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Selective inhibition of Ezh2 by a small molecule inhibitor blocks tumor cells proliferation

Qi, Wei ; Chan, Homan ; Teng, Lin ; Li, Ling ; Chuai, Shannon ; Zhang, Ruipeng ; Zeng, Jue ; Li, Min ; Fan, Hong ; Lin, Ying ; Gu, Justin ; Ardayfio, Ophelia ; Zhang, Ji-Hu ; Yan, Xiaoxia ; Fang, Jialuo ; Mi, Yuan ; Zhang, Man ; Zhou, Tao ; Feng, Grace ; Chen, Zijun ; Li, Guobin ; Yang, Teddy ; Zhao, Kehao ; Liu, Xianghui ; Yu, Zhengtian ; Lu, Chris X ; Atadja, Peter ; Li, En

Proceedings of the National Academy of Sciences of the United States of America, 26 December 2012, Vol.109(52), pp.21360-5 [Peer Reviewed Journal]

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Discovery and Molecular Basis of a Diverse Set of Polycomb Repressive Complex 2 Inhibitors Recognition by EED

Li, Ling ; Zhang, Hailong ; Zhang, Man ; Zhao, Mengxi ; Feng, Lijian ; Luo, Xiao ; Gao, Zhenting ; Huang, Ying ; Ardayfio, Ophelia ; Ji-Hu, Zhang ; Lin, Ying ; Fan, Hong ; Li, Guobin ; Liu, Lei ; Feng, Leying ; Luo, Fangjun ; Lin, Teng ; Qi, Wei ; Ottl, Johannes ; Lingel, Andreas ; Bussiere, Dirksen ; Yu, Zhengtian ; Atadja, Peter ; Lu, Chris ; Li, En ; Gu, Justin ; Zhao, Kehao

PLoS One, Jan 2017, Vol.12(1), p.e0169855 [Peer Reviewed Journal]

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Application of Titration-Based Screening for the Rapid Pilot Testing of High-Throughput Assays

Zhang, Ji-Hu ; Kang, Zhao B ; Ardayfio, Ophelia ; Ho, Pei-I ; Smith, Thomas ; Wallace, Iain ; Bowes, Scott ; Hill, W. Adam ; Auld, Douglas S

Journal of Biomolecular Screening, June 2014, Vol.19(5), pp.651-660 [Peer Reviewed Journal]

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Identification of orally available naphthyridine protein kinase D inhibitors

Meredith, Erik L ; Ardayfio, Ophelia ; Beattie, Kimberly ; Dobler, Markus R ; Enyedy, Istvan ; Gaul, Christoph ; Hosagrahara, Vinayak ; Jewell, Charles ; Koch, Keith ; Lee, Wendy ; Lehmann, Hansjoerg ; Mckinsey, Timothy A ; Miranda, Karl ; Pagratis, Nikos ; Pancost, Margaret ; Patnaik, Anup ; Phan, Dillon ; Plato, Craig ; Qian, Ming ; Rajaraman, Vasumathy ; Rao, Chang ; Rozhitskaya, Olga ; Ruppen, Thomas ; Shi, Jie ; Siska, Sarah J ; Springer, Clayton ; Van Eis, Maurice ; Vega, Richard B ; Von Matt, Anette ; Yang, Lihua ; Yoon, Taeyoung ; Zhang, Ji-Hu ; Zhu, Na ; Monovich, Lauren G

Journal of medicinal chemistry, 12 August 2010, Vol.53(15), pp.5400-21 [Peer Reviewed Journal]

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