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1,3,8-Triazaspiro4.5decane-2,4-diones as efficacious pan-inhibitors of hypoxia-inducible factor prolyl hydroxylase 1-3 (HIF PHD1-3) for the treatment of anemia

Vachal, Petr ; Miao, Shouwu ; Pierce, Joan M ; Guiadeen, Deodial ; Colandrea, Vincent J ; Wyvratt, Matthew J ; Salowe, Scott P ; Sonatore, Lisa M ; Milligan, James A ; Hajdu, Richard ; Gollapudi, Anantha ; Keohane, Carol A ; Lingham, Russell B ; Mandala, Suzanne M ; Demartino, Julie A ; Tong, Xinchun ; Wolff, Michael ; Steinhuebel, Dietrich ; Kieczykowski, Gerard R ; Fleitz

Journal of medicinal chemistry, 12 April 2012, Vol.55(7), pp.2945-59 [Peer Reviewed Journal]

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Discovery of novel BTK inhibitors with carboxylic acids

Gao, Xiaolei ; Wang, James ; Liu, Jian ; Guiadeen, Deodial ; Krikorian, Arto ; Boga, Sobhana Babu ; Alhassan, Abdul-Basit ; Selyutin, Oleg ; Yu, Wensheng ; Yu, Younong ; Anand, Rajan ; Liu, Shilan ; Yang, Chundao ; Wu, Hao ; Cai, Jiaqiang ; Cooper, Alan ; Zhu, Hugh ; Maloney, Kevin ; Gao, Ying-Duo ; Fischmann, Thierry O

Bioorganic & Medicinal Chemistry Letters, 15 March 2017, Vol.27(6), pp.1471-1477 [Peer Reviewed Journal]

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Discovery of 3-morpholino-imidazole[1,5-a]pyrazine BTK inhibitors for rheumatoid arthritis

Boga, Sobhana Babu ; Alhassan, Abdul-Basit ; Liu, Jian ; Guiadeen, Deodial ; Krikorian, Arto ; Gao, Xiaolei ; Wang, James ; Yu, Younong ; Anand, Rajan ; Liu, Shilan ; Yang, Chundao ; Wu, Hao ; Cai, Jiaqiang ; Zhu, Hugh ; Desai, Jagdish ; Maloney, Kevin ; Gao, Ying-Duo ; Fischmann, Thierry O ; Presland, Jeremy ; Mansueto, My

Bioorganic & Medicinal Chemistry Letters, 15 August 2017, Vol.27(16), pp.3939-3943 [Peer Reviewed Journal]

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Potent DGAT1 Inhibitors in the Benzimidazole Class with a Pyridyl-oxy-cyclohexanecarboxylic Acid Moiety

He, Shuwen ; Hong, Qingmei ; Lai, Zhong ; Wu, Zhicai ; Yu, Yang ; Kim, David W ; Ting, Pauline C ; Kuethe, Jeffrey T ; Yang, Ginger X ; Jian, Tianying ; Liu, Jian ; Guiadeen, Deodial ; Krikorian, Arto D ; Sperbeck, Donald M ; Sonatore, Lisa M ; Wiltsie, Judyann ; Chung, Christine C ; Gibson, Jack T ; Lisnock, Jeanmarie ; Murphy

ACS medicinal chemistry letters, 08 August 2013, Vol.4(8), pp.773-8 [Peer Reviewed Journal]

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Discovery of 8-Amino-imidazo[1,5- a ]pyrazines as Reversible BTK Inhibitors for the Treatment of Rheumatoid Arthritis

Liu, Jian ; Guiadeen, Deodial ; Krikorian, Arto ; Gao, Xiaolei ; Wang, James ; Boga, Sobhana Babu ; Alhassan, Abdul-Basit ; Yu, Younong ; Vaccaro, Henry ; Liu, Shilan ; Yang, Chundao ; Wu, Hao ; Cooper, Alan ; de Man, Jos ; Kaptein, Allard ; Maloney, Kevin ; Hornak, Viktor ; Gao, Ying-Duo ; Fischmann, Thierry O ; Raaijmakers, Hans ; Vu-Pham, Diep ; Presland, Jeremy ; Mansueto, My ; Xu, Zangwei ; Leccese, Erica ; Zhang-Hoover, Jie ; Knemeyer, Ian ; Garlisi, Charles G ; Bays, Nathan ; Stivers, Peter ; Brandish, Philip E ; Hicks, Alexandra ; Kim, Ronald ; Kozlowski, Joseph A Argonne National Lab. (Anl), Argonne, Il (United States). Advanced Photon Source (APS) (Corporate Author)

ACS Medicinal Chemistry Letters, 11 February 2016, Vol.7(2) [Peer Reviewed Journal]

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Discovery of a Potent and Selective DGAT1 Inhibitor with a Piperidinyl-oxy-cyclohexanecarboxylic Acid Moiety

He, Shuwen ; Hong, Qingmei ; Lai, Zhong ; Yang, David X ; Ting, Pauline C ; Kuethe, Jeffrey T ; Cernak, Timothy A ; Dykstra, Kevin D ; Sperbeck, Donald M ; Wu, Zhicai ; Yu, Yang ; Yang, Ginger X ; Jian, Tianying ; Liu, Jian ; Guiadeen, Deodial ; Krikorian, Arto D ; Sonatore, Lisa M ; Wiltsie, Judyann ; Liu, Jinqi ; Gorski

ACS medicinal chemistry letters, 09 October 2014, Vol.5(10), pp.1082-7 [Peer Reviewed Journal]

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Accelerating the discovery of DGAT1 inhibitors through the application of parallel medicinal chemistry (PMC)

Yu, Yang ; Wu, Zhicai ; Shi, Zhi-Cai ; He, Shuwen ; Lai, Zhong ; Cernak, Timothy A ; Vachal, Petr ; Liu, Min ; Liu, Jian ; Hong, Qingmei ; Jian, Tianying ; Guiadeen, Deodial ; Krikorian, Arto ; Sperbeck, Donald M ; Verras, Andreas ; Sonatore, Lisa M ; Murphy, Beth A ; Wiltsie, Judyann ; Chung, Christine C ; Gorski, Judith N

Bioorganic & Medicinal Chemistry Letters, 01 June 2019, Vol.29(11), pp.1380-1385 [Peer Reviewed Journal]

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Benzimidazole-based DGAT1 inhibitors with a [3.1.0] bicyclohexane carboxylic acid moiety

He, Shuwen ; Lai, Zhong ; Hong, Qingmei ; Shang, Jackie ; Reibarkh, Mikhail ; Kuethe, Jeffrey T ; Liu, Jian ; Guiadeen, Deodial ; Krikorian, Arto D ; Cernak, Timothy A ; Dykstra, Kevin D ; Sperbeck, Donald M ; Wu, Zhicai ; Yu, Yang ; Yang, Ginger X ; Jian, Tianying ; Verras, Andreas ; Sonatore, Lisa M ; Wiltsie, Judyann ; Chung, Christine C

Bioorganic & Medicinal Chemistry Letters, 15 May 2019, Vol.29(10), pp.1182-1186 [Peer Reviewed Journal]

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11
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15
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Graphical abstract TOC

Bioorganic & Medicinal Chemistry Letters, 15 May 2019, Vol.29(10), pp.IBC-IBC [Peer Reviewed Journal]

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U.S. Patent and Trademark Office Receives Merck Sharp & Dohme's Patent Application for Btk Inhibitors

Global IP News. Pharmaceutical Patent News, Dec 3, 2017

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Intervet International BV Submits Patent Application for Imidazole Derivatives

Global IP News. Pharmaceutical Patent News, Jul 1, 2014

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18
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Intervet Int BV Files Australian Patent Application for Imidazole Derivatives

Global IP News. Pharmaceutical Patent News, Dec 19, 2013

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19
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WIPO PUBLISHES PATENT OF MERCK SHARP & DOHME FOR "IMIDAZOLE DERIVATIVES" (AMERICAN INVENTORS)

US Fed News Service, Including US State News, Feb 7, 2012

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U.S. Patent and Trademark Office Releases Merck Sharp & Dohme's Patent Application for Btk Inhibitors

Global IP News. Pharmaceutical Patent News, Dec 8, 2017

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Merck Sharp & Dohme Gets Patent for Substituted Imidazo[1,5-A]Pyrazines as Btk Inhibitors

Global IP News. Pharmaceutical Patent News, Aug 8, 2018

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Merck Sharp & Dohme Assigned Patent for Allosteric Modulators of Nicotinic Acetylcholine Receptors

Targeted News Service, Dec 15, 2017

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23
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Merck Sharp & Dohme Corp Files Patent Application for Allosteric Modulators of Nicotinic Acetylcholine Receptors

Indian Patents News, Oct 12, 2018

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Merck Sharp & Dohme Gets Patent for Benzamide Imidazopyrazine Btk Inhibitors

Global IP News. Pharmaceutical Patent News, Oct 3, 2018

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25
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Merck Sharp & Dohme Applies for Patent on Tertiary Alcohol Imidazopyrazine Btk Inhibitors

Global IP News. Pharmaceutical Patent News, Dec 1, 2017

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Merck Sharp & Dohme Gets Patent for BTK Inhibitors

Global IP News. Pharmaceutical Patent News, Nov 21, 2018

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27
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WIPO PUBLISHES PATENT OF MERCK SHARP & DOHME FOR "IMIDAZOLE DERIVATIVES" (AMERICAN INVENTORS)

US Fed News Service, Including US State News, Apr 5, 2012

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U.S. Patent and Trademark Office Releases Merck Sharp & Dohme's Patent Application for Btk Inhibitors

Global IP News. Pharmaceutical Patent News, May 4, 2018

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Merck Sharp & Dohme Gets Patent for Allosteric Modulators of Nicotinic Acetylcholine Receptors

Global IP News. Pharmaceutical Patent News, Dec 12, 2017

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Merck Sharp & Dohme Granted Patent for BTK Inhibitors

Global IP News. Pharmaceutical Patent News, Feb 27, 2019

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31
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Merck Sharp & Dohme Obtains Patent for Tertiary Alcohol Imidazopyrazine BTK Inhibitors

Global IP News. Pharmaceutical Patent News, Feb 20, 2019

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Merck Sharp & Dohme Applies for Patent on Allosteric Modulators of Nicotinic Acetylcholine Receptors

Global IP News. Pharmaceutical Patent News, Nov 8, 2019

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Merck Sharp & Dohme Files United States Patent Application for Substituted Bicyclic Heteroaryl Allosteric Modulators of Nicotinic Acetylcholine Receptors

Global IP News. Pharmaceutical Patent News, Oct 11, 2019

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US Patent Issued to Merck Sharp & Dohme on Feb. 19 for "Tertiary alcohol imidazopyrazine BTK inhibitors" (American, Chinese Inventors)

US Fed News Service, Including US State News, Feb 19, 2019

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Graphical abstract TOC continued

Bioorganic & Medicinal Chemistry Letters, 01 June 2019, Vol.29(11), pp.I-VII [Peer Reviewed Journal]

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U.S. Patents Awarded to Inventors in Pennsylvania (Dec. 15)

Targeted News Service, Dec 15, 2017

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37
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U.S. Patents Awarded to Inventors in New Jersey (Dec. 15)

Targeted News Service, Dec 15, 2017

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