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1
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From libraries to candidate: the discovery of new ultra long-acting dibasic β₂-adrenoceptor agonists

Alcaraz, Lilian ; Bailey, Andrew ; Cadogan, Elaine ; Connolly, Stephen ; Jewell, Robert ; Jordan, Stephen ; Kindon, Nicholas ; Lister, Andrew ; Lawson, Mandy ; Mullen, Alexander ; Dainty, Ian ; Nicholls, David ; Paine, Stuart ; Pairaudeau, Garry ; Stocks, Michael J ; Thorne, Phillip ; Young, Alan

Bioorganic & medicinal chemistry letters, 01 January 2012, Vol.22(1), pp.689-95 [Peer Reviewed Journal]

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Synthesis of the marine sponge derived beta2-adrenoceptor agonist S1319

Fairhurst, Robin A ; Janus, Diana ; Lawrence, Annabel

Organic letters, 13 October 2005, Vol.7(21), pp.4697-700 [Peer Reviewed Journal]

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3
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2-Amino-4-benzyl-4,5,6,7-tetrahydrothiazolo5,4-cpyridines: novel selective beta3-adrenoceptor agonists

Zheng, W ; Nikulin, V I ; Konkar, A A ; Vansal, S S ; Shams, G ; Feller, D R ; Miller, D D

Journal of medicinal chemistry, 17 June 1999, Vol.42(12), pp.2287-94 [Peer Reviewed Journal]

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4
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Asymmetric hydrogenation of alpha-primary and secondary amino ketones: efficient asymmetric syntheses of (-)-arbutamine and (-)-denopamine

Shang, Gao ; Liu, Duan ; Allen, Scott E ; Yang, Qin ; Zhang, Xumu

Chemistry (Weinheim an der Bergstrasse, Germany), 2007, Vol.13(27), pp.7780-4 [Peer Reviewed Journal]

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5
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Inhalation by design: novel ultra-long-acting β(2)-adrenoreceptor agonists for inhaled once-daily treatment of asthma and chronic obstructive pulmonary disease that utilize a sulfonamide agonist headgroup

Glossop, Paul A ; Lane, Charlotte A L ; Price, David A ; Bunnage, Mark E ; Lewthwaite, Russell A ; James, Kim ; Brown, Alan D ; Yeadon, Michael ; Perros-Huguet, Christelle ; Trevethick, Michael A ; Clarke, Nicholas P ; Webster, Robert ; Jones, Rhys M ; Burrows, Jane L ; Feeder, Neil ; Taylor, Stefan C J ; Spence, Fiona J

Journal of medicinal chemistry, 23 September 2010, Vol.53(18), pp.6640-52 [Peer Reviewed Journal]

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6
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Novel (4-piperidin-1-yl)-phenyl sulfonamides as potent and selective human beta(3) agonists

Hu, B ; Ellingboe, J ; Han, S ; Largis, E ; Lim, K ; Malamas, M ; Mulvey, R ; Niu, C ; Oliphant, A ; Pelletier, J ; Singanallore, T ; Sum, F W ; Tillett, J ; Wong, V

Bioorganic & medicinal chemistry, August 2001, Vol.9(8), pp.2045-59 [Peer Reviewed Journal]

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7
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Iodinated analogs of trimetoquinol as highly potent and selective beta 2-adrenoceptor ligands

De Los Angeles, J E ; Nikulin, V I ; Shams, G ; Konkar, A A ; Mehta, R ; Feller, D R ; Miller, D D

Journal of medicinal chemistry, 13 September 1996, Vol.39(19), pp.3701-11 [Peer Reviewed Journal]

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8
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Synthesis and human beta-adrenoceptor activity of 1-(3,5-diiodo-4- methoxybenzyl)-1,2,3,4-tetrahydroisoquinolin-6-ol derivatives in vitro

He, Y ; Nikulin, V I ; Vansal, S S ; Feller, D R ; Miller, D D

Journal of medicinal chemistry, 24 February 2000, Vol.43(4), pp.591-8 [Peer Reviewed Journal]

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9
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A heterobimetallic Pd/La/Schiff base complex for anti-selective catalytic asymmetric nitroaldol reactions and applications to short syntheses of beta-adrenoceptor agonists

Handa, Shinya ; Nagawa, Keita ; Sohtome, Yoshihiro ; Matsunaga, Shigeki ; Shibasaki, Masakatsu

Angewandte Chemie (International ed. in English), 2008, Vol.47(17), pp.3230-3 [Peer Reviewed Journal]

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10
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(4-Piperidin-1-yl)phenyl amides: potent and selective human beta(3) agonists

Hu, B ; Ellingboe, J ; Han, S ; Largis, E ; Mulvey, R ; Oliphant, A ; Sum, F W ; Tillett, J

Journal of medicinal chemistry, 26 April 2001, Vol.44(9), pp.1456-66 [Peer Reviewed Journal]

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11
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Relationship between stereochemistry and the beta3-adrenoceptor agonistic activity of 4'-hydroxynorephedrine derivative as an agent for treatment of frequent urination and urinary incontinence

Tanaka, Nobuyuki ; Tamai, Tetsuro ; Mukaiyama, Harunobu ; Hirabayashi, Akihito ; Muranaka, Hideyuki ; Ishikawa, Takehiro ; Kobayashi, Junichi ; Akahane, Satoshi ; Akahane, Masuo

Journal of medicinal chemistry, 02 January 2003, Vol.46(1), pp.105-12 [Peer Reviewed Journal]

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12
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Discovery of novel N-phenylglycine derivatives as potent and selective beta(3)-adrenoceptor agonists for the treatment of frequent urination and urinary incontinence

Tanaka, N ; Tamai, T ; Mukaiyama, H ; Hirabayashi, A ; Muranaka, H ; Akahane, S ; Miyata, H ; Akahane, M

Journal of medicinal chemistry, 26 April 2001, Vol.44(9), pp.1436-45 [Peer Reviewed Journal]

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13
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Synthesis and evaluation of potent and selective beta(3) adrenergic receptor agonists containing acylsulfonamide, sulfonylsulfonamide, and sulfonylurea carboxylic acid isosteres

Uehling, David E ; Donaldson, Kelly H ; Deaton, David N ; Hyman, Clifton E ; Sugg, Elizabeth E ; Barrett, David G ; Hughes, Robert G ; Reitter, Barbara ; Adkison, Kim K ; Lancaster, Mary E ; Lee, Frank ; Hart, Robert ; Paulik, Mark A ; Sherman, Bryan W ; True, Timothy ; Cowan, Conrad

Journal of medicinal chemistry, 31 January 2002, Vol.45(3), pp.567-83 [Peer Reviewed Journal]

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14
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Synthesis and evaluation of trimetoquinol derivatives: novel thromboxane A2/prostaglandin H2 antagonists with diminished beta-adrenergic agonist activity

Christoff, J J ; Bradley, L ; Miller, D D ; Lei, L ; Rodriguez, F ; Fraundorfer, P ; Romstedt, K ; Shams, G ; Feller, D R

Journal of medicinal chemistry, 03 January 1997, Vol.40(1), pp.85-91 [Peer Reviewed Journal]

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15
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Discovery of a potent, orally bioavailable beta(3) adrenergic receptor agonist, (R)-N-4-2-2-hydroxy-2-(3-pyridinyl)ethylaminoethylphenyl-4-4 -4-(trifluoromethyl)phenylthiazol-2-ylbenzenesulfonamide

Mathvink, R J ; Tolman, J S ; Chitty, D ; Candelore, M R ; Cascieri, M A ; Colwell, L F ; Deng, L ; Feeney, W P ; Forrest, M J ; Hom, G J ; Macintyre, D E ; Miller, R R ; Stearns, R A ; Tota, L ; Wyvratt, M J ; Fisher, M H ; Weber, A E

Journal of medicinal chemistry, 19 October 2000, Vol.43(21), pp.3832-6 [Peer Reviewed Journal]

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16
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Synthesis of new delta 2-isoxazoline derivatives and their pharmacological characterization as beta-adrenergic receptor antagonists

Conti, P ; Dallanoce, C ; De Amici, M ; De Micheli, C ; Klotz, K N

Bioorganic & medicinal chemistry, April 1998, Vol.6(4), pp.401-8 [Peer Reviewed Journal]

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17
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Discovery of a novel, potent and selective human beta3-adrenergic receptor agonist

Nakajima, Yutaka ; Hamashima, Hitoshi ; Washizuka, Ken-Ichi ; Tomishima, Yasuyo ; Ohtake, Hiroaki ; Imamura, Emiko ; Miura, Toshiko ; Kayakiri, Hiroshi ; Kato, Masayuki

Bioorganic & medicinal chemistry letters, 17 January 2005, Vol.15(2), pp.251-4 [Peer Reviewed Journal]

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18
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Cyclic amine sulfonamides as linkers in the design and synthesis of novel human beta(3) adrenergic receptor agonists

Sum, Fuk Wah ; Wong, Victoria ; Han, Stella ; Largis, Elwood ; Mulvey, Ruth ; Tillett, Jeff

Bioorganic & medicinal chemistry letters, 07 July 2003, Vol.13(13), pp.2191-4 [Peer Reviewed Journal]

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19
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Human beta3 adrenergic receptor agonists containing cyanoguanidine and nitroethylenediamine moieties

Brockunier, L L ; Candelore, M R ; Cascieri, M A ; Liu, Y ; Tota, L ; Wyvratt, M J ; Fisher, M H ; Weber, A E ; Parmee, E R

Bioorganic & medicinal chemistry letters, 12 February 2001, Vol.11(3), pp.379-82 [Peer Reviewed Journal]

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20
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Synthesis, beta-adrenoceptor pharmacology and toxicology of S-(-)-1-(4-(2-ethoxyethoxy)phenoxy)-2-hydroxy-3-(2-(3,4-dimethoxyphenyl)ethylamino)propane hydrochloride, a short acting beta(1)-specific antagonist

Jackman, Graham P ; Iakovidis, Dimitri ; Nero, Tracy L ; Anavekar, Nagesh S ; Rezmann-Vitti, Linda A ; Louis, Simon N S ; Mori, Masanori ; Drummer, Olaf H ; Louis, William J

European journal of medicinal chemistry, September 2002, Vol.37(9), pp.731-41 [Peer Reviewed Journal]

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21
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Synthesis and pharmacological characterization of beta2-adrenergic agonist enantiomers: zilpaterol

Kern, Christopher ; Meyer, Thorsten ; Droux, Serge ; Schollmeyer, Dieter ; Miculka, Christian

Journal of medicinal chemistry, 26 March 2009, Vol.52(6), pp.1773-7 [Peer Reviewed Journal]

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22
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Dual D2-receptor and beta2-adrenoceptor agonists for the treatment of airway diseases. 1. Discovery and biological evaluation of some 7-(2-aminoethyl)-4-hydroxybenzothiazol-2(3H)-one analogues

Bonnert, R V ; Brown, R C ; Chapman, D ; Cheshire, D R ; Dixon, J ; Ince, F ; Kinchin, E C ; Lyons, A J ; Davis, A M ; Hallam, C ; Harper, S T ; Unitt, J F ; Dougall, I G ; Jackson, D M ; Mckechnie, K ; Young, A ; Simpson, W T

Journal of medicinal chemistry, 03 December 1998, Vol.41(25), pp.4915-7 [Peer Reviewed Journal]

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23
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Human beta3 adrenergic receptor agonists containing imidazolidinone and imidazolone benzenesulfonamides

Naylor, E M ; Parmee, E R ; Colandrea, V J ; Perkins, L ; Brockunier, L ; Candelore, M R ; Cascieri, M A ; Colwell, L F ; Deng, L ; Feeney, W P ; Forrest, M J ; Hom, G J ; Macintyre, D E ; Strader, C D ; Tota, L ; Wang, P R ; Wyvratt, M J ; Fisher, M H ; Weber, A E

Bioorganic & medicinal chemistry letters, 08 March 1999, Vol.9(5), pp.755-8 [Peer Reviewed Journal]

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24
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Potent oxindole based human beta3 adrenergic receptor agonists

Stevens, F Craig ; Bloomquist, William E ; Borel, Anthony G ; Cohen, Marlene L ; Droste, Christine A ; Heiman, Mark L ; Kriauciunas, Aidas ; Sall, Daniel J ; Tinsley, Frank C ; Jesudason, Cynthia D

Bioorganic & medicinal chemistry letters, 15 November 2007, Vol.17(22), pp.6270-3 [Peer Reviewed Journal]

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25
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QSAR analysis of thiazole benzenesulfonamide substituted 3-pyridylethanolamines as beta3-adrenergic receptor agonist

Hanumantharao, P ; Sambasivarao, S V ; Soni, Love K ; Gupta, A K ; Kaskhedikar, S G

Bioorganic & medicinal chemistry letters, 15 June 2005, Vol.15(12), pp.3167-73 [Peer Reviewed Journal]

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26
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Tryptamine-based human beta3-adrenergic receptor agonists. Part 2: SAR of the methylene derivatives

Sawa, Masaaki ; Tateishi, Hirotaka ; Mizuno, Kazuhiro ; Harada, Hiroshi ; Oue, Mayumi ; Tsujiuchi, Hiroshi ; Furutani, Yasuji ; Kato, Shiro

Bioorganic & medicinal chemistry letters, 20 December 2004, Vol.14(24), pp.5963-6 [Peer Reviewed Journal]

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27
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Tryptamine-based human beta3-adrenergic receptor agonists. Part 1: SAR studies of the 7-position of the indole ring

Mizuno, Kazuhiro ; Sawa, Masaaki ; Harada, Hiroshi ; Tateishi, Hirotaka ; Oue, Mayumi ; Tsujiuchi, Hiroshi ; Furutani, Yasuji ; Kato, Shiro

Bioorganic & medicinal chemistry letters, 20 December 2004, Vol.14(24), pp.5959-62 [Peer Reviewed Journal]

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28
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Novel and potent human and rat beta3-adrenergic receptor agonists containing substituted 3-indolylalkylamines

Harada, Hiroshi ; Hirokawa, Yoshimi ; Suzuki, Kenji ; Hiyama, Yoichi ; Oue, Mayumi ; Kawashima, Hitoshi ; Yoshida, Naoyuki ; Furutani, Yasuji ; Kato, Shiro

Bioorganic & medicinal chemistry letters, 07 April 2003, Vol.13(7), pp.1301-5 [Peer Reviewed Journal]

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29
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Development of 3D-QSAR models in cyclic ureidobenzenesulfonamides: human beta3-adrenergic receptor agonist

Kashaw, Sushil K ; Rathi, Lalit ; Mishra, Pradeep ; Saxena, Anil K

Bioorganic & medicinal chemistry letters, 04 August 2003, Vol.13(15), pp.2481-4 [Peer Reviewed Journal]

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30
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Novel substituted 4-aminomethylpiperidines as potent and selective human beta3-agonists. Part 2: arylethanolaminomethylpiperidines

Steffan, Robert J ; Ashwell, Mark A ; Solvibile, William R ; Matelan, Edward ; Largis, Elwood ; Han, Stella ; Tillet, Jeffery ; Mulvey, Ruth

Bioorganic & medicinal chemistry letters, 21 October 2002, Vol.12(20), pp.2963-7 [Peer Reviewed Journal]

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31
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Synthesis and beta-adrenergic activity of new completely aliphatic 3-(methyleneaminoxy)propanolamine derivatives

Balsamo, A ; Gentili, D ; Lapucci, A ; Macchia, M ; Martinelli, A ; Orlandini, E ; Ferni, G ; Pinza, M

Farmaco (Societa chimica italiana : 1989), December 1994, Vol.49(12), pp.759-66 [Peer Reviewed Journal]

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32
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3-Pyridylethanolamines: potent and selective human beta 3 adrenergic receptor agonists

Naylor, E M ; Colandrea, V J ; Candelore, M R ; Cascieri, M A ; Colwell, L F ; Deng, L ; Feeney, W P ; Forrest, M J ; Hom, G J ; Macintyre, D E ; Strader, C D ; Tota, L ; Wang, P R ; Wyvratt, M J ; Fisher, M H ; Weber, A E

Bioorganic & medicinal chemistry letters, 03 November 1998, Vol.8(21), pp.3087-92 [Peer Reviewed Journal]

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33
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Substituted oxazole benzenesulfonamides as potent human beta3 adrenergic receptor agonists

Ok, H O ; Reigle, L B ; Candelore, M R ; Cascieri, M A ; Colwell, L F ; Deng, L ; Feeney, W P ; Forrest, M J ; Hom, G J ; Macintyre, D E ; Strader, C D ; Tota, L ; Wang, P ; Wyvratt, M J ; Fisher, M H ; Weber, A E

Bioorganic & medicinal chemistry letters, 17 July 2000, Vol.10(14), pp.1531-4 [Peer Reviewed Journal]

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34
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Synthesis and beta-adrenergic activity of a series of 3-(substituted-benzylideneaminoxy)propanolamine derivatives

Gentili, D ; Lapucci, A ; Macchia, B ; Macchia, M ; Martinelli, A ; Nencetti, S ; Orlandini, E ; Ferni, G ; Pinza, M

Farmaco (Societa chimica italiana : 1989), 1995, Vol.50(7-8), pp.519-26 [Peer Reviewed Journal]

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35
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3-Pyridyloxypropanolamine agonists of the beta 3 adrenergic receptor with improved pharmacokinetic properties

Weber, A E ; Ok, H O ; Alvaro, R F ; Candelore, M R ; Cascieri, M A ; Chiu, S H ; Deng, L ; Forrest, M J ; Hom, G J ; Hutchins, J E ; Kao, J ; Macintyre, D E ; Mathvink, R J ; Mcloughlin, D ; Miller, R R ; Newbold, R C ; Olah, T V ; Parmee, E R ; Perkins, L ; Stearns

Bioorganic & medicinal chemistry letters, 18 August 1998, Vol.8(16), pp.2111-6 [Peer Reviewed Journal]

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36
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Discovery of L-755,507: a subnanomolar human beta 3 adrenergic receptor agonist

Parmee, E R ; Ok, H O ; Candelore, M R ; Tota, L ; Deng, L ; Strader, C D ; Wyvratt, M J ; Fisher, M H ; Weber, A E

Bioorganic & medicinal chemistry letters, 05 May 1998, Vol.8(9), pp.1107-12 [Peer Reviewed Journal]

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37
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Tetrahydroisoquinoline derivatives containing a benzenesulfonamide moiety as potent, selective human beta3 adrenergic receptor agonists

Parmee, E R ; Brockunier, L L ; He, J ; Singh, S B ; Candelore, M R ; Cascieri, M A ; Deng, L ; Liu, Y ; Tota, L ; Wyvratt, M J ; Fisher, M H ; Weber, A E

Bioorganic & medicinal chemistry letters, 16 October 2000, Vol.10(20), pp.2283-6 [Peer Reviewed Journal]

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