skip to main content
Language:
Search Limited to: Search Limited to: Resource type Show Results with: Show Results with: Index

Results 1 - 50 of 236  for Everything (Includes Articles)

Results 1 2 3 4 5 next page
Show only
Result Number Material Type Add to My Shelf Action Record Details and Options
1
Material Type:
Article
Add to e-Shelf

Organic chemistry in drug discovery

Maccoss, Malcolm ; Baillie, Thomas A

Science (New York, N.Y.), 19 March 2004, Vol.303(5665), pp.1810-3 [Peer Reviewed Journal]

Full text available

View all versions
2
Material Type:
Article
Add to e-Shelf

A notable conversion of a thiolacetate to its corresponding sulfonyl chloride

Huang, Yuhua ; Bennett, Frank ; Verma, Vishal ; George Njoroge, F. ; Maccoss, Malcolm

Tetrahedron Letters, 27 June 2012, Vol.53(26), pp.3203-3205 [Peer Reviewed Journal]

Full text available

View all versions
3
Material Type:
Article
Add to e-Shelf

Importance of Rigidity in Designing Small Molecule Drugs To Tackle Protein-Protein Interactions (PPIs) through Stabilization of Desired Conformers

Lawson, Alastair D G ; Maccoss, Malcolm ; Heer, Jag P

Journal of medicinal chemistry, 24 May 2018, Vol.61(10), pp.4283-4289 [Peer Reviewed Journal]

Full text available

View all versions
4
Material Type:
Article
Add to e-Shelf

Rings in drugs

Taylor, Richard D ; Maccoss, Malcolm ; Lawson, Alastair D G

Journal of medicinal chemistry, 24 July 2014, Vol.57(14), pp.5845-59 [Peer Reviewed Journal]

Full text available

View all versions
5
Material Type:
Article
Add to e-Shelf

Combining Molecular Scaffolds from FDA Approved Drugs: Application to Drug Discovery

Taylor, Richard D ; Maccoss, Malcolm ; Lawson, Alastair D G

Journal of medicinal chemistry, 09 March 2017, Vol.60(5), pp.1638-1647 [Peer Reviewed Journal]

Full text available

View all versions
6
Material Type:
Article
Add to e-Shelf

Novel methods to functionalize thiazolo[4,5- c]pyridines

Girijavallabhan, Vinay ; Arasappan, Ashok ; Bennett, Frank ; Huang, Yuhua ; George Njoroge, F. ; Maccoss, Malcolm

Tetrahedron Letters, 2010, Vol.51(21), pp.2797-2799 [Peer Reviewed Journal]

Full text available

View all versions
7
Material Type:
Article
Add to e-Shelf

Syntheses of 4- and 6-substituted thiazolo[4,5- c]pyridines

Huang, Yuhua ; Bennett, Frank ; Girijavallabhan, Vinay ; Alvarez, Carmen ; Chan, Tze-Ming ; Osterman, Rebecca ; Senior, Mary ; Kwong, Cecil ; Bansal, Namita ; George Njoroge, F. ; Maccoss, Malcolm

Tetrahedron Letters, 2010, Vol.51(21), pp.2800-2802 [Peer Reviewed Journal]

Full text available

View all versions
8
Material Type:
Article
Add to e-Shelf

C−H Cyanation of 6‐Ring N‐Containing Heteroaromatics

Elbert, Bryony L. ; Farley, Alistair J. M. ; Gorman, Timothy W. ; Johnson, Tarn C. ; Genicot, Christophe ; Lallemand, Bénédicte ; Pasau, Patrick ; Flasz, Jakub ; Castro, José L. ; Maccoss, Malcolm ; Paton, Robert S. ; Schofield, Christopher J. ; Smith, Martin D. ; Willis, Michael C. ; Dixon, Darren J.

Chemistry – A European Journal, 20 October 2017, Vol.23(59), pp.14733-14737 [Peer Reviewed Journal]

Full text available

View all versions
9
Material Type:
Article
Add to e-Shelf

Sustained viral response in a hepatitis C virus-infected chimpanzee via a combination of direct-acting antiviral agents

Olsen, David B ; Davies, Mary-Ellen ; Handt, Larry ; Koeplinger, Kenneth ; Zhang, Nanyan Rena ; Ludmerer, Steven W ; Graham, Donald ; Liverton, Nigel ; Maccoss, Malcolm ; Hazuda, Daria ; Carroll, Steven S

Antimicrobial agents and chemotherapy, February 2011, Vol.55(2), pp.937-9 [Peer Reviewed Journal]

Full text available

View all versions
10
Material Type:
Article
Add to e-Shelf

Synthesis and SAR of geminal substitutions at the C5′ carbosugar position of pyrimidine-derived HCV inhibitors

Verma, Vishal A. ; Rossman, Randall ; Bennett, Frank ; Chen, Lei ; Gavalas, Stephen ; Girijavallabhan, Vinay ; Huang, Yuhua ; Kim, Seong-Heon ; Kosinski, Aneta ; Pinto, Patrick ; Rizvi, Razia ; Shankar, Bandarpalle ; Tong, Ling ; Velazquez, Francisco ; Venkatraman, Srikanth ; Kozlowski, Joseph ; Maccoss, Malcolm ; Kwong, Cecil D. ; Bansal, Namita ; Kezar, Hollis S. ; Reynolds, Robert C. ; Maddry, Joseph A. ; Ananthan, Subramaniam ; Secrist, John A. ; Li, Cheng ; Chase, Robert ; Curry, Stephanie ; Huang, Hsueh-Cheng ; Tong, Xiao ; Njoroge, F. George ; Arasappan, Ashok

Bioorganic & Medicinal Chemistry Letters, 15 November 2012, Vol.22(22), pp.6967-6973 [Peer Reviewed Journal]

Full text available

View all versions
11
Material Type:
Article
Add to e-Shelf

Pyridofuran substituted pyrimidine derivatives as HCV replication (replicase) inhibitors

Bennett, Frank ; Kezar, Hollis S. ; Girijavallabhan, Vinay ; Huang, Yuhua ; Huelgas, Regina ; Rossman, Randall ; Shih, Neng-Yang ; Piwinski, John J. ; Maccoss, Malcolm ; Kwong, Cecil D. ; Clark, Jeremy L. ; Fowler, Anita T. ; Geng, Feng ; Roychowdhury, Abhijit ; Reynolds, Robert C. ; Maddry, Joseph A. ; Ananthan, Subramaniam ; Secrist, John A. ; Li, Cheng ; Chase, Robert ; Curry, Stephanie ; Huang, Hsueh-Cheng ; Tong, Xiao ; George Njoroge, F. ; Arasappan, Ashok

Bioorganic & Medicinal Chemistry Letters, 1 August 2012, Vol.22(15), pp.5144-5149 [Peer Reviewed Journal]

Full text available

View all versions
12
Material Type:
Article
Add to e-Shelf

An expeditious synthesis of 3-(difluoromethoxy)- and 3-(trifluoromethoxy)-5,6,7,8-tetrahydro-1,6-naphthyridines

Guiadeen, Deodialsingh ; Kothandaraman, Shankaran ; Yang, Lihu ; Mills, Sander G. ; Maccoss, Malcolm

Tetrahedron Letters, 2008, Vol.49(44), pp.6368-6370 [Peer Reviewed Journal]

Full text available

View all versions
13
Material Type:
Article
Add to e-Shelf

Concise preparation of 8-trifluoromethyltetrahydro-6 H-pyrido [1,2- a] pyrazine-6-one

Kothandaraman, Shankaran ; Guiadeen, Deodialsingh ; Butora, Gabor ; Doss, George ; Mills, Sander G. ; Maccoss, Malcolm ; Yang, Lihu

Tetrahedron Letters, 2009, Vol.50(28), pp.4050-4053 [Peer Reviewed Journal]

Full text available

View all versions
14
Material Type:
Article
Add to e-Shelf

5-Benzothiazole substituted pyrimidine derivatives as HCV replication (replicase) inhibitors

Arasappan, Ashok ; Bennett, Frank ; Girijavallabhan, Vinay ; Huang, Yuhua ; Huelgas, Regina ; Alvarez, Carmen ; Chen, Lei ; Gavalas, Stephen ; Kim, Seong-Heon ; Kosinski, Aneta ; Pinto, Patrick ; Rizvi, Razia ; Rossman, Randall ; Shankar, Bandarpalle ; Tong, Ling ; Velazquez, Francisco ; Venkatraman, Srikanth ; Verma, Vishal A. ; Kozlowski, Joseph ; Shih, Neng-Yang ; Piwinski, John J. ; Maccoss, Malcolm ; Kwong, Cecil D. ; Clark, Jeremy L. ; Fowler, Anita T. ; Geng, Feng ; Kezar, Hollis S. ; Roychowdhury, Abhijit ; Reynolds, Robert C. ; Maddry, Joseph A. ; Ananthan, Subramaniam ; Secrist, John A. ; Li, Cheng ; Chase, Robert ; Curry, Stephanie ; Huang, Hsueh-Cheng ; Tong, Xiao ; Njoroge, F. George

Bioorganic & Medicinal Chemistry Letters, 1 May 2012, Vol.22(9), pp.3229-3234 [Peer Reviewed Journal]

Full text available

View all versions
15
Material Type:
Article
Add to e-Shelf

Synthesis and SAR of pyridothiazole substituted pyrimidine derived HCV replication inhibitors

Girijavallabhan, Vinay M. ; Alvarez, Carmen ; Bennett, Frank ; Chen, Lei ; Gavalas, Stephen ; Huang, Yuhua ; Kim, Seong-Heon ; Kosinski, Aneta ; Pinto, Patrick ; Rizvi, Razia ; Rossman, Randall ; Shankar, Bandarpalle ; Tong, Ling ; Velazquez, Francisco ; Venkatraman, Srikanth ; Verma, Vishal A. ; Kozlowski, Joseph ; Shih, Neng-Yang ; Piwinski, John J. ; Maccoss, Malcolm ; Kwong, Cecil D. ; Bansal, Namita ; Clark, Jeremy L. ; Fowler, Anita T. ; Kezar, Hollis S. ; Valiyaveettil, Jacob ; Reynolds, Robert C. ; Maddry, Joseph A. ; Ananthan, Subramaniam ; Secrist, John A. ; Li, Cheng ; Chase, Robert ; Curry, Stephanie ; Huang, Hsueh-Cheng ; Tong, Xiao ; Njoroge, F. George ; Arasappan, Ashok

Bioorganic & Medicinal Chemistry Letters, 1 September 2012, Vol.22(17), pp.5652-5657 [Peer Reviewed Journal]

Full text available

View all versions
16
Material Type:
Article
Add to e-Shelf

Cyclic hydroxyamidines as amide isosteres: discovery of oxadiazolines and oxadiazines as potent and highly efficacious γ-secretase modulators in vivo

Sun, Zhong-Yue ; Asberom, Theodros ; Bara, Thomas ; Bennett, Chad ; Burnett, Duane ; Chu, Inhou ; Clader, John ; Cohen-Williams, Mary ; Cole, David ; Czarniecki, Michael ; Durkin, James ; Gallo, Gioconda ; Greenlee, William ; Josien, Hubert ; Huang, Xianhai ; Hyde, Lynn ; Jones, Nicholas ; Kazakevich, Irina ; Li, Hongmei ; Liu, Xiaoxiang ; Lee, Julie ; Maccoss, Malcolm ; Mandal, Mihir B ; Mccracken, Troy ; Nomeir, Amin ; Mazzola, Robert ; Palani, Anandan ; Parker, Eric M ; Pissarnitski, Dmitri A ; Qin, Jun ; Song, Lixin ; Terracina, Giuseppe ; Vicarel, Monica ; Voigt, Johannes ; Xu, Ruo ; Zhang, Lili ; Zhang, Qi ; Zhao, Zhiqiang ; Zhu, Xiaohong ; Zhu, Zhaoning

Journal of medicinal chemistry, 12 January 2012, Vol.55(1), pp.489-502 [Peer Reviewed Journal]

Full text available

View all versions
17
Material Type:
Article
Add to e-Shelf

Syntheses of all four possible diastereomers of the acyclonucleoside 9-(1,3,4-trihydroxy-2-butoxymethyl)guanine from carbohydrate precursors

Maccoss, Malcolm ; Chen, Anna ; Tolman, Richard L.

Tetrahedron Letters, 1985, Vol.26(36), pp.4287-4290 [Peer Reviewed Journal]

Full text available

View all versions
18
Material Type:
Article
Add to e-Shelf

Synthesis of the chiral acyclonucleoside antiherpetic agent (S)-9-(2,3-dihydroxy-1-propoxymethyl)guanine

Maccoss, Malcolm ; Chen, Anna ; Tolman, Richard L.

Tetrahedron Letters, 1985, Vol.26(15), pp.1815-1818 [Peer Reviewed Journal]

Full text available

View all versions
19
Material Type:
Article
Add to e-Shelf

The elusive 8-fluoroadenosine: a simple non-enzymatic synthesis and characterization

Butora, Gabor ; Schmitt, Christoph ; Levorse, Dorothy A. ; Streckfuss, Eric ; Doss, George A. ; Maccoss, Malcolm

Tetrahedron, 2007, Vol.63(18), pp.3782-3789 [Peer Reviewed Journal]

Full text available

View all versions
20
Material Type:
Article
Add to e-Shelf

Synthesis of 2′-β- C-methyl-neplanocin derivatives as anti-HCV agents

Liao, Xibin ; Butora, Gabor ; Olsen, David B. ; Carroll, Steven S. ; Mcmasters, Daniel R. ; Leone, Joseph F. ; Stahlhut, Mark ; Doss, George A. ; Yang, Lihu ; Maccoss, Malcolm

Tetrahedron Letters, 2008, Vol.49(26), pp.4149-4152 [Peer Reviewed Journal]

Full text available

View all versions
21
Material Type:
Article
Add to e-Shelf

Synthesis and structure determination of [8- 13C]guanosine 5′-diphosphate

Poe, Martin ; Germershausen, John I. ; Maccoss, Malcolm

Analytical Biochemistry, 1987, Vol.164(2), pp.450-456 [Peer Reviewed Journal]

Full text available

View all versions
22
Material Type:
Article
Add to e-Shelf

17O NMR spectroscopy of nucleoside derivatives; bonding characteristics of pyrimidine carbonyls

Schwartz, Herbert M. ; Maccoss, Malcolm ; Danyluk, Steven S.

Tetrahedron Letters, 1980, Vol.21(40), pp.3837-3840 [Peer Reviewed Journal]

Full text available

View all versions
23
Material Type:
Article
Add to e-Shelf

L-tryptophan urea amides as NK 1 NK 2 dual antagonists

Qi, Hongbo ; Shah, Shrenik K. ; Cascieri, Margaret A. ; Sadowski, Sharon J. ; Maccoss, Malcolm

Bioorganic & Medicinal Chemistry Letters, 1998, Vol.8(16), pp.2259-2262 [Peer Reviewed Journal]

Full text available

View all versions
24
Material Type:
Article
Add to e-Shelf

Synthesis of a peptidyl 2,2-difluoro-4-phenylbutyl ketone and its evaluation as an inhibitor of interleukin-1β converting enzyme.

Mjalli, Adnan M.M. ; Chapman, Kevin T. ; Maccoss, Malcolm

Bioorganic & Medicinal Chemistry Letters, 1993, Vol.3(12), pp.2693-2698 [Peer Reviewed Journal]

Full text available

View all versions
25
Material Type:
Article
Add to e-Shelf

A facile synthesis of the novel Neurokinin A antagonist SR 48968

Hale, Jeffrey J. ; Finke, Paul E. ; Maccoss, Malcolm

Bioorganic & Medicinal Chemistry Letters, 1993, Vol.3(2), pp.319-322 [Peer Reviewed Journal]

Full text available

View all versions
26
Material Type:
Article
Add to e-Shelf

Highly constrained bicyclic VLA-4 antagonists

Chang, Linda L. ; Truong, Quang ; Doss, George A. ; Maccoss, Malcolm ; Lyons, Kathryn ; Mccauley, Ermengilda ; Mumford, Richard ; Forrest, Gail ; Vincent, Stella ; Schmidt, John A. ; Hagmann, William K.

Bioorganic & Medicinal Chemistry Letters, 2007, Vol.17(3), pp.597-601 [Peer Reviewed Journal]

Full text available

View all versions
27
Material Type:
Article
Add to e-Shelf

4-Amino-2-alkyl-butyramides as small molecule CCR2 antagonists with favorable pharmacokinetic properties

Butora, Gabor ; Morriello, Gregori J. ; Kothandaraman, Shankaran ; Guiadeen, Deodialsingh ; Pasternak, Alexander ; Parsons, William H. ; Maccoss, Malcolm ; Vicario, Pasquale P. ; Cascieri, Margaret A. ; Yang, Lihu

Bioorganic & Medicinal Chemistry Letters, 2006, Vol.16(18), pp.4715-4722 [Peer Reviewed Journal]

Full text available

View all versions
28
Material Type:
Article
Add to e-Shelf

Novel, orally bioavailable gamma-aminoamide CC chemokine receptor 2 (CCR2) antagonists

Pasternak, Alexander ; Marino, Dominick ; Vicario, Pasquale P ; Ayala, Julia Marie ; Cascierri, Margaret A ; Parsons, William ; Mills, Sander G ; Maccoss, Malcolm ; Yang, Lihu

Journal of medicinal chemistry, 10 August 2006, Vol.49(16), pp.4801-4 [Peer Reviewed Journal]

Full text available

View all versions
29
Material Type:
Article
Add to e-Shelf

Synthesis and HCV inhibitory properties of 9-deaza- and 7,9-dideaza-7-oxa-2′- C-methyladenosine

Butora, Gabor ; Olsen, David B. ; Carroll, Steven S. ; Mcmasters, Daniel R. ; Schmitt, Christoph ; Leone, Joseph F. ; Stahlhut, Mark ; Burlein, Christine ; Maccoss, Malcolm

Bioorganic & Medicinal Chemistry, 2007, Vol.15(15), pp.5219-5229 [Peer Reviewed Journal]

Full text available

View all versions
30
Material Type:
Article
Add to e-Shelf

Synthesis and evaluation of optically pure dioxolanes as inhibitors of hepatitis C virus RNA replication

Bera, Sanjib ; Malik, Leila ; Bhat, Balkrishen ; Carroll, Steven S ; Maccoss, Malcolm ; Olsen, David B ; Tomassini, Joanne E ; Eldrup, Anne B

Bioorganic & Medicinal Chemistry Letters, 15 December 2003, Vol.13(24), pp.4455-4458 [Peer Reviewed Journal]

Full text available

View all versions
31
Material Type:
Article
Add to e-Shelf

1,3,4-Trisubstituted pyrrolidine CCR5 receptor antagonists. Part 1: discovery of the pyrrolidine scaffold and determination of its stereochemical requirements

Hale, Jeffrey J. ; Budhu, Richard J. ; Mills, Sander G. ; Maccoss, Malcolm ; Malkowitz, Lorraine ; Siciliano, Salvatore ; Gould, Sandra L. ; Demartino, Julie A. ; Springer, Martin S.

Bioorganic & Medicinal Chemistry Letters, 2001, Vol.11(11), pp.1437-1440 [Peer Reviewed Journal]

Full text available

View all versions
32
Material Type:
Article
Add to e-Shelf

Antiviral efficacy upon administration of a HepDirect prodrug of 2'-C-methylcytidine to hepatitis C virus-infected chimpanzees

Carroll, Steven S ; Koeplinger, Kenneth ; Vavrek, Marissa ; Zhang, Nanyan Rena ; Handt, Laurence ; Maccoss, Malcolm ; Olsen, David B ; Reddy, K Raja ; Sun, Zhili ; Van Poelje, Paul D ; Fujitaki, James M ; Boyer, Serge H ; Linemeyer, David L ; Hecker, Scott J ; Erion, Mark D

Antimicrobial agents and chemotherapy, August 2011, Vol.55(8), pp.3854-60 [Peer Reviewed Journal]

Full text available

View all versions
33
Material Type:
Article
Add to e-Shelf

Direct sulfonylation of anilines mediated by visible light

Johnson, Tarn C ; Elbert, Bryony L ; Farley, Alistair J M ; Gorman, Timothy W ; Genicot, Christophe ; Lallemand, Bénédicte ; Pasau, Patrick ; Flasz, Jakub ; Castro, José L ; Maccoss, Malcolm ; Dixon, Darren J ; Paton, Robert S ; Schofield, Christopher J ; Smith, Martin D ; Willis, Michael C

Chemical science, 21 January 2018, Vol.9(3), pp.629-633 [Peer Reviewed Journal]

Full text available

View all versions
34
Material Type:
Article
Add to e-Shelf

Design, synthesis, and structure–activity relationship of novel CCR2 antagonists

Kothandaraman, Shankaran ; Donnely, Karla L. ; Butora, Gabor ; Jiao, Richard ; Pasternak, Alexander ; Morriello, Gregori J. ; Goble, Stephen D. ; Zhou, Changyou ; Mills, Sander G. ; Maccoss, Malcolm ; Vicario, Pasquale P. ; Ayala, Julia M. ; Demartino, Julie A. ; Struthers, Mary ; Cascieri, Margaret A. ; Yang, Lihu

Bioorganic & Medicinal Chemistry Letters, 2009, Vol.19(6), pp.1830-1834 [Peer Reviewed Journal]

Full text available

View all versions
35
Material Type:
Article
Add to e-Shelf

Synthesis and biological evaluation of platensimycin analogs

Shen, Hong C. ; Ding, Fa-Xiang ; Singh, Sheo B. ; Parthasarathy, Gopalakrishnan ; Soisson, Stephen M. ; Ha, Sookhee N. ; Chen, Xun ; Kodali, Srinivas ; Wang, Jun ; Dorso, Karen ; Tata, James R. ; Hammond, Milton L. ; Maccoss, Malcolm ; Colletti, Steven L.

Bioorganic & Medicinal Chemistry Letters, 2009, Vol.19(6), pp.1623-1627 [Peer Reviewed Journal]

Full text available

View all versions
36
Material Type:
Article
Add to e-Shelf

Phosphoramidate prodrugs of 2'-C-methylcytidine for therapy of hepatitis C virus infection

Gardelli, Cristina ; Attenni, Barbara ; Donghi, Monica ; Meppen, Malte ; Pacini, Barbara ; Harper, Steven ; Di Marco, Annalise ; Fiore, Fabrizio ; Giuliano, Claudio ; Pucci, Vincenzo ; Laufer, Ralph ; Gennari, Nadia ; Marcucci, Isabella ; Leone, Joseph F ; Olsen, David B ; Maccoss, Malcolm ; Rowley, Michael ; Narjes, Frank

Journal of medicinal chemistry, 10 September 2009, Vol.52(17), pp.5394-407 [Peer Reviewed Journal]

Full text available

View all versions
37
Material Type:
Article
Add to e-Shelf

Phenylalkyl ketones as potent reversible inhibitors of interleukin-1β converting enzyme

Mjalli, Adnan M.M. ; Chapman, Kevin T. ; Maccoss, Malcolm ; Thornberry, Nancy A.

Bioorganic & Medicinal Chemistry Letters, 1993, Vol.3(12), pp.2689-2692 [Peer Reviewed Journal]

Full text available

View all versions
38