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Biphenyl-substituted oxazolidinones as cholesteryl ester transfer protein inhibitors: modifications of the oxazolidinone ring leading to the discovery of anacetrapib

Smith, Cameron J ; Ali, Amjad ; Hammond, Milton L ; Li, Hong ; Lu, Zhijian ; Napolitano, Joann ; Taylor, Gayle E ; Thompson, Christopher F ; Anderson, Matt S ; Chen, Ying ; Eveland, Suzanne S ; Guo, Qiu ; Hyland, Sheryl A ; Milot, Denise P ; Sparrow, Carl P ; Wright, Samuel D ; Cumiskey, Anne-Marie ; Latham, Melanie ; Peterson, Laurence B ; Rosa

Journal of medicinal chemistry, 14 July 2011, Vol.54(13), pp.4880-95 [Peer Reviewed Journal]

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Cholesterol efflux potential and antiinflammatory properties of high-density lipoprotein after treatment with niacin or anacetrapib

Yvan-Charvet, Laurent ; Kling, Jelena ; Pagler, Tamara ; Li, Hongna ; Hubbard, Brian ; Fisher, Tim ; Sparrow, Carl P ; Taggart, Andrew K ; Tall, Alan R

Arteriosclerosis, thrombosis, and vascular biology, July 2010, Vol.30(7), pp.1430-8 [Peer Reviewed Journal]

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2-(4-Carbonylphenyl)benzoxazole inhibitors of CETP: Attenuation of hERG binding and improved HDLc-raising efficacy

Sweis, Ramzi F ; Hunt, Julianne A ; Sinclair, Peter J ; Chen, Ying ; Eveland, Suzanne S ; Guo, Qiu ; Hyland, Sheryl A ; Milot, Denise P ; Cumiskey, Anne-Marie ; Latham, Melanie ; Rosa, Raymond ; Peterson, Larry ; Sparrow, Carl P ; Anderson, Matt S

Bioorganic & Medicinal Chemistry Letters, 2011, Vol.21(9), pp.2597-2600 [Peer Reviewed Journal]

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Discovery of substituted biphenyl oxazolidinone inhibitors of cholesteryl ester transfer protein

Thompson, Christopher F ; Ali, Amjad ; Quraishi, Nazia ; Lu, Zhijian ; Hammond, Milton L ; Sinclair, Peter J ; Anderson, Matt S ; Eveland, Suzanne S ; Guo, Qiu ; Hyland, Sheryl A ; Milot, Denise P ; Sparrow, Carl P ; Wright, Samuel D

ACS medicinal chemistry letters, 09 June 2011, Vol.2(6), pp.424-7 [Peer Reviewed Journal]

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2-(4-Carbonylphenyl)benzoxazole inhibitors of CETP: Scaffold design and advancement in HDLc-raising efficacy

Sweis, Ramzi F ; Hunt, Julianne A ; Kallashi, Florida ; Hammond, Milton L ; Chen, Ying ; Eveland, Suzanne S ; Guo, Qiu ; Hyland, Sheryl A ; Milot, Denise P ; Cumiskey, Anne-Marie ; Latham, Melanie ; Rosa, Raymond ; Peterson, Larry ; Sparrow, Carl P ; Wright, Samuel D ; Anderson, Matt S ; Sinclair, Peter J

Bioorganic & Medicinal Chemistry Letters, 2011, Vol.21(6), pp.1890-1895 [Peer Reviewed Journal]

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Measurement of fractional synthetic rates of multiple protein analytes by triple quadrupole mass spectrometry

Lee, Anita Y H ; Yates, Nathan A ; Ichetovkin, Marina ; Deyanova, Ekaterina ; Southwick, Katie ; Fisher, Timothy S ; Wang, Weixun ; Loderstedt, James ; Walker, Nykia ; Zhou, Haihong ; Zhao, Xuemei ; Sparrow, Carl P ; Hubbard, Brian K ; Rader, Daniel J ; Sitlani, Ayesha ; Millar, John S ; Hendrickson, Ronald C

Clinical chemistry, March 2012, Vol.58(3), pp.619-27 [Peer Reviewed Journal]

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SAR studies on the central phenyl ring of substituted biphenyl oxazolidinone-potent CETP inhibitors

Lu, Zhijian ; Chen, Yi-Heng ; Napolitano, Joann B ; Taylor, Gayle ; Ali, Amjad ; Hammond, Milton L ; Deng, Qiaolin ; Tan, Eugene ; Tong, Xinchun ; Xu, Suoyu S ; Latham, Melanie J ; Peterson, Laurence B ; Anderson, Matt S ; Eveland, Suzanne S ; Guo, Qiu ; Hyland, Sheryl A ; Milot, Denise P ; Chen, Ying ; Sparrow, Carl P ; Wright, Samuel D

Bioorganic & Medicinal Chemistry Letters, 01 January 2012, Vol.22(1), pp.199-203 [Peer Reviewed Journal]

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Reconstituted HDL Elicits Marked Changes in Plasma Lipids Following Single-Dose Injection in C57Bl/6 Mice

Chen, Zhu ; O'Neill, Edward A ; Meurer, Roger D ; Gagen, Karen ; Luell, Silvi ; Wang, Sheng-Ping ; Ichetovkin, Marina ; Frantz-Wattley, Betsy ; Eveland, Suzanne ; Strack, Alison M ; Fisher, Timothy S ; Johns, Douglas G ; Sparrow, Carl P ; Wright, Samuel D ; Hubbard, Brian K ; Carballo-Jane, Ester

Journal of Cardiovascular Pharmacology and Therapeutics, September 2012, Vol.17(3), pp.315-323 [Peer Reviewed Journal]

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2-Arylbenzoxazoles as CETP inhibitors: Substitution of the benzoxazole moiety

Smith, Cameron J ; Ali, Amjad ; Chen, Liya ; Hammond, Milton L ; Anderson, Matt S ; Chen, Ying ; Eveland, Suzanne S ; Guo, Qiu ; Hyland, Sheryl A ; Milot, Denise P ; Sparrow, Carl P ; Wright, Samuel D ; Sinclair, Peter J

Bioorganic & Medicinal Chemistry Letters, 2010, Vol.20(1), pp.346-349 [Peer Reviewed Journal]

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Effects of pH and low density lipoprotein (LDL) on PCSK9-dependent LDL receptor regulation

Fisher, Timothy S ; Lo Surdo, Paola ; Pandit, Shilpa ; Mattu, Marco ; Santoro, Joseph C ; Wisniewski, Doug ; Cummings, Richard T ; Calzetta, Alessandra ; Cubbon, Rose M ; Fischer, Paul A ; Tarachandani, Anil ; De Francesco, Raffaele ; Wright, Samuel D ; Sparrow, Carl P ; Carfi, Andrea ; Sitlani, Ayesha

The Journal of biological chemistry, 13 July 2007, Vol.282(28), pp.20502-12 [Peer Reviewed Journal]

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Structural and biochemical characterization of the wild type PCSK9-EGF(AB) complex and natural familial hypercholesterolemia mutants

Bottomley, Matthew J ; Cirillo, Agostino ; Orsatti, Laura ; Ruggeri, Lionello ; Fisher, Timothy S ; Santoro, Joseph C ; Cummings, Richard T ; Cubbon, Rose M ; Lo Surdo, Paola ; Calzetta, Alessandra ; Noto, Alessia ; Baysarowich, Jennifer ; Mattu, Marco ; Talamo, Fabio ; De Francesco, Raffaele ; Sparrow, Carl P ; Sitlani, Ayesha ; Carfí, Andrea

The Journal of biological chemistry, 09 January 2009, Vol.284(2), pp.1313-23 [Peer Reviewed Journal]

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Nicotinic acid and DP1 blockade: studies in mouse models of atherosclerosis

Strack, Alison M ; Carballo-Jane, Ester ; Wang, Sheng-Ping ; Xue, Jiyan ; Ping, Xiaoli ; Mcnamara, Lesley Ann ; Thankappan, Anil ; Price, Olga ; Wolff, Michael ; Wu, T J ; Kawka, Douglas ; Mariano, Michele ; Burton, Charlotte ; Chang, Ching H ; Chen, Jing ; Menke, John ; Luell, Silvi ; Zycband, Emanuel I ; Tong, Xinchun ; Raubertas

Journal of lipid research, January 2013, Vol.54(1), pp.177-88 [Peer Reviewed Journal]

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2-Arylbenzoxazoles as CETP inhibitors: raising HDL-C in cynoCETP transgenic mice

Kallashi, Florida ; Kim, Dooseop ; Kowalchick, Jennifer ; Park, You Jung ; Hunt, Julianne A ; Ali, Amjad ; Smith, Cameron J ; Hammond, Milton L ; Pivnichny, James V ; Tong, Xinchun ; Xu, Suoyu S ; Anderson, Matt S ; Chen, Ying ; Eveland, Suzanne S ; Guo, Qiu ; Hyland, Sheryl A ; Milot, Denise P ; Cumiskey, Anne-Marie ; Latham, Melanie ; Peterson

Bioorganic & medicinal chemistry letters, 01 January 2011, Vol.21(1), pp.558-61 [Peer Reviewed Journal]

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14
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2-Arylbenzoxazoles as CETP inhibitors: Substitution and modification of the α-alkoxyamide moiety

Hunt, Julianne A ; Gonzalez, Silvia ; Kallashi, Florida ; Hammond, Milton L ; Pivnichny, James V ; Tong, Xinchun ; Xu, Suoyu S ; Anderson, Matt S ; Chen, Ying ; Eveland, Suzanne S ; Guo, Qiu ; Hyland, Sheryl A ; Milot, Denise P ; Sparrow, Carl P ; Wright, Samuel D ; Sinclair, Peter J

Bioorganic & Medicinal Chemistry Letters, 2010, Vol.20(3), pp.1019-1022 [Peer Reviewed Journal]

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Design of a novel class of biphenyl CETP inhibitors

Lu, Zhijian ; Napolitano, Joann B ; Theberge, Ashleigh ; Ali, Amjad ; Hammond, Milton L ; Tan, Eugene ; Tong, Xinchun ; Xu, Suoyu S ; Latham, Melanie J ; Peterson, Laurence B ; Anderson, Matt S ; Eveland, Suzanne S ; Guo, Qiu ; Hyland, Sheryl A ; Milot, Denise P ; Chen, Ying ; Sparrow, Carl P ; Wright, Samuel D ; Sinclair, Peter J

Bioorganic & Medicinal Chemistry Letters, 2010, Vol.20(24), pp.7469-7472 [Peer Reviewed Journal]

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A potent synthetic LXR agonist is more effective than cholesterol loading at inducing ABCA1 mRNA and stimulating cholesterol efflux

Sparrow, Carl P ; Baffic, Joanne ; Lam, My-Hanh ; Lund, Erik G ; Adams, Alan D ; Fu, Xuan ; Hayes, Nancy ; Jones, A Brian ; Macnaul, Karen L ; Ondeyka, John ; Singh, Sheo ; Wang, Jianhua ; Zhou, Gaochao ; Moller, David E ; Wright, Samuel D ; Menke, John G

The Journal of biological chemistry, 22 March 2002, Vol.277(12), pp.10021-7 [Peer Reviewed Journal]

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Liver X receptor agonists as potential therapeutic agents for dyslipidemia and atherosclerosis

Lund, Erik G ; Menke, John G ; Sparrow, Carl P

Arteriosclerosis, thrombosis, and vascular biology, 01 July 2003, Vol.23(7), pp.1169-77 [Peer Reviewed Journal]

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Corrigendum to “2-Arylbenzoxazoles as CETP inhibitors: Substitution of the benzoxazole moiety” [Bioorg. Med. Chem. Lett. 20 (2010) 346]

Smith, Cameron J ; Ali, Amjad ; Chen, Liya ; Hammond, Milton L ; Anderson, Matt S ; Chen, Ying ; Eveland, Suzanne S ; Guo, Qiu ; Hyland, Sheryl A ; Milot, Denise P ; Sparrow, Carl P ; Wright, Samuel D ; Sinclair, Peter J

Bioorganic & Medicinal Chemistry Letters, 2010, Vol.20(24), pp.7555-7555 [Peer Reviewed Journal]

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19
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A PCSK9-binding antibody that structurally mimics the EGF(A) domain of LDL-receptor reduces LDL cholesterol in vivo

Ni, Yan G ; Di Marco, Stefania ; Condra, Jon H ; Peterson, Laurence B ; Wang, Weirong ; Wang, Fubao ; Pandit, Shilpa ; Hammond, Holly A ; Rosa, Ray ; Cummings, Richard T ; Wood, Dana D ; Liu, Xiaomei ; Bottomley, Matthew J ; Shen, Xun ; Cubbon, Rose M ; Wang, Sheng-Ping ; Johns, Douglas G ; Volpari, Cinzia ; Hamuro, Lora ; Chin

Journal of lipid research, January 2011, Vol.52(1), pp.78-86 [Peer Reviewed Journal]

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20
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An anti-PCSK9 antibody reduces LDL-cholesterol on top of a statin and suppresses hepatocyte SREBP-regulated genes

Zhang, Liwen ; Mccabe, Timothy ; Condra, Jon H ; Ni, Yan G ; Peterson, Laurence B ; Wang, Weirong ; Strack, Alison M ; Wang, Fubao ; Pandit, Shilpa ; Hammond, Holly ; Wood, Dana ; Lewis, Dale ; Rosa, Ray ; Mendoza, Vivienne ; Cumiskey, Anne Marie ; Johns, Douglas G ; Hansen, Barbara C ; Shen, Xun ; Geoghagen, Neil ; Jensen

International journal of biological sciences, 2012, Vol.8(3), pp.310-27 [Peer Reviewed Journal]

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21
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Activation of PPARδ alters lipid metabolism in db/db mice

Leibowitz, Mark D ; Fiévet, Catherine ; Hennuyer, Nathalie ; Peinado-Onsurbe, Julia ; Duez, Hélène ; Berger, Joel ; Cullinan, Catherine A ; Sparrow, Carl P ; Baffic, Joanne ; Berger, Gregory D ; Santini, Conrad ; Marquis, Robert W ; Tolman, Richard L ; Smith, Roy G ; Moller, David E ; Auwerx, Johan

FEBS Letters, 2000, Vol.473(3), pp.333-336 [Peer Reviewed Journal]

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22
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A high-precision fluorogenic cholesteryl ester transfer protein assay compatible with animal serum and 3456-well assay technology

Eveland, Suzanne S ; Milot, Denise P ; Guo, Qiu ; Chen, Ying ; Hyland, Sheryl A ; Peterson, Laurence B ; Jezequel-Sur, Sylvie ; O’donnell, Gregory T ; Zuck, Paul D ; Ferrer, Marc ; Strulovici, Berta ; Wagner, John A ; Tanaka, Wesley K ; Hilliard, Deborah A ; Laterza, Omar ; Wright, Samuel D ; Sparrow, Carl P ; Anderson, Matt S

Analytical Biochemistry, 2007, Vol.368(2), pp.239-249 [Peer Reviewed Journal]

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23
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SAR studies: Designing potent and selective LXR agonists

Szewczyk, Jason W ; Huang, Shaei ; Chin, Jayne ; Tian, Jenny ; Mitnaul, Lyndon ; Rosa, Raymond L ; Peterson, Larry ; Sparrow, Carl P ; Adams, Alan D

Bioorganic & Medicinal Chemistry Letters, 2006, Vol.16(11), pp.3055-3060 [Peer Reviewed Journal]

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24
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Deficiency in [formula omitted] does not affect HDL levels or atherosclerosis in mice

Burton, Charlotte A ; Patel, Sushma ; Mundt, Steven ; Hassing, Heide ; Zhang, Donghui ; Hermanowski-Vosatka, Anne ; Wright, Samuel D ; Chao, Yu-Sheng ; Detmers, Patricia A ; Sparrow, Carl P

Biochemical and Biophysical Research Communications, 2002, Vol.294(1), pp.88-94 [Peer Reviewed Journal]

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25
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Functional analysis of sites within PCSK9 responsible for hypercholesterolemia

Pandit, Shilpa ; Wisniewski, Doug ; Santoro, Joseph C ; Ha, Sookhee ; Ramakrishnan, Vijayalakshmi ; Cubbon, Rose M ; Cummings, Richard T ; Wright, Samuel D ; Sparrow, Carl P ; Sitlani, Ayesha ; Fisher, Timothy S

Journal of lipid research, June 2008, Vol.49(6), pp.1333-43 [Peer Reviewed Journal]

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26
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Cholesterol esters selectively taken up from high-density lipoproteins are hydrolyzed extralysosomally

Sparrow, Carl P ; Pittman, Ray C

Biochimica et Biophysica Acta (BBA)/Lipids and Lipid Metabolism, 1990, Vol.1043(2), pp.203-210

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27
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Design, synthesis, and structure-activity relationship of podocarpic acid amides as liver X receptor agonists for potential treatment of atherosclerosis

Liu, Weiguo ; Chen, Steve ; Dropinski, James ; Colwell, Lawrence ; Robins, Michael ; Szymonifka, Michael ; Hayes, Nancy ; Sharma, Neelam ; Macnaul, Karen ; Hernandez, Melba ; Burton, Charlotte ; Sparrow, Carl P ; Menke, John G ; Singh, Sheo B

Bioorganic & medicinal chemistry letters, 15 October 2005, Vol.15(20), pp.4574-8 [Peer Reviewed Journal]

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28
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Design, synthesis, and structure–activity relationship of podocarpic acid amides as liver X receptor agonists for potential treatment of atherosclerosis

Liu, Weiguo ; Chen, Steve ; Dropinski, James ; Colwell, Lawrence ; Robins, Michael ; Szymonifka, Michael ; Hayes, Nancy ; Sharma, Neelam ; Macnaul, Karen ; Hernandez, Melba ; Burton, Charlotte ; Sparrow, Carl P ; Menke, John G ; Singh, Sheo B

Bioorganic & Medicinal Chemistry Letters, 2005, Vol.15(20), pp.4574-4578 [Peer Reviewed Journal]

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29
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Fluorogenic substrates for high-throughput measurements of endothelial lipase activity

Mitnaul, Lyndon J ; Tian, Jenny ; Burton, Charlotte ; Lam, My-Hanh ; Zhu, Yuping ; Olson, Steve H ; Schneeweis, Jonathan E ; Zuck, Paul ; Pandit, Shilpa ; Anderson, Matt ; Maletic, Milana M ; Waddell, Sherman T ; Wright, Samuel D ; Sparrow, Carl P ; Lund, Erik G

Journal of lipid research, February 2007, Vol.48(2), pp.472-82 [Peer Reviewed Journal]

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30
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Discovery and development of dimeric podocarpic acid leads as potent agonists of liver X receptor with HDL cholesterol raising activity in mice and hamsters

Singh, Sheo B ; Ondeyka, John G ; Liu, Weiguo ; Chen, Steve ; Chen, Tom S ; Li, Xiaohua ; Bouffard, Aileen ; Dropinski, James ; Jones, A. Brian ; Mccormick, Sherrie ; Hayes, Nancy ; Wang, Jianhua ; Sharma, Neelam ; Macnaul, Karen ; Hernandez, Melba ; Chao, Yu-Sheng ; Baffic, Joanne ; Lam, My-Hanh ; Burton, Charlotte ; Sparrow, Carl P

Bioorganic & Medicinal Chemistry Letters, 2005, Vol.15(11), pp.2824-2828 [Peer Reviewed Journal]

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31
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Infectious Agents Are Not Necessary for Murine Atherogenesis

Wright, Samuel D ; Burton, Charlotte ; Hernandez, Melba ; Hassing, Heide ; Montenegro, Judy ; Mundt, Steve ; Patel, Sushma ; Card, Deborah J ; Hermanowski-Vosatka, Anne ; Bergstrom, James D ; Sparrow, Carl P ; Detmers, Patricia A ; Chao, Yu-Sheng

The Journal of Experimental Medicine, 2000, Vol.191(8), p.1437-1442 [Peer Reviewed Journal]

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32
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Escherichia coli membrane vesicles with elevated phosphatidic acid levels : A detergent-free system for in vitro phospholipid synthesis

Sparrow, Carl P ; Ganong, Barry R ; Raetz, Christian R.H

Biochimica et Biophysica Acta (BBA)/Lipids and Lipid Metabolism, 1984, Vol.796(3), pp.373-383

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Different roles of liver X receptor α and β in lipid metabolism: Effects of an α-selective and a dual agonist in mice deficient in each subtype

Lund, Erik G ; Peterson, Laurence B ; Adams, Alan D ; Lam, My-Hanh N ; Burton, Charlotte A ; Chin, Jayne ; Guo, Qiu ; Huang, Shaei ; Latham, Melanie ; Lopez, Jacqueline C ; Menke, John G ; Milot, Denise P ; Mitnaul, Lyndon J ; Rex-Rabe, Sandra E ; Rosa, Raymond L ; Tian, Jenny Y ; Wright, Samuel D ; Sparrow, Carl P

Biochemical Pharmacology, 2006, Vol.71(4), pp.453-463 [Peer Reviewed Journal]

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