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14 Results  for Everything (Includes Articles)

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1
Potent 1,3,4-trisubstituted pyrrolidine CCR5 receptor antagonists: effects of fused heterocycles on antiviral activity and pharmacokinetic properties
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Potent 1,3,4-trisubstituted pyrrolidine CCR5 receptor antagonists: effects of fused heterocycles on antiviral activity and pharmacokinetic properties

Kim, Dooseop ; Wang, Liping ; Hale, Jeffrey J ; Lynch, Christopher L ; Budhu, Richard J ; MacCoss, Malcolm ; Mills, Sander G ; Malkowitz, Lorraine ; Gould, Sandra L ; DeMartino, Julie A ; Springer, Martin S ; Hazuda, Daria ; Miller, Michael ; Kessler, Joseph ; Hrin, Renee C ; Carver, Gwen ; Carella, Anthony ; Henry, Karen ; Lineberger, Janet ; Schleif, William A ; Emini, Emilio A

Bioorganic & medicinal chemistry letters, 2005, Vol.15 (8), p.2129-2134 [Peer Reviewed Journal]

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2
Antagonists of the human CCR5 receptor as anti-HIV-1 agents. Part 1: Discovery and initial structure–activity relationships for 1-amino-2-phenyl-4-(piperidin-1-yl)butanes
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Antagonists of the human CCR5 receptor as anti-HIV-1 agents. Part 1: Discovery and initial structure–activity relationships for 1-amino-2-phenyl-4-(piperidin-1-yl)butanes

Dorn, Conrad P ; Finke, Paul E ; Oates, Bryan ; Budhu, Richard J ; Mills, Sander G ; MacCoss, Malcolm ; Malkowitz, Lorraine ; Springer, Martin S ; Daugherty, Bruce L ; Gould, Sandra L ; DeMartino, Julie A ; Siciliano, Salvatore J ; Carella, Anthony ; Carver, Gwen ; Holmes, Karen ; Danzeisen, Renee ; Hazuda, Daria ; Kessler, Joseph ; Lineberger, Janet ; Miller, Michael ; Schleif, William A ; Emini, Emilio A

Bioorganic & medicinal chemistry letters, 2001, Vol.11 (2), p.259-264 [Peer Reviewed Journal]

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3
2-Aryl(pyrrolidin-4-yl)acetic acids are potent agonists of sphingosine-1-phosphate (S1P) receptors
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2-Aryl(pyrrolidin-4-yl)acetic acids are potent agonists of sphingosine-1-phosphate (S1P) receptors

Yan, Lin ; Budhu, Richard ; Huo, Pei ; Lynch, Christopher L ; Hale, Jeffrey J ; Mills, Sander G ; Hajdu, Richard ; Keohane, Carol A ; Rosenbach, Mark J ; Milligan, James A ; Shei, Gan-Ju ; Chrebet, Gary ; Bergstrom, James ; Card, Deborah ; Mandala, Suzanne M

Bioorganic & medicinal chemistry letters, 2006, Vol.16 (13), p.3564-3568 [Peer Reviewed Journal]

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4
1,3,4-Trisubstituted pyrrolidine CCR5 receptor antagonists. Part 1: discovery of the pyrrolidine scaffold and determination of its stereochemical requirements
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1,3,4-Trisubstituted pyrrolidine CCR5 receptor antagonists. Part 1: discovery of the pyrrolidine scaffold and determination of its stereochemical requirements

Hale, Jeffrey J ; Budhu, Richard J ; Mills, Sander G ; MacCoss, Malcolm ; Malkowitz, Lorraine ; Siciliano, Salvatore ; Gould, Sandra L ; DeMartino, Julie A ; Springer, Martin S

Bioorganic & medicinal chemistry letters, 2001, Vol.11 (11), p.1437-1440 [Peer Reviewed Journal]

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5
1,3,4-Trisubstituted pyrrolidine CCR5 receptor antagonists. Part 2: lead optimization affording selective, orally bioavailable compounds with potent Anti-HIV activity
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1,3,4-Trisubstituted pyrrolidine CCR5 receptor antagonists. Part 2: lead optimization affording selective, orally bioavailable compounds with potent Anti-HIV activity

Hale, Jeffrey J ; Budhu, Richard J ; Holson, Edward B ; Finke, Paul E ; Oates, Bryan ; Mills, Sander G ; MacCoss, Malcolm ; Gould, Sandra L ; DeMartino, Julie A ; Springer, Martin S ; Siciliano, Salvatore ; Malkowitz, Lorraine ; Schleif, William A ; Hazuda, Daria ; Miller, Michael ; Kessler, Joseph ; Danzeisen, Renee ; Holmes, Karen ; Lineberger, Janet ; Carella, Anthony ; Carver, Gwen ; Emini, Emilio

Bioorganic & medicinal chemistry letters, 2001, Vol.11 (20), p.2741-2745 [Peer Reviewed Journal]

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6
Design and synthesis of conformationally constrained 3-(N-alkylamino)propylphosphonic acids as potent agonists of sphingosine-1-phosphate (S1P) receptors
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Design and synthesis of conformationally constrained 3-(N-alkylamino)propylphosphonic acids as potent agonists of sphingosine-1-phosphate (S1P) receptors

Yan, Lin ; Hale, Jeffrey J ; Lynch, Christopher L ; Budhu, Richard ; Gentry, Amy ; Mills, Sander G ; Hajdu, Richard ; Keohane, Carol Ann ; Rosenbach, Mark J ; Milligan, James A ; Shei, Gan-Ju ; Chrebet, Gary ; Bergstrom, James ; Card, Deborah ; Rosen, Hugh ; Mandala, Suzanne M

Bioorganic & medicinal chemistry letters, 2004, Vol.14 (19), p.4861-4866 [Peer Reviewed Journal]

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7
Phosphorylated Morpholine Acetal Human Neurokinin-1 Receptor Antagonists as Water-Soluble Prodrugs
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Phosphorylated Morpholine Acetal Human Neurokinin-1 Receptor Antagonists as Water-Soluble Prodrugs

Hale, Jeffrey J ; Mills, Sander G ; MacCoss, Malcolm ; Dorn, Conrad P ; Finke, Paul E ; Budhu, Richard J ; Reamer, Robert A ; Huskey, Su-Er W ; Luffer-Atlas, Debra ; Dean, Brian J ; McGowan, Erin M ; Feeney, William P ; Chiu, Shuet-Hing Lee ; Cascieri, Margaret A ; Chicchi, Gary G ; Kurtz, Marc M ; Sadowski, Sharon ; Ber, Elzbieta ; Tattersall, F. David ; Rupniak, Nadia M. J ; Williams, Angela R ; Rycroft, Wayne ; Hargreaves, Richard ; Metzger, Joseph M ; MacIntyre, D. Euan

Journal of medicinal chemistry, 2000-03-23, Vol.43 (6), p.1234-1241 [Peer Reviewed Journal]

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8
1,3,4-Trisubstituted pyrrolidine CCR5 receptor antagonists. Part 4: Synthesis of N-1 acidic functionality affording analogues with enhanced antiviral activity against HIV
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1,3,4-Trisubstituted pyrrolidine CCR5 receptor antagonists. Part 4: Synthesis of N-1 acidic functionality affording analogues with enhanced antiviral activity against HIV

Lynch, Christopher L ; Hale, Jeffrey J ; Budhu, Richard J ; Gentry, Amy L ; Mills, Sander G ; Chapman, Kevin T ; MacCoss, Malcolm ; Malkowitz, Lorraine ; Springer, Martin S ; Gould, Sandra L ; DeMartino, Julie A ; Siciliano, Salvatore J ; Cascieri, Margaret A ; Carella, Anthony ; Carver, Gwen ; Holmes, Karen ; Schleif, William A ; Danzeisen, Renee ; Hazuda, Daria ; Kessler, Joseph ; Lineberger, Janet ; Miller, Michael ; Emini, Emilio A

Bioorganic & medicinal chemistry letters, 2002, Vol.12 (20), p.3001-3004 [Peer Reviewed Journal]

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9
1,3,4 trisubstituted pyrrolidine CCR5 receptor antagonists bearing 4-aminoheterocycle substituted piperidine side chains
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1,3,4 trisubstituted pyrrolidine CCR5 receptor antagonists bearing 4-aminoheterocycle substituted piperidine side chains

Willoughby, Christopher A ; Rosauer, Keith G ; Hale, Jeffery J ; Budhu, Richard J ; Mills, Sander G ; Chapman, Kevin T ; MacCoss, Malcolm ; Malkowitz, Lorraine ; Springer, Martin S ; Gould, Sandra L ; DeMartino, Julie A ; Siciliano, Salvatore J ; Cascieri, Margaret A ; Carella, Anthony ; Carver, Gwen ; Holmes, Karen ; Schleif, William A ; Danzeisen, Renee ; Hazuda, Daria ; Kessler, Joseph ; Lineberger, Janet ; Miller, Michael ; Emini, Emilio A

Bioorganic & medicinal chemistry letters, 2003, Vol.13 (3), p.427-431 [Peer Reviewed Journal]

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10
1,3,4-Trisubstituted pyrrolidine CCR5 receptor antagonists: modifications of the arylpropylpiperidine side chains
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1,3,4-Trisubstituted pyrrolidine CCR5 receptor antagonists: modifications of the arylpropylpiperidine side chains

Lynch, Christopher L ; Willoughby, Christopher A ; Hale, Jeffrey J ; Holson, Edward J ; Budhu, Richard J ; Gentry, Amy L ; Rosauer, Keith G ; Caldwell, Charles G ; Chen, Ping ; Mills, Sander G ; MacCoss, Malcolm ; Berk, Scott ; Chen, Liya ; Chapman, Kevin T ; Malkowitz, Lorraine ; Springer, Martin S ; Gould, Sandra L ; DeMartino, Julie A ; Siciliano, Salvatore J ; Cascieri, Margaret A ; Carella, Anthony ; Carver, Gwen ; Holmes, Karen ; Schleif, William A ; Danzeisen, Renee ; Hazuda, Daria ; Kessler, Joseph ; Lineberger, Janet ; Miller, Michael ; Emini, Emilio A

Bioorganic & medicinal chemistry letters, 2003, Vol.13 (1), p.119-123 [Peer Reviewed Journal]

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11
1,3,4-Trisubstituted pyrrolidine CCR5 receptor antagonists. Part 3: polar functionality and its effect on anti-HIV-1 activity
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1,3,4-Trisubstituted pyrrolidine CCR5 receptor antagonists. Part 3: polar functionality and its effect on anti-HIV-1 activity

Hale, Jeffrey J ; Budhu, Richard J ; Mills, Sander G ; MacCoss, Malcolm ; Gould, Sandra L ; DeMartino, Julie A ; Springer, Martin S ; Siciliano, Salvatore J ; Malkowitz, Lorraine ; Schleif, William A ; Hazuda, Daria ; Miller, Michael ; Kessler, Joseph ; Danzeisen, Renee ; Holmes, Karen ; Lineberger, Janet ; Carella, Anthony ; Carver, Gwen ; Emini, Emilio A

Bioorganic & medicinal chemistry letters, 2002, Vol.12 (20), p.2997-3000 [Peer Reviewed Journal]

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12
CCR5 Antagonists:  3-(Pyrrolidin-1-yl)propionic Acid Analogues with Potent Anti-HIV Activity
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CCR5 Antagonists:  3-(Pyrrolidin-1-yl)propionic Acid Analogues with Potent Anti-HIV Activity

Lynch, Christopher L ; Hale, Jeffrey J ; Budhu, Richard J ; Gentry, Amy L ; Finke, Paul E ; Caldwell, Charles G ; Mills, Sander G ; MacCoss, Malcolm ; Shen, Dong-Ming ; Chapman, Kevin T ; Malkowitz, Lorraine ; Springer, Martin S ; Gould, Sandra L ; DeMartino, Julie A ; Siciliano, Salvatore J ; Cascieri, Margaret A ; Carella, Anthony ; Carver, Gwen ; Holmes, Karen ; Schleif, William A ; Danzeisen, Renee ; Hazuda, Daria ; Kessler, Joseph ; Lineberger, Janet ; Miller, Michael ; Emini, Emilio

Organic letters, 2003-07-10, Vol.5 (14), p.2473-2475 [Peer Reviewed Journal]

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13
1,4-Diacylpiperazine-2-(S)-[(N-aminoalkyl)carboxamides] as novel, potent substance P receptor antagonists
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1,4-Diacylpiperazine-2-(S)-[(N-aminoalkyl)carboxamides] as novel, potent substance P receptor antagonists

Mills, Sander G ; Wu, Mu Tsu ; MacCoss, Malcolm ; Budhu, Richard J ; Dorn, Conrad P ; Cascieri, Margaret A ; Sadowski, Sharon ; Strader, Catherine D ; Greenlee, William J

Bioorganic & medicinal chemistry letters, 1993, Vol.3 (12), p.2707-2712 [Peer Reviewed Journal]

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14
1,2,3-Trisubstituted cyclohexyl substance P antagonists: significance of the ring nitrogen in piperidine-based NK-1 receptor antagonists
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1,2,3-Trisubstituted cyclohexyl substance P antagonists: significance of the ring nitrogen in piperidine-based NK-1 receptor antagonists

Mills, Sander G ; MacCoss, Malcolm ; Underwood, Dennis ; Shah, Shrenik K ; Finke, Paul E ; Miller, Daniel J ; Budhu, Richard J ; Cascieri, Margaret A ; Sadowski, Sharon ; Strader, Catherine D

Bioorganic & medicinal chemistry letters, 1995, Vol.5 (13), p.1345-1350 [Peer Reviewed Journal]

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14 Results  for Everything (Includes Articles)

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