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6 Results  for Everything (Includes Articles)

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Pharmacokinetics, pharmacodynamics, safety, and tolerability of pradigastat, a novel diacylglycerol acyltransferase 1 inhibitor in overweight or obese, but otherwise healthy human subjects

Meyers, Charles D. ; Amer, Ahmed ; Majumdar, Tapan ; Chen, Jin

Journal of Clinical Pharmacology, September 2015, Vol.55(9), pp.1031-1041 [Peer Reviewed Journal]

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Potential mechanism of enhanced postprandial glucagon-like peptide-1 release following treatment with a diacylglycerol acyltransferase 1 inhibitor

Liu, Jinqi ; Mclaren, David G ; Chen, Dunlu ; Kan, Yanqing ; Stout, Steven J ; Shen, Xiaolan ; Murphy, Beth Ann ; Forrest, Gail ; Karanam, Bindhu ; Sonatore, Lisa ; He, Shuwen ; Roddy, Thomas P ; Pinto, Shirly

Pharmacology research & perspectives, December 2015, Vol.3(6), pp.e00193 [Peer Reviewed Journal]

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Discovery of novel quinoline carboxylic acid series as DGAT1 inhibitors

Zhou, Gang ; Ting, Pauline C ; Wishart, Grant ; Zorn, Nicolas ; Aslanian, Robert G ; Lin, Mingxiang ; Smith, Michelle ; Walker, Scott S ; Cook, John ; Van Heek, Margaret ; Lachowicz, Jean

Bioorganic & Medicinal Chemistry Letters, 01 April 2014, Vol.24(7), pp.1790-1794 [Peer Reviewed Journal]

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DS-7250, a Diacylglycerol Acyltransferase 1 Inhibitor, Enhances Hepatic Steatosis in Zucker Fatty Rats via Upregulation of Fatty Acid Synthesis

Yasuno, Kyohei ; Kumagai, Kazuyoshi ; Iguchi, Takuma ; Tsuchiya, Yoshimi ; Kai, Kiyonori ; Mori, Kazuhiko

Toxicologic Pathology, April 2018, Vol.46(3), pp.302-311 [Peer Reviewed Journal]

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A pharmacologic increase in activity of plasma transaminase derived from small intestine in animals receiving an acyl CoA: diacylglycerol transferase (DGAT) 1 inhibitor

Yokoyama, Hideaki ; Kobayashi, Akio ; Kondo, Kazuma ; Oshida, Shin-Ichi ; Takahashi, Tadakazu ; Masuyama, Taku ; Shoda, Toshiyuki ; Sugai, Shoichiro

The Journal of Toxicological Sciences, 2018, Vol.43(2), pp.135-157 [Peer Reviewed Journal]

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Accelerating the discovery of DGAT1 inhibitors through the application of parallel medicinal chemistry (PMC)

Yu, Yang ; Wu, Zhicai ; Shi, Zhi-Cai ; He, Shuwen ; Lai, Zhong ; Cernak, Timothy A ; Vachal, Petr ; Liu, Min ; Liu, Jian ; Hong, Qingmei ; Jian, Tianying ; Guiadeen, Deodial ; Krikorian, Arto ; Sperbeck, Donald M ; Verras, Andreas ; Sonatore, Lisa M ; Murphy, Beth A ; Wiltsie, Judyann ; Chung, Christine C ; Gorski, Judith N

Bioorganic & Medicinal Chemistry Letters, 01 June 2019, Vol.29(11), pp.1380-1385 [Peer Reviewed Journal]

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