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Integrin alpha4beta7 is downregulated on the surfaces of simian immunodeficiency virus SIVmac239-infected cells

Budde, Melisa L ; Lhost, Jennifer J ; Dudley, Dawn M ; Rakasz, Eva G ; O'Connor, David H

Journal of virology, July 2010, Vol.84(13), pp.6344-51 [Peer Reviewed Journal]

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Cation-pi interaction regulates ligand-binding affinity and signaling of integrin alpha4beta7

Pan, Youdong ; Zhang, Kun ; Qi, Junpeng ; Yue, Jiao ; Springer, Timothy A ; Chen, Jianfeng

Proceedings of the National Academy of Sciences of the United States of America, 14 December 2010, Vol.107(50), pp.21388-93 [Peer Reviewed Journal]

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An integrin alpha4beta7•IgG heterodimeric chimera binds to MAdCAM-1 on high endothelial venules in gut-associated lymphoid tissue

Hoshino, Hitomi ; Kobayashi, Motohiro ; Mitoma, Junya ; Sato, Yoshiko ; Fukuda, Minoru ; Nakayama, Jun

The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society, June 2011, Vol.59(6), pp.572-83 [Peer Reviewed Journal]

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Integrin alpha4beta7 and its counterreceptor MAdCAM-1 contribute to hematopoietic progenitor recruitment into bone marrow following transplantation

Katayama, Yoshio ; Hidalgo, Andrés ; Peired, Anna ; Frenette, Paul S

Blood, 01 October 2004, Vol.104(7), pp.2020-6 [Peer Reviewed Journal]

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Aberrant activation of integrin [alpha]^sub 4^[beta]^sub 7^ suppresses lymphocyte migration to the gut

Carman, Christopher ; Chen, Jianfeng

Journal of Clinical Investigation, Sep 2007, pp.2526-38 [Peer Reviewed Journal]

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The CC' and DE loops in Ig domains 1 and 2 of MAdCAM-1 play different roles in MAdCAM-1 binding to low- and high-affinity integrin alpha4beta7

Sun, Hao ; Wu, Yumei ; Qi, Junpeng ; Pan, Youdong ; Ge, Gaoxiang ; Chen, Jianfeng

The Journal of biological chemistry, 08 April 2011, Vol.286(14), pp.12086-92 [Peer Reviewed Journal]

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Synthesis and structure-activity relationship of mannose-based peptidomimetics selectively blocking integrin alpha4beta7 binding to mucosal addressin cell adhesion molecule-1

Locardi, Elsa ; Boer, Jürgen ; Modlinger, Armin ; Schuster, Anja ; Holzmann, Bernhard ; Kessler, Horst

Journal of medicinal chemistry, 18 December 2003, Vol.46(26), pp.5752-62 [Peer Reviewed Journal]

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The relative influence of metal ion binding sites in the I-like domain and the interface with the hybrid domain on rolling and firm adhesion by integrin alpha4beta7

Chen, Jianfeng ; Takagi, Junichi ; Xie, Can ; Xiao, Tsan ; Luo, Bing-Hao ; Springer, Timothy A

The Journal of biological chemistry, 31 December 2004, Vol.279(53), pp.55556-61 [Peer Reviewed Journal]

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Antibody to alpha4beta7 integrin for ulcerative colitis

Danese, Silvio ; De La Rue, Sarah A ; Gasbarrini, Antonio

The New England journal of medicine, 15 September 2005, Vol.353(11), pp.1180-1; author reply 1180-1 [Peer Reviewed Journal]

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HIV-1 envelope protein binds to and signals through integrin alpha4beta7, the gut mucosal homing receptor for peripheral T cells

Arthos, James ; Cicala, Claudia ; Martinelli, Elena ; Macleod, Katilyn ; Van Ryk, Donald ; Wei, Danlan ; Xiao, Zhen ; Veenstra, Timothy D ; Conrad, Thomas P ; Lempicki, Richard A ; Mclaughlin, Sherry ; Pascuccio, Massimiliano ; Gopaul, Ravindra ; Mcnally, Jonathan ; Cruz, Catherine C ; Censoplano, Nina ; Chung, Eva ; Reitano, Kristin N ; Kottilil, Shyam ; Goode, Diana J ; Fauci, Anthony S

Nature immunology, March 2008, Vol.9(3), pp.301-9 [Peer Reviewed Journal]

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Increased expression of mucosal addressin cell adhesion molecule 1 in the duodenum of patients with active celiac disease is associated with depletion of integrin [alpha] 4 [beta] 7-positive T cells in blood

Di Sabatino, Antonio ; Rovedatti, Laura ; Rosado, Manuela M. ; Carsetti, Rita ; Corazza, Gino R. ; Macdonald, Thomas T.

Human Pathology, May 2009, pp.699-704 [Peer Reviewed Journal]

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The integrin α4β7 forms a complex with cell-surface CD4 and defines a T-cell subset that is highly susceptible to infection by HIV-1

Claudia Cicala ; Elena Martinelli ; Jonathan P. Mcnally ; Diana J. Goode ; Ravindra Gopaul ; Joseph Hiatt ; Katija Jelicic ; Shyamasundaran Kottilil ; Katilyn Macleod ; Angeline O'Shea ; Nikita Patel ; Donald Van Ryk ; Danlan Wei ; Massimiliano Pascuccio ; Ling Yi ; Lyle Mckinnon ; Preson Izulla ; Joshua Kimani ; Rupert Kaul ; Anthony S. Fauci ; James Arthos

Proceedings of the National Academy of Sciences, 08 December 2009, Vol.106(49), p.20877 [Peer Reviewed Journal]

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Preferential expression of the mucosal homing receptor integrin alpha4beta7 in gastrointestinal non-Hodgkin's lymphomas

Drillenburg, Paul ; Koopman, Gerrit ; Dragosics, Brigitte

The American Journal of Pathology, Mar 1997, Vol.150(3), pp.919-27 [Peer Reviewed Journal]

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A pseudosymmetric cell adhesion regulatory domain in the beta7 tail of the integrin alpha4beta7 that interacts with focal adhesion kinase and src

Krissansen, Geoffrey W ; Singh, Jaison ; Kanwar, Rupinder K ; Chan, Yih-Chih ; Leung, Euphemia ; Lehnert, Klaus B ; Kanwar, Jagat R ; Yang, Yi

European journal of immunology, August 2006, Vol.36(8), pp.2203-14 [Peer Reviewed Journal]

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15
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Control of alpha4beta7 integrin expression and CD4 T cell homing by the beta1 integrin subunit

Denucci, Christopher C ; Pagán, Antonio J ; Mitchell, Jason S ; Shimizu, Yoji

Journal of immunology (Baltimore, Md. : 1950), 01 March 2010, Vol.184(5), pp.2458-67 [Peer Reviewed Journal]

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16
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Selective alpha4beta7 integrin antagonists and their potential as antiinflammatory agents

Dubree, Nathan J P ; Artis, Dean R ; Castanedo, Georgette ; Marsters, James ; Sutherlin, Daniel ; Caris, Lisa ; Clark, Kevin ; Keating, Susan M ; Beresini, Maureen H ; Chiu, Henry ; Fong, Sherman ; Lowman, Henry B ; Skelton, Nicholas J ; Jackson, David Y

Journal of medicinal chemistry, 01 August 2002, Vol.45(16), pp.3451-7 [Peer Reviewed Journal]

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17
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The development of experimental autoimmune encephalomyelitis in the mouse requires alpha4-integrin but not alpha4beta7-integrin

Engelhardt, B ; Laschinger, M ; Schulz, M ; Samulowitz, U ; Vestweber, D ; Hoch, G

The Journal of clinical investigation, 15 December 1998, Vol.102(12), pp.2096-105 [Peer Reviewed Journal]

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18
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Epicutaneous challenge of orally immunized mice redirects antigen-specific gut-homing T cells to the skin

Oyoshi, Michiko ; Elkhal, Abdallah ; Scott, Jordan ; Wurbel, Marc-Andre ; Hornick, Jason ; Campbell, James ; Geha, Raif

Journal of Clinical Investigation, Jun 2011, Vol.121(6), pp.2210-20 [Peer Reviewed Journal]

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19
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Alpha4beta7 integrin/MAdCAM-1 adhesion pathway is crucial for B cell migration into pancreatic lymph nodes in nonobese diabetic mice

Xu, Baohui ; Cook, Rachel E ; Michie, Sara A

Journal of autoimmunity, September 2010, Vol.35(2), pp.124-9 [Peer Reviewed Journal]

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20
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Combinatorial and rational strategies to develop nonpeptidic alpha4beta7-integrin antagonists from cyclic peptides

Gottschling, Dirk ; Boer, Jürgen ; Schuster, Anja ; Holzmann, Bernhard ; Kessler, Horst

Angewandte Chemie (International ed. in English), 16 August 2002, Vol.41(16), pp.3007-11 [Peer Reviewed Journal]

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21
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MAdCAM-1 costimulates T cell proliferation exclusively through integrin alpha4beta7, whereas VCAM-1 and CS-1 peptide use alpha4beta1: evidence for "remote" costimulation and induction of hyperresponsiveness to B7 molecules

Lehnert, K ; Print, C G ; Yang, Y ; Krissansen, G W

European journal of immunology, November 1998, Vol.28(11), pp.3605-15 [Peer Reviewed Journal]

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22
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Intestinal recruiting and activation profiles in peripheral blood mononuclear cells in response to pathogen-associated molecular patterns stimulation in patients with IBS

Rodriguez-Fandino, O ; Hernandez-Ruiz, J ; Lopez-Vidal, Y ; Charua, L ; Bandeh-Moghaddam, H ; Minzoni, A ; Guzman, C ; Schmulson, M

Neurogastroenterology and Motility, Nov 2013, Vol.25(11), pp.872-e699 [Peer Reviewed Journal]

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23
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Topographic distribution of homing receptors on B and T cells in human gut-associated lymphoid tissue: Relation of L-selectin and integrin alpha4beta7 to naive and memory phenotypes

Farstad, Inger ; Halstensen, Trond ; Kvale, Dag ; Fausa, Olav ; Brandtzaeg, Per

The American Journal of Pathology, Jan 1997, Vol.150(1), pp.187-99 [Peer Reviewed Journal]

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24
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The mucosal adhesion receptor alpha4beta7 integrin is selectively increased in lymphocytes stimulated with beta-lactoglobulin in children allergic to cow's milk

Eigenmann, P A ; Tropia, L ; Hauser, C

The Journal of allergy and clinical immunology, May 1999, Vol.103(5 Pt 1), pp.931-6 [Peer Reviewed Journal]

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25
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BindingDB Entry 50014010: Synthesis and structure-activity relationship of mannose-based peptidomimetics selectively blocking integrin alpha4beta7 binding to mucosal addressin cell adhesion molecule-1.

BindingDB Liu, Tiqing; Gilson, Michael

2009

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26
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Adhesion between epithelial cells and T lymphocytes mediated by E-cadherin and the alpha E beta 7 integrin.

Cepek, K ; Shaw, S ; Parker, C ; Russell, G ; Morrow, J ; Rimm, D ; Brenner, M

Nature, Nov 10, 1994, pp.190-3 [Peer Reviewed Journal]

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27
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Leukocyte counts in cerebrospinal fluid and blood following firategrast treatment in subjects with relapsing forms of multiple sclerosis

Grove, R. A. ; Shackelford, S. ; Sopper, S. ; Pirruccello, S. ; Horrigan, J. ; Havrdova, E. ; Gold, M. ; Graff, O.

European Journal of Neurology, Jul 2013, Vol.20(7), pp.1032-42 [Peer Reviewed Journal]

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28
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Selective imprinting of gut-homing T cells by Peyer's patch dendritic cells

Manjunath, N ; Weninger, Wolfgang

Nature, Jul 3, 2003, pp.88-93 [Peer Reviewed Journal]

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29
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BindingDB Entry 50037048: Selective alpha4beta7 integrin antagonists and their potential as antiinflammatory agents.

BindingDB Liu, Tiqing; Gilson, Michael

2012

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30
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Glutamate decarboxylase-reactive peripheral blood lymphocytes from patients with IDDM express gut-specific homing receptor alpha4 beta7-integrin

Paronen, Johanna ; Klemetti, Paula ; Kantele, Jussi ; Savilahti, Erkki

Diabetes, Apr 1997, Vol.46(4), pp.583-8 [Peer Reviewed Journal]

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31
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Intestinal dendritic cells increase T cell expression of alpha4beta7 integrin

Stagg, Andrew J ; Kamm, Michael A ; Knight, Stella C

European journal of immunology, May 2002, Vol.32(5), pp.1445-54 [Peer Reviewed Journal]

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32
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How HIV Guts the Immune System

Johnson, R Paul

The New England Journal of Medicine, May 22, 2008, Vol.358(21), pp.2287-9 [Peer Reviewed Journal]

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33
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Notch signaling is necessary for adult, but not fetal, development of ROR[gamma]t+ innate lymphoid cells

Possot, Cécilie ; Schmutz, Sandrine ; Chea, Sylvestre ; Boucontet, Laurent ; Louise, Anne ; Cumano, Ana ; Golub, Rachel

Nature Immunology, Oct 2011, pp.949-58 [Peer Reviewed Journal]

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34
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Treatment of ulcerative colitis with a humanized antibody to the alpha4beta7 integrin

Feagan, Brian G ; Greenberg, Gordon R ; Wild, Gary ; Fedorak, Richard N ; Paré, Pierre ; Mcdonald, John W D ; Dubé, Rejean ; Cohen, Albert ; Steinhart, A Hillary ; Landau, Steven ; Aguzzi, Rasha A ; Fox, Irving H ; Vandervoort, Margaret K

The New England journal of medicine, 16 June 2005, Vol.352(24), pp.2499-507 [Peer Reviewed Journal]

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35
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Despite high levels of lymphocyte homing receptor alpha4beta7 integrin after small bowel allotransplantation, it is not critical for rejection

Kellersmann, R ; Zhong, R ; Grant, D ; Garcia, B ; Blömer, A ; Liu, W ; Wagner, N ; Müller, W ; Jevnikar, A ; Thiede, A ; Lazarovits, A

Transplantation proceedings, September 2000, Vol.32(6), pp.1267-8 [Peer Reviewed Journal]

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36
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Critical amino acid residues of the alpha4 subunit for alpha4beta7 integrin function

Zeller, Y ; Mechtersheimer, S ; Altevogt, P

Journal of cellular biochemistry, 2001, Vol.83(2), pp.304-19 [Peer Reviewed Journal]

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37
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Intestinal mast cell progenitors require CD49dbeta7 (alpha4beta7 integrin) for tissue-specific homing

Gurish, M F ; Tao, H ; Abonia, J P ; Arya, A ; Friend, D S ; Parker, C M ; Austen, K F

The Journal of experimental medicine, 05 November 2001, Vol.194(9), pp.1243-52 [Peer Reviewed Journal]

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38
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Return to sender: Lymphocyte trafficking mechanisms as contributors to primary sclerosing cholangitis

de Krijger, Manon ; Wildenberg, Manon E ; de Jonge, Wouter J ; Ponsioen, Cyriel Y

Journal of Hepatology, September 2019, Vol.71(3), pp.603-615 [Peer Reviewed Journal]

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The Use of Biologics in Patients with Inflammatory Bowel Disease and Primary Sclerosing Cholangitis

Lynch, Kate ; Keshav, Satish ; Chapman, Roger

Current Hepatology Reports, 2019, Vol.18(1), pp.115-126 [Peer Reviewed Journal]

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