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1
Studies on non-covalent associations of immunosuppressive drugs with serum albumin using pneumatically assisted electrospray ionization mass spectrometry
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Studies on non-covalent associations of immunosuppressive drugs with serum albumin using pneumatically assisted electrospray ionization mass spectrometry

Bakhtiar, Ray ; Stearns, Ralph A.

Rapid Communications in Mass Spectrometry, 1995, Vol.9(3), pp.240-244 [Peer Reviewed Journal]

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2
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Studies on non‐covalent associations of immunosuppressive drugs with serum albumin using pneumatically assisted electrospray ionization mass spectrometry

Bakhtiar, Ray ; Stearns, Ralph A.

Rapid Communications in Mass Spectrometry, 1995, Vol.9(3), pp.240-244 [Peer Reviewed Journal]

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3
1-Amino-1,2,3,4-tetrahydronaphthalene-2-carboxylic acid as a Tic mimetic: Application in the synthesis of potent human melanocortin-4 receptor selective agonists
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1-Amino-1,2,3,4-tetrahydronaphthalene-2-carboxylic acid as a Tic mimetic: Application in the synthesis of potent human melanocortin-4 receptor selective agonists

Bakshi, Raman K. ; Hong, Qingmei ; Olson, J.T. ; Ye, Zhixiong ; Sebhat, Iyassue K. ; Weinberg, David H. ; Macneil, Tanya ; Kalyani, Rubana N. ; Tang, Rui ; Martin, William J. ; Strack, Alison ; Mcgowan, Erin ; Tamvakopoulos, Constantin ; Miller, Randy R. ; Stearns, Ralph A. ; Tang, Wei ; Maclntyre, D. Euan ; van Der Ploeg, Lex H.T. ; Patchett, Arthur A. ; Nargund, Ravi P.

Bioorganic & Medicinal Chemistry Letters, 7/2005, Vol.15(14), pp.3430-3433 [Peer Reviewed Journal]

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4
Synthesis and SAR of benzyl and phenoxymethylene oxadiazole benzenesulfonamides as selective β3 adrenergic receptor agonist antiobesity agents
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Synthesis and SAR of benzyl and phenoxymethylene oxadiazole benzenesulfonamides as selective β3 adrenergic receptor agonist antiobesity agents

Biftu, Tesfaye ; Feng, Dennis D ; Liang, Gui-Bai ; Kuo, Howard ; Qian, Xiaoxia ; Naylor, Elizabeth M ; Colandrea, Vincent J ; Candelore, Mari R ; Cascieri, Margaret A ; Colwell, Lawrence F ; Forrest, Michael J ; Hom, Gary J ; Macintyre, D.Euan ; Stearns, Ralph A ; Strader, Catherine D ; Wyvratt, Matthew J ; Fisher, Michael H ; Weber, Ann E

Bioorganic & Medicinal Chemistry Letters, 7/2000, Vol.10(13), pp.1431-1434 [Peer Reviewed Journal]

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5
Mechanism-Based Inhibition of Human Steroid 5α-Reductase by Finasteride:  Enzyme-Catalyzed Formation of NADP−Dihydrofinasteride, a Potent Bisubstrate Analog Inhibitor
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Mechanism-Based Inhibition of Human Steroid 5α-Reductase by Finasteride:  Enzyme-Catalyzed Formation of NADP−Dihydrofinasteride, a Potent Bisubstrate Analog Inhibitor

Bull, Herbert G. ; Garcia-Calvo, Margarita ; Andersson, Stefan ; Baginsky, Walter F. ; Chan, H. Karen ; Ellsworth, Dina E. ; Miller, Randall R. ; Stearns, Ralph A. ; Bakshi, Raman K. ; Rasmusson, Gary H. ; Tolman, Richard L. ; Myers, Robert W. ; Kozarich, John W. ; Harris, Georgianna S.

Journal of the American Chemical Society, 01/1996, Vol.118(10), pp.2359-2365 [Peer Reviewed Journal]

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6
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Cytochrome P450 3A4-mediated bioactivation of raloxifene: irreversible enzyme inhibition and thiol adduct formation

Chen, Qing ; Ngui, Jason S ; Doss, George A ; Wang, Regina W ; Cai, Xiaoxin ; Dininno, Frank P ; Blizzard, Timothy A ; Hammond, Milton L ; Stearns, Ralph A ; Evans, David C ; Baillie, Thomas A ; Tang, Wei

Chemical research in toxicology, July 2002, Vol.15(7), pp.907-14 [Peer Reviewed Journal]

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7
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Effect of quinidine on the 10-hydroxylation of R-warfarin: species differences and clearance projection

Chen, Qing ; Tan, Eugene ; Strauss, John R ; Zhang, Zhoupeng ; Fenyk-Melody, Judith E ; Booth-Genthe, Catherine ; Rushmore, Thomas H ; Stearns, Ralph A ; Evans, David C ; Baillie, Thomas A ; Tang, Wei

The Journal of pharmacology and experimental therapeutics, October 2004, Vol.311(1), pp.307-14 [Peer Reviewed Journal]

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8
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Metabolic activation of a 1,3-disubstituted piperazine derivative: evidence for a novel ring contraction to an imidazoline

Doss, George A ; Miller, Randall R ; Zhang, Zhoupeng ; Teffera, Yohannes ; Nargund, Ravi P ; Palucki, Brenda ; Park, Min K ; Tang, Yui S ; Evans, David C ; Baillie, Thomas A ; Stearns, Ralph A

Chemical research in toxicology, February 2005, Vol.18(2), pp.271-6 [Peer Reviewed Journal]

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9
Discovery of an orally bioavailable alkyl oxadiazole β3 adrenergic receptor agonist
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Discovery of an orally bioavailable alkyl oxadiazole β3 adrenergic receptor agonist

Feng, Danqing D ; Biftu, Tesfaye ; Candelore, Mari R ; Cascieri, Margaret A ; Colwell, Lawrence F ; Deng, Liping ; Feeney, William P ; Forrest, Michael J ; Hom, Gary J ; Macintyre, D.Euan ; Miller, Randall R ; Stearns, Ralph A ; Strader, Catherine D ; Tota, Laurie ; Wyvratt, Matthew J ; Fisher, Michael H ; Weber, Ann E

Bioorganic & Medicinal Chemistry Letters, 7/2000, Vol.10(13), pp.1427-1429 [Peer Reviewed Journal]

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10
The discovery of sulfonylated dipeptides as Potent VLA-4 antagonists
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The discovery of sulfonylated dipeptides as Potent VLA-4 antagonists

Hagmann, William K ; Durette, Philippe L ; Lanza, Thomas ; Kevin, Nancy Jo ; de Laszlo, Stephen E ; Kopka, Ihor E ; Young, David ; Magriotis, Plato A ; Li, Bing ; Lin, Linus S ; Yang, Ginger ; Kamenecka, Theodore ; Chang, Linda L ; Wilson, Jonathan ; Maccoss, Malcolm ; Mills, Sander G ; Van Riper, Gail ; Mccauley, Ermengilda ; Egger, Linda A ; Kidambi, Usha ; Lyons, Kathryn ; Vincent, Stella ; Stearns, Ralph ; Colletti, Adria ; Teffera, Johannes ; Tong, Sharon ; Fenyk-Melody, Judy ; Owens, Karen ; Levorse, Dorothy ; Kim, Philip ; Schmidt, John A ; Mumford, Richard A

Bioorganic & Medicinal Chemistry Letters, 10/2001, Vol.11(20), pp.2709-2713 [Peer Reviewed Journal]

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11
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Discovery of highly potent and efficacious MC4R agonists with spiroindane N-Me-1,2,4-triazole privileged structures for the treatment of obesity

He, Shuwen ; Ye, Zhixiong ; Dobbelaar, Peter H ; Bakshi, Raman K ; Hong, Qingmei ; Dellureficio, James P ; Sebhat, Iyassu K ; Guo, Liangqin ; Liu, Jian ; Jian, Tianying ; Lai, Yingjie ; Franklin, Christopher L ; Reibarkh, Mikhail ; Holmes, Mark A ; Weinberg, David H ; Macneil, Tanya ; Tang, Rui ; Tamvakopoulos, Constantin ; Peng, Qianping ; Miller, Randy R ; Stearns, Ralph A ; Chen, Howard Y ; Chen, Airu S ; Strack, Alison M ; Fong, Tung M ; Wyvratt, Matthew J ; Nargund, Ravi P

Bioorganic & medicinal chemistry letters, 15 November 2010, Vol.20(22), pp.6524-32 [Peer Reviewed Journal]

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12
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Discovery of a spiroindane based compound as a potent, selective, orally bioavailable melanocortin subtype-4 receptor agonist

He, Shuwen ; Ye, Zhixiong ; Dobbelaar, Peter H ; Sebhat, Iyassu K ; Guo, Liangqin ; Liu, Jian ; Jian, Tianying ; Lai, Yingjie ; Franklin, Christopher L ; Bakshi, Raman K ; Dellureficio, James P ; Hong, Qingmei ; Tsou, Nancy N ; Ball, Richard G ; Cashen, Doreen E ; Martin, William J ; Weinberg, David H ; Macneil, Tanya ; Tang, Rui ; Tamvakopoulos, Constantin ; Peng, Qianping ; Miller, Randy R ; Stearns, Ralph A ; Chen, Howard Y ; Chen, Airu S ; Strack, Alison M ; Fong, Tung M ; Macintyre, D Euan ; Wyvratt, Matthew J ; Nargund, Ravi P

Bioorganic & medicinal chemistry letters, 01 April 2010, Vol.20(7), pp.2106-10 [Peer Reviewed Journal]

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13
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Spiroindane based amides as potent and selective MC4R agonists for the treatment of obesity

He, Shuwen ; Ye, Zhixiong ; Dobbelaar, Peter H ; Sebhat, Iyassu K ; Guo, Liangqin ; Liu, Jian ; Jian, Tianying ; Lai, Yingjie ; Franklin, Christopher L ; Bakshi, Raman K ; Dellureficio, James P ; Hong, Qingmei ; Weinberg, David H ; Macneil, Tanya ; Tang, Rui ; Strack, Alison M ; Tamvakopoulos, Constantin ; Peng, Qianping ; Miller, Randy R ; Stearns, Ralph A ; Chen, Howard Y ; Chen, Airu S ; Fong, Tung M ; Wyvratt, Matthew J ; Nargund, Ravi P

Bioorganic & medicinal chemistry letters, 01 August 2010, Vol.20(15), pp.4399-405 [Peer Reviewed Journal]

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14
Optimization of privileged structures for selective and potent melanocortin subtype-4 receptor ligands
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Optimization of privileged structures for selective and potent melanocortin subtype-4 receptor ligands

Hong, Qingmei ; Bakshi, Raman K. ; Dellureficio, James ; He, Shuwen ; Ye, Zhixiong ; Dobbelaar, Peter H. ; Sebhat, Iyassu K. ; Guo, Liangqin ; Liu, Jian ; Jian, Tianying ; Tang, Rui ; Kalyani, Rubana N. ; Macneil, Tanya ; Vongs, Aurawan ; Rosenblum, Charles I. ; Weinberg, David H. ; Peng, Qingping ; Tamvakopoulos, Constantin ; Miller, Randy R. ; Stearns, Ralph A. ; Cashen, Doreen ; Martin, Willian J. ; Chen, Airu S. ; Metzger, Joseph M. ; Chen, Howard Y. ; Strack, Allison M. ; Fong, Tung M. ; Maclntyre, Euan ; Van Der Ploeg, Lex H.T. ; Wyvratt, Matthew J. ; Nargund, Ravi P.

Bioorganic & Medicinal Chemistry Letters, 08/2010, Vol.20(15), pp.4483-4486 [Peer Reviewed Journal]

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15
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Discovery of a piperazine urea based compound as a potent, selective, orally bioavailable melanocortin subtype-4 receptor partial agonist

Hong, Qingmei ; Bakshi, Raman K ; Palucki, Brenda L ; Park, Min K ; Ye, Zhixiong ; He, Shuwen ; Pollard, Patrick G ; Sebhat, Iyassu K ; Liu, Jian ; Guo, Liangqin ; Cashen, Doreen E ; Martin, William J ; Weinberg, David H ; Macneil, Tanya ; Tang, Rui ; Tamvakopoulos, Constantin ; Peng, Qianping ; Miller, Randy R ; Stearns, Ralph A ; Chen, Howard Y ; Chen, Airu S ; Strack, Alison M ; Fong, Tung M ; Macintyre, D Euan ; Wyvratt, Matthew J ; Nargund, Ravi P

Bioorganic & medicinal chemistry letters, 15 April 2011, Vol.21(8), pp.2330-4 [Peer Reviewed Journal]

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16
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Amidines as amide bond replacements in VLA-4 antagonists

Kamenecka, Theodore M ; Park, You-Jung ; Lin, Linus S ; De Laszlo, Stephen ; Mccauley, Ermengilda D ; Van Riper, Gail ; Egger, Linda ; Kidambi, Usha ; Mumford, Richard A ; Tong, Sharon ; Tang, Wei ; Colletti, Adria ; Teffera, Yohannes ; Stearns, Ralph ; Maccoss, Malcolm ; Schmidt, John A ; Hagmann, William K

Bioorganic & medicinal chemistry letters, 03 May 2004, Vol.14(9), pp.2323-6 [Peer Reviewed Journal]

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17
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Substituted 3-amino biaryl propionic acids as potent VLA-4 antagonists

Kopka, Ihor E ; Lin, Linus S ; Mumford, Richard A ; Lanza, Thomas ; Magriotis, Plato A ; Young, David ; Delaszlo, Stephen E ; Maccoss, Malcolm ; Mills, Sander G ; Van Riper, Gail ; Mccauley, Ermengilda ; Lyons, Kathryn ; Vincent, Stella ; Egger, Linda A ; Kidambi, Usha ; Stearns, Ralph ; Colletti, Adria ; Teffera, Yohannes ; Tong, Sharon ; Owens, Karen ; Levorse, Dorothy ; Schmidt, John A ; Hagmann, William K

Bioorganic & medicinal chemistry letters, 02 September 2002, Vol.12(17), pp.2415-8 [Peer Reviewed Journal]

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18
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Substituted N-(3,5-dichlorobenzenesulfonyl)-L-prolyl-phenylalanine analogues as potent VLA-4 antagonists

Kopka, Ihor E ; Young, David N ; Lin, Linus S ; Mumford, Richard A ; Magriotis, Plato A ; Maccoss, Malcolm ; Mills, Sander G ; Van Riper, Gail ; Mccauley, Ermengilda ; Egger, Linda E ; Kidambi, Usha ; Schmidt, John A ; Lyons, Kathryn ; Stearns, Ralph ; Vincent, Stella ; Colletti, Adria ; Wang, Zhen ; Tong, Sharon ; Wang, Junying ; Zheng, Song ; Owens, Karen ; Levorse, Dorothy ; Hagmann, William K

Bioorganic & medicinal chemistry letters, 25 February 2002, Vol.12(4), pp.637-40 [Peer Reviewed Journal]

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19
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Extrapolation of diclofenac clearance from in vitro microsomal metabolism data: role of acyl glucuronidation and sequential oxidative metabolism of the acyl glucuronide

Kumar, Sanjeev ; Samuel, Koppara ; Subramanian, Ramaswamy ; Braun, Matthew P ; Stearns, Ralph A ; Chiu, Shuet-Hing Lee ; Evans, David C ; Baillie, Thomas A

The Journal of pharmacology and experimental therapeutics, December 2002, Vol.303(3), pp.969-78 [Peer Reviewed Journal]

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20
Mechanism of bioactivation and covalent binding of 2,4,6-trinitrotoluene
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Mechanism of bioactivation and covalent binding of 2,4,6-trinitrotoluene

Leung, Kwan H. ; Yao, Ming ; Stearns, Ralph ; Chiu, Shuet-Hing Lee

Chemico-Biological Interactions, 06/1995, Vol.97(1), pp.37-51 [Peer Reviewed Journal]

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21
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Discovery of Novel Allosteric HCV NS5B Inhibitors. 2. Lactam-Containing Thiophene Carboxylates

Li, Pan ; Dorsch, Warren ; Lauffer, David J ; Bilimoria, Darius ; Chauret, Nathalie ; Court, John J ; Das, Sanjoy Kumar ; Denis, Francois ; Mani, Nagraj ; Nanthakumar, Suganthini ; Nicolas, Olivier ; Rao, B Govinda ; Ronkin, Steven ; Selliah, Subajini ; Shawgo, Rebecca S ; Stearns, Ralph ; Tang, Qing ; Waal, Nathan D ; Green, Jeremy

ACS medicinal chemistry letters, 09 February 2017, Vol.8(2), pp.251-255 [Peer Reviewed Journal]

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22
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CorrigendumCorrigendum to "The discovery of acylated β-Amino acids as potent and orally bioavailable VLA-4 antagonists"[Bioorg. Med. Chem. Lett. 12 (2002) 611]

Lin, Linus S ; Kopka, Ihor E ; Mumford, Richard A ; Magriotis, Plato A ; Lanza, Jr, Thomas ; Durette, Philippe L ; Kamenecka, Theodore ; Young, David N ; de Laszlo, Stephen E ; Mccauley, Ermenegilda ; Van Riper, Gail ; Kidambi, Usha ; Egger, Linda A ; Tong, Xinchun ; Lyons, Kathryn ; Vincent, Stella ; Stearns, Ralph ; Colletti, Adria ; Teffera, Yohannes ; Fenyk-Melody, Judy ; Schmidt, John A ; Maccoss, Malcolm ; Hagmann, William K

Bioorganic & Medicinal Chemistry Letters, 2002, Vol.12(12), pp.1695-1695 [Peer Reviewed Journal]

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23
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The discovery of acylated beta-amino acids as potent and orally bioavailable VLA-4 antagonists

Lin, Linus S ; Kopka, Ihor E ; Mumford, Richard A ; Magriotis, Plato A ; Lanza, Thomas ; Durette, Philippe L ; Kamenecka, Theodore ; Young, David N ; De Laszlo, Stephen E ; Mccauley, Ermenegilda ; Riper, Gail Van ; Kidambi, Usha ; Egger, Linda A ; Tong, Xinchun ; Lyons, Kathryn ; Vincent, Stella ; Stearns, Ralph ; Colletti, Adria ; Teffera, Yohannes ; Fenyk-Melody, Judy ; Schmidt, John A ; Maccoss, Malcolm ; Hagmann, William K

Bioorganic & medicinal chemistry letters, 25 February 2002, Vol.12(4), pp.611-4 [Peer Reviewed Journal]

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24
The Discovery of acylated β-Amino acids as potent and orally bioavailable VLA-4 antagonists
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The Discovery of acylated β-Amino acids as potent and orally bioavailable VLA-4 antagonists

Lin, Linus S. ; Kopka, Ihor E. ; Mumford, Richard A. ; Magriotis, Plato A. ; Lanza, Thomas ; Durette, Philippe L. ; Kamenecka, Theodore ; Young, David N. ; Laszlo, Stephen E.de ; Mccauley, Ermenegilda ; Riper, Gail Van ; Kidambi, Usha ; Egger, Linda A. ; Tong, Xinchun ; Lyons, Kathryn ; Vincent, Stella ; Stearns, Ralph ; Colletti, Adria ; Teffera, Yohannes ; Fenyk-Melody, Judy ; Schmidt, John A. ; Maccoss, Malcolm ; Hagmann, William K.

Bioorganic & Medicinal Chemistry Letters, 2/2002, Vol.12(4), pp.611-614 [Peer Reviewed Journal]

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25
In vivo covalent binding of [14C]trinitrotoluene to proteins in the rat
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In vivo covalent binding of [14C]trinitrotoluene to proteins in the rat

Liu, Yu-Ying ; Lu, Anthony Y.H. ; Stearns, Ralph A. ; Chiu, Shuet-Hing Lee

Chemico-Biological Interactions, 03/1992, Vol.82(1), pp.1-19 [Peer Reviewed Journal]

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26
Discovery of a Potent, Orally Bioavailable β 3 Adrenergic Receptor Agonist, ( R )- N -[4-[2-[[2-Hydroxy-2-(3-pyridinyl)ethyl]amino]ethyl]phenyl]-4-[4-[4-(trifluoromethyl)phenyl]thiazol-2-yl]benzenesulfonamide
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Discovery of a Potent, Orally Bioavailable β 3 Adrenergic Receptor Agonist, ( R )- N -[4-[2-[[2-Hydroxy-2-(3-pyridinyl)ethyl]amino]ethyl]phenyl]-4-[4-[4-(trifluoromethyl)phenyl]thiazol-2-yl]benzenesulfonamide

Mathvink, Robert J. ; Tolman, J. Samuel ; Chitty, Dawn ; Candelore, Mari R. ; Cascieri, Margaret A. ; Colwell, Lawrence F. ; Deng, Liping ; Feeney, William P. ; Forrest, Michael J. ; Hom, Gary J. ; Macintyre, D. Euan ; Miller, Randall R. ; Stearns, Ralph A. ; Tota, Laurie ; Wyvratt, Matthew J. ; Fisher, Michael H. ; Weber, Ann E.

Journal of Medicinal Chemistry, 10/2000, Vol.43(21), pp.3832-3836 [Peer Reviewed Journal]

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27
2-Piperazinecarboxamides as potent and selective melanocortin subtype-4 receptor agonists
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2-Piperazinecarboxamides as potent and selective melanocortin subtype-4 receptor agonists

Palucki, Brenda L. ; Park, Min K. ; Nargund, Ravi P. ; Tang, Rui ; Macneil, Tanya ; Weinberg, David H. ; Vongs, Aurawan ; Rosenblum, Charles I. ; Doss, George A. ; Miller, Randall R. ; Stearns, Ralph A. ; Peng, Qianping ; Tamvakopoulos, Constantin ; Van Der Ploeg, Lex H.T. ; Patchett, Arthur A.

Bioorganic & Medicinal Chemistry Letters, 4/2005, Vol.15(8), pp.1993-1996 [Peer Reviewed Journal]

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28
Discovery of (2S)-N-[(1R)-2-[4-cyclohexyl-4-[[(1,1-dimethylethyl)amino]carbonyl]-1-piperidinyl]-1-[(4-fluorophenyl)methyl]-2-oxoethyl]-4-methyl-2-piperazinecarboxamide (MB243), a potent and selective melanocortin subtype-4 receptor agonist
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Discovery of (2S)-N-[(1R)-2-[4-cyclohexyl-4-[[(1,1-dimethylethyl)amino]carbonyl]-1-piperidinyl]-1-[(4-fluorophenyl)methyl]-2-oxoethyl]-4-methyl-2-piperazinecarboxamide (MB243), a potent and selective melanocortin subtype-4 receptor agonist

Palucki, Brenda L. ; Park, Min K. ; Nargund, Ravi P. ; Ye, Zhixiong ; Sebhat, Iyassu K. ; Pollard, Patrick G. ; Kalyani, Rubana N. ; Tang, Rui ; Macneil, Tanya ; Weinberg, David H. ; Vongs, Aurawan ; Rosenblum, Charles I. ; Doss, George A. ; Miller, Randall R. ; Stearns, Ralph A. ; Peng, Qianping ; Tamvakopoulos, Constantin ; Mcgowan, Erin ; Martin, William J. ; Metzger, Joseph M. ; Shepherd, Cherrie A. ; Strack, Alison M. ; Macintyre, D. Euan ; Van Der Ploeg, Lex H.T. ; Patchett, Arthur A.

Bioorganic & Medicinal Chemistry Letters, 1/2005, Vol.15(1), pp.171-175 [Peer Reviewed Journal]

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29
Human β3 adrenergic receptor agonists containing cyclic ureidobenzenesulfonamides
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Human β3 adrenergic receptor agonists containing cyclic ureidobenzenesulfonamides

Parmee, Emma R. ; Naylor, Elizabeth M. ; Perkins, Leroy ; Colandrea, Vincent J. ; Ok, Hyun O. ; Candelore, Mari R. ; Cascieri, Margaret A. ; Deng, Liping ; Feeney, William P. ; Forrest, Michael J. ; Hom, Gary J. ; Macintyre, D.Euan ; Miller, Randall R. ; Stearns, Ralph A. ; Strader, Catherine D. ; Tota, Laurie ; Wyvratt, Matthew J. ; Fisher, Michael H. ; Weber, Ann E.

Bioorganic & Medicinal Chemistry Letters, 3/1999, Vol.9(5), pp.749-754 [Peer Reviewed Journal]

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30
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Addressing the metabolic activation potential of new leads in drug discovery: a case study using ion trap mass spectrometry and tritium labeling techniques

Samuel, Koppara ; Yin, Wenji ; Stearns, Ralph A ; Tang, Yui S ; Chaudhary, Ashok G ; Jewell, James P ; Lanza, Thomas ; Lin, Linus S ; Hagmann, William K ; Evans, David C ; Kumar, Sanjeev

Journal of mass spectrometry : JMS, February 2003, Vol.38(2), pp.211-21 [Peer Reviewed Journal]

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31
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Design and pharmacology of N-(3R)-1,2,3,4-tetrahydroisoquinolinium- 3-ylcarbonyl-(1R)-1-(4-chlorobenzyl)- 2-4-cyclohexyl-4-(1H-1,2,4-triazol- 1-ylmethyl)piperidin-1-yl-2-oxoethylamine (1), a potent, selective, melanocortin subtype-4 receptor agonist

Sebhat, Iyassu K ; Martin, William J ; Ye, Zhixiong ; Barakat, Khaled ; Mosley, Ralph T ; Johnston, David B R ; Bakshi, Raman ; Palucki, Brenda ; Weinberg, David H ; Macneil, Tanya ; Kalyani, Rubana N ; Tang, Rui ; Stearns, Ralph A ; Miller, Randy R ; Tamvakopoulos, Constantin ; Strack, Alison M ; Mcgowan, Erin ; Cashen, Doreen E ; Drisko, Jennifer E ; Hom, Gary J ; Howard, Andrew D ; Macintyre, D Euan ; Van Der Ploeg, Lex H T ; Patchett, Arthur A ; Nargund, Ravi P

Journal of medicinal chemistry, 10 October 2002, Vol.45(21), pp.4589-93 [Peer Reviewed Journal]

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32
L-770,644: A potent and selective human β3 adrenergic receptor agonist with improved oral bioavailability
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L-770,644: A potent and selective human β3 adrenergic receptor agonist with improved oral bioavailability

Shih, Thomas L. ; Candelore, Mari R. ; Cascieri, Margaret A. ; Chiu, Shuet-Hing L. ; Colwell, Lawrence F. ; Deng, Liping ; Feeney, William P. ; Forrest, Michael J. ; Hom, Gary J. ; Macintyre, D.Euan ; Miller, Randall R. ; Stearns, Ralph A. ; Strader, Catherine D. ; Tota, Laurie ; Wyvratt, Matthew J. ; Fisher, Michael H. ; Weber, Ann E.

Bioorganic & Medicinal Chemistry Letters, 5/1999, Vol.9(9), pp.1251-1254 [Peer Reviewed Journal]

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33
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L-770,644: A potent and selective human β 3 adrenergic receptor agonist with improved oral bioavailability

Shih, Thomas L. ; Candelore, Mari R. ; Cascieri, Margaret A. ; Chiu, Shuet-Hing L. ; Colwell, Lawrence F. ; Deng, Liping ; Feeney, William P. ; Forrest, Michael J. ; Hom, Gary J. ; Macintyre, D.Euan ; Miller, Randall R. ; Stearns, Ralph A. ; Strader, Catherine D. ; Tota, Laurie ; Wyvratt, Matthew J. ; Fisher, Michael H. ; Weber, Ann E.

Bioorganic & Medicinal Chemistry Letters, 1999, Vol.9(9), pp.1251-1254 [Peer Reviewed Journal]

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34
Roles of Human Hepatic Cytochrome P450s 2C9 and 3A4 in the Metabolic Activation of Diclofenac †
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Roles of Human Hepatic Cytochrome P450s 2C9 and 3A4 in the Metabolic Activation of Diclofenac †

Tang, Wei ; Stearns, Ralph A. ; Wang, Regina W. ; Chiu, Shuet-Hing L. ; Baillie, Thomas A.

Chemical Research in Toxicology, 02/1999, Vol.12(2), pp.192-199 [Peer Reviewed Journal]

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35
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A role for the melanocortin 4 receptor in sexual function

Van Der Ploeg, Lex H T ; Martin, William J ; Howard, Andrew D ; Nargund, Ravi P ; Austin, Christopher P ; Guan, Xiaoming ; Drisko, Jennifer ; Cashen, Doreen ; Sebhat, Iyassu ; Patchett, Arthur A ; Figueroa, David J ; Dilella, Anthony G ; Connolly, Brett M ; Weinberg, David H ; Tan, Carina P ; Palyha, Oksana C ; Pong, Sheng-Shung ; Macneil, Tanya ; Rosenblum, Charles ; Vongs, Aurawan ; Tang, Rui ; Yu, Hong ; Sailer, Andreas W ; Fong, Tung Ming ; Huang, Cathy ; Tota, Michael R ; Chang, Ray S ; Stearns, Ralph ; Tamvakopoulos, Constantin ; Christ, George ; Drazen, Deborah L ; Spar, Brian D ; Nelson, Randy J ; Macintyre, D Euan

Proceedings of the National Academy of Sciences of the United States of America, 20 August 2002, Vol.99(17), pp.11381-6 [Peer Reviewed Journal]

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