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1,2,3-Trisubstituted cyclohexyl substance P antagonists: significance of the ring nitrogen in piperidine-based NK-1 receptor antagonists

Mills, Sander G ; Maccoss, Malcolm ; Underwood, Dennis ; Shah, Shrenik K ; Finke, Paul E ; Miller, Daniel J ; Budhu, Richard J ; Cascieri, Margaret A ; Sadowski, Sharon ; Strader, Catherine D

Bioorganic & Medicinal Chemistry Letters, 1995, Vol.5(13), pp.1345-1350 [Peer Reviewed Journal]

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1,2,4-Triacylpiperidine substance p antagonists: Separation of affinities for the NK-1 receptor and the L-type calcium channel

Mills, Sander G ; Maccoss, Malcolm ; Cascieri, Margaret A ; Sadowski, Sharon ; Patel, Smita ; Chapman, Kerry L ; Hutson, Peter H

Bioorganic & Medicinal Chemistry Letters, 1995, Vol.5(6), pp.599-604 [Peer Reviewed Journal]

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1,3,4 Trisubstituted pyrrolidine CCR5 receptor antagonists bearing 4-aminoheterocycle substituted piperidine side chains

Willoughby, Christopher A ; Rosauer, Keith G ; Hale, Jeffery J ; Budhu, Richard J ; Mills, Sander G ; Chapman, Kevin T ; Maccoss, Malcolm ; Malkowitz, Lorraine ; Springer, Martin S ; Gould, Sandra L ; Demartino, Julie A ; Siciliano, Salvatore J ; Cascieri, Margaret A ; Carella, Anthony ; Carver, Gwen ; Holmes, Karen ; Schleif, William A ; Danzeisen, Renee ; Hazuda, Daria ; Kessler, Joseph ; Lineberger, Janet ; Miller, Michael ; Emini, Emilio A

Bioorganic & medicinal chemistry letters, 10 February 2003, Vol.13(3), pp.427-31 [Peer Reviewed Journal]

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1,3,4-Trisubstituted pyrrolidine CCR5 receptor antagonists: modifications of the arylpropylpiperidine side chains

Lynch, Christopher L ; Willoughby, Christopher A ; Hale, Jeffrey J ; Holson, Edward J ; Budhu, Richard J ; Gentry, Amy L ; Rosauer, Keith G ; Caldwell, Charles G ; Chen, Ping ; Mills, Sander G ; Maccoss, Malcolm ; Berk, Scott ; Chen, Liya ; Chapman, Kevin T ; Malkowitz, Lorraine ; Springer, Martin S ; Gould, Sandra L ; Demartino, Julie A ; Siciliano, Salvatore J ; Cascieri, Margaret A ; Carella, Anthony ; Carver, Gwen ; Holmes, Karen ; Schleif, William A ; Danzeisen, Renee ; Hazuda, Daria ; Kessler, Joseph ; Lineberger, Janet ; Miller, Michael ; Emini, Emilio A

Bioorganic & Medicinal Chemistry Letters, 2003, Vol.13(1), pp.119-123 [Peer Reviewed Journal]

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1,3,4-Trisubstituted pyrrolidine CCR5 receptor antagonists. Part 1: discovery of the pyrrolidine scaffold and determination of its stereochemical requirements

Hale, Jeffrey J ; Budhu, Richard J ; Mills, Sander G ; Maccoss, Malcolm ; Malkowitz, Lorraine ; Siciliano, Salvatore ; Gould, Sandra L ; Demartino, Julie A ; Springer, Martin S

Bioorganic & Medicinal Chemistry Letters, 2001, Vol.11(11), pp.1437-1440 [Peer Reviewed Journal]

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1,3,4-Trisubstituted pyrrolidine CCR5 receptor antagonists. Part 2: lead optimization affording selective, orally bioavailable compounds with potent Anti-HIV activity

Hale, Jeffrey J ; Budhu, Richard J ; Holson, Edward B ; Finke, Paul E ; Oates, Bryan ; Mills, Sander G ; Maccoss, Malcolm ; Gould, Sandra L ; Demartino, Julie A ; Springer, Martin S ; Siciliano, Salvatore ; Malkowitz, Lorraine ; Schleif, William A ; Hazuda, Daria ; Miller, Michael ; Kessler, Joseph ; Danzeisen, Renee ; Holmes, Karen ; Lineberger, Janet ; Carella, Anthony ; Carver, Gwen ; Emini, Emilio

Bioorganic & Medicinal Chemistry Letters, 2001, Vol.11(20), pp.2741-2745 [Peer Reviewed Journal]

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1,3,4-Trisubstituted pyrrolidine CCR5 receptor antagonists. Part 3: polar functionality and its effect on anti-HIV-1 activity

Hale, Jeffrey J ; Budhu, Richard J ; Mills, Sander G ; Maccoss, Malcolm ; Gould, Sandra L ; Demartino, Julie A ; Springer, Martin S ; Siciliano, Salvatore J ; Malkowitz, Lorraine ; Schleif, William A ; Hazuda, Daria ; Miller, Michael ; Kessler, Joseph ; Danzeisen, Renee ; Holmes, Karen ; Lineberger, Janet ; Carella, Anthony ; Carver, Gwen ; Emini, Emilio A

Bioorganic & Medicinal Chemistry Letters, 21 October 2002, Vol.12(20), pp.2997-3000 [Peer Reviewed Journal]

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1,3,4-Trisubstituted pyrrolidine CCR5 receptor antagonists. Part 4: Synthesis of N-1 acidic functionality affording analogues with enhanced antiviral activity against HIV

Lynch, Christopher L ; Hale, Jeffrey J ; Budhu, Richard J ; Gentry, Amy L ; Mills, Sander G ; Chapman, Kevin T ; Maccoss, Malcolm ; Malkowitz, Lorraine ; Springer, Martin S ; Gould, Sandra L ; Demartino, Julie A ; Siciliano, Salvatore J ; Cascieri, Margaret A ; Carella, Anthony ; Carver, Gwen ; Holmes, Karen ; Schleif, William A ; Danzeisen, Renee ; Hazuda, Daria ; Kessler, Joseph ; Lineberger, Janet ; Miller, Michael ; Emini, Emilio A

Bioorganic & Medicinal Chemistry Letters, 21 October 2002, Vol.12(20), pp.3001-3004 [Peer Reviewed Journal]

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1,4-Diacylpiperazine-2-(S)-[(N-aminoalkyl)carboxamides] as novel, potent substance P receptor antagonists

Mills, Sander G ; Wu, Mu Tsu ; Maccoss, Malcolm ; Budhu, Richard J ; Dorn, Conrad P ; Cascieri, Margaret A ; Sadowski, Sharon ; Strader, Catherine D ; Greenlee, William J

Bioorganic & Medicinal Chemistry Letters, 1993, Vol.3(12), pp.2707-2712 [Peer Reviewed Journal]

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2-(3aR,4R,5S,7aS)-5-{(1S)-1-3,5-bis(trifluoromethyl)phenyl-2-hydroxyethoxy}-4-(2-methylphenyl)octahydro-2H-isoindol-2-yl-1,3-oxazol-4(5H)-one: a potent human NK1 receptor antagonist with multiple clearance pathways

Kassick, Andrew J ; Jiang, Jinlong ; Bunda, Jaime ; Wilson, David ; Bao, Jianming ; Lu, Huagang ; Lin, Peter ; Ball, Richard G ; Doss, George A ; Tong, Xinchun ; Tsao, Kwei-Lan C ; Wang, Hong ; Chicchi, Gary ; Karanam, Bindhu ; Tschirret-Guth, Richard ; Samuel, Koppara ; Hora, Donald F ; Kumar, Sanjeev ; Madeira, Maria ; Eng, Waisi ; Hargreaves, Richard ; Purcell, Mona ; Gantert, Liza ; Cook, Jacquelyn ; Devita, Robert J ; Mills, Sander G

Journal of medicinal chemistry, 25 July 2013, Vol.56(14), pp.5940-8 [Peer Reviewed Journal]

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2-Aryl(pyrrolidin-4-yl)acetic acids are potent agonists of sphingosine-1-phosphate (S1P) receptors

Yan, Lin ; Budhu, Richard ; Huo, Pei ; Lynch, Christopher L ; Hale, Jeffrey J ; Mills, Sander G ; Hajdu, Richard ; Keohane, Carol A ; Rosenbach, Mark J ; Milligan, James A ; Shei, Gan-Ju ; Chrebet, Gary ; Bergstrom, James ; Card, Deborah ; Mandala, Suzanne M

Bioorganic & Medicinal Chemistry Letters, 01 July 2006, Vol.16(13), pp.3564-3568 [Peer Reviewed Journal]

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12
2( S )-((3,5-Bis(trifluoromethyl)benzyl)oxy)-3( S )-phenyl-4-((3-oxo-1,2,4-triazol- 5-yl)methyl)morpholine ( 1 ):  A Potent, Orally Active, Morpholine-Based Human Neurokinin-1 Receptor Antagonist
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2( S )-((3,5-Bis(trifluoromethyl)benzyl)oxy)-3( S )-phenyl-4-((3-oxo-1,2,4-triazol- 5-yl)methyl)morpholine ( 1 ):  A Potent, Orally Active, Morpholine-Based Human Neurokinin-1 Receptor Antagonist

Hale, Jeffrey J. ; Mills, Sander G. ; Maccoss, Malcolm ; Shah, Shrenik K. ; Qi, Hongbo ; Mathre, David J. ; Cascieri, Margaret A. ; Sadowski, Sharon ; Strader, Catherine D. ; Macintyre, D. Euan ; Metzger, Joseph M.

Journal of Medicinal Chemistry, 01/1996, Vol.39(9), pp.1760-1762 [Peer Reviewed Journal]

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13
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2,5-Disubstituted pyrrolidine carboxylates as potent, orally active sphingosine-1-phosphate (S1P) receptor agonists

Colandrea, Vincent J ; Legiec, Irene E ; Huo, Pei ; Yan, Lin ; Hale, Jeffrey J ; Mills, Sander G ; Bergstrom, James ; Card, Deborah ; Chebret, Gary ; Hajdu, Richard ; Keohane, Carol Ann ; Milligan, James A ; Rosenbach, Mark J ; Shei, Gan-Ju ; Mandala, Suzanne M

Bioorganic & Medicinal Chemistry Letters, 2006, Vol.16(11), pp.2905-2908 [Peer Reviewed Journal]

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14
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3-Substituted 3-(4-aryloxyaryl)-propanoic acids as GPR40 agonists

Walsh, Shawn P ; Severino, Alexandra ; Zhou, Changyou ; He, Jiafang ; Liang, Gui-Bai ; Tan, Carina P ; Cao, Jin ; Eiermann, George J ; Xu, Ling ; Salituro, Gino ; Howard, Andrew D ; Mills, Sander G ; Yang, Lihu

Bioorganic & medicinal chemistry letters, 01 June 2011, Vol.21(11), pp.3390-4 [Peer Reviewed Journal]

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15
A Rational Utilization of High-Throughput Screening Affords Selective, Orally Bioavailable 1-Benzyl-3-carboxyazetidine Sphingosine-1-phosphate-1 Receptor Agonists
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A Rational Utilization of High-Throughput Screening Affords Selective, Orally Bioavailable 1-Benzyl-3-carboxyazetidine Sphingosine-1-phosphate-1 Receptor Agonists

Hale, Jeffrey J. ; Lynch, Christopher L. ; Neway, William ; Mills, Sander G. ; Hajdu, Richard ; Keohane, Carol Ann ; Rosenbach, Mark J. ; Milligan, James A. ; Shei, Gan-Ju ; Parent, Stephen A. ; Chrebet, Gary ; Bergstrom, James ; Card, Deborah ; Ferrer, Marc ; Hodder, Peter ; Strulovici, Berta ; Rosen, Hugh ; Mandala, Suzanne

Journal of Medicinal Chemistry, 12/2004, Vol.47(27), pp.6662-6665 [Peer Reviewed Journal]

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16
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Alpha-aminothiazole-gamma-aminobutanoic amides as potent, small molecule CCR2 receptor antagonists

Zhou, Changyou ; Guo, Liangqin ; Parsons, William H ; Mills, Sander G ; Maccoss, Malcolm ; Vicario, Pasquale P ; Zweerink, Hans ; Cascieri, Margaret A ; Springer, Martin S ; Yang, Lihu

Bioorganic & medicinal chemistry letters, 15 January 2007, Vol.17(2), pp.309-14 [Peer Reviewed Journal]

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17
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An expeditious synthesis of 3-(difluoromethoxy)- and 3-(trifluoromethoxy)-5,6,7,8-tetrahydro-1,6-naphthyridines

Guiadeen, Deodialsingh ; Kothandaraman, Shankaran ; Yang, Lihu ; Mills, Sander G ; Maccoss, Malcolm

Tetrahedron Letters, 2008, Vol.49(44), pp.6368-6370 [Peer Reviewed Journal]

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18
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Antagonists of human CCR5 receptor containing 4-(pyrazolyl)piperidine side chains. Part 1: Discovery and SAR study of 4-pyrazolylpiperidine side chains

Shen, Dong-Ming ; Shu, Min ; Mills, Sander G ; Chapman, Kevin T ; Malkowitz, Lorraine ; Springer, Martin S ; Gould, Sandra L ; Demartino, Julie A ; Siciliano, Salvatore J ; Kwei, Gloria Y ; Carella, Anthony ; Carver, Gwen ; Holmes, Karen ; Schleif, William A ; Danzeisen, Renee ; Hazuda, Daria ; Kessler, Joseph ; Lineberger, Janet ; Miller, Michael D ; Emini, Emilio A

Bioorganic & Medicinal Chemistry Letters, 23 February 2004, Vol.14(4), pp.935-939 [Peer Reviewed Journal]

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Antagonists of human CCR5 receptor containing 4-(pyrazolyl)piperidine side chains. Part 2: Discovery of potent, selective, and orally bioavailable compounds

Shen, Dong-Ming ; Shu, Min ; Willoughby, Christopher A ; Shah, Shrenik ; Lynch, Christopher L ; Hale, Jeffrey J ; Mills, Sander G ; Chapman, Kevin T ; Malkowitz, Lorraine ; Springer, Martin S ; Gould, Sandra L ; Demartino, Julie A ; Siciliano, Salvatore J ; Lyons, Kathy ; Pivnichny, James V ; Kwei, Gloria Y ; Carella, Anthony ; Carver, Gwen ; Holmes, Karen ; Schleif, William A ; Danzeisen, Renee ; Hazuda, Daria ; Kessler, Joseph ; Lineberger, Janet ; Miller, Michael D ; Emini, Emilio A

Bioorganic & Medicinal Chemistry Letters, 23 February 2004, Vol.14(4), pp.941-945 [Peer Reviewed Journal]

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20
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Antagonists of human CCR5 receptor containing 4-(pyrazolyl)piperidine side chains. Part 3: SAR studies on the benzylpyrazole segment

Shu, Min ; Loebach, Jennifer L ; Parker, Kerry A ; Mills, Sander G ; Chapman, Kevin T ; Shen, Dong-Ming ; Malkowitz, Lorraine ; Springer, Martin S ; Gould, Sandra L ; Demartino, Julie A ; Siciliano, Salvatore J ; Salvo, Jerry Di ; Lyons, Kathy ; Pivnichny, James V ; Kwei, Gloria Y ; Carella, Anthony ; Carver, Gwen ; Holmes, Karen ; Schleif, William A ; Danzeisen, Renee ; Hazuda, Daria ; Kessler, Joseph ; Lineberger, Janet ; Miller, Michael D ; Emini, Emilio A

Bioorganic & Medicinal Chemistry Letters, 23 February 2004, Vol.14(4), pp.947-952 [Peer Reviewed Journal]

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21
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Antagonists of the human CCR5 receptor as anti-HIV-1 agents. Part 2: structure–activity relationships for substituted 2-aryl-1-[N-(methyl)-N-(phenylsulfonyl)amino]-4-(piperidin-1-yl)butanes

Finke, Paul E ; Meurer, Laura C ; Oates, Bryan ; Mills, Sander G ; Maccoss, Malcolm ; Malkowitz, Lorraine ; Springer, Martin S ; Daugherty, Bruce L ; Gould, Sandra L ; Demartino, Julie A ; Siciliano, Salvatore J ; Carella, Anthony ; Carver, Gwen ; Holmes, Karen ; Danzeisen, Renee ; Hazuda, Daria ; Kessler, Joseph ; Lineberger, Janet ; Miller, Michael ; Schleif, William A ; Emini, Emilio A

Bioorganic & Medicinal Chemistry Letters, January 2001, Vol.11(2), pp.265-270 [Peer Reviewed Journal]

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22
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Antagonists of the human CCR5 receptor as anti-HIV-1 agents. Part 4: synthesis and structure–Activity relationships for 1-[ N-(Methyl)- N-(phenylsulfonyl)amino]-2-(phenyl)-4-(4-( N-(alkyl)- N-(benzyloxycarbonyl)amino)piperidin-1-yl)butanes

Finke, Paul E ; Oates, Bryan ; Mills, Sander G ; Maccoss, Malcolm ; Malkowitz, Lorraine ; Springer, Martin S ; Gould, Sandra L ; Demartino, Julie A ; Carella, Anthony ; Carver, Gwen ; Holmes, Karen ; Danzeisen, Renee ; Hazuda, Daria ; Kessler, Joseph ; Lineberger, Janet ; Miller, Michael ; Schleif, William A ; Emini, Emilio A

Bioorganic & Medicinal Chemistry Letters, 2001, Vol.11(18), pp.2475-2479 [Peer Reviewed Journal]

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23
Binding of 2-Aryl-4-(piperidin-1-yl)butanamines and 1,3,4-Trisubstituted Pyrrolidines to Human CCR5:  A Molecular Modeling-Guided Mutagenesis Study of the Binding Pocket
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Binding of 2-Aryl-4-(piperidin-1-yl)butanamines and 1,3,4-Trisubstituted Pyrrolidines to Human CCR5:  A Molecular Modeling-Guided Mutagenesis Study of the Binding Pocket

Castonguay, Laurie A. ; Weng, Youmin ; Adolfsen, William ; Di Salvo, Jerry ; Kilburn, Ruth ; Caldwell, Charles G. ; Daugherty, Bruce L. ; Finke, Paul E. ; Hale, Jeffrey J. ; Lynch, Christopher L. ; Mills, Sander G. ; Maccoss, Malcolm ; Springer, Martin S. ; Demartino, Julie A.

Biochemistry, 02/2003, Vol.42(6), pp.1544-1550 [Peer Reviewed Journal]

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24
CCR5 Antagonists: 3-(Pyrrolidin-1-yl)propionic Acid Analogues with Potent Anti-HIV Activity
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CCR5 Antagonists: 3-(Pyrrolidin-1-yl)propionic Acid Analogues with Potent Anti-HIV Activity

Lynch, Christopher L. ; Hale, Jeffrey J. ; Budhu, Richard J. ; Gentry, Amy L. ; Finke, Paul E. ; Caldwell, Charles G. ; Mills, Sander G. ; Maccoss, Malcolm ; Shen, Dong-Ming ; Chapman, Kevin T. ; Malkowitz, Lorraine ; Springer, Martin S. ; Gould, Sandra L. ; Demartino, Julie A. ; Siciliano, Salvatore J. ; Cascieri, Margaret A. ; Carella, Anthony ; Carver, Gwen ; Holmes, Karen ; Schleif, William A. ; Danzeisen, Renee ; Hazuda, Daria ; Kessler, Joseph ; Lineberger, Janet ; Miller, Michael ; Emini, Emilio

Organic Letters, 07/2003, Vol.5(14), pp.2473-2475 [Peer Reviewed Journal]

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25
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CCR5 antagonists: bicyclic isoxazolidines as conformationally constrained N-1-substituted pyrrolidines

Lynch, Christopher L ; Gentry, Amy L ; Hale, Jeffrey J ; Mills, Sander G ; Maccoss, Malcolm ; Malkowitz, Lorraine ; Springer, Martin S ; Gould, Sandra L ; Demartino, Julie A ; Siciliano, Salvatore J ; Cascieri, Margaret A ; Doss, George ; Carella, Anthony ; Carver, Gwen ; Holmes, Karen ; Schleif, William A ; Danzeisen, Renee ; Hazuda, Daria ; Kessler, Joseph ; Lineberger, Janet ; Miller, Michael ; Emini, Emilio A

Bioorganic & Medicinal Chemistry Letters, 2002, Vol.12(4), pp.677-679 [Peer Reviewed Journal]

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26
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CCR5 blockade modulates inflammation and alloimmunity in primates

Schröder, Carsten ; Pierson, Richard N ; Nguyen, Bao-Ngoc H ; Kawka, Douglas W ; Peterson, Laurence B ; Wu, Guosheng ; Zhang, Tianshu ; Springer, Martin S ; Siciliano, Sal J ; Iliff, Susan ; Ayala, Julia M ; Lu, Min ; Mudgett, John S ; Lyons, Kathy ; Mills, Sander G ; Miller, Geraldine G ; Singer, Irwin I ; Azimzadeh, Agnes M ; Demartino, Julie A

Journal of immunology (Baltimore, Md. : 1950), 15 August 2007, Vol.179(4), pp.2289-99 [Peer Reviewed Journal]

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27
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Characterization of a novel and selective cannabinoid CB 1 receptor inverse agonist, Imidazole 24b, in rodents

Shearman, Lauren P ; Stribling, D. Sloan ; Camacho, Ramon E ; Rosko, Kimberly M ; Wang, Junying ; Tong, Sharon ; Feng, Yue ; Marsh, Donald J ; Yu, Hong ; Guan, Xiaoming ; Spann, Stephanie K ; Macneil, Douglas J ; Fong, Tung M ; Metzger, Joseph M ; Goulet, Mark T ; Hagmann, William K ; Plummer, Christopher W ; Finke, Paul E ; Mills, Sander G ; Shah, Shrenik K ; Truong, Quang ; Van Der Ploeg, L.H.T ; Macintyre, D. Euan ; Strack, Alison M

European Journal of Pharmacology, 2008, Vol.579(1), pp.215-224 [Peer Reviewed Journal]

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28
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Comparison of the functional blockade of rat substance P (NK 1) receptors by GR205171, RP67580, SR140333 and NKP-608

Rupniak, Nadia M.J ; Carlson, Emma J ; Shepheard, Sara ; Bentley, Graham ; Williams, Angela R ; Hill, Alastair ; Swain, Christopher ; Mills, Sander G ; Di Salvo, Jerry ; Kilburn, Ruth ; Cascieri, Margaret A ; Kurtz, Marc M ; Tsao, Kwei-Lan ; Gould, Sandra L ; Chicchi, Gary G

Neuropharmacology, 2003, Vol.45(2), pp.231-241 [Peer Reviewed Journal]

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29
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Concise preparation of 8-trifluoromethyltetrahydro-6 H-pyrido [1,2- a] pyrazine-6-one

Kothandaraman, Shankaran ; Guiadeen, Deodialsingh ; Butora, Gabor ; Doss, George ; Mills, Sander G ; Maccoss, Malcolm ; Yang, Lihu

Tetrahedron Letters, 2009, Vol.50(28), pp.4050-4053 [Peer Reviewed Journal]

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30
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Conformational studies of 3-amino-1-alkyl-cyclopentane carboxamide CCR2 antagonists leading to new spirocyclic antagonists

Pasternak, Alexander ; Goble, Stephen D ; Doss, George A ; Tsou, Nancy N ; Butora, Gabor ; Vicario, Pasquale P ; Ayala, Julia Marie ; Struthers, Mary ; Demartino, Julie A ; Mills, Sander G ; Yang, Lihu

Bioorganic & medicinal chemistry letters, 15 February 2008, Vol.18(4), pp.1374-7 [Peer Reviewed Journal]

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31
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Corrigendum to “Synthesis and SAR of 5,6-diarylpyridines as human CB1 inverse agonists”: [Bioorg. Med. Chem. Lett. 15 (2005) 645]

Meurer, Laura C ; Finke, Paul E ; Mills, Sander G ; Walsh, Thomas F ; Toupence, Richard B ; Debenham, John S ; Goulet, Mark T ; Wang, Junying ; Tong, Xinchun ; Fong, Tung M ; Lao, Julie ; Schaeffer, Marie-Therese ; Chen, Jing ; Shen, Chun-Pyn ; Stribling, D. Sloan ; Shearman, Lauren P ; Strack, Alison M ; Van Der Ploeg, Lex H.T

Bioorganic & Medicinal Chemistry Letters, 2005, Vol.15(6), pp.1755-1755 [Peer Reviewed Journal]

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32
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Cyclopentane-based human NK1 antagonists. Part 1: Discovery and initial SAR

Finke, Paul E ; Meurer, Laura C ; Levorse, Dorothy A ; Mills, Sander G ; Maccoss, Malcolm ; Sadowski, Sharon ; Cascieri, Margaret A ; Tsao, Kwei-Lan ; Chicchi, Gary G ; Metzger, Joseph M ; Macintyre, D. Euan

Bioorganic & Medicinal Chemistry Letters, 2006, Vol.16(17), pp.4497-4503 [Peer Reviewed Journal]

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33
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Cyclopentane-based human NK1 antagonists. Part 2: Development of potent, orally active, water-soluble derivatives

Meurer, Laura C ; Finke, Paul E ; Owens, Karen A ; Tsou, Nancy N ; Ball, Richard G ; Mills, Sander G ; Maccoss, Malcolm ; Sadowski, Sharon ; Cascieri, Margaret A ; Tsao, Kwei-Lan ; Chicchi, Gary G ; Egger, Linda A ; Luell, Silvi ; Metzger, Joseph M ; Macintyre, D. Euan ; Rupniak, Nadia M.J ; Williams, Angela R ; Hargreaves, Richard J

Bioorganic & Medicinal Chemistry Letters, 2006, Vol.16(17), pp.4504-4511 [Peer Reviewed Journal]

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34
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Design and synthesis of a new class of malonyl-CoA decarboxylase inhibitors with anti-obesity and anti-diabetic activities

Tang, Haifeng ; Yan, Yan ; Feng, Zhe ; De Jesus, Reynalda K ; Yang, Lihu ; Levorse, Dorothy A ; Owens, Karen A ; Akiyama, Taro E ; Bergeron, Raynald ; Castriota, Gino A ; Doebber, Thomas W ; Ellsworth, Kenneth P ; Lassman, Michael E ; Li, Cai ; Wu, Margaret S ; Zhang, Bei B ; Chapman, Kevin T ; Mills, Sander G ; Berger, Joel P ; Pasternak, Alexander

Bioorganic & medicinal chemistry letters, 15 October 2010, Vol.20(20), pp.6088-92 [Peer Reviewed Journal]

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35
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Design and synthesis of conformationally constrained 3-(N-alkylamino)propylphosphonic acids as potent agonists of sphingosine-1-phosphate (S1P) receptors

Yan, Lin ; Hale, Jeffrey J ; Lynch, Christopher L ; Budhu, Richard ; Gentry, Amy ; Mills, Sander G ; Hajdu, Richard ; Keohane, Carol Ann ; Rosenbach, Mark J ; Milligan, James A ; Shei, Gan-Ju ; Chrebet, Gary ; Bergstrom, James ; Card, Deborah ; Rosen, Hugh ; Mandala, Suzanne M

Bioorganic & medicinal chemistry letters, 04 October 2004, Vol.14(19), pp.4861-6 [Peer Reviewed Journal]

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