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Tetrahydroindolizinone NK1 antagonists

Bao, Jianming ; Lu, Huagang ; Morriello, Gregori J ; Carlson, Emma J ; Wheeldon, Alan ; Chicchi, Gary G ; Kurtz, Marc M ; Tsao, Kwei-Lan C ; Zheng, Song ; Tong, Xinchun ; Mills, Sander G ; Devita, Robert J

Bioorganic & medicinal chemistry letters, 01 April 2010, Vol.20(7), pp.2354-8 [Peer Reviewed Journal]

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Phosphinic acid inhibitors of matrix metalloproteinases

Caldwell, Charles G ; Sahoo, Soumya P ; Polo, Scott A ; Eversole, Randall R ; Lanza, Thomas J ; Mills, Sander G ; Niedzwiecki, Lisa M ; Izquierdo-Martin, Maria ; Chang, Benedict C ; Harrison, Richard K ; Kuo, David W ; Lin, T.-Y ; Stein, Ross L ; Durette, Philippe L ; Hagmann, William K

Bioorganic & Medicinal Chemistry Letters, 1996, Vol.6(3), pp.323-328 [Peer Reviewed Journal]

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Binding of 2-aryl-4-(piperidin-1-yl)butanamines and 1,3,4-trisubstituted pyrrolidines to human CCR5: a molecular modeling-guided mutagenesis study of the binding pocket

Castonguay, Laurie A ; Weng, Youmin ; Adolfsen, William ; Di Salvo, Jerry ; Kilburn, Ruth ; Caldwell, Charles G ; Daugherty, Bruce L ; Finke, Paul E ; Hale, Jeffrey J ; Lynch, Christopher L ; Mills, Sander G ; Maccoss, Malcolm ; Springer, Martin S ; Demartino, Julie A

Biochemistry, 18 February 2003, Vol.42(6), pp.1544-50 [Peer Reviewed Journal]

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2,5-Disubstituted pyrrolidine carboxylates as potent, orally active sphingosine-1-phosphate (S1P) receptor agonists

Colandrea, Vincent J ; Legiec, Irene E ; Huo, Pei ; Yan, Lin ; Hale, Jeffrey J ; Mills, Sander G ; Bergstrom, James ; Card, Deborah ; Chebret, Gary ; Hajdu, Richard ; Keohane, Carol Ann ; Milligan, James A ; Rosenbach, Mark J ; Shei, Gan-Ju ; Mandala, Suzanne M

Bioorganic & Medicinal Chemistry Letters, 2006, Vol.16(11), pp.2905-2908 [Peer Reviewed Journal]

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Identification of Leu276 of the S1P1 receptor and Phe263 of the S1P3 receptor in interaction with receptor specific agonists by molecular modeling, site-directed mutagenesis, and affinity studies

Deng, Qiaolin ; Clemas, Joseph A ; Chrebet, Gary ; Fischer, Paul ; Hale, Jeffrey J ; Li, Zhen ; Mills, Sander G ; Bergstrom, James ; Mandala, Suzanne ; Mosley, Ralph ; Parent, Stephen A

Molecular pharmacology, March 2007, Vol.71(3), pp.724-35 [Peer Reviewed Journal]

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Cyclopentane-based human NK1 antagonists. Part 1: Discovery and initial SAR

Finke, Paul E ; Meurer, Laura C ; Levorse, Dorothy A ; Mills, Sander G ; Maccoss, Malcolm ; Sadowski, Sharon ; Cascieri, Margaret A ; Tsao, Kwei-Lan ; Chicchi, Gary G ; Metzger, Joseph M ; Macintyre, D. Euan

Bioorganic & Medicinal Chemistry Letters, 2006, Vol.16(17), pp.4497-4503 [Peer Reviewed Journal]

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Antagonists of the human CCR5 receptor as anti-HIV-1 agents. Part 2: structure–activity relationships for substituted 2-aryl-1-[N-(methyl)-N-(phenylsulfonyl)amino]-4-(piperidin-1-yl)butanes

Finke, Paul E ; Meurer, Laura C ; Oates, Bryan ; Mills, Sander G ; Maccoss, Malcolm ; Malkowitz, Lorraine ; Springer, Martin S ; Daugherty, Bruce L ; Gould, Sandra L ; Demartino, Julie A ; Siciliano, Salvatore J ; Carella, Anthony ; Carver, Gwen ; Holmes, Karen ; Danzeisen, Renee ; Hazuda, Daria ; Kessler, Joseph ; Lineberger, Janet ; Miller, Michael ; Schleif, William A ; Emini, Emilio A

Bioorganic & Medicinal Chemistry Letters, January 2001, Vol.11(2), pp.265-270 [Peer Reviewed Journal]

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Antagonists of the human CCR5 receptor as anti-HIV-1 agents. Part 4: synthesis and structure–Activity relationships for 1-[ N-(Methyl)- N-(phenylsulfonyl)amino]-2-(phenyl)-4-(4-( N-(alkyl)- N-(benzyloxycarbonyl)amino)piperidin-1-yl)butanes

Finke, Paul E ; Oates, Bryan ; Mills, Sander G ; Maccoss, Malcolm ; Malkowitz, Lorraine ; Springer, Martin S ; Gould, Sandra L ; Demartino, Julie A ; Carella, Anthony ; Carver, Gwen ; Holmes, Karen ; Danzeisen, Renee ; Hazuda, Daria ; Kessler, Joseph ; Lineberger, Janet ; Miller, Michael ; Schleif, William A ; Emini, Emilio A

Bioorganic & Medicinal Chemistry Letters, 2001, Vol.11(18), pp.2475-2479 [Peer Reviewed Journal]

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An expeditious synthesis of 3-(difluoromethoxy)- and 3-(trifluoromethoxy)-5,6,7,8-tetrahydro-1,6-naphthyridines

Guiadeen, Deodialsingh ; Kothandaraman, Shankaran ; Yang, Lihu ; Mills, Sander G ; Maccoss, Malcolm

Tetrahedron Letters, 2008, Vol.49(44), pp.6368-6370 [Peer Reviewed Journal]

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The discovery of sulfonylated dipeptides as Potent VLA-4 antagonists

Hagmann, William K ; Durette, Philippe L ; Lanza, Thomas ; Kevin, Nancy Jo ; de Laszlo, Stephen E ; Kopka, Ihor E ; Young, David ; Magriotis, Plato A ; Li, Bing ; Lin, Linus S ; Yang, Ginger ; Kamenecka, Theodore ; Chang, Linda L ; Wilson, Jonathan ; Maccoss, Malcolm ; Mills, Sander G ; Van Riper, Gail ; Mccauley, Ermengilda ; Egger, Linda A ; Kidambi, Usha ; Lyons, Kathryn ; Vincent, Stella ; Stearns, Ralph ; Colletti, Adria ; Teffera, Johannes ; Tong, Sharon ; Fenyk-Melody, Judy ; Owens, Karen ; Levorse, Dorothy ; Kim, Philip ; Schmidt, John A ; Mumford, Richard A

Bioorganic & Medicinal Chemistry Letters, 2001, Vol.11(20), pp.2709-2713 [Peer Reviewed Journal]

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1,3,4-Trisubstituted pyrrolidine CCR5 receptor antagonists. Part 2: lead optimization affording selective, orally bioavailable compounds with potent Anti-HIV activity

Hale, Jeffrey J ; Budhu, Richard J ; Holson, Edward B ; Finke, Paul E ; Oates, Bryan ; Mills, Sander G ; Maccoss, Malcolm ; Gould, Sandra L ; Demartino, Julie A ; Springer, Martin S ; Siciliano, Salvatore ; Malkowitz, Lorraine ; Schleif, William A ; Hazuda, Daria ; Miller, Michael ; Kessler, Joseph ; Danzeisen, Renee ; Holmes, Karen ; Lineberger, Janet ; Carella, Anthony ; Carver, Gwen ; Emini, Emilio

Bioorganic & Medicinal Chemistry Letters, 2001, Vol.11(20), pp.2741-2745 [Peer Reviewed Journal]

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1,3,4-Trisubstituted pyrrolidine CCR5 receptor antagonists. Part 3: polar functionality and its effect on anti-HIV-1 activity

Hale, Jeffrey J ; Budhu, Richard J ; Mills, Sander G ; Maccoss, Malcolm ; Gould, Sandra L ; Demartino, Julie A ; Springer, Martin S ; Siciliano, Salvatore J ; Malkowitz, Lorraine ; Schleif, William A ; Hazuda, Daria ; Miller, Michael ; Kessler, Joseph ; Danzeisen, Renee ; Holmes, Karen ; Lineberger, Janet ; Carella, Anthony ; Carver, Gwen ; Emini, Emilio A

Bioorganic & Medicinal Chemistry Letters, 21 October 2002, Vol.12(20), pp.2997-3000 [Peer Reviewed Journal]

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1,3,4-Trisubstituted pyrrolidine CCR5 receptor antagonists. Part 1: discovery of the pyrrolidine scaffold and determination of its stereochemical requirements

Hale, Jeffrey J ; Budhu, Richard J ; Mills, Sander G ; Maccoss, Malcolm ; Malkowitz, Lorraine ; Siciliano, Salvatore ; Gould, Sandra L ; Demartino, Julie A ; Springer, Martin S

Bioorganic & Medicinal Chemistry Letters, 2001, Vol.11(11), pp.1437-1440 [Peer Reviewed Journal]

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14
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The discovery of 3-(N-alkyl)aminopropylphosphonic acids as potent S1P receptor agonists

Hale, Jeffrey J ; Doherty, George ; Toth, Leslie ; Li, Zhen ; Mills, Sander G ; Hajdu, Richard ; Ann Keohane, Carol ; Rosenbach, Mark ; Milligan, James ; Shei, Gan-Ju ; Chrebet, Gary ; Bergstrom, James ; Card, Deborah ; Rosen, Hugh ; Mandala, Suzanne

Bioorganic & Medicinal Chemistry Letters, 2004, Vol.14(13), pp.3495-3499 [Peer Reviewed Journal]

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Selecting against S1P3 enhances the acute cardiovascular tolerability of 3-(N-benzyl)aminopropylphosphonic acid S1P receptor agonists

Hale, Jeffrey J ; Doherty, George ; Toth, Leslie ; Mills, Sander G ; Hajdu, Richard ; Keohane, Carol Ann ; Rosenbach, Mark ; Milligan, James ; Shei, Gan-Ju ; Chrebet, Gary ; Bergstrom, James ; Card, Deborah ; Forrest, Michael ; Sun, Shu-Yu ; West, Sarah ; Xie, Huijuan ; Nomura, Naomi ; Rosen, Hugh ; Mandala, Suzanne

Bioorganic & medicinal chemistry letters, 05 July 2004, Vol.14(13), pp.3501-5 [Peer Reviewed Journal]

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A rational utilization of high-throughput screening affords selective, orally bioavailable 1-benzyl-3-carboxyazetidine sphingosine-1-phosphate-1 receptor agonists

Hale, Jeffrey J ; Lynch, Christopher L ; Neway, William ; Mills, Sander G ; Hajdu, Richard ; Keohane, Carol Ann ; Rosenbach, Mark J ; Milligan, James A ; Shei, Gan-Ju ; Parent, Stephen A ; Chrebet, Gary ; Bergstrom, James ; Card, Deborah ; Ferrer, Marc ; Hodder, Peter ; Strulovici, Berta ; Rosen, Hugh ; Mandala, Suzanne

Journal of medicinal chemistry, 30 December 2004, Vol.47(27), pp.6662-5 [Peer Reviewed Journal]

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Phosphorylated Morpholine Acetal Human Neurokinin-1 Receptor Antagonists as Water-Soluble Prodrugs
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Phosphorylated Morpholine Acetal Human Neurokinin-1 Receptor Antagonists as Water-Soluble Prodrugs

Hale, Jeffrey J. ; Mills, Sander G. ; Maccoss, Malcolm ; Dorn, Conrad P. ; Finke, Paul E. ; Budhu, Richard J. ; Reamer, Robert A. ; Huskey, Su-Er W. ; Luffer-Atlas, Debra ; Dean, Brian J. ; Mcgowan, Erin M. ; Feeney, William P. ; Chiu, Shuet-Hing Lee ; Cascieri, Margaret A. ; Chicchi, Gary G. ; Kurtz, Marc M. ; Sadowski, Sharon ; Ber, Elzbieta ; Tattersall, F. David ; Rupniak, Nadia M. J. ; Williams, Angela R. ; Rycroft, Wayne ; Hargreaves, Richard ; Metzger, Joseph M. ; Macintyre, D. Euan

Journal of Medicinal Chemistry, 03/2000, Vol.43(6), pp.1234-1241 [Peer Reviewed Journal]

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18
Structural Optimization Affording 2-( R )-(1-( R )-3,5-Bis(trifluoromethyl)phenylethoxy)-3-( S )-(4-fluoro)phenyl-4- (3-oxo-1,2,4-triazol-5-yl)methylmorpholine, a Potent, Orally Active, Long-Acting Morpholine Acetal Human NK-1 Receptor Antagonist
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Structural Optimization Affording 2-( R )-(1-( R )-3,5-Bis(trifluoromethyl)phenylethoxy)-3-( S )-(4-fluoro)phenyl-4- (3-oxo-1,2,4-triazol-5-yl)methylmorpholine, a Potent, Orally Active, Long-Acting Morpholine Acetal Human NK-1 Receptor Antagonist

Hale, Jeffrey J. ; Mills, Sander G. ; Maccoss, Malcolm ; Finke, Paul E. ; Cascieri, Margaret A. ; Sadowski, Sharon ; Ber, Elzbieta ; Chicchi, Gary G. ; Kurtz, Marc ; Metzger, Joseph ; Eiermann, George ; Tsou, Nancy N. ; Tattersall, F. David ; Rupniak, Nadia M. J. ; Williams, Angela R. ; Rycroft, Wayne ; Hargreaves, Richard ; Macintyre, D. Euan

Journal of Medicinal Chemistry, 11/1998, Vol.41(23), pp.4607-4614 [Peer Reviewed Journal]

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2( S )-((3,5-Bis(trifluoromethyl)benzyl)oxy)-3( S )-phenyl-4-((3-oxo-1,2,4-triazol- 5-yl)methyl)morpholine ( 1 ):  A Potent, Orally Active, Morpholine-Based Human Neurokinin-1 Receptor Antagonist
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2( S )-((3,5-Bis(trifluoromethyl)benzyl)oxy)-3( S )-phenyl-4-((3-oxo-1,2,4-triazol- 5-yl)methyl)morpholine ( 1 ):  A Potent, Orally Active, Morpholine-Based Human Neurokinin-1 Receptor Antagonist

Hale, Jeffrey J. ; Mills, Sander G. ; Maccoss, Malcolm ; Shah, Shrenik K. ; Qi, Hongbo ; Mathre, David J. ; Cascieri, Margaret A. ; Sadowski, Sharon ; Strader, Catherine D. ; Macintyre, D. Euan ; Metzger, Joseph M.

Journal of Medicinal Chemistry, 01/1996, Vol.39(9), pp.1760-1762 [Peer Reviewed Journal]

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20
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Potent S1P receptor agonists replicate the pharmacologic actions of the novel immune modulator FTY720

Hale, Jeffrey J ; Neway, William ; Mills, Sander G ; Hajdu, Richard ; Ann Keohane, Carol ; Rosenbach, Mark ; Milligan, James ; Shei, Gan-Ju ; Chrebet, Gary ; Bergstrom, James ; Card, Deborah ; Koo, Gloria C ; Koprak, Sam L ; Jackson, Jesse J ; Rosen, Hugh ; Mandala, Suzanne

Bioorganic & Medicinal Chemistry Letters, 2004, Vol.14(12), pp.3351-3355 [Peer Reviewed Journal]

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21
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Spiroimidazolidinone NPC1L1 inhibitors. Part 2: structure-activity studies and in vivo efficacy

Howell, Kobporn L ; Devita, Robert J ; Garcia-Calvo, Margarita ; Meurer, Roger D ; Lisnock, Jeanmarie ; Bull, Herbert G ; Mcmasters, Daniel R ; Mccann, Margaret E ; Mills, Sander G

Bioorganic & medicinal chemistry letters, 01 December 2010, Vol.20(23), pp.6929-32 [Peer Reviewed Journal]

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22
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Disubstituted pyrimidines as Lck inhibitors

Hunt, Julianne A ; Beresis, Richard T ; Goulet, Joung L ; Holmes, Mark A ; Hong, Xinfang J ; Kovacs, Ernest ; Mills, Sander G ; Ruzek, Rowena D ; Wong, Frederick ; Hermes, Jeffrey D ; Park, Young-Whan ; Salowe, Scott P ; Sonatore, Lisa M ; Wu, Lin ; Woods, Andrea ; Zaller, Dennis M ; Sinclair, Peter J

Bioorganic & medicinal chemistry letters, 15 September 2009, Vol.19(18), pp.5440-3 [Peer Reviewed Journal]

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23
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Potent, brain-penetrant, hydroisoindoline-based human neurokinin-1 receptor antagonists

Jiang, Jinlong ; Bunda, Jaime L ; Doss, Geoge A ; Chicchi, Gary G ; Kurtz, Marc M ; Tsao, Kwei-Lan C ; Tong, Xinchun ; Zheng, Song ; Upthagrove, Alana ; Samuel, Koppara ; Tschirret-Guth, Richard ; Kumar, Sanjeev ; Wheeldon, Alan ; Carlson, Emma J ; Hargreaves, Richard ; Burns, Donald ; Hamill, Terence ; Ryan, Christine ; Krause, Stephen M ; Eng, Waisi ; Devita, Robert J ; Mills, Sander G

Journal of medicinal chemistry, 14 May 2009, Vol.52(9), pp.3039-46 [Peer Reviewed Journal]

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24
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Expression and characterization of the chemokine receptor CCR2B from rhesus monkey

Jin, Hong ; Vicario, Pasquale P ; Zweerink, Hans ; Goyal, Shefali ; Hanlon, William A ; Dorn, Conrad P ; Mills, Sander G ; Demartino, Julie A ; Cascieri, Margaret A ; Struthers, Mary

Biochemical Pharmacology, 2003, Vol.66(2), pp.321-330 [Peer Reviewed Journal]

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2-(3aR,4R,5S,7aS)-5-{(1S)-1-3,5-bis(trifluoromethyl)phenyl-2-hydroxyethoxy}-4-(2-methylphenyl)octahydro-2H-isoindol-2-yl-1,3-oxazol-4(5H)-one: a potent human NK1 receptor antagonist with multiple clearance pathways

Kassick, Andrew J ; Jiang, Jinlong ; Bunda, Jaime ; Wilson, David ; Bao, Jianming ; Lu, Huagang ; Lin, Peter ; Ball, Richard G ; Doss, George A ; Tong, Xinchun ; Tsao, Kwei-Lan C ; Wang, Hong ; Chicchi, Gary ; Karanam, Bindhu ; Tschirret-Guth, Richard ; Samuel, Koppara ; Hora, Donald F ; Kumar, Sanjeev ; Madeira, Maria ; Eng, Waisi ; Hargreaves, Richard ; Purcell, Mona ; Gantert, Liza ; Cook, Jacquelyn ; Devita, Robert J ; Mills, Sander G

Journal of medicinal chemistry, 25 July 2013, Vol.56(14), pp.5940-8 [Peer Reviewed Journal]

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26
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Discovery of human CCR5 antagonists containing hydantoins for the treatment of HIV-1 infection

Kim, Dooseop ; Wang, Liping ; Caldwell, Charles G ; Chen, Ping ; Finke, Paul E ; Oates, Bryan ; Maccoss, Malcolm ; Mills, Sander G ; Malkowitz, Lorraine ; Gould, Sandra L ; Demartino, Julie A ; Springer, Martin S ; Hazuda, Daria ; Miller, Michael ; Kessler, Joseph ; Danzeisen, Renee ; Carver, Gwen ; Carella, Anthony ; Holmes, Karen ; Lineberger, Janet ; Schleif, William A ; Emini, Emilio A

Bioorganic & Medicinal Chemistry Letters, 2001, Vol.11(24), pp.3099-3102 [Peer Reviewed Journal]

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Design, synthesis, and SAR of heterocycle-containing antagonists of the human CCR5 receptor for the treatment of HIV-1 infection

Kim, Dooseop ; Wang, Liping ; Caldwell, Charles G ; Chen, Ping ; Finke, Paul E ; Oates, Bryan ; Maccoss, Malcolm ; Mills, Sander G ; Malkowitz, Lorraine ; Gould, Sandra L ; Demartino, Julie A ; Springer, Martin S ; Hazuda, Daria ; Miller, Michael ; Kessler, Joseph ; Danzeisen, Renee ; Carver, Gwen ; Carella, Anthony ; Holmes, Karen ; Lineberger, Janet ; Schleif, William A ; Emini, Emilio A

Bioorganic & Medicinal Chemistry Letters, 2001, Vol.11(24), pp.3103-3106 [Peer Reviewed Journal]

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Potent 1,3,4-trisubstituted pyrrolidine CCR5 receptor antagonists: effects of fused heterocycles on antiviral activity and pharmacokinetic properties

Kim, Dooseop ; Wang, Liping ; Hale, Jeffrey J ; Lynch, Christopher L ; Budhu, Richard J ; Maccoss, Malcolm ; Mills, Sander G ; Malkowitz, Lorraine ; Gould, Sandra L ; Demartino, Julie A ; Springer, Martin S ; Hazuda, Daria ; Miller, Michael ; Kessler, Joseph ; Hrin, Renee C ; Carver, Gwen ; Carella, Anthony ; Henry, Karen ; Lineberger, Janet ; Schleif, William A ; Emini, Emilio A

Bioorganic & Medicinal Chemistry Letters, 2005, Vol.15(8), pp.2129-2134 [Peer Reviewed Journal]

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29
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Substituted 3-amino biaryl propionic acids as potent VLA-4 antagonists

Kopka, Ihor E ; Lin, Linus S ; Mumford, Richard A ; Lanza, Thomas ; Magriotis, Plato A ; Young, David ; Delaszlo, Stephen E ; Maccoss, Malcolm ; Mills, Sander G ; Van Riper, Gail ; Mccauley, Ermengilda ; Lyons, Kathryn ; Vincent, Stella ; Egger, Linda A ; Kidambi, Usha ; Stearns, Ralph ; Colletti, Adria ; Teffera, Yohannes ; Tong, Sharon ; Owens, Karen ; Levorse, Dorothy ; Schmidt, John A ; Hagmann, William K

Bioorganic & Medicinal Chemistry Letters, 2002, Vol.12(17), pp.2415-2418 [Peer Reviewed Journal]

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30
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Substituted N-(3,5-dichlorobenzenesulfonyl)-L-prolyl-phenylalanine analogues as potent VLA-4 antagonists

Kopka, Ihor E ; Young, David N ; Lin, Linus S ; Mumford, Richard A ; Magriotis, Plato A ; Maccoss, Malcolm ; Mills, Sander G ; Van Riper, Gail ; Mccauley, Ermengilda ; Egger, Linda E ; Kidambi, Usha ; Schmidt, John A ; Lyons, Kathryn ; Stearns, Ralph ; Vincent, Stella ; Colletti, Adria ; Wang, Zhen ; Tong, Sharon ; Wang, Junying ; Zheng, Song ; Owens, Karen ; Levorse, Dorothy ; Hagmann, William K

Bioorganic & medicinal chemistry letters, 25 February 2002, Vol.12(4), pp.637-40 [Peer Reviewed Journal]

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31
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Design, synthesis, and structure-activity relationship of novel CCR2 antagonists

Kothandaraman, Shankaran ; Donnely, Karla L ; Butora, Gabor ; Jiao, Richard ; Pasternak, Alexander ; Morriello, Gregori J ; Goble, Stephen D ; Zhou, Changyou ; Mills, Sander G ; Maccoss, Malcolm ; Vicario, Pasquale P ; Ayala, Julia M ; Demartino, Julie A ; Struthers, Mary ; Cascieri, Margaret A ; Yang, Lihu

Bioorganic & medicinal chemistry letters, 15 March 2009, Vol.19(6), pp.1830-4 [Peer Reviewed Journal]

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Concise preparation of 8-trifluoromethyltetrahydro-6 H-pyrido [1,2- a] pyrazine-6-one

Kothandaraman, Shankaran ; Guiadeen, Deodialsingh ; Butora, Gabor ; Doss, George ; Mills, Sander G ; Maccoss, Malcolm ; Yang, Lihu

Tetrahedron Letters, 2009, Vol.50(28), pp.4050-4053 [Peer Reviewed Journal]

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Discovery of potent 3,5-diphenyl-1,2,4-oxadiazole sphingosine-1-phosphate-1 (S1P1) receptor agonists with exceptional selectivity against S1P2 and S1P3

Li, Zhen ; Chen, Weirong ; Hale, Jeffrey J ; Lynch, Christopher L ; Mills, Sander G ; Hajdu, Richard ; Keohane, Carol Ann ; Rosenbach, Mark J ; Milligan, James A ; Shei, Gan-Ju ; Chrebet, Gary ; Parent, Stephen A ; Bergstrom, James ; Card, Deborah ; Forrest, Michael ; Quackenbush, Elizabeth J ; Wickham, L Alexandra ; Vargas, Hugo ; Evans, Rose M ; Rosen, Hugh ; Mandala, Suzanne

Journal of medicinal chemistry, 06 October 2005, Vol.48(20), pp.6169-73 [Peer Reviewed Journal]

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The discovery of potent, selective, and orally bioavailable hNK 1 antagonists derived from pyrrolidine

Lin, Peter ; Chang, Lehua ; Devita, Robert J ; Young, Jonathan R ; Eid, Ronsar ; Tong, Xinchun ; Zheng, Song ; Ball, Richard G ; Tsou, Nancy N ; Chicchi, Gary G ; Kurtz, Marc M ; Tsao, Kwei-Lan C ; Wheeldon, Alan ; Carlson, Emma J ; Eng, Waisi ; Burns, H. Donald ; Hargreaves, Richard J ; Mills, Sander G

Bioorganic & Medicinal Chemistry Letters, 2007, Vol.17(18), pp.5191-5198 [Peer Reviewed Journal]

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Novel 1-(2-aminopyrazin-3-yl)methyl-2-thioureas as potent inhibitors of mitogen-activated protein kinase-activated protein kinase 2 (MK-2)

Lin, Songnian ; Lombardo, Matthew ; Malkani, Sunita ; Hale, Jeffrey J ; Mills, Sander G ; Chapman, Kevin ; Thompson, James E ; Zhang, Wen Xiao ; Wang, Ruixiu ; Cubbon, Rose M ; O’neill, Edward A ; Luell, Silvi ; Carballo-Jane, Ester ; Yang, Lihu

Bioorganic & Medicinal Chemistry Letters, 2009, Vol.19(12), pp.3238-3242 [Peer Reviewed Journal]

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