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Discovery of a Potent and Selective DGAT1 Inhibitor with a Piperidinyl-oxy-cyclohexanecarboxylic Acid Moiety

He, Shuwen ; Hong, Qingmei ; Lai, Zhong ; Yang, David X ; Ting, Pauline C ; Kuethe, Jeffrey T ; Cernak, Timothy A ; Dykstra, Kevin D ; Sperbeck, Donald M ; Wu, Zhicai ; Yu, Yang ; Yang, Ginger X ; Jian, Tianying ; Liu, Jian ; Guiadeen, Deodial ; Krikorian, Arto D ; Sonatore, Lisa M ; Wiltsie, Judyann ; Liu, Jinqi ; Gorski, Judith N ; Chung, Christine C ; Gibson, Jack T ; Lisnock, Jeanmarie ; Xiao, Jianying ; Wolff, Michael ; Tong, Sharon X ; Madeira, Maria ; Karanam, Bindhu V ; Shen, Dong-Ming ; Balkovec, James M ; Pinto, Shirly ; Nargund, Ravi P ; Devita, Robert J

ACS medicinal chemistry letters, 09 October 2014, Vol.5(10), pp.1082-7 [Peer Reviewed Journal]

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Potent DGAT1 Inhibitors in the Benzimidazole Class with a Pyridyl-oxy-cyclohexanecarboxylic Acid Moiety

He, Shuwen ; Hong, Qingmei ; Lai, Zhong ; Wu, Zhicai ; Yu, Yang ; Kim, David W ; Ting, Pauline C ; Kuethe, Jeffrey T ; Yang, Ginger X ; Jian, Tianying ; Liu, Jian ; Guiadeen, Deodial ; Krikorian, Arto D ; Sperbeck, Donald M ; Sonatore, Lisa M ; Wiltsie, Judyann ; Chung, Christine C ; Gibson, Jack T ; Lisnock, Jeanmarie ; Murphy, Beth A ; Gorski, Judith N ; Liu, Jinqi ; Chen, Dunlu ; Chen, Xiaoli ; Wolff, Michael ; Tong, Sharon X ; Madeira, Maria ; Karanam, Bindhu V ; Shen, Dong-Ming ; Balkovec, James M ; Pinto, Shirly ; Nargund, Ravi P ; Devita, Robert J

ACS medicinal chemistry letters, 08 August 2013, Vol.4(8), pp.773-8 [Peer Reviewed Journal]

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Investigation of Cardiovascular Effects of Tetrahydro-β-carboline sstr3 antagonists

He, Shuwen ; Lai, Zhong ; Ye, Zhixiong ; Dobbelaar, Peter H ; Shah, Shrenik K ; Truong, Quang ; Du, Wu ; Guo, Liangqin ; Liu, Jian ; Jian, Tianying ; Qi, Hongbo ; Bakshi, Raman K ; Hong, Qingmei ; Dellureficio, James ; Reibarkh, Mikhail ; Samuel, Koppara ; Reddy, Vijay B ; Mitelman, Stan ; Tong, Sharon X ; Chicchi, Gary G ; Tsao, Kwei-Lan ; Trusca, Dorina ; Wu, Margaret ; Shao, Qing ; Trujillo, Maria E ; Fernandez, Guillermo ; Nelson, Donald ; Bunting, Patricia ; Kerr, Janet ; Fitzgerald, Patrick ; Morissette, Pierre ; Volksdorf, Sylvia ; Eiermann, George J ; Li, Cai ; Zhang, Bei ; Howard, Andrew D ; Zhou, Yun-Ping ; Nargund, Ravi P ; Hagmann, William K

ACS medicinal chemistry letters, 10 July 2014, Vol.5(7), pp.748-53 [Peer Reviewed Journal]

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SAR exploration at the C-3 position of tetrahydro-β-carboline sstr3 antagonists

He, Shuwen ; Dobbelaar, Peter H ; Guo, Liangqin ; Ye, Zhixiong ; Liu, Jian ; Jian, Tianying ; Truong, Quang ; Shah, Shrenik K ; Du, Wu ; Qi, Hongbo ; Bakshi, Raman K ; Hong, Qingmei ; Dellureficio, James D ; Sherer, Edward ; Pasternak, Alexander ; Feng, Zhe ; Reibarkh, Mikhail ; Lin, Melissa ; Samuel, Koppara ; Reddy, Vijay B ; Mitelman, Stan ; Tong, Sharon X ; Chicchi, Gary G ; Tsao, Kwei-Lan ; Trusca, Dorina ; Wu, Margaret ; Shao, Qing ; Trujillo, Maria E ; Fernandez, Guillermo ; Nelson, Donald ; Bunting, Patricia ; Kerr, Janet ; Fitzgerald, Patrick ; Morissette, Pierre ; Volksdorf, Sylvia ; Eiermann, George J ; Li, Cai ; Zhang, Bei B ; Howard, Andrew D ; Zhou, Yun-Ping ; Nargund, Ravi P ; Hagmann, William K

Bioorganic & Medicinal Chemistry Letters, 15 March 2016, Vol.26(6), pp.1529-1535 [Peer Reviewed Journal]

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Discovery of MK-1421, a Potent, Selective sstr3 Antagonist, as a Development Candidate for Type 2 Diabetes

Shah, Shrenik K ; He, Shuwen ; Guo, Liangqin ; Truong, Quang ; Qi, Hongbo ; Du, Wu ; Lai, Zhong ; Liu, Jian ; Jian, Tianying ; Hong, Qingmei ; Dobbelaar, Peter ; Ye, Zhixiong ; Sherer, Edward ; Feng, Zhe ; Yu, Yang ; Wong, Frederick ; Samuel, Koppara ; Madiera, Maria ; Karanam, Bindhu V ; Reddy, Vijay B ; Mitelman, Stan ; Tong, Sharon X ; Chicchi, Gary G ; Tsao, Kwei-Lan ; Trusca, Dorina ; Feng, Yue ; Wu, Margaret ; Shao, Qing ; Trujillo, Maria E ; Eiermann, George J ; Li, Cai ; Pachanski, Michele ; Fernandez, Guillermo ; Nelson, Donald ; Bunting, Patricia ; Morissette, Pierre ; Volksdorf, Sylvia ; Kerr, Janet ; Zhang, Bei B ; Howard, Andrew D ; Zhou, Yun-Ping ; Pasternak, Alexander ; Nargund, Ravi P ; Hagmann, William K

ACS medicinal chemistry letters, 14 May 2015, Vol.6(5), pp.513-7 [Peer Reviewed Journal]

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The Discovery of MK-4256, a Potent SSTR3 Antagonist as a Potential Treatment of Type 2 Diabetes

He, Shuwen ; Ye, Zhixiong ; Truong, Quang ; Shah, Shrenik ; Du, Wu ; Guo, Liangqin ; Dobbelaar, Peter H ; Lai, Zhong ; Liu, Jian ; Jian, Tianying ; Qi, Hongbo ; Bakshi, Raman K ; Hong, Qingmei ; Dellureficio, James ; Pasternak, Alexander ; Feng, Zhe ; Dejesus, Reynalda ; Yang, Lihu ; Reibarkh, Mikhail ; Bradley, Scott A ; Holmes, Mark A ; Ball, Richard G ; Ruck, Rebecca T ; Huffman, Mark A ; Wong, Frederick ; Samuel, Koppara ; Reddy, Vijay B ; Mitelman, Stan ; Tong, Sharon X ; Chicchi, Gary G ; Tsao, Kwei-Lan ; Trusca, Dorina ; Wu, Margaret ; Shao, Qing ; Trujillo, Maria E ; Eiermann, George J ; Li, Cai ; Zhang, Bei B ; Howard, Andrew D ; Zhou, Yun-Ping ; Nargund, Ravi P ; Hagmann, William K

ACS medicinal chemistry letters, 14 June 2012, Vol.3(6), pp.484-9 [Peer Reviewed Journal]

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Accelerating the discovery of DGAT1 inhibitors through the application of parallel medicinal chemistry (PMC)

Yu, Yang ; Wu, Zhicai ; Shi, Zhi-Cai ; He, Shuwen ; Lai, Zhong ; Cernak, Timothy A ; Vachal, Petr ; Liu, Min ; Liu, Jian ; Hong, Qingmei ; Jian, Tianying ; Guiadeen, Deodial ; Krikorian, Arto ; Sperbeck, Donald M ; Verras, Andreas ; Sonatore, Lisa M ; Murphy, Beth A ; Wiltsie, Judyann ; Chung, Christine C ; Gorski, Judith N ; Liu, Jinqi ; Xiao, Jianying ; Wolff, Michael ; Tong, Sharon X ; Madeira, Maria ; Karanam, Bindhu V ; Shen, Dong-Ming ; Balkovec, James M ; De Vita, Robert J ; Pinto, Shirly ; Nargund, Ravi P

Bioorganic & Medicinal Chemistry Letters, 01 June 2019, Vol.29(11), pp.1380-1385 [Peer Reviewed Journal]

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Benzimidazole-based DGAT1 inhibitors with a [3.1.0] bicyclohexane carboxylic acid moiety

He, Shuwen ; Lai, Zhong ; Hong, Qingmei ; Shang, Jackie ; Reibarkh, Mikhail ; Kuethe, Jeffrey T ; Liu, Jian ; Guiadeen, Deodial ; Krikorian, Arto D ; Cernak, Timothy A ; Dykstra, Kevin D ; Sperbeck, Donald M ; Wu, Zhicai ; Yu, Yang ; Yang, Ginger X ; Jian, Tianying ; Verras, Andreas ; Sonatore, Lisa M ; Wiltsie, Judyann ; Chung, Christine C ; Murphy, Beth A ; Gorski, Judith N ; Liu, Jinqi ; Xiao, Jianying ; Wolff, Michael ; Tong, Sharon X ; Madeira, Maria ; Karanam, Bindhu V ; Shen, Dong-Ming ; Balkovec, James M ; Pinto, Shirly ; Nargund, Ravi P ; Devita, Robert J

Bioorganic & Medicinal Chemistry Letters, 15 May 2019, Vol.29(10), pp.1182-1186 [Peer Reviewed Journal]

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B-Cell Epitopes in GroEL of Francisella tularensis

Lu, Zhaohua ; Rynkiewicz, Michael ; Madico, Guillermo ; Li, Sheng ; Chiou-Ying, Yang ; Perkins, Hillary ; Sompuram, Seshi ; Kodela, Vani ; Liu, Tong ; Morris, Timothy ; Wang, Daphne ; Roche, Marly ; Seaton, Barbara ; Sharon, Jacqueline

PLoS One, Jun 2014, p.e99847 [Peer Reviewed Journal]

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Dynamic structural changes are observed upon collagen and metal ion binding to the integrin α1 I domain

Weinreb, Paul H ; Li, Sheng ; Gao, Sharon X ; Liu, Tong ; Pepinsky, R Blake ; Caravella, Justin A ; Lee, Jun H ; Woods, Virgil L

The Journal of biological chemistry, 21 September 2012, Vol.287(39), pp.32897-912 [Peer Reviewed Journal]

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Luminescent ruffled iridium(iii) porphyrin complexes containing N-heterocyclic carbene ligands: structures, spectroscopies and potent antitumor activities under dark and light irradiation conditions

Lam, Tsz-Lung ; Tong, Ka-Chung ; Yang, Chen ; Kwong, Wai-Lun ; Guan, Xiangguo ; Li, Ming-De ; Kar-Yan Lo, Vanessa ; Lai-Fung Chan, Sharon ; Lee Phillips, David ; Lok, Chun-Nam ; Che, Chi-Ming

Chemical science, 07 January 2019, Vol.10(1), pp.293-309 [Peer Reviewed Journal]

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Eosinophilia and clinical outcome of chronic obstructive pulmonary disease: a meta-analysis

Ho, Jeffery ; He, Wajia ; Chan, Matthew T V ; Tse, Gary ; Liu, Tong ; Wong, Sunny H ; Leung, Czarina C H ; Wong, Wai T ; Tsang, Sharon ; Zhang, Lin ; Chan, Rose Y P ; Gin, Tony ; Leung, Joseph ; Lau, Benson W M ; Wu, William K K ; Ngai, Shirley P C

Scientific reports, 18 October 2017, Vol.7(1), pp.13451 [Peer Reviewed Journal]

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A novel molecular signature for elevated tricuspid regurgitation velocity in sickle cell disease

Desai, Ankit A ; Zhou, Tong ; Ahmad, Homaa ; Zhang, Wei ; Mu, Wenbo ; Trevino, Sharon ; Wade, Michael S ; Raghavachari, Nalini ; Kato, Gregory J ; Peters-Lawrence, Marlene H ; Thiruvoipati, Tejas ; Turner, Kristin ; Artz, Nicole ; Huang, Yong ; Patel, Amit R ; Yuan, Jason X-J ; Gordeuk, Victor R ; Lang, Roberto M ; Garcia, Joe G N ; Machado, Roberto F

American journal of respiratory and critical care medicine, 15 August 2012, Vol.186(4), pp.359-68 [Peer Reviewed Journal]

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Poor correlation between coronary artery calcification and obstructive coronary artery disease in an end‐stage renal disease patient

Tong, Li‐Li ; Mehrotra, Rajnish ; Shavelle, David M. ; Budoff, Matthew ; Adler, Sharon

Hemodialysis International, January 2008, Vol.12(1), pp.16-22 [Peer Reviewed Journal]

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15
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N-Isonicotinoyl-( l)-4-aminophenylalanine derivatives as tight binding VLA-4 antagonists

Doherty, George A ; Yang, Ginger X ; Borges, Edite ; Tong, Sharon ; Mccauley, Ermengilda D ; Treonz, Kelly M ; Van Riper, Gail ; Pacholok, Stephen ; Si, Qian ; Koo, Gloria C ; Shah, Kashmira ; Mumford, Richard A ; Hagmann, William K

Bioorganic & Medicinal Chemistry Letters, 2003, Vol.13(11), pp.1891-1895 [Peer Reviewed Journal]

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Corrigendum to “ N-Isonicotinoyl-( l)-4-aminophenylalanine Derivatives as Tight Binding VLA-4 Antagonists”[Bioorg. Med. Chem. Lett. 13 (2003) 1891]

Doherty, George A ; Yang, Ginger X ; Borges, Edite ; Tong, Sharon ; Mccauley, Ermengilda D ; Treonz, Kelly M ; Van Riper, Gail ; Pacholok, Stephen ; Si, Qian ; Koo, Gloria C ; Shah, Kashmira ; Mumford, Richard A ; Hagmann, William K

Bioorganic & Medicinal Chemistry Letters, 2003, Vol.13(17), pp.2937-2938 [Peer Reviewed Journal]

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17
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Substituted tetrahydrofuroyl-1-phenylalanine derivatives as potent and specific VLA-4 antagonists

Doherty, George A ; Yang, Ginger X ; Borges, Edite ; Chang, Linda L ; Maccoss, Malcolm ; Tong, Sharon ; Kidambi, Usha ; Egger, Linda A ; Mccauley, Ermenegilda ; Van Riper, Gail ; Mumford, Richard A ; Schmidt, John A ; Hagmann, William K

Bioorganic & Medicinal Chemistry Letters, 2002, Vol.12(11), pp.1501-1505 [Peer Reviewed Journal]

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18
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Acknowledgement to Reviewers of Materials in 2018

Materials, Jan 2019, Vol.12(1) [Peer Reviewed Journal]

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19
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Editor-in-Chief’s Note – Thank you to Reviewers

Carcinogenesis, 2013, Vol. 34(12), pp.2930-2934 [Peer Reviewed Journal]

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20
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Insights into Animal and Plant Lectins with Antimicrobial Activities

Dias, Renata ; Machado, Leandro ; Migliolo, Ludovico ; Franco, Octavio

Molecules, Vol.20(1), pp.519-541 [Peer Reviewed Journal]

2015

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21
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Regulation of seedling growth by ethylene and the ethylene-auxin crosstalk

Hu, Yuming ; Vandenbussche, Filip ; Van Der Straeten, Dominique

Planta, pp.467-489 [Peer Reviewed Journal]

Mar 2017

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22
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Discovery and Development of Anti-HBV Agents and Their Resistance

Kim, Kyun-Hwan ; Kim, Nam ; Seong, Baik-Lin

Molecules, pp.5878-5908 [Peer Reviewed Journal]

2010

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23
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Intracellular lectins are involved in quality control of glycoproteins

Yamamoto, Kazuo

Proceedings of the Japan Academy, Feb 2014, Vol.90(2), pp.67-82 [Peer Reviewed Journal]

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24
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Acknowledgement to Reviewers of Nutrients in 2014

Nutrients, 2015, pp.349-359 [Peer Reviewed Journal]

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25
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Composite Polymer Electrolytes: Nanoparticles Affect Structure and Properties

Wang, Wei ; Alexandridis, Paschalis

Polymers, p.387 [Peer Reviewed Journal]

2016

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26
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Mushroom Lectins: Specificity, Structure and Bioactivity Relevant to Human Disease

Hassan, Mohamed ; Rouf, Razina ; Tiralongo, Evelin ; May, Tom ; Tiralongo, Joe

International Journal of Molecular Sciences, pp.7802-7838 [Peer Reviewed Journal]

2015

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27
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Acknowledgement to Reviewers of IJERPH in 2017

Ijerph Editorial Office;

International Journal of Environmental Research and Public Health, 2018, Vol.15(1) [Peer Reviewed Journal]

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28
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Applications of Azide-Based Bioorthogonal Click Chemistry in Glycobiology

Zhang, Xiu ; Zhang, Yan

Molecules, Vol.18(6), pp.7145-7159 [Peer Reviewed Journal]

2013

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29
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Acknowledgement to Reviewers of IJERPH in 2016

Ijerph Editorial Office;

International Journal of Environmental Research and Public Health, 2017, Vol.14(1) [Peer Reviewed Journal]

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30
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Potential Use of Biological Proteins for Liver Failure Therapy

Taguchi, Kazuaki ; Yamasaki, Keishi ; Seo, Hakaru ; Otagiri, Masaki

Pharmaceutics, Vol.7(3), pp.255-274 [Peer Reviewed Journal]

2015

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31
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Current Perspectives and Mechanisms of Relationship between Intestinal Microbiota Dysfunction and Dementia: A Review

Welcome, Menizibeya

Dementia and Geriatric Cognitive Disorders Extra, Vol.8(3), pp.360-381 [Peer Reviewed Journal]

Sep-Dec 2018

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32
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Activation of Defense Mechanisms against Pathogens in Mosses and Flowering Plants

León, Ines ; Montesano, Marcos

International Journal of Molecular Sciences, pp.3178-3200 [Peer Reviewed Journal]

2013

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33
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Advances in Mammalian Cell Line Development Technologies for Recombinant Protein Production

Lai, Tingfeng ; Yang, Yuansheng ; Ng, Say

Pharmaceuticals, pp.579-603 [Peer Reviewed Journal]

2013

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34
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Acknowledgement to Reviewers of Molecules in 2013

Molecules, 2014, Vol.19(3), p.2707-2732 [Peer Reviewed Journal]

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35
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Gut microbiota, obesity and diabetes

Patterson, Elaine ; Ryan, Paul M ; Cryan, John F ; Dinan, Timothy G ; Ross, R Paul ; Fitzgerald, Gerald F ; Stanton, Catherine

Postgraduate Medical Journal, Vol.92(1087), p.286 [Peer Reviewed Journal]

May 2016

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36
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Plasma-Enabled Carbon Nanostructures for Early Diagnosis of Neurodegenerative Diseases

Pineda, Shafique ; Han, Zhao ; Ostrikov, Kostya

Materials, Vol.7(7), pp.4896-4929 [Peer Reviewed Journal]

2014

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37
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Hgc1-Cdc28-how much does a single protein kinase do in the regulation of hyphal development in Candida albicans?

Wang, Yue

The Journal of Microbiology, Vol.54(3), pp.170-177 [Peer Reviewed Journal]

Mar 2016

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Acknowledgement of Assessors

British Journal of Anaesthesia, 2015, Vol. 114(1), pp.176-179 [Peer Reviewed Journal]

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