2011, Vol.21(13), pp.4083-7 [Peer Reviewed Journal]

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13
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Development of a Cell-Based Assay for Measurement of c-Met Phosphorylation Using AlphaScreenTM Technology and High-Content Imaging Analysis

Smotrov, Nadya ; Mathur, Anjili ; Kariv, Ilona ; Moxham, Christopher M ; Bays, Nathan

Journal of Biomolecular Screening, April 2009, Vol.14(4), pp.404-411 [Peer Reviewed Journal]

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14
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Discovery of 8-Amino-imidazo[1,5- a ]pyrazines as Reversible BTK Inhibitors for the Treatment of Rheumatoid Arthritis

Liu, Jian ; Guiadeen, Deodial ; Krikorian, Arto ; Gao, Xiaolei ; Wang, James ; Boga, Sobhana Babu ; Alhassan, Abdul-Basit ; Yu, Younong ; Vaccaro, Henry ; Liu, Shilan ; Yang, Chundao ; Wu, Hao ; Cooper, Alan ; de Man, Jos ; Kaptein, Allard ; Maloney, Kevin ; Hornak, Viktor ; Gao, Ying-Duo ; Fischmann, Thierry O ; Raaijmakers, Hans ; Vu-Pham, Diep ; Presland, Jeremy ; Mansueto, My ; Xu, Zangwei ; Leccese, Erica ; Zhang-Hoover, Jie ; Knemeyer, Ian ; Garlisi, Charles G ; Bays, Nathan ; Stivers, Peter ; Brandish, Philip E ; Hicks, Alexandra ; Kim, Ronald ; Kozlowski, Joseph A Argonne National Lab. (Anl), Argonne, Il (United States). Advanced Photon Source (APS) (Corporate Author)

ACS Medicinal Chemistry Letters, 11 February 2016, Vol.7(2) [Peer Reviewed Journal]

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15
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Hrd1p/Der3p is a membrane-anchored ubiquitin ligase required for ER-associated degradation

Bays, Nathan ; Gardner, Richard ; Seelig, Linda ; Joazeiro, Claudio ; Hampton, Randolph

Nature Cell Biology, Jan 2001, Vol.3(1), pp.24-9 [Peer Reviewed Journal]

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16
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3-Aryl-4-hydroxyquinolin-2(1 H)-one derivatives as type I fatty acid synthase inhibitors

Rivkin, Alexey ; Kim, Yoona R ; Goulet, Mark T ; Bays, Nathan ; Hill, Armetta D ; Kariv, Ilona ; Krauss, Stefan ; Ginanni, Nicole ; Strack, Peter R ; Kohl, Nancy E ; Chung, Christine C ; Varnerin, Jeffrey P ; Goudreau, Paul N ; Chang, Amy ; Tota, Michael R ; Munoz, Benito

Bioorganic & Medicinal Chemistry Letters, 2006, Vol.16(17), pp.4620-4623 [Peer Reviewed Journal]

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