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Corrigendum to "Synthesis and SAR of 5,6-diarylpyridines as human CB1 inverse agonists"

Meurer, Laura C. ; Finke, Paul E. ; Mills, Sander G. ; Walsh, Thomas F. ; Toupence, Richard B. ; Debenham, John S. ; Goulet, Mark T. ; Wang, Junying ; Tong, Xinchun ; Fong, Tung M. ; Lao, Julie ; Schaeffer, Marie-Therese ; Chen, Jing ; Shen, Chun-Pyn ; Stribling, D. Sloan ; Shearman, Lauren P. ; Strack, Alison M. ; Van Der Ploeg, Lex H.T.

Bioorganic & Medicinal Chemistry Letters, 2005, Vol.15(6), pp.1755-1755 [Peer Reviewed Journal]

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3-Substituted 3-(4-aryloxyaryl)-propanoic acids as GPR40 agonists

Walsh, Shawn P. ; Severino, Alexandra ; Zhou, Changyou ; He, Jiafang ; Liang, Gui-Bai ; Tan, Carina P. ; Cao, Jin ; Eiermann, George J. ; Xu, Ling ; Salituro, Gino ; Howard, Andrew D. ; Mills, Sander G. ; Yang, Lihu

Bioorganic & Medicinal Chemistry Letters, 2011, Vol.21(11), pp.3390-3394 [Peer Reviewed Journal]

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Spiroimidazolidinone NPC1L1 inhibitors. Part 2: Structure–activity studies and in vivo efficacy

Howell, Kobporn L. ; Devita, Robert J. ; Garcia-Calvo, Margarita ; Meurer, Roger D. ; Lisnock, Jeanmarie ; Bull, Herbert G. ; Mcmasters, Daniel R. ; Mccann, Margaret E. ; Mills, Sander G.

Bioorganic & Medicinal Chemistry Letters, 2010, Vol.20(23), pp.6929-6932 [Peer Reviewed Journal]

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Tetrahydroindolizinone NK 1 antagonists

Bao, Jianming ; Lu, Huagang ; Morriello, Gregori J. ; Carlson, Emma J. ; Wheeldon, Alan ; Chicchi, Gary G. ; Kurtz, Marc M. ; Tsao, Kwei-Lan C. ; Zheng, Song ; Tong, Xinchun ; Mills, Sander G. ; Devita, Robert J.

Bioorganic & Medicinal Chemistry Letters, 2010, Vol.20(7), pp.2354-2358 [Peer Reviewed Journal]

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2-(3aR,4R,5S,7aS)-5-{(1S)-1-3,5-bis(trifluoromethyl)phenyl-2-hydroxyethoxy}-4-(2-methylphenyl)octahydro-2H-isoindol-2-yl-1,3-oxazol-4(5H)-one: a potent human NK1 receptor antagonist with multiple clearance pathways

Kassick, Andrew J ; Jiang, Jinlong ; Bunda, Jaime ; Wilson, David ; Bao, Jianming ; Lu, Huagang ; Lin, Peter ; Ball, Richard G ; Doss, George A ; Tong, Xinchun ; Tsao, Kwei-Lan C ; Wang, Hong ; Chicchi, Gary ; Karanam, Bindhu ; Tschirret-Guth, Richard ; Samuel, Koppara ; Hora, Donald F ; Kumar, Sanjeev ; Madeira, Maria ; Eng, Waisi ; Hargreaves, Richard ; Purcell, Mona ; Gantert, Liza ; Cook, Jacquelyn ; Devita, Robert J ; Mills, Sander G

Journal of medicinal chemistry, 25 July 2013, Vol.56(14), pp.5940-8 [Peer Reviewed Journal]

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An expeditious synthesis of 3-(difluoromethoxy)- and 3-(trifluoromethoxy)-5,6,7,8-tetrahydro-1,6-naphthyridines

Guiadeen, Deodialsingh ; Kothandaraman, Shankaran ; Yang, Lihu ; Mills, Sander G. ; Maccoss, Malcolm

Tetrahedron Letters, 2008, Vol.49(44), pp.6368-6370 [Peer Reviewed Journal]

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Fused tricyclic pyrrolizinones that exhibit pseudo-irreversible blockade of the NK 1 receptor

Morriello, Gregori J. ; Chicchi, Gary ; Johnson, Tricia ; Mills, Sander G. ; Demartino, Julie ; Kurtz, Marc ; Tsao, K.L.C. ; Zheng, Song ; Tong, Xinchun ; Carlson, Emma ; Townson, Karen ; Wheeldon, Alan ; Boyce, Susan ; Collinson, Neil ; Rupniak, Nadia ; Devita, Robert J.

Bioorganic & Medicinal Chemistry Letters, 2010, Vol.20(19), pp.5925-5932 [Peer Reviewed Journal]

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Substituted fused bicyclic pyrrolizinones as potent, orally bioavailable hNK 1 antagonists

Morriello, Gregori J. ; Mills, Sander G. ; Johnson, Tricia ; Reibarkh, Mikhail ; Chicchi, Gary ; Demartino, Julie ; Kurtz, Marc ; Davies, P. ; Tsao, K.L.C. ; Zheng, Song ; Tong, Xinchun ; Carlson, Emma ; Townson, Karen ; Tattersall, F.D. ; Wheeldon, Alan ; Boyce, Susan ; Collinson, Neil ; Rupniak, Nadia ; Moore, Stephen ; Devita, Robert J.

Bioorganic & Medicinal Chemistry Letters, 2010, Vol.20(6), pp.2007-2012 [Peer Reviewed Journal]

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Concise preparation of 8-trifluoromethyltetrahydro-6 H-pyrido [1,2- a] pyrazine-6-one

Kothandaraman, Shankaran ; Guiadeen, Deodialsingh ; Butora, Gabor ; Doss, George ; Mills, Sander G. ; Maccoss, Malcolm ; Yang, Lihu

Tetrahedron Letters, 2009, Vol.50(28), pp.4050-4053 [Peer Reviewed Journal]

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Discovery of 5-aryloxy-2,4-thiazolidinediones as potent GPR40 agonists

Zhou, Changyou ; Tang, Cheng ; Chang, Eric ; Ge, Min ; Lin, Songnian ; Cline, Eric ; Tan, Carina P. ; Feng, Yue ; Zhou, Yun-Ping ; Eiermann, George J. ; Petrov, Aleksandr ; Salituro, Gino ; Meinke, Peter ; Mosley, Ralph ; Akiyama, Taro E. ; Einstein, Monica ; Kumar, Sanjeev ; Berger, Joel ; Howard, Andrew D. ; Thornberry, Nancy ; Mills, Sander G. ; Yang, Lihu

Bioorganic & Medicinal Chemistry Letters, 2010, Vol.20(3), pp.1298-1301 [Peer Reviewed Journal]

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Discovery of a Potent and Orally Bioavailable CCR2 and CCR5 Dual Antagonist
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Discovery of a Potent and Orally Bioavailable CCR2 and CCR5 Dual Antagonist

Pasternak, Alexander ; Goble, Stephen D. ; Struthers, Mary ; Vicario, Pasquale P. ; Ayala, Julia M. ; Di Salvo, Jerry ; Kilburn, Ruth ; Wisniewski, Thomas ; Demartino, Julie A. ; Mills, Sander G. ; Yang, Lihu

ACS Medicinal Chemistry Letters, 04/08/2010, Vol.1(1), pp.14-18 [Peer Reviewed Journal]

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Discovery and optimization of novel 4-[(aminocarbonyl)amino]- N-[4-(2-aminoethyl)phenyl]benzenesulfonamide ghrelin receptor antagonists

Pasternak, Alexander ; Goble, Stephen D. ; Dejesus, Reynalda K. ; Hreniuk, Donna L. ; Chung, Christine C. ; Tota, Michael R. ; Mazur, Paul ; Feighner, Scott D. ; Howard, Andrew D. ; Mills, Sander G. ; Yang, Lihu

Bioorganic & Medicinal Chemistry Letters, 2009, Vol.19(21), pp.6237-6240 [Peer Reviewed Journal]

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Design, synthesis, and biological evaluation of aminopyrazine derivatives as inhibitors of mitogen-activated protein kinase-activated protein kinase 2 (MK-2)

Lin, Songnian ; Malkani, Sunita ; Lombardo, Matthew ; Yang, Lihu ; Mills, Sander G. ; Chapman, Kevin ; Thompson, James E. ; Zhang, Wen Xiao ; Wang, Ruixiu ; Cubbon, Rose M. ; O’neill, Edward A. ; Hale, Jeffrey J.

Bioorganic & Medicinal Chemistry Letters, 15 November 2015, Vol.25(22), pp.5402-5408 [Peer Reviewed Journal]

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14
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Conformational studies of 3-amino-1-alkyl-cyclopentane carboxamide CCR2 antagonists leading to new spirocyclic antagonists

Pasternak, Alexander ; Goble, Stephen D. ; Doss, George A. ; Tsou, Nancy N. ; Butora, Gabor ; Vicario, Pasquale P. ; Ayala, Julia Marie ; Struthers, Mary ; Demartino, Julie A. ; Mills, Sander G. ; Yang, Lihu

Bioorganic & Medicinal Chemistry Letters, 2008, Vol.18(4), pp.1374-1377 [Peer Reviewed Journal]

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15
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Potent heteroarylpiperidine and carboxyphenylpiperidine 1-alkyl-cyclopentane carboxamide CCR2 antagonists

Pasternak, Alexander ; Goble, Stephen D. ; Vicario, Pasquale P. ; Di Salvo, Jerry ; Ayala, Julia M. ; Struthers, Mary ; Demartino, Julie A. ; Mills, Sander G. ; Yang, Lihu

Bioorganic & Medicinal Chemistry Letters, 2008, Vol.18(3), pp.994-998 [Peer Reviewed Journal]

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16
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Novel, orally bioavailable gamma-aminoamide CC chemokine receptor 2 (CCR2) antagonists

Pasternak, Alexander ; Marino, Dominick ; Vicario, Pasquale P ; Ayala, Julia Marie ; Cascierri, Margaret A ; Parsons, William ; Mills, Sander G ; Maccoss, Malcolm ; Yang, Lihu

Journal of medicinal chemistry, 10 August 2006, Vol.49(16), pp.4801-4 [Peer Reviewed Journal]

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17
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1,3,4-Trisubstituted pyrrolidine CCR5 receptor antagonists. Part 1: discovery of the pyrrolidine scaffold and determination of its stereochemical requirements

Hale, Jeffrey J. ; Budhu, Richard J. ; Mills, Sander G. ; Maccoss, Malcolm ; Malkowitz, Lorraine ; Siciliano, Salvatore ; Gould, Sandra L. ; Demartino, Julie A. ; Springer, Martin S.

Bioorganic & Medicinal Chemistry Letters, 2001, Vol.11(11), pp.1437-1440 [Peer Reviewed Journal]

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18
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Design, synthesis, and structure–activity relationship of novel CCR2 antagonists

Kothandaraman, Shankaran ; Donnely, Karla L. ; Butora, Gabor ; Jiao, Richard ; Pasternak, Alexander ; Morriello, Gregori J. ; Goble, Stephen D. ; Zhou, Changyou ; Mills, Sander G. ; Maccoss, Malcolm ; Vicario, Pasquale P. ; Ayala, Julia M. ; Demartino, Julie A. ; Struthers, Mary ; Cascieri, Margaret A. ; Yang, Lihu

Bioorganic & Medicinal Chemistry Letters, 2009, Vol.19(6), pp.1830-1834 [Peer Reviewed Journal]

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19
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Novel 1-(2-aminopyrazin-3-yl)methyl-2-thioureas as potent inhibitors of mitogen-activated protein kinase-activated protein kinase 2 (MK-2)

Lin, Songnian ; Lombardo, Matthew ; Malkani, Sunita ; Hale, Jeffrey J. ; Mills, Sander G. ; Chapman, Kevin ; Thompson, James E. ; Zhang, Wen Xiao ; Wang, Ruixiu ; Cubbon, Rose M. ; O’neill, Edward A. ; Luell, Silvi ; Carballo-Jane, Ester ; Yang, Lihu

Bioorganic & Medicinal Chemistry Letters, 2009, Vol.19(12), pp.3238-3242 [Peer Reviewed Journal]

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20
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1,2,4-Triacylpiperidine substance p antagonists: Separation of affinities for the NK-1 receptor and the L-type calcium channel

Mills, Sander G. ; Maccoss, Malcolm ; Cascieri, Margaret A. ; Sadowski, Sharon ; Patel, Smita ; Chapman, Kerry L. ; Hutson, Peter H.

Bioorganic & Medicinal Chemistry Letters, 1995, Vol.5(6), pp.599-604 [Peer Reviewed Journal]

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21
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SAR studies of 3-arylpropionic acids as potent and selective agonists of sphingosine-1-phosphate receptor-1 (S1P 1) with enhanced pharmacokinetic properties

Yan, Lin ; Huo, Pei ; Hale, Jeffrey J. ; Mills, Sander G. ; Hajdu, Richard ; Keohane, Carol A. ; Rosenbach, Mark J. ; Milligan, James A. ; Shei, Gan-Ju ; Chrebet, Gary ; Bergstrom, James ; Card, Deborah ; Mandala, Suzanne M.

Bioorganic & Medicinal Chemistry Letters, 2007, Vol.17(3), pp.828-831 [Peer Reviewed Journal]

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22
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Pyrrolidine-carboxamides and oxadiazoles as potent hNK 1 antagonists

Young, Jonathan R. ; Eid, Ronsar ; Turner, Cherilyn ; Devita, Robert J. ; Kurtz, Marc M. ; Tsao, Kwei-Lan C. ; Chicchi, Gary G. ; Wheeldon, Alan ; Carlson, Emma ; Mills, Sander G.

Bioorganic & Medicinal Chemistry Letters, 2007, Vol.17(19), pp.5310-5315 [Peer Reviewed Journal]

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23
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Discovery of 3-piperidinyl-1-cyclopentanecarboxamide as a novel scaffold for highly potent CC chemokine receptor 2 antagonists

Yang, Lihu ; Butora, Gabor ; Jiao, Richard X ; Pasternak, Alex ; Zhou, Changyou ; Parsons, William H ; Mills, Sander G ; Vicario, Pasquale P ; Ayala, Julia M ; Cascieri, Margaret A ; Maccoss, Malcolm

Journal of medicinal chemistry, 31 May 2007, Vol.50(11), pp.2609-11 [Peer Reviewed Journal]

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24
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Cyclopentane-based human NK1 antagonists. Part 1: Discovery and initial SAR

Finke, Paul E. ; Meurer, Laura C. ; Levorse, Dorothy A. ; Mills, Sander G. ; Maccoss, Malcolm ; Sadowski, Sharon ; Cascieri, Margaret A. ; Tsao, Kwei-Lan ; Chicchi, Gary G. ; Metzger, Joseph M. ; Macintyre, D. Euan

Bioorganic & Medicinal Chemistry Letters, 2006, Vol.16(17), pp.4497-4503 [Peer Reviewed Journal]

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25
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Highly selective and potent agonists of sphingosine-1-phosphate 1 (S1P 1) receptor

Vachal, Petr ; Toth, Leslie M. ; Hale, Jeffrey J. ; Yan, Lin ; Mills, Sander G. ; Chrebet, Gary L. ; Koehane, Carol A. ; Hajdu, Richard ; Milligan, James A. ; Rosenbach, Mark J. ; Mandala, Suzanne

Bioorganic & Medicinal Chemistry Letters, 2006, Vol.16(14), pp.3684-3687 [Peer Reviewed Journal]

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26
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Synthesis and study of alendronate derivatives as potential prodrugs of alendronate sodium for the treatment of low bone density and osteoporosis

Vachal, Petr ; Hale, Jeffrey J ; Lu, Zhe ; Streckfuss, Eric C ; Mills, Sander G ; Maccoss, Malcolm ; Yin, Daniel H ; Algayer, Kimberly ; Manser, Kimberly ; Kesisoglou, Filippos ; Ghosh, Soumojeet ; Alani, Laman L

Journal of medicinal chemistry, 01 June 2006, Vol.49(11), pp.3060-3 [Peer Reviewed Journal]

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27
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The discovery of 3-(N-alkyl)aminopropylphosphonic acids as potent S1P receptor agonists

Hale, Jeffrey J. ; Doherty, George ; Toth, Leslie ; Li, Zhen ; Mills, Sander G. ; Hajdu, Richard ; Ann Keohane, Carol ; Rosenbach, Mark ; Milligan, James ; Shei, Gan-Ju ; Chrebet, Gary ; Bergstrom, James ; Card, Deborah ; Rosen, Hugh ; Mandala, Suzanne

Bioorganic & Medicinal Chemistry Letters, 2004, Vol.14(13), pp.3495-3499 [Peer Reviewed Journal]

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28
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Antagonists of the human CCR5 receptor as anti-HIV-1 agents. Part 4: synthesis and structure–Activity relationships for 1-[ N-(Methyl)- N-(phenylsulfonyl)amino]-2-(phenyl)-4-(4-( N-(alkyl)- N-(benzyloxycarbonyl)amino)piperidin-1-yl)butanes

Finke, Paul E. ; Oates, Bryan ; Mills, Sander G. ; Maccoss, Malcolm ; Malkowitz, Lorraine ; Springer, Martin S. ; Gould, Sandra L. ; Demartino, Julie A. ; Carella, Anthony ; Carver, Gwen ; Holmes, Karen ; Danzeisen, Renee ; Hazuda, Daria ; Kessler, Joseph ; Lineberger, Janet ; Miller, Michael ; Schleif, William A. ; Emini, Emilio A.

Bioorganic & Medicinal Chemistry Letters, 2001, Vol.11(18), pp.2475-2479 [Peer Reviewed Journal]

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29
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Discovery of Selective Small Molecule ROMK Inhibitors as Potential New Mechanism Diuretics

Tang, Haifeng ; Walsh, Shawn P ; Yan, Yan ; De Jesus, Reynalda K ; Shahripour, Aurash ; Teumelsan, Nardos ; Zhu, Yuping ; Ha, Sookhee ; Owens, Karen A ; Thomas-Fowlkes, Brande S ; Felix, John P ; Liu, Jessica ; Kohler, Martin ; Priest, Birgit T ; Bailey, Timothy ; Brochu, Richard ; Alonso-Galicia, Magdalena ; Kaczorowski, Gregory J ; Roy, Sophie ; Yang, Lihu ; Mills, Sander G ; Garcia, Maria L ; Pasternak, Alexander

ACS medicinal chemistry letters, 10 May 2012, Vol.3(5), pp.367-72 [Peer Reviewed Journal]

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30
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Stimulation of Glucose-Dependent Insulin Secretion by a Potent, Selective sst3 Antagonist

Pasternak, Alexander ; Feng, Zhe ; De Jesus, Reynalda ; Ye, Zhixiong ; He, Shuwen ; Dobbelaar, Peter ; Bradley, Scott A ; Chicchi, Gary G ; Tsao, Kwei-Lan ; Trusca, Dorina ; Eiermann, George J ; Li, Cai ; Feng, Yue ; Wu, Margaret ; Shao, Qing ; Zhang, Bei B ; Nargund, Ravi ; Mills, Sander G ; Howard, Andrew D ; Yang, Lihu ; Zhou, Yun-Ping

ACS medicinal chemistry letters, 12 April 2012, Vol.3(4), pp.289-93 [Peer Reviewed Journal]

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31
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Design and synthesis of a new class of malonyl-CoA decarboxylase inhibitors with anti-obesity and anti-diabetic activities

Tang, Haifeng ; Yan, Yan ; Feng, Zhe ; De Jesus, Reynalda K ; Yang, Lihu ; Levorse, Dorothy A ; Owens, Karen A ; Akiyama, Taro E ; Bergeron, Raynald ; Castriota, Gino A ; Doebber, Thomas W ; Ellsworth, Kenneth P ; Lassman, Michael E ; Li, Cai ; Wu, Margaret S ; Zhang, Bei B ; Chapman, Kevin T ; Mills, Sander G ; Berger, Joel P ; Pasternak, Alexander

Bioorganic & medicinal chemistry letters, 15 October 2010, Vol.20(20), pp.6088-92 [Peer Reviewed Journal]

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32
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Disubstituted pyrimidines as Lck inhibitors

Hunt, Julianne A. ; Beresis, Richard T. ; Goulet, Joung L. ; Holmes, Mark A. ; Hong, Xinfang J. ; Kovacs, Ernest ; Mills, Sander G. ; Ruzek, Rowena D. ; Wong, Frederick ; Hermes, Jeffrey D. ; Park, Young-Whan ; Salowe, Scott P. ; Sonatore, Lisa M. ; Wu, Lin ; Woods, Andrea ; Zaller, Dennis M. ; Sinclair, Peter J.

Bioorganic & Medicinal Chemistry Letters, 2009, Vol.19(18), pp.5440-5443 [Peer Reviewed Journal]

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33
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Potent, brain-penetrant, hydroisoindoline-based human neurokinin-1 receptor antagonists

Jiang, Jinlong ; Bunda, Jaime L ; Doss, Geoge A ; Chicchi, Gary G ; Kurtz, Marc M ; Tsao, Kwei-Lan C ; Tong, Xinchun ; Zheng, Song ; Upthagrove, Alana ; Samuel, Koppara ; Tschirret-Guth, Richard ; Kumar, Sanjeev ; Wheeldon, Alan ; Carlson, Emma J ; Hargreaves, Richard ; Burns, Donald ; Hamill, Terence ; Ryan, Christine ; Krause, Stephen M ; Eng, Waisi ; Devita, Robert J ; Mills, Sander G

Journal of medicinal chemistry, 14 May 2009, Vol.52(9), pp.3039-46 [Peer Reviewed Journal]

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34
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Selective small-molecule agonists of G protein-coupled receptor 40 promote glucose-dependent insulin secretion and reduce blood glucose in mice

Tan, Carina P ; Feng, Yue ; Zhou, Yun-Ping ; Eiermann, George J ; Petrov, Aleksandr ; Zhou, Changyou ; Lin, Songnian ; Salituro, Gino ; Meinke, Peter ; Mosley, Ralph ; Akiyama, Taro E ; Einstein, Monica ; Kumar, Sanjeev ; Berger, Joel P ; Mills, Sander G ; Thornberry, Nancy A ; Yang, Lihu ; Howard, Andrew D

Diabetes, August 2008, Vol.57(8), pp.2211-9 [Peer Reviewed Journal]

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35
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Fused bicyclic pyrrolizinones as new scaffolds for human NK 1 antagonists

Morriello, Gregori J. ; Devita, Robert J. ; Mills, Sander G. ; Young, Jonathan R. ; Lin, Peter ; Doss, George ; Chicchi, Gary G. ; Demartino, Julie ; Kurtz, Marc M. ; Tsao, Kwei-Lan C. ; Carlson, Emma ; Townson, Karen ; Wheeldon, Alan ; Boyce, Susan ; Collinson, Neil ; Rupniak, Nadia ; Moore, Stephen

Bioorganic & Medicinal Chemistry, 2008, Vol.16(5), pp.2156-2170 [Peer Reviewed Journal]

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