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A new system for catalytic enantioselective reduction of achiral ketones to chiral alcohols. Synthesis of chiral α-hydroxy acids

Corey, E.J ; Bakshi, Raman K

Tetrahedron Letters, 1990, Vol.31(5), pp.611-614 [Peer Reviewed Journal]

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2
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A stereoselective synthesis of 7β-phenyl and 7β-methylcholesterol

Bakshi, Raman K ; Rasmusson, Gary H

Tetrahedron Letters, 1993, Vol.34(13), pp.2055-2058 [Peer Reviewed Journal]

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3
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A mechanistic and structural analysis of the basis for high enantioselectivity in the oxazaborolidine-catalyzed reduction of trihalomethyl ketones by catecholborane

Corey, E.J ; Link, John O ; Bakshi, Raman K

Tetrahedron Letters, 1992, Vol.33(47), pp.7107-7110 [Peer Reviewed Journal]

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Discovery of a piperazine urea based compound as a potent, selective, orally bioavailable melanocortin subtype-4 receptor partial agonist

Hong, Qingmei ; Bakshi, Raman K ; Palucki, Brenda L ; Park, Min K ; Ye, Zhixiong ; He, Shuwen ; Pollard, Patrick G ; Sebhat, Iyassu K ; Liu, Jian ; Guo, Liangqin ; Cashen, Doreen E ; Martin, William J ; Weinberg, David H ; Macneil, Tanya ; Tang, Rui ; Tamvakopoulos, Constantin ; Peng, Qianping ; Miller, Randy R ; Stearns, Ralph A ; Chen, Howard Y

Bioorganic & Medicinal Chemistry Letters, 2011, Vol.21(8), pp.2330-2334 [Peer Reviewed Journal]

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5
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Investigation of Cardiovascular Effects of Tetrahydro-β-carboline sstr3 antagonists

He, Shuwen ; Lai, Zhong ; Ye, Zhixiong ; Dobbelaar, Peter H ; Shah, Shrenik K ; Truong, Quang ; Du, Wu ; Guo, Liangqin ; Liu, Jian ; Jian, Tianying ; Qi, Hongbo ; Bakshi, Raman K ; Hong, Qingmei ; Dellureficio, James ; Reibarkh, Mikhail ; Samuel, Koppara ; Reddy, Vijay B ; Mitelman, Stan ; Tong, Sharon X ; Chicchi

ACS medicinal chemistry letters, 10 July 2014, Vol.5(7), pp.748-53 [Peer Reviewed Journal]

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SAR exploration at the C-3 position of tetrahydro-β-carboline sstr3 antagonists

He, Shuwen ; Dobbelaar, Peter H ; Guo, Liangqin ; Ye, Zhixiong ; Liu, Jian ; Jian, Tianying ; Truong, Quang ; Shah, Shrenik K ; Du, Wu ; Qi, Hongbo ; Bakshi, Raman K ; Hong, Qingmei ; Dellureficio, James D ; Sherer, Edward ; Pasternak, Alexander ; Feng, Zhe ; Reibarkh, Mikhail ; Lin, Melissa ; Samuel, Koppara ; Reddy, Vijay B

Bioorganic & Medicinal Chemistry Letters, 15 March 2016, Vol.26(6), pp.1529-1535 [Peer Reviewed Journal]

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The Discovery of MK-4256, a Potent SSTR3 Antagonist as a Potential Treatment of Type 2 Diabetes

He, Shuwen ; Ye, Zhixiong ; Truong, Quang ; Shah, Shrenik ; Du, Wu ; Guo, Liangqin ; Dobbelaar, Peter H ; Lai, Zhong ; Liu, Jian ; Jian, Tianying ; Qi, Hongbo ; Bakshi, Raman K ; Hong, Qingmei ; Dellureficio, James ; Pasternak, Alexander ; Feng, Zhe ; Dejesus, Reynalda ; Yang, Lihu ; Reibarkh, Mikhail ; Bradley

ACS medicinal chemistry letters, 14 June 2012, Vol.3(6), pp.484-9 [Peer Reviewed Journal]

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8
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Higher isoprenoids —XIX : Guggulsterones to dexamethasone

Swaminathan, Shankar ; Bakshi, Raman K ; Dev, Sukh

Tetrahedron, 1987, Vol.43(16), pp.3827-3838 [Peer Reviewed Journal]

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9
Higher isoprenoids —XIX
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Higher isoprenoids —XIX

Swaminathan, Shankar ; Bakshi, Raman K. ; Dev, Sukh

Tetrahedron, 1/1987, Vol.43(16), pp.3827-3838 [Peer Reviewed Journal]

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10
Mechanism-Based Inhibition of Human Steroid 5α-Reductase by Finasteride:  Enzyme-Catalyzed Formation of NADP−Dihydrofinasteride, a Potent Bisubstrate Analog Inhibitor
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Mechanism-Based Inhibition of Human Steroid 5α-Reductase by Finasteride:  Enzyme-Catalyzed Formation of NADP−Dihydrofinasteride, a Potent Bisubstrate Analog Inhibitor

Bull, Herbert G. ; Garcia-Calvo, Margarita ; Andersson, Stefan ; Baginsky, Walter F. ; Chan, H. Karen ; Ellsworth, Dina E. ; Miller, Randall R. ; Stearns, Ralph A. ; Bakshi, Raman K. ; Rasmusson, Gary H. ; Tolman, Richard L. ; Myers, Robert W. ; Kozarich, John W. ; Harris, Georgianna S.

Journal of the American Chemical Society, 01/1996, Vol.118(10), pp.2359-2365 [Peer Reviewed Journal]

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11
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Discovery of MK-4409, a Novel Oxazole FAAH Inhibitor for the Treatment of Inflammatory and Neuropathic Pain

Chobanian, Harry R ; Guo, Yan ; Liu, Ping ; Chioda, Marc D ; Fung, Selena ; Lanza, Thomas J ; Chang, Linda ; Bakshi, Raman K ; Dellureficio, James P ; Hong, Qingmei ; Mclaughlin, Mark ; Belyk, Kevin M ; Krska, Shane W ; Makarewicz, Amanda K ; Martel, Elliot J ; Leone, Joseph F ; Frey, Lisa ; Karanam, Bindhu ; Madeira, Maria ; Alvaro

ACS medicinal chemistry letters, 12 June 2014, Vol.5(6), pp.717-21 [Peer Reviewed Journal]

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12
4-Aza-3-oxo-5α-androst-1-ene-17β- N -arylcarboxamides as Dual Inhibitors of Human Type 1 and Type 2 Steroid 5α-Reductases. Dramatic Effect of N -Aryl Substituents on Type 1 and Type 2 5α-Reductase Inhibitory Potency
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4-Aza-3-oxo-5α-androst-1-ene-17β- N -arylcarboxamides as Dual Inhibitors of Human Type 1 and Type 2 Steroid 5α-Reductases. Dramatic Effect of N -Aryl Substituents on Type 1 and Type 2 5α-Reductase Inhibitory Potency

Bakshi, Raman K. ; Rasmusson, Gary H. ; Patel, Gool F. ; Mosley, Ralph T. ; Chang, Benedict ; Ellsworth, Kenneth ; Harris, Georgianna S. ; Tolman, Richard L.

Journal of Medicinal Chemistry, 01/1996, Vol.39(5), pp.1192-1192 [Peer Reviewed Journal]

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13
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Discovery of a spiroindane based compound as a potent, selective, orally bioavailable melanocortin subtype-4 receptor agonist

He, Shuwen ; Ye, Zhixiong ; Dobbelaar, Peter H ; Sebhat, Iyassu K ; Guo, Liangqin ; Liu, Jian ; Jian, Tianying ; Lai, Yingjie ; Franklin, Christopher L ; Bakshi, Raman K ; Dellureficio, James P ; Hong, Qingmei ; Tsou, Nancy N ; Ball, Richard G ; Cashen, Doreen E ; Martin, William J ; Weinberg, David H ; Macneil, Tanya ; Tang, Rui ; Tamvakopoulos, Constantin

Bioorganic & Medicinal Chemistry Letters, 2010, Vol.20(7), pp.2106-2110 [Peer Reviewed Journal]

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14
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Discovery of potent, selective, and orally bioavailable 3 H-spiro[isobenzofuran-1,4′-piperidine] based melanocortin subtype-4 receptor agonists

Guo, Liangqin ; Ye, Zhixiong ; Liu, Jian ; He, Shuwen ; Bakshi, Raman K ; Sebhat, Iyassu K ; Dobbelaar, Peter H ; Hong, Qingmei ; Jian, Tianying ; Dellureficio, James P ; Tsou, Nancy N ; Ball, Richard G ; Weinberg, David H ; Macneil, Tanya ; Tang, Rui ; Tamvakopoulos, Constantin ; Peng, Qianping ; Chen, Howard Y ; Chen, Airu S ; Martin, William J

Bioorganic & Medicinal Chemistry Letters, 2010, Vol.20(16), pp.4895-4900 [Peer Reviewed Journal]

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15
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Spiroindane based amides as potent and selective MC4R agonists for the treatment of obesity

He, Shuwen ; Ye, Zhixiong ; Dobbelaar, Peter H ; Sebhat, Iyassu K ; Guo, Liangqin ; Liu, Jian ; Jian, Tianying ; Lai, Yingjie ; Franklin, Christopher L ; Bakshi, Raman K ; Dellureficio, James P ; Hong, Qingmei ; Weinberg, David H ; Macneil, Tanya ; Tang, Rui ; Strack, Alison M ; Tamvakopoulos, Constantin ; Peng, Qianping ; Miller, Randy R ; Stearns, Ralph A

Bioorganic & Medicinal Chemistry Letters, 01 August 2010, Vol.20(15), pp.4399-4405 [Peer Reviewed Journal]

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16
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Optimization of privileged structures for selective and potent melanocortin subtype-4 receptor ligands

Hong, Qingmei ; Bakshi, Raman K ; Dellureficio, James ; He, Shuwen ; Ye, Zhixiong ; Dobbelaar, Peter H ; Sebhat, Iyassu K ; Guo, Liangqin ; Liu, Jian ; Jian, Tianying ; Tang, Rui ; Kalyani, Rubana N ; Macneil, Tanya ; Vongs, Aurawan ; Rosenblum, Charles I ; Weinberg, David H ; Peng, Qingping ; Tamvakopoulos, Constantin ; Miller, Randy R ; Stearns, Ralph A

Bioorganic & Medicinal Chemistry Letters, 01 August 2010, Vol.20(15), pp.4483-4486 [Peer Reviewed Journal]

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17
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Discovery of highly potent and efficacious MC4R agonists with spiroindane N-Me-1,2,4-triazole privileged structures for the treatment of obesity

He, Shuwen ; Ye, Zhixiong ; Dobbelaar, Peter H ; Bakshi, Raman K ; Hong, Qingmei ; Dellureficio, James P ; Sebhat, Iyassu K ; Guo, Liangqin ; Liu, Jian ; Jian, Tianying ; Lai, Yingjie ; Franklin, Christopher L ; Reibarkh, Mikhail ; Holmes, Mark A ; Weinberg, David H ; Macneil, Tanya ; Tang, Rui ; Tamvakopoulos, Constantin ; Peng, Qianping ; Miller, Randy R

Bioorganic & Medicinal Chemistry Letters, 2010, Vol.20(22), pp.6524-6532 [Peer Reviewed Journal]

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18
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Optimization of a privileged structure leading to potent and selective human melanocortin subtype-4 receptor ligands

Bakshi, Raman K ; Hong, Qingmei ; Tang, Rui ; Kalyani, Rubana N ; Macneil, Tanya ; Weinberg, David H ; Van Der Ploeg, Lex H.T ; Patchett, Arthur A ; Nargund, Ravi P

Bioorganic & Medicinal Chemistry Letters, 2006, Vol.16(5), pp.1130-1133 [Peer Reviewed Journal]

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19
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4-Methyl-3-oxo-4-aza-5α-androst-1-ene-17β-N-aryl-carboxamides: an approach to combined androgen blockade [5α-reductase inhibition with androgen receptor binding in vitro]

Tolman, Richard L ; Sahoo, Soumya P ; Bakshi, Raman K ; Gratale, Dominick ; Patel, Gool ; Patel, Sushma ; Toney, Jeffrey ; Chang, Benedict ; Harris, Georgianna S

Journal of Steroid Biochemistry and Molecular Biology, 1997, Vol.60(5), pp.303-309 [Peer Reviewed Journal]

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20
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1-Amino-1,2,3,4-tetrahydronaphthalene-2-carboxylic acid as a Tic mimetic: Application in the synthesis of potent human melanocortin-4 receptor selective agonists

Bakshi, Raman K ; Hong, Qingmei ; Olson, J.T ; Ye, Zhixiong ; Sebhat, Iyassue K ; Weinberg, David H ; Macneil, Tanya ; Kalyani, Rubana N ; Tang, Rui ; Martin, William J ; Strack, Alison ; Mcgowan, Erin ; Tamvakopoulos, Constantin ; Miller, Randy R ; Stearns, Ralph A ; Tang, Wei ; Maclntyre, D. Euan ; van Der Ploeg, Lex H.T ; Patchett, Arthur A ; Nargund, Ravi P

Bioorganic & Medicinal Chemistry Letters, 2005, Vol.15(14), pp.3430-3433 [Peer Reviewed Journal]

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21
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Discovery and activity of (1 R,4 S,6 R)- N-[(1 R)-2-[4-cyclohexyl-4-[[(1,1-dimethylethyl)amino]carbonyl]-1-piperidinyl]-1-[(4-fluorophenyl)methyl]-2-oxoethyl]-2-methyl-2-azabicyclo[2.2.2]octane-6-carboxamide (3, RY764), a potent and selective melanocortin subtype-4 receptor agonist

Ye, Zhixiong ; Guo, Liangqin ; Barakat, Khaled J ; Pollard, Patrick G ; Palucki, Brenda L ; Sebhat, Iyassu K ; Bakshi, Raman K ; Tang, Rui ; Kalyani, Rubana N ; Vongs, Aurawan ; Chen, Airu S ; Chen, Howard Y ; Rosenblum, Charles I ; Macneil, Tanya ; Weinberg, David H ; Peng, Qianping ; Tamvakopoulos, Constantin ; Miller, Randy R ; Stearns, Ralph A ; Cashen, Doreen E

Bioorganic & Medicinal Chemistry Letters, 2005, Vol.15(15), pp.3501-3505 [Peer Reviewed Journal]

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22
Modeling directed design and biological evaluation of quinazolinones as non-peptidic growth hormone secretagogues
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Modeling directed design and biological evaluation of quinazolinones as non-peptidic growth hormone secretagogues

Ye, Zhixiong ; Gao, Yingduo ; Bakshi, Raman K. ; Chen, Meng-Hsin ; Rohrer, Susan P. ; Feighner, Scott D. ; Pong, Sheng-Shung ; Howard, Andrew D. ; Blake, Allan ; Birzin, Elizabeth T. ; Locco, Louis ; Parmar, Rupa M. ; Chan, Wanda W.-S. ; Schaeffer, James M. ; Smith, Roy G. ; Patchett, Arthur A. ; Nargund, Ravi P.

Bioorganic & Medicinal Chemistry Letters, 01/2000, Vol.10(1), pp.5-8 [Peer Reviewed Journal]

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23
A Comparative Study of Dialkylboron Chlorides and Triflates for the Enolization of Ketones. The Controlled Stereospecific Synthesis of Either (E)- or (Z)-Enol Borinates
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A Comparative Study of Dialkylboron Chlorides and Triflates for the Enolization of Ketones. The Controlled Stereospecific Synthesis of Either (E)- or (Z)-Enol Borinates

Brown, Herbert C ; Singaram, Bakthan ; Bakshi, Raman K ; Pandiarajan, Paul K ; Dhar, Raj K Purdue Univ Lafayette In (Corporate Author)

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24
Major Effect of the Leaving Group in Dialkylboron Chlorides and Triflates in Controlling the Stereospecific Conversion of Ketones into Either (E)- or (Z)- Enol Borinatesxxb
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Major Effect of the Leaving Group in Dialkylboron Chlorides and Triflates in Controlling the Stereospecific Conversion of Ketones into Either (E)- or (Z)- Enol Borinatesxxb

Brown, Herbert C ; Dhar, Raj K ; Bakshi, Raman K ; Pandiarajan, Paul K ; Singaram, Bakthan Purdue Univ Lafayette In Richard B Wetherill Lab (Corporate Author)

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25
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Major Effect of the Leaving Group in Dialkylboron Chlorides and Triflates in Controlling the Stereospecific Conversion of Ketones into Either (E)- or (Z)- Enol Borinatesxxb

Brown, Herbert C. ; Dhar, Raj K. ; Bakshi, Raman K. ; Pandiarajan, Paul K. ; Singaram, Bakthan US Dept of the Navy; PURDUE UNIV LAFAYETTE IN RICHARD B WETHERILL LAB

1989

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