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The Total Synthesis of Proteasome Inhibitors TMC‐95A and TMC‐95B: Discovery of a New Method To Generate cis ‐Propenyl Amides

Lin, Songnian ; Danishefsky, Samuel J.

Angewandte Chemie, 01 February 2002, Vol.114(3), pp.530-533 [Peer Reviewed Journal]

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Late-stage lipidation of fully elaborated tryptophan-containing peptides for improved pharmacokinetics

Huang, Chunhui ; Wille, Cannon B ; He, Huaibing ; Reddy, Vijay Bhasker Gangula ; Nargund, Ravi P ; Lin, Songnian ; Palani, Anandan

Tetrahedron Letters, 22 March 2017, Vol.58(12), pp.1219-1222 [Peer Reviewed Journal]

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3
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A simple and efficient procedure for the synthesis of benzimidazoles using air as the oxidant

Lin, Songnian ; Yang, Lihu

Tetrahedron Letters, 2005, Vol.46(25), pp.4315-4319 [Peer Reviewed Journal]

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Superior Glycemic Control With a Glucose-Responsive Insulin Analog: Hepatic and Nonhepatic Impacts

Moore, Mary ; Kelley, David ; Camacho, Raul ; Zafian, Peter ; Ye, Tian ; Lin, Songnian ; Kaarsholm, Niels ; Nargund, Ravi ; Kelly, Terri ; Heek, Margaret ; Previs, Stephen ; Moyes, Christopher ; Smith, Marta ; Farmer, Ben ; Williams, Phil ; Cherrington, Alan

Diabetes, Jun 1, 2018, Vol.67(6), p.1173 [Peer Reviewed Journal]

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5
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Mechanism of cis-enamide formation from N-(alpha-silyl)allyl amides: synthetic potential of stepwise dyotropic rearrangements

Zhang, Xiyun ; Houk, K N ; Lin, Songnian ; Danishefsky, Samuel J

Journal of the American Chemical Society, 30 April 2003, Vol.125(17), pp.5111-4 [Peer Reviewed Journal]

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6
Efficient Asymmetric Syntheses of β-Lactams Bearing a Cyclopropane or an Epoxide Moiety and Their Application to the Syntheses of Novel Isoserines and Taxoids
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Efficient Asymmetric Syntheses of β-Lactams Bearing a Cyclopropane or an Epoxide Moiety and Their Application to the Syntheses of Novel Isoserines and Taxoids

Ojima, Iwao ; Lin, Songnian

The Journal of Organic Chemistry, 01/1998, Vol.63(2), pp.224-225 [Peer Reviewed Journal]

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7
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Engineering Glucose Responsiveness Into Insulin

Kaarsholm, Niels C ; Lin, Songnian ; Yan, Lin ; Kelly, Theresa ; Van Heek, Margaret ; Mu, James ; Wu, Margaret ; Dai, Ge ; Cui, Yan ; Zhu, Yonghua ; Carballo-Jane, Ester ; Reddy, Vijay ; Zafian, Peter ; Huo, Pei ; Shi, Shuai ; Antochshuk, Valentyn ; Ogawa, Aimie ; Liu, Franklin ; Souza, Sandra C ; Seghezzi, Wolfgang ; Duffy, Joseph L ; Erion, Mark ; Nargund, Ravi P ; Kelley, David E

Diabetes, February 2018, Vol.67(2), pp.299-308 [Peer Reviewed Journal]

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8
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A common pharmacophore for cytotoxic natural products that stabilize microtubules

Ojima, Iwao ; Chakravarty, Subrata ; Inoue, Tadashi ; Lin, Songnian

Proceedings of the National Academy of Sciences of the United States of America, Apr 13, 1999, Vol.96(8), pp.4256-4261 [Peer Reviewed Journal]

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9
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The total synthesis of proteasome inhibitors TMC-95A and TMC-95B: discovery of a new method to generate cis-propenyl amides

Lin, Songnian ; Danishefsky, Samuel J

Angewandte Chemie (International ed. in English), 01 February 2002, Vol.41(3), pp.512-5 [Peer Reviewed Journal]

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10
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Synthesis of the Functionalized Macrocyclic Core of Proteasome Inhibitors TMC‐95A and B

Lin, Songnian ; Danishefsky, Samuel J.

Angewandte Chemie International Edition, 18 May 2001, Vol.40(10), pp.1967-1970 [Peer Reviewed Journal]

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11
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Total synthesis of TMC-95A and -B via a new reaction leading to Z-enamides. Some preliminary findings as to SAR

Lin, Songnian ; Yang, Zhi-Qiang ; Kwok, Benjamin H B ; Koldobskiy, Michael ; Crews, Craig M ; Danishefsky, Samuel J

Journal of the American Chemical Society, 26 May 2004, Vol.126(20), pp.6347-55 [Peer Reviewed Journal]

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12
Synthesis of Novel C2−C3‘N-Linked Macrocyclic Taxoids by Means of Highly Regioselective Heck Macrocyclization
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Synthesis of Novel C2−C3‘N-Linked Macrocyclic Taxoids by Means of Highly Regioselective Heck Macrocyclization

Geng, Xudong ; Miller, Michael L. ; Lin, Songnian ; Ojima, Iwao

Organic Letters, 10/2003, Vol.5(20), pp.3733-3736 [Peer Reviewed Journal]

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13
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Synthesis of novel C2-C3'N-linked macrocyclic taxoids by means of highly regioselective Heck macrocyclization

Geng, Xudong ; Miller, Michael L ; Lin, Songnian ; Ojima, Iwao

Organic letters, 02 October 2003, Vol.5(20), pp.3733-6 [Peer Reviewed Journal]

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14
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The Total Synthesis of Proteasome Inhibitors TMC‐95A and TMC‐95B: Discovery of a New Method To Generate cis ‐Propenyl Amides

Lin, Songnian ; Danishefsky, Samuel J.

Angewandte Chemie International Edition, 01 February 2002, Vol.41(3), pp.512-515 [Peer Reviewed Journal]

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15
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Total synthesis of guanacastepene a: a route to enantiomeric control

Mandal, Mihirbaran ; Yun, Heedong ; Dudley, Gregory B ; Lin, Songnian ; Tan, Derek S ; Danishefsky, Samuel J

The Journal of organic chemistry, 23 December 2005, Vol.70(26), pp.10619-37 [Peer Reviewed Journal]

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16
Macrocycle Formation by Ring-Closing Metathesis. Application to the Syntheses of Novel Macrocyclic Taxoids
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Macrocycle Formation by Ring-Closing Metathesis. Application to the Syntheses of Novel Macrocyclic Taxoids

Ojima, Iwao ; Lin, Songnian ; Inoue, Tadashi ; Miller, Michael L. ; Borella, Christopher P. ; Geng, Xudong ; Walsh, John J.

Journal of the American Chemical Society, 06/2000, Vol.122(22), pp.5343-5353 [Peer Reviewed Journal]

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17
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Design and synthesis of a novel photoaffinity taxoid as a potential probe for the study of paclitaxel–microtubules interactions

Lin, Songnian ; Fang, Kan ; Hashimoto, Masaru ; Nakanishi, Koji ; Ojima, Iwao

Tetrahedron Letters, 2000, Vol.41(22), pp.4287-4290 [Peer Reviewed Journal]

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18
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A Stereoselective Route to Guanacastepene A through a Surprising Epoxidation

Lin, Songnian ; Dudley, Gregory B. ; Tan, Derek S. ; Danishefsky, Samuel J.

Angewandte Chemie International Edition, 17 June 2002, Vol.41(12), pp.2188-2191 [Peer Reviewed Journal]

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19
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A novel series of indazole-/indole-based glucagon receptor antagonists

Lin, Songnian ; Zhang, Fengqi ; Jiang, Guoqiang ; Qureshi, Sajjad A ; Yang, Xiaodong ; Chicchi, Gary G ; Tota, Laurie ; Bansal, Alka ; Brady, Edward ; Trujillo, Maria ; Salituro, Gino ; Miller, Corey ; Tata, James R ; Zhang, Bei B ; Parmee, Emma R

Bioorganic & Medicinal Chemistry Letters, 01 October 2015, Vol.25(19), pp.4143-4147 [Peer Reviewed Journal]

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20
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Design, synthesis, and biological evaluation of aminopyrazine derivatives as inhibitors of mitogen-activated protein kinase-activated protein kinase 2 (MK-2)

Lin, Songnian ; Malkani, Sunita ; Lombardo, Matthew ; Yang, Lihu ; Mills, Sander G ; Chapman, Kevin ; Thompson, James E ; Zhang, Wen Xiao ; Wang, Ruixiu ; Cubbon, Rose M ; O’neill, Edward A ; Hale, Jeffrey J

Bioorganic & Medicinal Chemistry Letters, 15 November 2015, Vol.25(22), pp.5402-5408 [Peer Reviewed Journal]

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21
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Synthesis of the Functionalized Macrocyclic Core of Proteasome Inhibitors TMC‐95A and B

Lin, Songnian ; Danishefsky, Samuel J.

Angewandte Chemie, 18 May 2001, Vol.113(10), pp.2021-2024 [Peer Reviewed Journal]

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22
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Pharmacokinetic and pharmacodynamic properties of the glucokinase activator MK-0941 in rodent models of type 2 diabetes and healthy dogs

Eiki, Jun-Ichi ; Nagata, Yasufumi ; Futamura, Mayumi ; Sasaki-Yamamoto, Kaori ; Iino, Tomoharu ; Nishimura, Teruyuki ; Chiba, Masato ; Ohyama, Sumika ; Yoshida-Yoshimioto, Riki ; Fujii, Kenji ; Hosaka, Hideka ; Goto-Shimazaki, Hiroko ; Kadotani, Akito ; Ohe, Tomoyuki ; Lin, Songnian ; Langdon, Ronald B ; Berger, Joel P

Molecular pharmacology, December 2011, Vol.80(6), pp.1156-65 [Peer Reviewed Journal]

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23
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Superior Glycemic Control With a Glucose-Responsive Insulin Analog: Hepatic and Nonhepatic Impacts

Moore, Mary Courtney ; Kelley, David E ; Camacho, Raul C ; Zafian, Peter ; Ye, Tian ; Lin, Songnian ; Kaarsholm, Niels C ; Nargund, Ravi ; Kelly, Terri M ; Van Heek, Margaret ; Previs, Stephen F ; Moyes, Christopher ; Smith, Marta S ; Farmer, Ben ; Williams, Phil ; Cherrington, Alan D

Diabetes, June 2018, Vol.67(6), pp.1173-1181 [Peer Reviewed Journal]

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24
Syntheses and Structure−Activity Relationships of Novel Nor-seco Taxoids
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Syntheses and Structure−Activity Relationships of Novel Nor-seco Taxoids

Ojima, Iwao ; Lin, Songnian ; Chakravarty, Subrata ; Fenoglio, Ivana ; Park, Young Hoon ; Sun, Chung-Ming ; Appendino, Giovanni ; Pera, Paula ; Veith, Jean M. ; Bernacki, Ralph J.

The Journal of Organic Chemistry, 03/1998, Vol.63(5), pp.1637-1645 [Peer Reviewed Journal]

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25
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Structural significance of the acyl group at the C-10 position and the A ring of the taxane core of paclitaxel for inducing nitric oxide and tumor necrosis factor production by murine macrophages

Kirikae, Teruo ; Ojima, Iwao ; Fuero-Oderda, Cecilia ; Lin, Songnian ; Kirikae, Fumiko ; Hashimoto, Masahito ; Nakano, Masayasu

FEBS Letters, 2000, Vol.478(3), pp.221-226 [Peer Reviewed Journal]

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26
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Syntheses and biological activity of C-3′-difluoromethyl-taxoids

Ojima, Iwao ; Lin, Songnian ; Slater, John C ; Wang, Tao ; Pera, Paula ; Bernacki, Ralph J ; Ferlini, Cristiano ; Scambia, Giovanni

Bioorganic & Medicinal Chemistry, July 2000, Vol.8(7), pp.1619-1628 [Peer Reviewed Journal]

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27
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Erratum. Engineering Glucose Responsiveness Into Insulin. Diabetes 2018;67:299-308

Kaarsholm, Niels C ; Lin, Songnian ; Yan, Lin ; Kelly, Theresa ; Van Heek, Margaret ; Mu, James ; Wu, Margaret ; Dai, Ge ; Cui, Yan ; Zhu, Yonghua ; Carballo-Jane, Ester ; Reddy, Vijay ; Zafian, Peter ; Huo, Pei ; Shi, Shuai ; Antochshuk, Valentyn ; Ogawa, Aimie ; Liu, Franklin ; Souza, Sandra C ; Seghezzi, Wolfgang ; Duffy, Joseph L ; Erion, Mark ; Nargund, Ravi P ; Kelley, David E

Diabetes, May 2018, Vol.67(5), pp.1030 [Peer Reviewed Journal]

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28
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Glucagon receptor antagonism induces increased cholesterol absorption

Guan, Hong-Ping ; Yang, Xiaodong ; Lu, Ku ; Wang, Sheng-Ping ; Castro-Perez, Jose M ; Previs, Stephen ; Wright, Michael ; Shah, Vinit ; Herath, Kithsiri ; Xie, Dan ; Szeto, Daphne ; Forrest, Gail ; Xiao, Jing Chen ; Palyha, Oksana ; Sun, Li-Ping ; Andryuk, Paula J ; Engel, Samuel S ; Xiong, Yusheng ; Lin, Songnian ; Kelley, David E ; Erion, Mark D ; Davis, Harry R ; Wang, Liangsu

Journal of lipid research, November 2015, Vol.56(11), pp.2183-95 [Peer Reviewed Journal]

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29
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Discovery of orally active hepatoselective glucokinase activators for treatment of Type II Diabetes Mellitus

Xu, Jiayi ; Lin, Songnian ; Myers, Robert W ; Trujillo, Maria E ; Pachanski, Michele J ; Malkani, Sunita ; Chen, Hsuan-Shen ; Chen, Zhesheng ; Campbell, Brian ; Eiermann, George J ; Elowe, Nadine ; Farrer, Brian T ; Feng, Wen ; Fu, Qinghong ; Kats-Kagan, Roman ; Kavana, Michael ; Mcmasters, Daniel R ; Mitra, Kaushik ; Tong, Xinchun ; Xu, Libo ; Zhang, Fengqi ; Zhang, Rui ; Addona, George H ; Berger, Joel P ; Zhang, Bei ; Parmee, Emma R

Bioorganic & Medicinal Chemistry Letters, 01 May 2017, Vol.27(9), pp.2063-2068 [Peer Reviewed Journal]

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30
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Novel, highly potent systemic glucokinase activators for the treatment of Type 2 Diabetes Mellitus

Xu, Jiayi ; Lin, Songnian ; Myers, Robert W ; Addona, George ; Berger, Joel P ; Campbell, Brian ; Chen, Hsuan-Shen ; Chen, Zhesheng ; Eiermann, George J ; Elowe, Nadine H ; Farrer, Brian T ; Feng, Wen ; Fu, Qinghong ; Kats-Kagan, Roman ; Kavana, Michael ; Malkani, Sunita ; Mcmasters, Daniel R ; Mitra, Kaushik ; Pachanski, Michele J ; Tong, Xinchun ; Trujillo, Maria E ; Xu, Libo ; Zhang, Bei ; Zhang, Fengqi ; Zhang, Rui ; Parmee, Emma R

Bioorganic & Medicinal Chemistry Letters, 01 May 2017, Vol.27(9), pp.2069-2073 [Peer Reviewed Journal]

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31
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A glucose-responsive insulin therapy protects animals against hypoglycemia

Yang, Ruojing ; Wu, Margaret ; Lin, Songnian ; Nargund, Ravi P ; Li, Xinghai ; Kelly, Theresa ; Yan, Lin ; Dai, Ge ; Qian, Ying ; Dallas-Yang, Qing ; Fischer, Paul A ; Cui, Yan ; Shen, Xiaolan ; Huo, Pei ; Feng, Danqing Dennis ; Erion, Mark D ; Kelley, David E ; Mu, James

JCI insight, 11 January 2018, Vol.3(1)

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32
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Discovery of 5-aryloxy-2,4-thiazolidinediones as potent GPR40 agonists

Zhou, Changyou ; Tang, Cheng ; Chang, Eric ; Ge, Min ; Lin, Songnian ; Cline, Eric ; Tan, Carina P ; Feng, Yue ; Zhou, Yun-Ping ; Eiermann, George J ; Petrov, Aleksandr ; Salituro, Gino ; Meinke, Peter ; Mosley, Ralph ; Akiyama, Taro E ; Einstein, Monica ; Kumar, Sanjeev ; Berger, Joel ; Howard, Andrew D ; Thornberry, Nancy ; Mills, Sander G ; Yang, Lihu

Bioorganic & Medicinal Chemistry Letters, 2010, Vol.20(3), pp.1298-1301 [Peer Reviewed Journal]

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33
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Design, synthesis, and biological evaluation of new-generation taxoids

Ojima, Iwao ; Chen, Jin ; Sun, Liang ; Borella, Christopher P ; Wang, Tao ; Miller, Michael L ; Lin, Songnian ; Geng, Xudong ; Kuznetsova, Larisa ; Qu, Chuanxing ; Gallager, David ; Zhao, Xianrui ; Zanardi, Ilaria ; Xia, Shujun ; Horwitz, Susan B ; Mallen-St Clair, Jon ; Guerriero, Jennifer L ; Bar-Sagi, Dafna ; Veith, Jean M ; Pera, Paula ; Bernacki, Ralph J

Journal of medicinal chemistry, 12 June 2008, Vol.51(11), pp.3203-21 [Peer Reviewed Journal]

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34
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Selective small-molecule agonists of G protein-coupled receptor 40 promote glucose-dependent insulin secretion and reduce blood glucose in mice

Tan, Carina P ; Feng, Yue ; Zhou, Yun-Ping ; Eiermann, George J ; Petrov, Aleksandr ; Zhou, Changyou ; Lin, Songnian ; Salituro, Gino ; Meinke, Peter ; Mosley, Ralph ; Akiyama, Taro E ; Einstein, Monica ; Kumar, Sanjeev ; Berger, Joel P ; Mills, Sander G ; Thornberry, Nancy A ; Yang, Lihu ; Howard, Andrew D

Diabetes, August 2008, Vol.57(8), pp.2211-9 [Peer Reviewed Journal]

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35
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Selective Small-Molecule Agonists of G Protein-Coupled Receptor 40 Promote Glucose-Dependent Insulin Secretion and Reduce Blood Glucose in Mice

Tan, Carina ; Feng, Yue ; Zhou, Yun-Ping ; Eiermann, George ; Petrov, Aleksandr ; Zhou, Changyou ; Lin, Songnian ; Salituro, Gino ; Meinke, Peter ; Mosley, Ralph ; Akiyama, Taro ; Einstein, Monica ; Kumar, Sanjeev ; Berger, Joel ; Mills, Sander ; Thornberry, Nancy ; Yang, Lihu ; Howard, Andrew

Diabetes, Aug 2008, Vol.57(8), pp.2211-9 [Peer Reviewed Journal]

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36
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Design, synthesis and biological activity of novel C2-C3′ N-Linked macrocyclic taxoids

Ojima, Iwao ; Geng, Xudong ; Lin, Songnian ; Pera, Paula ; Bernacki, Ralph J

Bioorganic & Medicinal Chemistry Letters, 2002, Vol.12(3), pp.349-352 [Peer Reviewed Journal]

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