skip to main content
Language:
Search Limited to: Search Limited to: Resource type Show Results with: Show Results with: Index

32 Results  for Everything (Includes Articles)

Show only
Result Number Material Type Add to My Shelf Action Record Details and Options
1
Discovery of Highly Potent and Selective Small Molecule ADAMTS‑5 Inhibitors That Inhibit Human Cartilage Degradation via Encoded Library Technology (ELT)
Material Type:
Article
Add to e-Shelf

Discovery of Highly Potent and Selective Small Molecule ADAMTS5 Inhibitors That Inhibit Human Cartilage Degradation via Encoded Library Technology (ELT)

Deng, Hongfeng ; O’Keefe, Heather ; Davie, Christopher P ; Lind, Kenneth E ; Acharya, Raksha A ; Franklin, G. Joseph ; Larkin, Jonathan ; Matico, Rosalie ; Neeb, Michael ; Thompson, Monique M ; Lohr, Thomas ; Gross, Jeffrey W ; Centrella, Paolo A ; O’Donovan, Gary K ; Bedard, Katie L. (Sargent) ; van Vloten, Kurt ; Mataruse, Sibongile ; Skinner, Steven R ; Belyanskaya, Svetlana L ; Carpenter, Tiffany Y ; Shearer, Todd W ; Clark, Matthew A ; Cuozzo, John W ; Arico-Muendel, Christopher C ; Morgan, Barry A

Journal of medicinal chemistry, 2012-08-23, Vol.55 (16), p.7061-7079 [Peer Reviewed Journal]

Full text available

2
Studies from State University of Campinas (UNICAMP) Provide New Data on Medicinal Chemistry (Discovery of highly potent and selective antiparasitic new oxadiazole and hydroxy-oxindole small molecule hybrids)
Material Type:
Journal
Add to e-Shelf

Studies from State University of Campinas (UNICAMP) Provide New Data on Medicinal Chemistry (Discovery of highly potent and selective antiparasitic new oxadiazole and hydroxy-oxindole small molecule hybrids)

Health & Medicine Week, 2020-07-17, p.6765

Full text available

3
Discovery of Highly Potent, Selective, and Efficacious Small Molecule Inhibitors of ERK1/2
Material Type:
Article
Add to e-Shelf

Discovery of Highly Potent, Selective, and Efficacious Small Molecule Inhibitors of ERK1/2

Ren, Li ; Grina, Jonas ; Moreno, David ; Blake, James F ; Gaudino, John J ; Garrey, Rustam ; Metcalf, Andrew T ; Burkard, Michael ; Martinson, Matthew ; Rasor, Kevin ; Chen, Huifen ; Dean, Brian ; Gould, Stephen E ; Pacheco, Patricia ; Shahidi-Latham, Sheerin ; Yin, Jianping ; West, Kristina ; Wang, Weiru ; Moffat, John G ; Schwarz, Jacob B

Journal of medicinal chemistry, 2015-02-26, Vol.58 (4), p.1976-1991 [Peer Reviewed Journal]

Full text available

4
Discovery of highly potent and selective antiparasitic new oxadiazole and hydroxy-oxindole small molecule hybrids
Material Type:
Article
Add to e-Shelf

Discovery of highly potent and selective antiparasitic new oxadiazole and hydroxy-oxindole small molecule hybrids

Fernandes, Fábio S ; Santos, Hugo ; Lima, Samia R ; Conti, Caroline ; Rodrigues, Manoel T ; Zeoly, Lucas A ; Ferreira, Leonardo L.G ; Krogh, Renata ; Andricopulo, Adriano D ; Coelho, Fernando

European journal of medicinal chemistry, 2020-09-01, Vol.201, p.112418 [Peer Reviewed Journal]

Full text available

5
Discovery of a Potent, Highly Selective, and Orally Efficacious Small-Molecule Activator of the Insulin Receptor
Material Type:
Article
Add to e-Shelf

Discovery of a Potent, Highly Selective, and Orally Efficacious Small-Molecule Activator of the Insulin Receptor

Liu, Kun ; Xu, Libo ; Szalkowski, Deborah ; Li, Zhihua ; Ding, Victor ; Kwei, Gloria ; Huskey, Su ; Moller, David E ; Heck, James V ; Zhang, Bei B ; Jones, A. Brian

Journal of medicinal chemistry, 2000-09-21, Vol.43 (19), p.3487-3494 [Peer Reviewed Journal]

Full text available

6
Abstract 797: Discovery of a highly selective and potent small molecule inhibitor against c-MET for cancer therapy
Material Type:
Article
Add to e-Shelf

Abstract 797: Discovery of a highly selective and potent small molecule inhibitor against c-MET for cancer therapy

Bao, Rudi ; Pan, Zhongzong ; Zhao, Zhiming ; Yu, Hongping ; Xu, Yaochang

Cancer research (Chicago, Ill.), 2015-08-01, Vol.75 (15 Supplement), p.797-797 [Peer Reviewed Journal]

Full text available

7
Discovery of Highly Potent, Selective, and Brain-Penetrable Leucine-Rich Repeat Kinase 2 (LRRK2) Small Molecule Inhibitors
Material Type:
Article
Add to e-Shelf

Discovery of Highly Potent, Selective, and Brain-Penetrable Leucine-Rich Repeat Kinase 2 (LRRK2) Small Molecule Inhibitors

Estrada, Anthony A ; Liu, Xingrong ; Baker-Glenn, Charles ; Beresford, Alan ; Burdick, Daniel J ; Chambers, Mark ; Chan, Bryan K ; Chen, Huifen ; Ding, Xiao ; DiPasquale, Antonio G ; Dominguez, Sara L ; Dotson, Jennafer ; Drummond, Jason ; Flagella, Michael ; Flynn, Sean ; Fuji, Reina ; Gill, Andrew ; Gunzner-Toste, Janet ; Harris, Seth F ; Heffron, Timothy P ; Kleinheinz, Tracy ; Lee, Donna W ; Le Pichon, Claire E ; Lyssikatos, Joseph P ; Medhurst, Andrew D ; Moffat, John G ; Mukund, Susmith ; Nash, Kevin ; Scearce-Levie, Kimberly ; Sheng, Zejuan ; Shore, Daniel G ; Tran, Thuy ; Trivedi, Naimisha ; Wang, Shumei ; Zhang, Shuo ; Zhang, Xiaolin ; Zhao, Guiling ; Zhu, Haitao ; Sweeney, Zachary K

Journal of medicinal chemistry, 2012-11-26, Vol.55 (22), p.9416-9433 [Peer Reviewed Journal]

Full text available

8
Abstract 2939: Discovery and synthesis of highly potent and selective small molecule inhibitors of the histone methyltransferase EZH2
Material Type:
Article
Add to e-Shelf

Abstract 2939: Discovery and synthesis of highly potent and selective small molecule inhibitors of the histone methyltransferase EZH2

Verma, Sharad K ; LaFrance, Louis V ; Tian, Xinrong ; Newlander, Ken ; Duquenne, Céline ; Suarez, Dominic ; Knight, Steven D ; Burgess, Joelle ; Brackley, James ; Johnson, Neil W ; Graves, Alan P ; Mellinger, Mark ; Romeril, Stuart ; Grant, Seth W ; Scherzer, Daryl ; Shu, Art ; Creasy, Caretha L ; Kruger, Ryan ; Diaz, Elsie ; Le, Baochau ; Thompson, Christine ; Morgan-Ott, Heidi ; McCabe, Michael T ; McHugh, Charles F ; Miller, William H ; Tummino, Peter ; Dhanak, Dash

Cancer research (Chicago, Ill.), 2012-04-15, Vol.72 (8 Supplement), p.2939-2939 [Peer Reviewed Journal]

Full text available

9
Discovery of Highly Potent, Selective, and Brain-Penetrant Aminopyrazole Leucine-Rich Repeat Kinase 2 (LRRK2) Small Molecule Inhibitors
Material Type:
Article
Add to e-Shelf

Discovery of Highly Potent, Selective, and Brain-Penetrant Aminopyrazole Leucine-Rich Repeat Kinase 2 (LRRK2) Small Molecule Inhibitors

Estrada, Anthony A ; Chan, Bryan K ; Baker-Glenn, Charles ; Beresford, Alan ; Burdick, Daniel J ; Chambers, Mark ; Chen, Huifen ; Dominguez, Sara L ; Dotson, Jennafer ; Drummond, Jason ; Flagella, Michael ; Fuji, Reina ; Gill, Andrew ; Halladay, Jason ; Harris, Seth F ; Heffron, Timothy P ; Kleinheinz, Tracy ; Lee, Donna W ; Pichon, Claire E. Le ; Liu, Xingrong ; Lyssikatos, Joseph P ; Medhurst, Andrew D ; Moffat, John G ; Nash, Kevin ; Scearce-Levie, Kimberly ; Sheng, Zejuan ; Shore, Daniel G ; Wong, Susan ; Zhang, Shuo ; Zhang, Xiaolin ; Zhu, Haitao ; Sweeney, Zachary K

Journal of medicinal chemistry, 2014-02-13, Vol.57 (3), p.921-936 [Peer Reviewed Journal]

Full text available

10
Discovery of Highly Potent and Selective Small-Molecule Reversible Factor D Inhibitors Demonstrating Alternative Complement Pathway Inhibition in Vivo
Material Type:
Article
Add to e-Shelf

Discovery of Highly Potent and Selective Small-Molecule Reversible Factor D Inhibitors Demonstrating Alternative Complement Pathway Inhibition in Vivo

Lorthiois, Edwige ; Anderson, Karen ; Vulpetti, Anna ; Rogel, Olivier ; Cumin, Frederic ; Ostermann, Nils ; Steinbacher, Stefan ; Mac Sweeney, Aengus ; Delgado, Omar ; Liao, Sha-Mei ; Randl, Stefan ; Rüdisser, Simon ; Dussauge, Solene ; Fettis, Kamal ; Kieffer, Laurence ; de Erkenez, Andrea ; Yang, Louis ; Hartwieg, Constanze ; Argikar, Upendra A ; La Bonte, Laura R ; Newton, Ronald ; Kansara, Viral ; Flohr, Stefanie ; Hommel, Ulrich ; Jaffee, Bruce ; Maibaum, Jürgen

Journal of medicinal chemistry, 2017-07-13, Vol.60 (13), p.5717-5735 [Peer Reviewed Journal]

Full text available

11
Discovery of fruquintinib, a potent and highly selective small molecule inhibitor of VEGFR 1, 2, 3 tyrosine kinases for cancer therapy
Material Type:
Article
Add to e-Shelf

Discovery of fruquintinib, a potent and highly selective small molecule inhibitor of VEGFR 1, 2, 3 tyrosine kinases for cancer therapy

Sun, Qiaoling ; Zhou, Jinghong ; Zhang, Zheng ; Guo, Mingchuan ; Liang, Junqing ; Zhou, Feng ; Long, Jingwen ; Zhang, Wei ; Yin, Fang ; Cai, Huaqing ; Yang, Haibin ; Zhang, Weihan ; Gu, Yi ; Ni, Liang ; Sai, Yang ; Cui, Yumin ; Zhang, Meifang ; Hong, Minhua ; Sun, Junen ; Yang, Zheng ; Qing, Weiguo ; Su, Weiguo ; Ren, Yongxin

Cancer Biology & Therapy, 2014-12-02, Vol.15 (12), p.1635-1645 [Peer Reviewed Journal]

Full text available

12
Researchers from Novartis Report Recent Findings in Medicinal Chemistry (Discovery of Highly Potent and Selective Small-Molecule Reversible Factor D Inhibitors Demonstrating Alternative Complement Pathway Inhibition in Vivo)
Material Type:
Journal
Add to e-Shelf
13
Health and Medicine - Medicinal Chemistry; Studies from State University of Campinas (UNICAMP) Provide New Data on Medicinal Chemistry (Discovery of highly potent and selective antiparasitic new oxadiazole and hydroxy-oxindole small molecule hybrids)
Material Type:
Newspaper Article
Add to e-Shelf
14
Health and Medicine - Medicinal Chemistry; Researchers from Novartis Report Recent Findings in Medicinal Chemistry (Discovery of Highly Potent and Selective Small-Molecule Reversible Factor D Inhibitors Demonstrating Alternative Complement Pathway Inhibition in Vivo)
Material Type:
Newspaper Article
Add to e-Shelf
15
Current and emerging therapeutic strategies for preventing inflammation and aggrecanase-mediated cartilage destruction in arthritis
Material Type:
Article
Add to e-Shelf

Current and emerging therapeutic strategies for preventing inflammation and aggrecanase-mediated cartilage destruction in arthritis

Dancevic, Carolyn M ; McCulloch, Daniel R

Arthritis research & therapy, 2014, Vol.16 (5), p.429 [Peer Reviewed Journal]

Full text available

16
Prioritizing multiple therapeutic targets in parallel using automated DNA-encoded library screening
Material Type:
Article
Add to e-Shelf

Prioritizing multiple therapeutic targets in parallel using automated DNA-encoded library screening

Machutta, Carl A ; Kollmann, Christopher S ; Lind, Kenneth E ; Bai, Xiaopeng ; Chan, Pan F ; Huang, Jianzhong ; Ballell, Lluis ; Belyanskaya, Svetlana ; Besra, Gurdyal S ; Barros-Aguirre, David ; Bates, Robert H ; Centrella, Paolo A ; Chang, Sandy S ; Chai, Jing ; Choudhry, Anthony E ; Coffin, Aaron ; Davie, Christopher P ; Deng, Hongfeng ; Deng, Jianghe ; Ding, Yun ; Dodson, Jason W ; Fosbenner, David T ; Gao, Enoch N ; Graham, Taylor L ; Graybill, Todd L ; Ingraham, Karen ; Johnson, Walter P ; King, Bryan W ; Kwiatkowski, Christopher R ; Lelièvre, Joël ; Li, Yue ; Liu, Xiaorong ; Lu, Quinn ; Lehr, Ruth ; Mendoza-Losana, Alfonso ; Martin, John ; McCloskey, Lynn ; McCormick, Patti ; O’Keefe, Heather P ; O’Keeffe, Thomas ; Pao, Christina ; Phelps, Christopher B ; Qi, Hongwei ; Rafferty, Keith ; Scavello, Genaro S ; Steiginga, Matt S ; Sundersingh, Flora S ; Sweitzer, Sharon M ; Szewczuk, Lawrence M ; Taylor, Amy ; Toh, May Fern ; Wang, Juan ; Wang, Minghui ; Wilkins, Devan J ; Xia, Bing ; Yao, Gang ; Zhang, Jean ; Zhou, Jingye ; Donahue, Christine P ; Messer, Jeffrey A ; Holmes, David ; Arico-Muendel, Christopher C ; Pope, Andrew J ; Gross, Jeffrey W ; Evindar, Ghotas

Nature communications, 2017, Vol.8 (1), p.16081 [Peer Reviewed Journal]

Full text available

17
Encoded Library Synthesis Using Chemical Ligation and the Discovery of sEH Inhibitors from a 334-Million Member Library
Material Type:
Article
Add to e-Shelf

Encoded Library Synthesis Using Chemical Ligation and the Discovery of sEH Inhibitors from a 334-Million Member Library

Litovchick, Alexander ; Dumelin, Christoph E ; Habeshian, Sevan ; Gikunju, Diana ; Guié, Marie-Aude ; Centrella, Paolo ; Zhang, Ying ; Sigel, Eric A ; Cuozzo, John W ; Keefe, Anthony D ; Clark, Matthew A

Scientific reports, 2015, Vol.5 (1), p.10916 [Peer Reviewed Journal]

Full text available

18
Directed Chemical Evolution with an Outsized Genetic Code
Material Type:
Article
Add to e-Shelf

Directed Chemical Evolution with an Outsized Genetic Code

Krusemark, Casey J ; Tilmans, Nicolas P ; Brown, Patrick O ; Harbury, Pehr B Isalan, Mark

PloS one, 2016, Vol.11 (8), p.e0154765 [Peer Reviewed Journal]

Full text available

19
The IL-1[beta]/AP-1/miR-30a/ADAMTS-5 axis regulates cartilage matrix degradation in human osteoarthritis
Material Type:
Article
Add to e-Shelf

The IL-1[beta]/AP-1/miR-30a/ADAMTS-5 axis regulates cartilage matrix degradation in human osteoarthritis

Quanbo Ji ; Xiaojie Xu ; Qiang Zhang ; Lei Kang ; Yameng Xu ; Ke Zhang ; Ling Li ; Yingchun Liang ; Tian Hong ; Qinong Ye ; Yan Wang

Journal of molecular medicine (Berlin, Germany), 2016-07-01, Vol.94 (7), p.771 [Peer Reviewed Journal]

Full text available

20
Tendons – time to revisit inflammation
Material Type:
Article
Add to e-Shelf

Tendons – time to revisit inflammation

Rees, Jonathan D ; Stride, Matthew ; Scott, Alex

British Journal of Sports Medicine, 2014-11, Vol.48 (21), p.1553-1557 [Peer Reviewed Journal]

Full text available

21
The role of aggrecan in normal and osteoarthritic cartilage
Material Type:
Article
Add to e-Shelf

The role of aggrecan in normal and osteoarthritic cartilage

Roughley, Peter J ; Mort, John S

Journal of experimental orthopaedics, 2014, Vol.1 (1), p.1-11 [Peer Reviewed Journal]

Full text available

22
Versatile protein recognition by the encoded display of multiple chemical elements on a constant macrocyclic scaffold
Material Type:
Article
Add to e-Shelf

Versatile protein recognition by the encoded display of multiple chemical elements on a constant macrocyclic scaffold

Yizhou Li ; Roberto De Luca ; Samuele Cazzamalli ; Francesca Pretto ; Davor Bajic ; Jörg Scheuermann ; Dario Neri

Nature chemistry, 2018-04-01, Vol.10 (4), p.441-448 [Peer Reviewed Journal]

Full text available

23
Design and Construction of a Focused DNA-Encoded Library for Multivalent Chromatin Reader Proteins
Material Type:
Article
Add to e-Shelf

Design and Construction of a Focused DNA-Encoded Library for Multivalent Chromatin Reader Proteins

Rectenwald, Justin M ; Guduru, Shiva Krishna Reddy ; Dang, Zhao ; Collins, Leonard B ; Liao, Yi-En ; Norris-Drouin, Jacqueline L ; Cholensky, Stephanie H ; Kaufmann, Kyle W ; Hammond, Scott M ; Kireev, Dmitri B ; Frye, Stephen V ; Pearce, Kenneth H

Molecules (Basel, Switzerland), 2020-02-22, Vol.25 (4), p.979 [Peer Reviewed Journal]

Full text available

24
Interleukin-1[beta]-mediated suppression of microRNA-27a-3p activity in human cartilage via MAPK and NF-[kappa]B pathways: A potential mechanism of osteoarthritis pathogenesis
Material Type:
Article
Add to e-Shelf