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1
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Regulation of P450 genes by liver-enriched transcription factors and nuclear receptors

Akiyama, Taro E ; Gonzalez, Frank J

BBA - General Subjects, 2003, Vol.1619(3), pp.223-234 [Peer Reviewed Journal]

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2
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PPARgamma and PPARdelta negatively regulate specific subsets of lipopolysaccharide and IFN-gamma target genes in macrophages

Welch, John S ; Ricote, Mercedes ; Akiyama, Taro E ; Gonzalez, Frank J ; Glass, Christopher K

Proceedings of the National Academy of Sciences of the United States of America, 27 May 2003, Vol.100(11), pp.6712-7 [Peer Reviewed Journal]

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Benzimidazolones: a new class of selective peroxisome proliferator-activated receptor γ (PPARγ) modulators

Liu, Weiguo ; Lau, Fiona ; Liu, Kun ; Wood, Harold B ; Zhou, Gaochao ; Chen, Yuli ; Li, Ying ; Akiyama, Taro E ; Castriota, Gino ; Einstein, Monica ; Wang, Chualin ; Mccann, Margaret E ; Doebber, Thomas W ; Wu, Margaret ; Chang, Ching H ; Mcnamara, Lesley ; Mckeever, Brian ; Mosley, Ralph T ; Berger, Joel P ; Meinke, Peter T

Journal of medicinal chemistry, 22 December 2011, Vol.54(24), pp.8541-54 [Peer Reviewed Journal]

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4
Correction to Discovery of (2 R )-2-(3-{3-[(4-Methoxyphenyl)carbonyl]-2-methyl-6-(trifluoromethoxy)-1 H -indol-1-yl}phenoxy)butanoic Acid (MK-0533): A Novel Selective Peroxisome Proliferator-Activated Receptor γ Modulator for the Treatment of Type 2 Diabetes Mellitus with a Reduced Potential to Increase Plasma and Extracellular Fluid Volume
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Correction to Discovery of (2 R )-2-(3-{3-[(4-Methoxyphenyl)carbonyl]-2-methyl-6-(trifluoromethoxy)-1 H -indol-1-yl}phenoxy)butanoic Acid (MK-0533): A Novel Selective Peroxisome Proliferator-Activated Receptor γ Modulator for the Treatment of Type 2 Diabetes Mellitus with a Reduced Potential to Increase Plasma and Extracellular Fluid Volume

Acton, John J. ; Akiyama, Taro E. ; Chang, Ching H. ; Colwell, Lawrence ; Debenham, Sheryl ; Doebber, Thomas ; Einstein, Monica ; Liu, Kun ; Mccann, Margaret E. ; Moller, David E. ; Muise, Eric S. ; Tan, Yejun ; Thompson, John R. ; Wong, Kenny K. ; Wu, Margaret ; Xu, Libo ; Meinke, Peter T. ; Berger, Joel P. ; Wood, Harold B.

Journal of Medicinal Chemistry, 11/27/2013, Vol.56(22), pp.9368-9368 [Peer Reviewed Journal]

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5
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Activation of peroxisome proliferator-activated receptor gamma (PPARgamma) by nitroalkene fatty acids: importance of nitration position and degree of unsaturation

Gorczynski, Michael J ; Smitherman, Pamela K ; Akiyama, Taro E ; Wood, Harold B ; Berger, Joel P ; King, S Bruce ; Morrow, Charles S

Journal of medicinal chemistry, 13 August 2009, Vol.52(15), pp.4631-9 [Peer Reviewed Journal]

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6
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Peroxisome proliferator-activated receptor beta/delta regulates very low density lipoprotein production and catabolism in mice on a Western diet

Akiyama, Taro E ; Lambert, Gilles ; Nicol, Christopher J ; Matsusue, Kimihiko ; Peters, Jeffrey M ; Brewer, H Bryan ; Gonzalez, Frank J

The Journal of biological chemistry, 14 May 2004, Vol.279(20), pp.20874-81 [Peer Reviewed Journal]

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7
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Diminished hepatocellular proliferation in mice humanized for the nuclear receptor peroxisome proliferator-activated receptor alpha

Cheung, Connie ; Akiyama, Taro E ; Ward, Jerrold M ; Nicol, Christopher J ; Feigenbaum, Lionel ; Vinson, Charles ; Gonzalez, Frank J

Cancer research, 01 June 2004, Vol.64(11), pp.3849-54 [Peer Reviewed Journal]

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8
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Dual roles for lipolysis and oxidation in peroxisome proliferation-activator receptor responses to electronegative low density lipoprotein

Ziouzenkova, Ouliana ; Asatryan, Liana ; Sahady, Deanna ; Orasanu, Gabriela ; Perrey, Stephan ; Cutak, Benjamin ; Hassell, Tom ; Akiyama, Taro E ; Berger, Joel P ; Sevanian, Alex ; Plutzky, Jorge

The Journal of biological chemistry, 10 October 2003, Vol.278(41), pp.39874-81 [Peer Reviewed Journal]

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9
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Ketohexokinase knockout mice, a model for essential fructosuria, exhibit altered fructose metabolism and are protected from diet-induced metabolic defects

Miller, Corin O ; Yang, Xiaodong ; Lu, Ku ; Cao, Jin ; Herath, Kithsiri ; Rosahl, Thomas W ; Askew, Roger ; Pavlovic, Guillaume ; Zhou, Gaochao ; Li, Cai ; Akiyama, Taro E

American journal of physiology. Endocrinology and metabolism, 01 September 2018, Vol.315(3), pp.E386-E393 [Peer Reviewed Journal]

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10
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Discovery of a peroxisome proliferator activated receptor gamma (PPARgamma) modulator with balanced PPARalpha activity for the treatment of type 2 diabetes and dyslipidemia

Liu, Weiguo ; Liu, Kun ; Wood, Harold B ; Mccann, Margaret E ; Doebber, Thomas W ; Chang, Ching H ; Akiyama, Taro E ; Einstein, Monica ; Berger, Joel P ; Meinke, Peter T

Journal of medicinal chemistry, 23 July 2009, Vol.52(14), pp.4443-53 [Peer Reviewed Journal]

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11
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Differential potencies of naturally occurring regioisomers of nitrolinoleic acid in PPARgamma activation

Alexander, Richard L ; Wright, Marcus W ; Gorczynski, Michael J ; Smitherman, Pamela K ; Akiyama, Taro E ; Wood, Harold B ; Berger, Joel P ; King, S Bruce ; Morrow, Charles S

Biochemistry, 20 January 2009, Vol.48(2), pp.492-8 [Peer Reviewed Journal]

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12
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Effects of small interfering RNA-mediated hepatic glucagon receptor inhibition on lipid metabolism in db/db mice

Han, Seongah ; Akiyama, Taro E ; Previs, Stephen F ; Herath, Kithsiri ; Roddy, Thomas P ; Jensen, Kristian K ; Guan, Hong-Ping ; Murphy, Beth A ; Mcnamara, Lesley A ; Shen, Xun ; Strapps, Walter ; Hubbard, Brian K ; Pinto, Shirly ; Li, Cai ; Li, Jing

Journal of lipid research, October 2013, Vol.54(10), pp.2615-22 [Peer Reviewed Journal]

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13
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CM-101: Type I Collagen-targeted MR Imaging Probe for Detection of Liver Fibrosis

Farrar, Christian T ; Gale, Eric M ; Kennan, Richard ; Ramsay, Ian ; Masia, Ricard ; Arora, Gunisha ; Looby, Kailyn ; Wei, Lan ; Kalpathy-Cramer, Jayashree ; Bunzel, Michelle M ; Zhang, Chunlian ; Zhu, Yonghua ; Akiyama, Taro E ; Klimas, Michael ; Pinto, Shirly ; Diyabalanage, Himashinie ; Tanabe, Kenneth K ; Humblet, Valerie ; Fuchs, Bryan C ; Caravan, Peter

Radiology, May 2018, Vol.287(2), pp.581-589 [Peer Reviewed Journal]

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14
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Peroxisome proliferator-activated receptor beta (delta)-dependent regulation of ubiquitin C expression contributes to attenuation of skin carcinogenesis

Kim, Dae J ; Akiyama, Taro E ; Harman, Fred S ; Burns, Amanda M ; Shan, Weiwei ; Ward, Jerrold M ; Kennett, Mary J ; Gonzalez, Frank J ; Peters, Jeffrey M

The Journal of biological chemistry, 28 May 2004, Vol.279(22), pp.23719-27 [Peer Reviewed Journal]

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15
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Retinaldehyde represses adipogenesis and diet-induced obesity

Ziouzenkova, Ouliana ; Orasanu, Gabriela ; Sharlach, Molly ; Akiyama, Taro E ; Berger, Joel P ; Viereck, Jason ; Hamilton, James A ; Tang, Guangwen ; Dolnikowski, Gregory G ; Vogel, Silke ; Duester, Gregg ; Plutzky, Jorge

Nature medicine, June 2007, Vol.13(6), pp.695-702 [Peer Reviewed Journal]

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16
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Corrigendum to “Discovery of benzofuran propanoic acid GPR120 agonists: From uHTS hit to mechanism-based pharmacodynamic effects” [Bioorg. Med. Chem. Lett. 26 (2016) 5724–5728]

Lombardo, Matthew ; Bender, Kate ; London, Clare ; Plotkin, Michael A ; Kirkland, Melissa ; Mane, Joel ; Pachanski, Michele ; Geissler, Wayne ; Cummings, John ; Habulihaz, Bahanu ; Akiyama, Taro E ; Di Salvo, Jerry ; Madeira, Maria ; Pols, Joanna ; Powles, Mary Ann ; Finley, Michael F ; Johnson, Eric ; Roussel, Thomas ; Uebele, Victor N ; Crespo, Alejandro ; Leung, Dennis ; Alleyne, Candice ; Trusca, Dorina ; Lei, Ying ; Howard, Andrew D ; Ujjainwalla, Feroze ; Tata, James R ; Sinz, Christopher J

Bioorganic & Medicinal Chemistry Letters, 01 March 2017, Vol.27(5), pp.1333-1333 [Peer Reviewed Journal]

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17
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Discovery and Pharmacology of a Novel Somatostatin Subtype 5 (SSTR5) Antagonist: Synergy with DPP-4 Inhibition

Liu, Weiguo ; Shao, Pengcheng P ; Liang, Gui-Bai ; Bawiec, John ; He, Jiafang ; Aster, Susan D ; Wu, Margaret ; Chicchi, Garry ; Wang, John ; Tsao, Kwei-Lan ; Shang, Jin ; Salituro, Gino ; Zhou, Yun-Ping ; Li, Cai ; Akiyama, Taro E ; Metzger, Daniel E ; Murphy, Beth Ann ; Howard, Andrew D ; Weber, Ann E ; Duffy, Joseph L

ACS medicinal chemistry letters, 08 November 2018, Vol.9(11), pp.1082-1087 [Peer Reviewed Journal]

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18
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A Gpr120-selective agonist improves insulin resistance and chronic inflammation in obese mice

Oh, Da Young ; Walenta, Evelyn ; Akiyama, Taro E ; Lagakos, William S ; Lackey, Denise ; Pessentheiner, Ariane R ; Sasik, Roman ; Hah, Nasun ; Chi, Tyler J ; Cox, Jason M ; Powels, Mary Ann ; Di Salvo, Jerry ; Sinz, Christopher ; Watkins, Steven M ; Armando, Aaron M ; Chung, Heekyung ; Evans, Ronald M ; Quehenberger, Oswald ; Mcnelis, Joanne ; Bogner-Strauss, Juliane G ; Olefsky, Jerrold M

Nature medicine, August 2014, Vol.20(8), pp.942-7 [Peer Reviewed Journal]

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19
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Discovery of Chromane Propionic Acid Analogues as Selective Agonists of GPR120 with Activity in Rodents

Adams, Gregory L ; Velazquez, Francisco ; Jayne, Charles ; Shah, Unmesh ; Miao, Shouwu ; Ashley, Eric R ; Madeira, Maria ; Akiyama, Taro E ; Di Salvo, Jerry ; Suzuki, Takao ; Wang, Nengxue ; Truong, Quang ; Gilbert, Eric ; Zhou, Dan ; Verras, Andreas ; Kirkland, Melissa ; Pachanski, Michele ; Powles, Maryann ; Yin, Wu ; Ujjainwalla, Feroze ; Venkatraman, Srikanth ; Edmondson, Scott D

ACS medicinal chemistry letters, 12 January 2017, Vol.8(1), pp.96-101 [Peer Reviewed Journal]

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20
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Discovery of benzofuran propanoic acid GPR120 agonists: From uHTS hit to mechanism-based pharmacodynamic effects

Lombardo, Matthew ; Bender, Kate ; London, Clare ; Plotkin, Michael A ; Kirkland, Melissa ; Mane, Joel ; Pachanski, Michele ; Geissler, Wayne ; Cummings, John ; Habulihaz, Bahanu ; Akiyama, Taro E ; Di Salvo, Jerry ; Madeira, Maria ; Pols, Joanna ; Powles, Mary Ann ; Finley, Michael F ; Johnson, Eric ; Roussel, Thomas ; Uebele, Victor N ; Crespo, Alejandro ; Leung, Dennis ; Alleyne, Candice ; Trusca, Dorina ; Lei, Ying ; Howard, Andrew D ; Ujjainwalla, Feroze ; Tata, James R ; Sinz, Christopher J

Bioorganic & Medicinal Chemistry Letters, 01 December 2016, Vol.26(23), pp.5724-5728 [Peer Reviewed Journal]

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21
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Seven transmembrane G protein-coupled receptor repertoire of gastric ghrelin cells

Engelstoft, Maja S ; Park, Won-Mee ; Sakata, Ichiro ; Kristensen, Line V ; Husted, Anna Sofie ; Osborne-Lawrence, Sherri ; Piper, Paul K ; Walker, Angela K ; Pedersen, Maria H ; Nøhr, Mark K ; Pan, Jie ; Sinz, Christopher J ; Carrington, Paul E ; Akiyama, Taro E ; Jones, Robert M ; Tang, Cong ; Ahmed, Kashan ; Offermanns, Stefan ; Egerod, Kristoffer L ; Zigman, Jeffrey M ; Schwartz, Thue W

Molecular Metabolism, November 2013, Vol.2(4), pp.376-392 [Peer Reviewed Journal]

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22
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Design and synthesis of a new class of malonyl-CoA decarboxylase inhibitors with anti-obesity and anti-diabetic activities

Tang, Haifeng ; Yan, Yan ; Feng, Zhe ; de Jesus, Reynalda K ; Yang, Lihu ; Levorse, Dorothy A ; Owens, Karen A ; Akiyama, Taro E ; Bergeron, Raynald ; Castriota, Gino A ; Doebber, Thomas W ; Ellsworth, Kenneth P ; Lassman, Michael E ; Li, Cai ; Wu, Margaret S ; Zhang, Bei B ; Chapman, Kevin T ; Mills, Sander G ; Berger, Joel P ; Pasternak, Alexander

Bioorganic & Medicinal Chemistry Letters, 2010, Vol.20(20), pp.6088-6092 [Peer Reviewed Journal]

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23
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Discovery of 5-aryloxy-2,4-thiazolidinediones as potent GPR40 agonists

Zhou, Changyou ; Tang, Cheng ; Chang, Eric ; Ge, Min ; Lin, Songnian ; Cline, Eric ; Tan, Carina P ; Feng, Yue ; Zhou, Yun-Ping ; Eiermann, George J ; Petrov, Aleksandr ; Salituro, Gino ; Meinke, Peter ; Mosley, Ralph ; Akiyama, Taro E ; Einstein, Monica ; Kumar, Sanjeev ; Berger, Joel ; Howard, Andrew D ; Thornberry, Nancy ; Mills, Sander G ; Yang, Lihu

Bioorganic & Medicinal Chemistry Letters, 2010, Vol.20(3), pp.1298-1301 [Peer Reviewed Journal]

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24
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Discovery of (2R)-2-(3-{3-(4-Methoxyphenyl)carbonyl-2-methyl-6-(trifluoromethoxy)-1H-indol-1-yl}phenoxy)butanoic acid (MK-0533): a novel selective peroxisome proliferator-activated receptor gamma modulator for the treatment of type 2 diabetes mellitus with a reduced potential to increase plasma and extracellular fluid volume

Acton, John J ; Akiyama, Taro E ; Chang, Ching H ; Colwell, Lawrence ; Debenham, Sheryl ; Doebber, Thomas ; Einstein, Monica ; Liu, Kun ; Mccann, Margaret E ; Moller, David E ; Muise, Eric S ; Tan, Yejun ; Tan, Yugen ; Thompson, John R ; Wong, Kenny K ; Wu, Margaret ; Xu, Libo ; Meinke, Peter T ; Berger, Joel P ; Wood, Harold B

Journal of medicinal chemistry, 09 July 2009, Vol.52(13), pp.3846-54 [Peer Reviewed Journal]

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25
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On par with PPARs

Akiyama, Taro E ; Nicol, Christopher J ; Gonzalez, Frank J

Trends in Genetics, 2001, Vol.17(6), pp.310-312 [Peer Reviewed Journal]

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26
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Conditional disruption of the peroxisome proliferator-activated receptor gamma gene in mice results in lowered expression of ABCA1, ABCG1, and apoE in macrophages and reduced cholesterol efflux

Akiyama, Taro E ; Sakai, Shuichi ; Lambert, Gilles ; Nicol, Christopher J ; Matsusue, Kimihiko ; Pimprale, Satish ; Lee, Ying-Hue ; Ricote, Mercedes ; Glass, Christopher K ; Brewer, H Bryan ; Gonzalez, Frank J

Molecular and cellular biology, April 2002, Vol.22(8), pp.2607-19 [Peer Reviewed Journal]

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27
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Selective small-molecule agonists of G protein-coupled receptor 40 promote glucose-dependent insulin secretion and reduce blood glucose in mice

Tan, Carina P ; Feng, Yue ; Zhou, Yun-Ping ; Eiermann, George J ; Petrov, Aleksandr ; Zhou, Changyou ; Lin, Songnian ; Salituro, Gino ; Meinke, Peter ; Mosley, Ralph ; Akiyama, Taro E ; Einstein, Monica ; Kumar, Sanjeev ; Berger, Joel P ; Mills, Sander G ; Thornberry, Nancy A ; Yang, Lihu ; Howard, Andrew D

Diabetes, August 2008, Vol.57(8), pp.2211-9 [Peer Reviewed Journal]

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28
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Design, Synthesis, and Evaluation of Novel and Selective G-protein Coupled Receptor 120 (GPR120) Spirocyclic Agonists

Cox, Jason M ; Chu, Hong D ; Chelliah, Mariappan V ; Debenham, John S ; Eagen, Keith ; Lan, Ping ; Lombardo, Matthew ; London, Clare ; Plotkin, Michael A ; Shah, Unmesh ; Sun, Zhongxiang ; Vaccaro, Henry M ; Venkatraman, Srikanth ; Suzuki, Takao ; Wang, Nengxue ; Ashley, Eric R ; Crespo, Alejandro ; Madeira, Maria ; Leung, Dennis H ; Alleyne, Candice ; Ogawa, Aimie M ; Souza, Sarah ; Thomas-Fowlkes, Brande ; Di Salvo, Jerry ; Weinglass, Adam ; Kirkland, Melissa ; Pachanski, Michele ; Powles, Mary Ann ; Tozzo, Effie ; Akiyama, Taro E ; Ujjainwalla, Feroze ; Tata, James R ; Sinz, Christopher J

ACS medicinal chemistry letters, 12 January 2017, Vol.8(1), pp.49-54 [Peer Reviewed Journal]

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29
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PPARs: therapeutic targets for metabolic disease

Berger, Joel P ; Akiyama, Taro E ; Meinke, Peter T

Trends in Pharmacological Sciences, 2005, Vol.26(5), pp.244-251 [Peer Reviewed Journal]

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30
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Hepatic expression of cytochrome P450s in hepatocyte nuclear factor 1-alpha (HNF1α)-deficient mice

Cheung, Connie ; Akiyama, Taro E ; Kudo, Gen ; Gonzalez, Frank J

Biochemical Pharmacology, 2003, Vol.66(10), pp.2011-2020 [Peer Reviewed Journal]

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31
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Positive regulation of connexin32 transcription by hepatocyte nuclear factor-1α

Koffler, Lucas D ; Fernstrom, Martha J ; Akiyama, Taro E ; Gonzalez, Frank J ; Ruch, Randall J

Archives of Biochemistry and Biophysics, 2002, Vol.407(2), pp.160-167 [Peer Reviewed Journal]

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32
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Selective intranuclear redistribution of PPAR isoforms by RXR alpha

Akiyama, Taro E ; Baumann, Christopher T ; Sakai, Shuichi ; Hager, Gordon L ; Gonzalez, Frank J

Molecular endocrinology (Baltimore, Md.), April 2002, Vol.16(4), pp.707-21 [Peer Reviewed Journal]

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33
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Plasma lipid profiling across species for the identification of optimal animal models of human dyslipidemia

Yin, Wu ; Carballo-Jane, Ester ; Mclaren, David G ; Mendoza, Vivienne H ; Gagen, Karen ; Geoghagen, Neil S ; Mcnamara, Lesley Ann ; Gorski, Judith N ; Eiermann, George J ; Petrov, Aleksandr ; Wolff, Michael ; Tong, Xinchun ; Wilsie, Larissa C ; Akiyama, Taro E ; Chen, Jing ; Thankappan, Anil ; Xue, Jiyan ; Ping, Xiaoli ; Andrews, Genevieve ; Wickham, L Alexandra ; Gai, Cesaire L ; Trinh, Tu ; Kulick, Alison A ; Donnelly, Marcie J ; Voronin, Gregory O ; Rosa, Ray ; Cumiskey, Anne-Marie ; Bekkari, Kavitha ; Mitnaul, Lyndon J ; Puig, Oscar ; Chen, Fabian ; Raubertas, Richard ; Wong, Peggy H ; Hansen, Barbara C ; Koblan, Ken S ; Roddy, Thomas P ; Hubbard, Brian K ; Strack, Alison M

Journal of lipid research, January 2012, Vol.53(1), pp.51-65 [Peer Reviewed Journal]

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34
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Effects of FXR in foam-cell formation and atherosclerosis development

Guo, Grace L ; Santamarina-Fojo, Silvia ; Akiyama, Taro E ; Amar, Marcelo J.A ; Paigen, Beverly J ; Brewer, Bryan ; Gonzalez, Frank J

BBA - Molecular and Cell Biology of Lipids, 2006, Vol.1761(12), pp.1401-1409 [Peer Reviewed Journal]

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35
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The differential interactions of peroxisome proliferator-activated receptor gamma ligands with Tyr473 is a physical basis for their unique biological activities

Einstein, Monica ; Akiyama, Taro E ; Castriota, Gino A ; Wang, Chuanlin F ; Mckeever, Brian ; Mosley, Ralph T ; Becker, Joseph W ; Moller, David E ; Meinke, Peter T ; Wood, Harold B ; Berger, Joel P

Molecular pharmacology, January 2008, Vol.73(1), pp.62-74 [Peer Reviewed Journal]

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36
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Cytochrome P450 CYP2E1, but not nicotinamide adenine dinucleotide phosphate oxidase, is required for ethanol‐induced oxidative DNA damage in rodent liver

Bradford, Blair U. ; Kono, Hiroshi ; Isayama, Fuyumi ; Kosyk, Oksana ; Wheeler, Michael D. ; Akiyama, Taro E. ; Bleye, Lisa ; Krausz, Kristopher W. ; Gonzalez, Frank J. ; Koop, Dennis R. ; Rusyn, Ivan

Hepatology, February 2005, Vol.41(2), pp.336-344 [Peer Reviewed Journal]

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37
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Highly functionalized 7-azaindoles as selective PPARγ modulators

Debenham, Sheryl D ; Chan, Audrey ; Lau, Fiona Waiyu ; Liu, Weiguo ; Wood, Harold B ; Lemme, Karen ; Colwell, Lawrence ; Habulihaz, Bahanu ; Akiyama, Taro E ; Einstein, Monica ; Doebber, Thomas W ; Sharma, Neelam ; Wang, Chaunlin F ; Wu, Margaret ; Berger, Joel P ; Meinke, Peter T

Bioorganic & Medicinal Chemistry Letters, 01 September 2008, Vol.18(17), pp.4798-4801 [Peer Reviewed Journal]

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