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33 Results  for Everything (Includes Articles)

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Preclinical Evaluation of the Stability, Safety, and Efficacy of CD101, a Novel Echinocandin

Ong, Voon ; Hough, Grayson ; Schlosser, Michael ; Bartizal, Ken ; Balkovec, James M ; James, Kenneth D ; Krishnan, B Radha

Antimicrobial agents and chemotherapy, November 2016, Vol.60(11), pp.6872-6879 [Peer Reviewed Journal]

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The First Stereoselective Total Synthesis of Quinine
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The First Stereoselective Total Synthesis of Quinine

Stork, Gilbert ; Niu, Deqiang ; Fujimoto, A. ; Koft, Emil R. ; Balkovec, James M. ; Tata, James R. ; Dake, Gregory R.

Journal of the American Chemical Society, 04/2001, Vol.123(14), pp.3239-3242 [Peer Reviewed Journal]

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The First Stereoselective Total Synthesis of Quinine [ J. Am. Chem. Soc. 2001 , 123 (14), 3239−3242].
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The First Stereoselective Total Synthesis of Quinine [ J. Am. Chem. Soc. 2001 , 123 (14), 3239−3242].

Stork, Gilbert ; Niu, Deqiang ; Fujimoto, Roger A. ; Koft, Emil R. ; Balkovec, James M. ; Tata, James R. ; Dake, Gregory R.

Journal of the American Chemical Society, 09/2001, Vol.123(35), pp.8644-8644 [Peer Reviewed Journal]

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Reduction studies of antifungal echinocandin lipopeptides. One step conversion of echinocandin B to echinocandin C

Balkovec, James M ; Black, Regina M

Tetrahedron Letters, 1992, Vol.33(32), pp.4529-4532 [Peer Reviewed Journal]

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The total synthesis of allamandin

Trost, Barry M ; Balkovec, James M

Tetrahedron Letters, 1985, Vol.26(15), pp.1807-1810 [Peer Reviewed Journal]

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6
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Synthesis of 4-methylene-1-cyclopentenes

Trost, Barry M ; Balkovec, James M ; Angle, Steven R

Tetrahedron Letters, 1986, Vol.27(13), pp.1445-1448 [Peer Reviewed Journal]

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7
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Synthesis and biological evaluation of antifungal derivatives of enfumafungin as orally bioavailable inhibitors of β-1,3-glucan synthase

Heasley, Brian H ; Pacofsky, Gregory J ; Mamai, Ahmed ; Liu, Hao ; Nelson, Kingsley ; Coti, Ghjuvanni ; Peel, Michael R ; Balkovec, James M ; Greenlee, Mark L ; Liberator, Paul ; Meng, Dongfang ; Parker, Dann L ; Wilkening, Robert R ; Apgar, James M ; Racine, F ; Hsu, Ming Jo ; Giacobbe, Robert A ; Kahn, Jennifer Nielsen

Bioorganic & Medicinal Chemistry Letters, 15 November 2012, Vol.22(22), pp.6811-6816 [Peer Reviewed Journal]

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Novel orally active inhibitors of β-1,3-glucan synthesis derived from enfumafungin

Apgar, James M ; Wilkening, Robert R ; Greenlee, Mark L ; Balkovec, James M ; Flattery, Amy M ; Abruzzo, George K ; Galgoci, Andrew M ; Giacobbe, Robert A ; Gill, Charles J ; Hsu, Ming Jo ; Liberator, Paul ; Misura, Andrew S ; Motyl, Mary ; Nielsen Kahn, Jennifer ; Powles, Maryann ; Racine, Fred ; Dragovic, Jasminka ; Habulihaz, Bahanu ; Fan, Weiming ; Kirwan, Robin ; Lee, Shu ; Liu, Hao ; Mamai, Ahmed ; Nelson, Kingsley ; Peel, Michael

Bioorganic & Medicinal Chemistry Letters, 15 December 2015, Vol.25(24), pp.5813-5818 [Peer Reviewed Journal]

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11β-HSD1 inhibition reduces atherosclerosis in mice by altering proinflammatory gene expression in the vasculature

Luo, Mingjuan J ; Thieringer, Rolf ; Springer, Martin S ; Wright, Samuel D ; Hermanowski-Vosatka, Anne ; Plump, Andrew ; Balkovec, James M ; Cheng, Kang ; Ding, Gloria J ; Kawka, Douglas W ; Koo, Gloria C ; Grand, Cheryl B Le ; Luo, Qi ; Maletic, Milana M ; Malkowitz, Lorraine ; Shah, Kashmira ; Singer, Irwin ; Waddell, Sherman T ; Wu, Kenneth K ; Yuan, Jeffrey ; Zhu, Jun ; Stepaniants, Serguei ; Yang, Xia ; Lum, Pek Yee ; Wang, I-Ming

Physiological genomics, 07 January 2013, Vol.45(1), pp.47-57 [Peer Reviewed Journal]

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The use of stable-isotopically labeled oleic acid to interrogate lipid assembly in vivo: assessing pharmacological effects in preclinical species

Mclaren, David G ; He, Timothy ; Wang, Sheng-Ping ; Mendoza, Vivienne ; Rosa, Raymond ; Gagen, Karen ; Bhat, Gowri ; Herath, Kithsiri ; Miller, Paul L ; Stribling, Sloan ; Taggart, Andrew ; Imbriglio, Jason ; Liu, Jinqi ; Chen, Dunlu ; Pinto, Shirly ; Balkovec, James M ; Devita, Robert J ; Marsh, Donald J ; Castro-Perez, Jose M ; Strack, Alison ; Johns, Douglas G ; Previs, Stephen F ; Hubbard, Brian K ; Roddy, Thomas P

Journal of lipid research, June 2011, Vol.52(6), pp.1150-61 [Peer Reviewed Journal]

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Discovery of betamethasone 17α-carbamates as dissociated glucocorticoid receptor modulators in the rat

Ali, Amjad ; Balkovec, James M ; Greenlee, Mark ; Hammond, Milton L ; Rouen, Greg ; Taylor, Gayle ; Einstein, Monica ; Ge, Lan ; Harris, Georgianna ; Kelly, Terri M ; Mazur, Paul ; Pandit, Shilpa ; Santoro, Joseph ; Sitlani, Ayesha ; Wang, Chuanlin ; Williamson, Joann ; Forrest, Michael J ; Carballo-Jane, Ester ; Luell, Silvi ; Lowitz, Karen ; Visco, Denise

Bioorganic & Medicinal Chemistry, 2008, Vol.16(16), pp.7535-7542 [Peer Reviewed Journal]

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Potent DGAT1 Inhibitors in the Benzimidazole Class with a Pyridyl-oxy-cyclohexanecarboxylic Acid Moiety

He, Shuwen ; Hong, Qingmei ; Lai, Zhong ; Wu, Zhicai ; Yu, Yang ; Kim, David W ; Ting, Pauline C ; Kuethe, Jeffrey T ; Yang, Ginger X ; Jian, Tianying ; Liu, Jian ; Guiadeen, Deodial ; Krikorian, Arto D ; Sperbeck, Donald M ; Sonatore, Lisa M ; Wiltsie, Judyann ; Chung, Christine C ; Gibson, Jack T ; Lisnock, Jeanmarie ; Murphy, Beth A ; Gorski, Judith N ; Liu, Jinqi ; Chen, Dunlu ; Chen, Xiaoli ; Wolff, Michael ; Tong, Sharon X ; Madeira, Maria ; Karanam, Bindhu V ; Shen, Dong-Ming ; Balkovec, James M ; Pinto, Shirly ; Nargund, Ravi P ; Devita, Robert J

ACS medicinal chemistry letters, 08 August 2013, Vol.4(8), pp.773-8 [Peer Reviewed Journal]

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Discovery of a Potent and Selective DGAT1 Inhibitor with a Piperidinyl-oxy-cyclohexanecarboxylic Acid Moiety

He, Shuwen ; Hong, Qingmei ; Lai, Zhong ; Yang, David X ; Ting, Pauline C ; Kuethe, Jeffrey T ; Cernak, Timothy A ; Dykstra, Kevin D ; Sperbeck, Donald M ; Wu, Zhicai ; Yu, Yang ; Yang, Ginger X ; Jian, Tianying ; Liu, Jian ; Guiadeen, Deodial ; Krikorian, Arto D ; Sonatore, Lisa M ; Wiltsie, Judyann ; Liu, Jinqi ; Gorski, Judith N ; Chung, Christine C ; Gibson, Jack T ; Lisnock, Jeanmarie ; Xiao, Jianying ; Wolff, Michael ; Tong, Sharon X ; Madeira, Maria ; Karanam, Bindhu V ; Shen, Dong-Ming ; Balkovec, James M ; Pinto, Shirly ; Nargund, Ravi P ; Devita, Robert J

ACS medicinal chemistry letters, 09 October 2014, Vol.5(10), pp.1082-7 [Peer Reviewed Journal]

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14
Efficacy of MK-991 (L-743,872), a Semisynthetic Pneumocandin, in Murine Models of Pneumocystis carinii
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Efficacy of MK-991 (L-743,872), a Semisynthetic Pneumocandin, in Murine Models of Pneumocystis carinii

Powles, Mary Ann ; Liberator, Paul ; Anderson, Jennifer ; Karkhanis, Yashwant ; Dropinski, James F. ; Bouffard, F. Aileen ; Balkovec, James M. ; Fujioka, Hisashi ; Aikawa, Masamichi ; Mcfadden, Diane ; Schmatz, Dennis

Antimicrobial Agents and Chemotherapy, 08/01/1998, Vol.42(8), pp.1985-1989 [Peer Reviewed Journal]

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15
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Novel N-arylpyrazolo3,2-c-based ligands for the glucocorticoid receptor: receptor binding and in vivo activity

Ali, Amjad ; Thompson, Christopher F ; Balkovec, James M ; Graham, Donald W ; Hammond, Milton L ; Quraishi, Nazia ; Tata, James R ; Einstein, Monica ; Ge, Lan ; Harris, Georgianna ; Kelly, Terri M ; Mazur, Paul ; Pandit, Shilpa ; Santoro, Joseph ; Sitlani, Ayesha ; Wang, Chuanlin ; Williamson, Joanne ; Miller, Douglas K ; Thompson, Chris M ; Zaller, Dennis M ; Forrest, Michael J ; Carballo-Jane, Ester ; Luell, Silvi

Journal of medicinal chemistry, 06 May 2004, Vol.47(10), pp.2441-52 [Peer Reviewed Journal]

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16
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4-Methyl-5-phenyl triazoles as selective inhibitors of 11β-hydroxysteroid dehydrogenase type I

Zhu, Yuping ; Olson, Steven H ; Hermanowski-Vosatka, Anne ; Mundt, Steven ; Shah, Kashmira ; Springer, Marty ; Thieringer, Rolf ; Wright, Samuel ; Xiao, Jianying ; Zokian, Hratch ; Balkovec, James M

Bioorganic & Medicinal Chemistry Letters, 2008, Vol.18(11), pp.3405-3411 [Peer Reviewed Journal]

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17
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Alkyl side-chain derivatives of sordaricin as potent antifungal agents against yeast

Tse, Bruno ; Balkovec, James M ; Blazey, Charles M ; Hsu, Ming-Jo ; Nielsen, Jennifer ; Schmatz, Dennis

Bioorganic & Medicinal Chemistry Letters, 1998, Vol.8(16), pp.2269-2272 [Peer Reviewed Journal]

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18
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Phenylcyclobutyl triazoles as selective inhibitors of 11β-hydroxysteroid dehydrogenase type I

Zhu, Yuping ; Olson, Steven H ; Graham, Donald ; Patel, Gool ; Hermanowski-Vosatka, Anne ; Mundt, Steven ; Shah, Kashmira ; Springer, Marty ; Thieringer, Rolf ; Wright, Samuel ; Xiao, Jianying ; Zokian, Hratch ; Dragovic, Jasminka ; Balkovec, James M

Bioorganic & Medicinal Chemistry Letters, 2008, Vol.18(11), pp.3412-3416 [Peer Reviewed Journal]

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19
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Synthesis and structure-activity relationships of novel 3′-Hty-substituted pneumocandins

Black, Regina M ; Balkovec, James M ; Nollstadt, Karl M ; Dreikorn, Sarah ; Bartizal, Kenneth F ; Abruzzo, George K

Bioorganic & Medicinal Chemistry Letters, 1997, Vol.7(22), pp.2879-2884 [Peer Reviewed Journal]

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20
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Bifunctional Small Molecules Enhance Neutrophil Activities Against and

Jones, Caroline N ; Ellett, Felix ; Robertson, Anne L ; Forrest, Kevin M ; Judice, Kevin ; Balkovec, James M ; Springer, Martin ; Markmann, James F ; Vyas, Jatin M ; Warren, H Shaw ; Irimia, Daniel

Frontiers in immunology, 2019, Vol.10, pp.644 [Peer Reviewed Journal]

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21
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Pneumocandin antifungal lipopeptides. The phenolic hydroxyl is required for 1,3-β-glucan synthesis inhibition

Balkovec, James M ; Black, Regina M ; Abruzzo, George K ; Bartizal, Ken ; Dreikorn, Sarah ; Karl, Nollstadt

Bioorganic & Medicinal Chemistry Letters, 1993, Vol.3(10), pp.2039-2042 [Peer Reviewed Journal]

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22
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Bis-aryl triazoles as selective inhibitors of 11β-hydroxysteroid dehydrogenase type 1

Aster, Susan D ; Graham, Donald W ; Kharbanda, Divya ; Patel, Gool ; Ponpipom, Mitree ; Santorelli, Gina M ; Szymonifka, Michael J ; Mundt, Steven S ; Shah, Kashmira ; Springer, Marty S ; Thieringer, Rolf ; Hermanowski-Vosatka, Anne ; Wright, Samuel D ; Xiao, Jianying ; Zokian, Hratch ; Balkovec, James M

Bioorganic & Medicinal Chemistry Letters, 2008, Vol.18(9), pp.2799-2804 [Peer Reviewed Journal]

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23
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Synthesis and SAR of thioester and thiol inhibitors of IMP-1 Metallo-β-Lactamase

Greenlee, Mark L ; Laub, Joanne B ; Balkovec, James M ; Hammond, Milton L ; Hammond, Gail G ; Pompliano, David L ; Epstein-Toney, Jeffrey H

Bioorganic & Medicinal Chemistry Letters, 1999, Vol.9(17), pp.2549-2554 [Peer Reviewed Journal]

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24
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Lipopeptide antifungal agents: Amine conjugates of the semi-synthetic pneumocandins L-731,373 and L-733,560

Zambias, Robert A ; James, Catherine ; Abruzzo, George K ; Bartizal, Kenneth F ; Hajdu, Richard ; Thompson, Randy ; Nollstadt, Karl H ; Marrinan, Jean ; Balkovec, James M

Bioorganic & Medicinal Chemistry Letters, 1997, Vol.7(15), pp.2021-2026 [Peer Reviewed Journal]

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25
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Antifungal lipopeptides: Structure-activity relationships of 3-hydroxyglutamine-modified pneumocandin B 0 derivatives

Zambias, Robert A ; James, Catherine ; Hammond, Milton L ; Abruzzo, George K ; Bartizal, Kenneth F ; Nollstadt, Karl H ; Douglas, Cameron ; Marrinan, Jean ; Balkovec, James M

Bioorganic & Medicinal Chemistry Letters, 1995, Vol.5(20), pp.2357-2362 [Peer Reviewed Journal]

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26
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Adamantyl triazoles as selective inhibitors of 11β-hydroxysteroid dehydrogenase type 1

Olson, Steven ; Aster, Susan D ; Brown, Kai ; Carbin, Linda ; Graham, Donald W ; Hermanowski-Vosatka, Anne ; Legrand, Cheryl B ; Mundt, Steven S ; Robbins, Michael A ; Schaeffer, James M ; Slossberg, Llnon H ; Szymonifka, Michael J ; Thieringer, Rolf ; Wright, Samuel D ; Balkovec, James M

Bioorganic & Medicinal Chemistry Letters, 2005, Vol.15(19), pp.4359-4362 [Peer Reviewed Journal]

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27
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Discovery of 4-heteroarylbicyclo[2.2.2]octyltriazoles as potent and selective inhibitors of 11β-HSD1: Novel therapeutic agents for the treatment of metabolic syndrome

Gu, Xin ; Dragovic, Jasminka ; Koo, Gloria C ; Koprak, Sam L ; Legrand, Cheryl ; Mundt, Steven S ; Shah, Kashmira ; Springer, Marty S ; Tan, Eugene Y ; Thieringer, Rolf ; Hermanowski-Vosatka, Anne ; Zokian, Hratch J ; Balkovec, James M ; Waddell, Sherman T

Bioorganic & Medicinal Chemistry Letters, 2005, Vol.15(23), pp.5266-5269 [Peer Reviewed Journal]

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28
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Novel glucocorticoids containing a 6,5-bicyclic core fused to a pyrazole ring: Synthesis, in vitro profile, molecular modeling studies, and in vivo experiments

Thompson, Christopher F ; Quraishi, Nazia ; Ali, Amjad ; Mosley, Ralph T ; Tata, James R ; Hammond, Milton L ; Balkovec, James M ; Einstein, Monica ; Ge, Lan ; Harris, Georgianna ; Kelly, Terri M ; Mazur, Paul ; Pandit, Shilpa ; Santoro, Joseph ; Sitlani, Ayesha ; Wang, Chuanlin ; Williamson, Joanne ; Miller, Douglas K ; Yamin, Ting-Ting D ; Thompson, Chris M ; O’neill, Edward A ; Zaller, Dennis ; Forrest, Michael J ; Carballo-Jane, Ester ; Luell, Silvi

Bioorganic & Medicinal Chemistry Letters, 2007, Vol.17(12), pp.3354-3361 [Peer Reviewed Journal]

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29
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Novel heterocyclic glucocorticoids: in vitro profile and in vivo efficacy

Thompson, Christopher F ; Quraishi, Nazia ; Ali, Amjad ; Tata, James R ; Hammond, Milton L ; Balkovec, James M ; Einstein, Monica ; Ge, Lan ; Harris, Georgianna ; Kelly, Theresa M ; Mazur, Paul ; Pandit, Shilpa ; Santoro, Joseph ; Sitlani, Ayesha ; Wang, Chuanlin ; Williamson, Joanne ; Miller, Douglas K ; Yamin, Ting-Ting D ; Thompson, Chris M ; O’neill, Edward A ; Zaller, Dennis ; Forrest, Michael J ; Carballo-Jane, Ester ; Luell, Silvi

Bioorganic & Medicinal Chemistry Letters, 2005, Vol.15(8), pp.2163-2167 [Peer Reviewed Journal]

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30
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Novel ketal ligands for the glucocorticoid receptor: in vitro and in vivo activity

Smith, Cameron J ; Ali, Amjad ; Balkovec, James M ; Graham, Donald W ; Hammond, Milton L ; Patel, Gool F ; Rouen, Gregory P ; Smith, Scott K ; Tata, James R ; Einstein, Monica ; Ge, Lan ; Harris, Georgianna S ; Kelly, Theresa M ; Mazur, Paul ; Thompson, Chris M ; Wang, Chuanlin F ; Williamson, Joanne M ; Miller, Douglas K ; Pandit, Shilpa ; Santoro, Joseph C ; Sitlani, Ayesha ; Yamin, Ting-Ting D ; O’neill, Edward A ; Zaller, Dennis M ; Carballo-Jane, Ester ; Forrest, Michael J ; Luell, Silvi

Bioorganic & Medicinal Chemistry Letters, 2005, Vol.15(11), pp.2926-2931 [Peer Reviewed Journal]

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31
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Accelerating the discovery of DGAT1 inhibitors through the application of parallel medicinal chemistry (PMC)

Yu, Yang ; Wu, Zhicai ; Shi, Zhi-Cai ; He, Shuwen ; Lai, Zhong ; Cernak, Timothy A ; Vachal, Petr ; Liu, Min ; Liu, Jian ; Hong, Qingmei ; Jian, Tianying ; Guiadeen, Deodial ; Krikorian, Arto ; Sperbeck, Donald M ; Verras, Andreas ; Sonatore, Lisa M ; Murphy, Beth A ; Wiltsie, Judyann ; Chung, Christine C ; Gorski, Judith N ; Liu, Jinqi ; Xiao, Jianying ; Wolff, Michael ; Tong, Sharon X ; Madeira, Maria ; Karanam, Bindhu V ; Shen, Dong-Ming ; Balkovec, James M ; De Vita, Robert J ; Pinto, Shirly ; Nargund, Ravi P

Bioorganic & Medicinal Chemistry Letters, 01 June 2019, Vol.29(11), pp.1380-1385 [Peer Reviewed Journal]

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32
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11beta-HSD1 inhibition ameliorates metabolic syndrome and prevents progression of atherosclerosis in mice

Hermanowski-Vosatka, Anne ; Balkovec, James M ; Cheng, Kang ; Chen, Howard Y ; Hernandez, Melba ; Koo, Gloria C ; Le Grand, Cheryl B ; Li, Zhihua ; Metzger, Joseph M ; Mundt, Steven S ; Noonan, Heather ; Nunes, Christian N ; Olson, Steven H ; Pikounis, Bill ; Ren, Ning ; Robertson, Nancy ; Schaeffer, James M ; Shah, Kashmira ; Springer, Martin S ; Strack, Alison M ; Strowski, Matthias ; Wu, Kenneth ; Wu, Tsueiju ; Xiao, Jianying ; Zhang, Bei B ; Wright, Samuel D ; Thieringer, Rolf

The Journal of experimental medicine, 15 August 2005, Vol.202(4), pp.517-27 [Peer Reviewed Journal]

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33
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Benzimidazole-based DGAT1 inhibitors with a [3.1.0] bicyclohexane carboxylic acid moiety

He, Shuwen ; Lai, Zhong ; Hong, Qingmei ; Shang, Jackie ; Reibarkh, Mikhail ; Kuethe, Jeffrey T ; Liu, Jian ; Guiadeen, Deodial ; Krikorian, Arto D ; Cernak, Timothy A ; Dykstra, Kevin D ; Sperbeck, Donald M ; Wu, Zhicai ; Yu, Yang ; Yang, Ginger X ; Jian, Tianying ; Verras, Andreas ; Sonatore, Lisa M ; Wiltsie, Judyann ; Chung, Christine C ; Murphy, Beth A ; Gorski, Judith N ; Liu, Jinqi ; Xiao, Jianying ; Wolff, Michael ; Tong, Sharon X ; Madeira, Maria ; Karanam, Bindhu V ; Shen, Dong-Ming ; Balkovec, James M ; Pinto, Shirly ; Nargund, Ravi P ; Devita, Robert J

Bioorganic & Medicinal Chemistry Letters, 15 May 2019, Vol.29(10), pp.1182-1186 [Peer Reviewed Journal]

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