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20 Results  for Everything (Includes Articles)

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Pharmacological modulation of eicosanoid levels and hyperalgesia in yeast-induced inflammation

Opas, Evan E ; Dallob, Aimee ; Herold, Eugene ; Luell, Silvi ; Humes, John L

Biochemical Pharmacology, 1987, Vol.36(4), pp.547-551 [Peer Reviewed Journal]

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ApoA-I mimetic peptides promote pre-β HDL formation in vivo causing remodeling of HDL and triglyceride accumulation at higher dose

Carballo-Jane, Ester ; Chen, Zhu ; O’neill, Edward ; Wang, Jun ; Burton, Charlotte ; Chang, Ching H ; Chen, Xun ; Eveland, Suzanne ; Frantz-Wattley, Betsy ; Gagen, Karen ; Hubbard, Brian ; Ichetovkin, Marina ; Luell, Silvi ; Meurer, Roger ; Song, Xuelei ; Strack, Alison ; Langella, Annunziata ; Cianetti, Simona ; Rech, Francesca ; Capitò, Elena ; Bufali, Simone ; Veneziano, Maria ; Verdirame, Maria ; Bonelli, Fabio ; Monteagudo, Edith ; Pessi, Antonello ; Ingenito, Raffaele ; Bianchi, Elisabetta

Bioorganic & Medicinal Chemistry, 2010, Vol.18(24), pp.8669-8678 [Peer Reviewed Journal]

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Discovery of a biaryl cyclohexene carboxylic acid (MK-6892): a potent and selective high affinity niacin receptor full agonist with reduced flushing profiles in animals as a preclinical candidate

Shen, Hong C ; Ding, Fa-Xiang ; Raghavan, Subharekha ; Deng, Qiaolin ; Luell, Silvi ; Forrest, Michael J ; Carballo-Jane, Ester ; Wilsie, Larissa C ; Krsmanovic, Mihajlo L ; Taggart, Andrew K ; Wu, Kenneth K ; Wu, Tsuei-Ju ; Cheng, Kang ; Ren, Ning ; Cai, Tian-Quan ; Chen, Qing ; Wang, Junying ; Wolff, Michael S ; Tong, Xinchun ; Holt, Tom G ; Waters, M Gerard ; Hammond, Milton L ; Tata, James R ; Colletti, Steven L

Journal of medicinal chemistry, 25 March 2010, Vol.53(6), pp.2666-70 [Peer Reviewed Journal]

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Altered lipoprotein metabolism in P2Y 13 knockout mice

Blom, Daniël ; Yamin, Ting-Ting ; Champy, Marie-France ; Selloum, Mohammed ; Bedu, Elodie ; Carballo-Jane, Ester ; Gerckens, Lynn ; Luell, Silvi ; Meurer, Roger ; Chin, Jayne ; Mudgett, John ; Puig, Oscar

BBA - Molecular and Cell Biology of Lipids, 2010, Vol.1801(12), pp.1349-1360 [Peer Reviewed Journal]

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Reconstituted HDL Elicits Marked Changes in Plasma Lipids Following Single-Dose Injection in C57Bl/6 Mice

Chen, Zhu ; O'Neill, Edward A ; Meurer, Roger D ; Gagen, Karen ; Luell, Silvi ; Wang, Sheng-Ping ; Ichetovkin, Marina ; Frantz-Wattley, Betsy ; Eveland, Suzanne ; Strack, Alison M ; Fisher, Timothy S ; Johns, Douglas G ; Sparrow, Carl P ; Wright, Samuel D ; Hubbard, Brian K ; Carballo-Jane, Ester

Journal of Cardiovascular Pharmacology and Therapeutics, September 2012, Vol.17(3), pp.315-323 [Peer Reviewed Journal]

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Chemical genetics define the roles of p38alpha and p38beta in acute and chronic inflammation

O'Keefe, Stephen J ; Mudgett, John S ; Cupo, Susan ; Parsons, Janey N ; Chartrain, Nicole A ; Fitzgerald, Catherine ; Chen, Shiow-Ling ; Lowitz, Karen ; Rasa, Cordelia ; Visco, Denise ; Luell, Silvi ; Carballo-Jane, Ester ; Owens, Karen ; Zaller, Dennis M

The Journal of biological chemistry, 30 November 2007, Vol.282(48), pp.34663-71 [Peer Reviewed Journal]

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Nicotinic acid and DP1 blockade: studies in mouse models of atherosclerosis

Strack, Alison M ; Carballo-Jane, Ester ; Wang, Sheng-Ping ; Xue, Jiyan ; Ping, Xiaoli ; Mcnamara, Lesley Ann ; Thankappan, Anil ; Price, Olga ; Wolff, Michael ; Wu, T J ; Kawka, Douglas ; Mariano, Michele ; Burton, Charlotte ; Chang, Ching H ; Chen, Jing ; Menke, John ; Luell, Silvi ; Zycband, Emanuel I ; Tong, Xinchun ; Raubertas, Richard ; Sparrow, Carl P ; Hubbard, Brian ; Woods, John ; O'Neill, Gary ; Waters, M Gerard ; Sitlani, Ayesha

Journal of lipid research, January 2013, Vol.54(1), pp.177-88 [Peer Reviewed Journal]

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Anthranilic acid replacements in a niacin receptor agonist

Schmidt, Darby ; Smenton, Abigail ; Raghavan, Subharekha ; Shen, Hong ; Ding, Fa-Xiang ; Carballo-Jane, Ester ; Luell, Silvi ; Ciecko, Tanya ; Holt, Tom G ; Wolff, Michael ; Taggart, Andrew ; Wilsie, Larissa ; Krsmanovic, Mihajlo ; Ren, Ning ; Blom, Daniel ; Cheng, Kang ; Mccann, Peggy E ; Waters, M.Gerard ; Tata, James ; Colletti, Steven

Bioorganic & Medicinal Chemistry Letters, 01 June 2010, Vol.20(11), pp.3426-3430 [Peer Reviewed Journal]

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Discovery of betamethasone 17α-carbamates as dissociated glucocorticoid receptor modulators in the rat

Ali, Amjad ; Balkovec, James M ; Greenlee, Mark ; Hammond, Milton L ; Rouen, Greg ; Taylor, Gayle ; Einstein, Monica ; Ge, Lan ; Harris, Georgianna ; Kelly, Terri M ; Mazur, Paul ; Pandit, Shilpa ; Santoro, Joseph ; Sitlani, Ayesha ; Wang, Chuanlin ; Williamson, Joann ; Forrest, Michael J ; Carballo-Jane, Ester ; Luell, Silvi ; Lowitz, Karen ; Visco, Denise

Bioorganic & Medicinal Chemistry, 2008, Vol.16(16), pp.7535-7542 [Peer Reviewed Journal]

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Discovery of biaryl anthranilides as full agonists for the high affinity niacin receptor

Shen, Hong C ; Ding, Fa-Xiang ; Luell, Silvi ; Forrest, Michael J ; Carballo-Jane, Ester ; Wu, Kenneth K ; Wu, Tsuei-Ju ; Cheng, Kang ; Wilsie, Larissa C ; Krsmanovic, Mihajlo L ; Taggart, Andrew K ; Ren, Ning ; Cai, Tian-Quan ; Deng, Qiaolin ; Chen, Qing ; Wang, Junying ; Wolff, Michael S ; Tong, Xinchun ; Holt, Tom G ; Waters, M Gerard ; Hammond, Milton L ; Tata, James R ; Colletti, Steven L

Journal of medicinal chemistry, 13 December 2007, Vol.50(25), pp.6303-6 [Peer Reviewed Journal]

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Novel N-arylpyrazolo3,2-c-based ligands for the glucocorticoid receptor: receptor binding and in vivo activity

Ali, Amjad ; Thompson, Christopher F ; Balkovec, James M ; Graham, Donald W ; Hammond, Milton L ; Quraishi, Nazia ; Tata, James R ; Einstein, Monica ; Ge, Lan ; Harris, Georgianna ; Kelly, Terri M ; Mazur, Paul ; Pandit, Shilpa ; Santoro, Joseph ; Sitlani, Ayesha ; Wang, Chuanlin ; Williamson, Joanne ; Miller, Douglas K ; Thompson, Chris M ; Zaller, Dennis M ; Forrest, Michael J ; Carballo-Jane, Ester ; Luell, Silvi

Journal of medicinal chemistry, 06 May 2004, Vol.47(10), pp.2441-52 [Peer Reviewed Journal]

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12
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Skeletal muscle: a dual system to measure glucocorticoid-dependent transactivation and transrepression of gene regulation

Carballo-Jane, Ester ; Pandit, Shilpa ; Santoro, Joseph C ; Freund, Concetta ; Luell, Silvi ; Harris, Georgianna ; Forrest, Michael J ; Sitlani, Ayesha

Journal of Steroid Biochemistry and Molecular Biology, 2004, Vol.88(2), pp.191-201 [Peer Reviewed Journal]

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13
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Novel 1-(2-aminopyrazin-3-yl)methyl-2-thioureas as potent inhibitors of mitogen-activated protein kinase-activated protein kinase 2 (MK-2)

Lin, Songnian ; Lombardo, Matthew ; Malkani, Sunita ; Hale, Jeffrey J ; Mills, Sander G ; Chapman, Kevin ; Thompson, James E ; Zhang, Wen Xiao ; Wang, Ruixiu ; Cubbon, Rose M ; O’neill, Edward A ; Luell, Silvi ; Carballo-Jane, Ester ; Yang, Lihu

Bioorganic & Medicinal Chemistry Letters, 2009, Vol.19(12), pp.3238-3242 [Peer Reviewed Journal]

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14
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Comparison of rat and dog models of vasodilatation and lipolysis for the calculation of a therapeutic index for GPR109A agonists

Carballo-Jane, Ester ; Gerckens, Lynn S ; Luell, Silvi ; Parlapiano, Allison S ; Wolff, Michael ; Colletti, Steven L ; Tata, James R ; Taggart, Andrew K.P ; Waters, M. Gerard ; Richman, Jeremy G ; Mccann, Margaret E ; Forrest, Michael J

Journal of Pharmacological and Toxicological Methods, 2007, Vol.56(3), pp.308-316 [Peer Reviewed Journal]

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15
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Bicyclic amidine inhibitors of nitric oxide synthase: discovery of perhydro-iminopyrindine and perhydro-iminoquinoline as potent, orally active inhibitors of inducible nitric oxide synthase

Guthikonda, Ravindra N ; Shah, Shrenik K ; Pacholok, Stephen G ; Humes, John L ; Mumford, Richard A ; Grant, Stephan K ; Chabin, Renee M ; Green, Barbara G ; Tsou, Nancy ; Ball, Richard ; Fletcher, Daniel S ; Luell, Silvi ; Euan Macintyre, D ; Maccoss, Malcolm

Bioorganic & Medicinal Chemistry Letters, 2005, Vol.15(8), pp.1997-2001 [Peer Reviewed Journal]

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16
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Novel glucocorticoids containing a 6,5-bicyclic core fused to a pyrazole ring: Synthesis, in vitro profile, molecular modeling studies, and in vivo experiments

Thompson, Christopher F ; Quraishi, Nazia ; Ali, Amjad ; Mosley, Ralph T ; Tata, James R ; Hammond, Milton L ; Balkovec, James M ; Einstein, Monica ; Ge, Lan ; Harris, Georgianna ; Kelly, Terri M ; Mazur, Paul ; Pandit, Shilpa ; Santoro, Joseph ; Sitlani, Ayesha ; Wang, Chuanlin ; Williamson, Joanne ; Miller, Douglas K ; Yamin, Ting-Ting D ; Thompson, Chris M ; O’neill, Edward A ; Zaller, Dennis ; Forrest, Michael J ; Carballo-Jane, Ester ; Luell, Silvi

Bioorganic & Medicinal Chemistry Letters, 2007, Vol.17(12), pp.3354-3361 [Peer Reviewed Journal]

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17
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Cyclopentane-based human NK1 antagonists. Part 2: Development of potent, orally active, water-soluble derivatives

Meurer, Laura C ; Finke, Paul E ; Owens, Karen A ; Tsou, Nancy N ; Ball, Richard G ; Mills, Sander G ; Maccoss, Malcolm ; Sadowski, Sharon ; Cascieri, Margaret A ; Tsao, Kwei-Lan ; Chicchi, Gary G ; Egger, Linda A ; Luell, Silvi ; Metzger, Joseph M ; Macintyre, D. Euan ; Rupniak, Nadia M.J ; Williams, Angela R ; Hargreaves, Richard J

Bioorganic & Medicinal Chemistry Letters, 2006, Vol.16(17), pp.4504-4511 [Peer Reviewed Journal]

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18
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Novel heterocyclic glucocorticoids: in vitro profile and in vivo efficacy

Thompson, Christopher F ; Quraishi, Nazia ; Ali, Amjad ; Tata, James R ; Hammond, Milton L ; Balkovec, James M ; Einstein, Monica ; Ge, Lan ; Harris, Georgianna ; Kelly, Theresa M ; Mazur, Paul ; Pandit, Shilpa ; Santoro, Joseph ; Sitlani, Ayesha ; Wang, Chuanlin ; Williamson, Joanne ; Miller, Douglas K ; Yamin, Ting-Ting D ; Thompson, Chris M ; O’neill, Edward A ; Zaller, Dennis ; Forrest, Michael J ; Carballo-Jane, Ester ; Luell, Silvi

Bioorganic & Medicinal Chemistry Letters, 2005, Vol.15(8), pp.2163-2167 [Peer Reviewed Journal]

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19
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Novel ketal ligands for the glucocorticoid receptor: in vitro and in vivo activity

Smith, Cameron J ; Ali, Amjad ; Balkovec, James M ; Graham, Donald W ; Hammond, Milton L ; Patel, Gool F ; Rouen, Gregory P ; Smith, Scott K ; Tata, James R ; Einstein, Monica ; Ge, Lan ; Harris, Georgianna S ; Kelly, Theresa M ; Mazur, Paul ; Thompson, Chris M ; Wang, Chuanlin F ; Williamson, Joanne M ; Miller, Douglas K ; Pandit, Shilpa ; Santoro, Joseph C ; Sitlani, Ayesha ; Yamin, Ting-Ting D ; O’neill, Edward A ; Zaller, Dennis M ; Carballo-Jane, Ester ; Forrest, Michael J ; Luell, Silvi

Bioorganic & Medicinal Chemistry Letters, 2005, Vol.15(11), pp.2926-2931 [Peer Reviewed Journal]

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Synthesis and biological activity of MK 287 (L-680,573): a potent, specific and orally active paf receptor antagonist

Sahoo, Soumya P ; Graham, Donald W ; Acton, John ; Biftu, Tesfaye ; Bugianesi, Robert L ; Girotra, Narindar N ; Kuo, Chan-Hwa ; Ponpipom, Mitree M ; Doebber, Thomas W ; Wu, Margaret S ; Hwang, San-Bao ; Lam, My-Hanh ; Macintyre, D.Euan ; Bach, Thomas J ; Luell, Silvi ; Meurer, Roger ; Davies, Philip ; Alberts, Alfred W ; Chabala, John C

Bioorganic & Medicinal Chemistry Letters, 1991, Vol.1(6), pp.327-332 [Peer Reviewed Journal]

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