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14 Results  for Everything (Includes Articles)

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1
Diastereoselective Intermolecular [4 + 3] Cycloadditions via an Extended Transition State:  A Route to Enantiomerically Enriched Cycloadducts
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Diastereoselective Intermolecular [4 + 3] Cycloadditions via an Extended Transition State:  A Route to Enantiomerically Enriched Cycloadducts

Lautens, Mark ; Aspiotis, Renee ; Colucci, John

Journal of the American Chemical Society, 01/1996, Vol.118(44), pp.10930-10931 [Peer Reviewed Journal]

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2
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Enantiomer discrimination illustrated by the high resolution crystal structures of type 4 phosphodiesterase

Huai, Qing ; Sun, Yingjie ; Wang, Huanchen ; Macdonald, Dwight ; Aspiotis, Renée ; Robinson, Howard ; Huang, Zheng ; Ke, Hengming

Journal of medicinal chemistry, 23 March 2006, Vol.49(6), pp.1867-73 [Peer Reviewed Journal]

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3
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The discovery and synthesis of highly potent subtype selective phosphodiesterase 4D inhibitors

Aspiotis, Renee ; Deschênes, Denis ; Dubé, Daniel ; Girard, Yves ; Huang, Zheng ; Laliberté, France ; Liu, Susana ; Papp, Robert ; Nicholson, Donald W ; Young, Robert N

Bioorganic & Medicinal Chemistry Letters, 2010, Vol.20(18), pp.5502-5505 [Peer Reviewed Journal]

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4
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Identification of a new biaryl scaffold generating potent renin inhibitors

Lacombe, Patrick ; Aspiotis, Renée ; Bayly, Christopher ; Chen, Austin ; Dubé, Daniel ; Fortin, Réjean ; Gallant, Michel ; Juteau, Hélène ; Liu, Suzanna ; Mckay, Dan ; Roy, Patrick ; Wu, Tom

Bioorganic & Medicinal Chemistry Letters, 2010, Vol.20(19), pp.5822-5826 [Peer Reviewed Journal]

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5
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The discovery and synthesis of potent zwitterionic inhibitors of renin

Aspiotis, Renee ; Chen, Austin ; Cauchon, Elizabeth ; Dubé, Daniel ; Falgueyret, Jean-Pierre ; Gagné, Sébastien ; Gallant, Michel ; Grimm, Erich L ; Houle, Robert ; Juteau, Hélène ; Lacombe, Patrick ; Laliberté, Sébastien ; Lévesque, Jean-François

Bioorganic & Medicinal Chemistry Letters, 2011, Vol.21(8), pp.2430-2436 [Peer Reviewed Journal]

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6
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Renin inhibitors for the treatment of hypertension: Design and optimization of a novel series of spirocyclic piperidines

Chen, Austin ; Aspiotis, Renee ; Campeau, Louis-Charles ; Cauchon, Elizabeth ; Chefson, Amadine ; Ducharme, Yves ; Falgueyret, Jean-Pierre ; Gagné, Sébastien ; Han, Yongxin ; Houle, Robert ; Laliberté, Sébastien ; Larouche, Guillaume ; Lévesque, Jean-François ; Mckay, Dan

Bioorganic & Medicinal Chemistry Letters, 2011, Vol.21(24), pp.7399-7404 [Peer Reviewed Journal]

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7
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3,4-Diarylpiperidines as potent renin inhibitors

Lacombe, Patrick ; Arbour, Mélissa ; Aspiotis, Renée ; Cauchon, Elizabeth ; Chen, Austin ; Dubé, Daniel ; Falgueyret, Jean-Pierre ; Fournier, Pierre-André ; Gallant, Michel ; Grimm, Erich ; Han, Yongxin ; Juteau, Hélène ; Liu, Suzanna ; Mellon, Christophe

Bioorganic & Medicinal Chemistry Letters, 01 March 2012, Vol.22(5), pp.1953-1957 [Peer Reviewed Journal]

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8
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Discovery of MK- 0952, a selective PDE4 inhibitor for the treatment of long-term memory loss and mild cognitive impairment

Gallant, Michel ; Aspiotis, Renee ; Day, Stephen ; Dias, Rebecca ; Dubé, Daniel ; Dubé, Laurence ; Friesen, Richard W ; Girard, Mario ; Guay, Daniel ; Hamel, Pierre ; Huang, Zheng ; Lacombe, Patrick ; Laliberté, Sebastien ; Lévesque, Jean-François ; Liu, Susana

Bioorganic & Medicinal Chemistry Letters, 2010, Vol.20(22), pp.6387-6393 [Peer Reviewed Journal]

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9
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Reducing the peptidyl features of caspase-3 inhibitors: a structural analysis

Becker, Joseph W ; Rotonda, Jennifer ; Soisson, Stephen M ; Aspiotis, Renee ; Bayly, Christopher ; Francoeur, Sébastien ; Gallant, Michel ; Garcia-Calvo, Marga ; Giroux, Andre ; Grimm, Erich ; Han, Yongxin ; Mckay, Dan ; Nicholson, Donald W ; Peterson, Erin ; Renaud, Johanne ; Roy, Sophie ; Thornberry, Nancy ; Zamboni, Robert

Journal of medicinal chemistry, 06 May 2004, Vol.47(10), pp.2466-74 [Peer Reviewed Journal]

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10
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Solid phase synthesis of selective caspase-3 peptide inhibitors

Grimm, Erich L ; Roy, Bruno ; Aspiotis, Renee ; Bayly, Christopher I ; Nicholson, Donald W ; Rasper, Dita M ; Renaud, Johanne ; Roy, Sophie ; Tam, John ; Tawa, Paul ; Vaillancourt, John P ; Xanthoudakis, Steven ; Zamboni, Robert J

Bioorganic & Medicinal Chemistry, 01 March 2004, Vol.12(5), pp.845-851 [Peer Reviewed Journal]

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11
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Inhibitors of the inducible microsomal prostaglandin E 2 synthase (mPGES-1) derived from MK-886

Riendeau, Denis ; Aspiotis, Renee ; Ethier, Diane ; Gareau, Yves ; Grimm, Erich L ; Guay, Jocelyne ; Guiral, Sébastien ; Juteau, Hélène ; Mancini, Joseph A ; Méthot, Nathalie ; Rubin, Joel ; Friesen, Richard W

Bioorganic & Medicinal Chemistry Letters, 2005, Vol.15(14), pp.3352-3355 [Peer Reviewed Journal]

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12
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Solid-phase analogue synthesis of caspase-3 inhibitors via palladium-catalyzed amination of 3-bromopyrazinones

Isabel, Elise ; Aspiotis, Renee ; Black, W. Cameron ; Colucci, John ; Fortin, Réjean ; Giroux, André ; Grimm, Erich L ; Han, Yongxin ; Mellon, Christophe ; Nicholson, Donald W ; Rasper, Dita M ; Renaud, Johanne ; Roy, Sophie ; Tam, John ; Tawa, Paul ; Vaillancourt, John P ; Xanthoudakis, Steven ; Zamboni, Robert J

Bioorganic & Medicinal Chemistry Letters, 2007, Vol.17(6), pp.1671-1674 [Peer Reviewed Journal]

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13
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Lipophilic versus hydrogen-bonding effect in P 3 on potency and selectivity of valine aspartyl ketones as caspase 3 inhibitors

Mellon, Christophe ; Aspiotis, Reneé ; Black, Cameron W ; Bayly, Christopher I ; Grimm, Erich L ; Giroux, André ; Han, Yongxin ; Isabel, Elise ; Mckay, Daniel J ; Nicholson, Donald W ; Rasper, Dita M ; Roy, Sophie ; Tam, John ; Thornberry, Nancy A ; Vaillancourt, John P ; Xanthoudakis, Steven ; Zamboni, Robert

Bioorganic & Medicinal Chemistry Letters, 2005, Vol.15(17), pp.3886-3890 [Peer Reviewed Journal]

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14
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Discovery of novel aspartyl ketone dipeptides as potent and selective caspase-3 inhibitors

Han, Yongxin ; Giroux, André ; Grimm, Erich L ; Aspiotis, Renée ; Francoeur, Sébastien ; Bayly, Christopher I ; Mckay, Daniel J ; Roy, Sophie ; Xanthoudakis, Steve ; Vaillancourt, John P ; Rasper, Dita M ; Tam, John ; Tawa, Paul ; Thornberry, Nancy A ; Paterson, Erin P ; Garcia-Calvo, Margarita ; Becker, Joseph W

Bioorganic & Medicinal Chemistry Letters, 2004, Vol.14(3), pp.805-808 [Peer Reviewed Journal]

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