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1
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Chemoselective Peptide Modification via Photocatalytic Tryptophan β-Position Conjugation

Yu, Younong ; Zhang, Li-Kang ; Buevich, Alexei V ; Li, Guoqing ; Tang, Haiqun ; Vachal, Petr ; Colletti, Steven L ; Shi, Zhi-Cai

Journal of the American Chemical Society, 06 June 2018, Vol.140(22), pp.6797-6800 [Peer Reviewed Journal]

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2
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A new synthesis of 3,4-disubstituted 1,2,5-thiadiazoles

Biju, Purakkattle ; Yu, Younong

Tetrahedron Letters, 2007, Vol.48(30), pp.5279-5282 [Peer Reviewed Journal]

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3
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Synthesis of the oxygenated pactamycin core

Knapp, Spencer ; Yu, Younong

Organic letters, 29 March 2007, Vol.9(7), pp.1359-62 [Peer Reviewed Journal]

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4
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Discovery of novel BTK inhibitors with carboxylic acids

Gao, Xiaolei ; Wang, James ; Liu, Jian ; Guiadeen, Deodial ; Krikorian, Arto ; Boga, Sobhana Babu ; Alhassan, Abdul-Basit ; Selyutin, Oleg ; Yu, Wensheng ; Yu, Younong ; Anand, Rajan ; Liu, Shilan ; Yang, Chundao ; Wu, Hao ; Cai, Jiaqiang ; Cooper, Alan ; Zhu, Hugh ; Maloney, Kevin ; Gao, Ying-Duo ; Fischmann, Thierry O

Bioorganic & Medicinal Chemistry Letters, 15 March 2017, Vol.27(6), pp.1471-1477 [Peer Reviewed Journal]

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5
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Quality by design (QbD) of amide isosteres: 5,5-Disubstituted isoxazolines as potent CRTh2 antagonists with favorable pharmacokinetic and drug-like properties

Xiao, Dong ; Zhu, Xiaohong ; Yu, Younong ; Shao, Ning ; Wu, Jie ; Mccormick, Kevin D ; Dhondi, Pawan ; Qin, Jun ; Mazzola, Robert ; Tang, Haiqun ; Rao, Ashwin ; Siliphaivanh, Phieng ; Qiu, Hongchen ; Yang, Xiaoxin ; Rivelli, Maria ; Garlisi, Charles G ; Eckel, Steve ; Mukhopadhyay, Gitali ; Correll, Craig ; Rindgen, Diane

Bioorganic & Medicinal Chemistry Letters, 15 March 2014, Vol.24(6), pp.1615-1620 [Peer Reviewed Journal]

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6
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Discovery of 3-morpholino-imidazole[1,5-a]pyrazine BTK inhibitors for rheumatoid arthritis

Boga, Sobhana Babu ; Alhassan, Abdul-Basit ; Liu, Jian ; Guiadeen, Deodial ; Krikorian, Arto ; Gao, Xiaolei ; Wang, James ; Yu, Younong ; Anand, Rajan ; Liu, Shilan ; Yang, Chundao ; Wu, Hao ; Cai, Jiaqiang ; Zhu, Hugh ; Desai, Jagdish ; Maloney, Kevin ; Gao, Ying-Duo ; Fischmann, Thierry O ; Presland, Jeremy ; Mansueto, My

Bioorganic & Medicinal Chemistry Letters, 15 August 2017, Vol.27(16), pp.3939-3943 [Peer Reviewed Journal]

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7
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Use of molecular modeling aided design to dial out hERG liability in adenosine A2A receptor antagonists

Deng, Qiaolin ; Lim, Yeon-Hee ; Anand, Rajan ; Yu, Younong ; Kim, Jae-Hun ; Zhou, Wei ; Zheng, Junying ; Tempest, Paul ; Levorse, Dorothy ; Zhang, Xiaoping ; Greene, Scott ; Mullins, Deborra ; Culberson, Chris ; Sherborne, Brad ; Parker, Eric M ; Stamford, Andrew ; Ali, Amjad

Bioorganic & Medicinal Chemistry Letters, 01 August 2015, Vol.25(15), pp.2958-2962 [Peer Reviewed Journal]

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8
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Substituted dibenzoc,hcinnolines: topoisomerase I-targeting anticancer agents

Yu, Younong ; Singh, Sudhir K ; Liu, Angela ; Li, Tsai-Kun ; Liu, Leroy F ; Lavoie, Edmond J

Bioorganic & medicinal chemistry, 03 April 2003, Vol.11(7), pp.1475-91 [Peer Reviewed Journal]

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Discovery of 8-Amino-imidazo[1,5- a ]pyrazines as Reversible BTK Inhibitors for the Treatment of Rheumatoid Arthritis

Liu, Jian ; Guiadeen, Deodial ; Krikorian, Arto ; Gao, Xiaolei ; Wang, James ; Boga, Sobhana Babu ; Alhassan, Abdul-Basit ; Yu, Younong ; Vaccaro, Henry ; Liu, Shilan ; Yang, Chundao ; Wu, Hao ; Cooper, Alan ; de Man, Jos ; Kaptein, Allard ; Maloney, Kevin ; Hornak, Viktor ; Gao, Ying-Duo ; Fischmann, Thierry O ; Raaijmakers, Hans ; Vu-Pham, Diep ; Presland, Jeremy ; Mansueto, My ; Xu, Zangwei ; Leccese, Erica ; Zhang-Hoover, Jie ; Knemeyer, Ian ; Garlisi, Charles G ; Bays, Nathan ; Stivers, Peter ; Brandish, Philip E ; Hicks, Alexandra ; Kim, Ronald ; Kozlowski, Joseph A Argonne National Lab. (Anl), Argonne, Il (United States). Advanced Photon Source (APS) (Corporate Author)

ACS Medicinal Chemistry Letters, 11 February 2016, Vol.7(2) [Peer Reviewed Journal]

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10
Identification of Oxidation Products of (−)-Epigallocatechin Gallate and (−)-Epigallocatechin with H 2 O 2
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Identification of Oxidation Products of (−)-Epigallocatechin Gallate and (−)-Epigallocatechin with H 2 O 2

Zhu, Nanqun ; Huang, Tzou-Chi ; Yu, Younong ; Lavoie, Edmond J. ; Yang, Chung S. ; Ho, Chi-Tang

Journal of Agricultural and Food Chemistry, 04/2000, Vol.48(4), pp.979-981 [Peer Reviewed Journal]

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11
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Discovery of 2-hydroxy-N,N-dimethyl-3-{2-(R)-1-(5- methylfuran-2-yl)propylamino-3,4-dioxocyclobut-1-enylamino}benzamide (SCH 527123): a potent, orally bioavailable CXCR2/CXCR1 receptor antagonist

Dwyer, Michael P ; Yu, Younong ; Chao, Jianping ; Aki, Cynthia ; Chao, Jianhua ; Biju, Purakkattle ; Girijavallabhan, Viyyoor ; Rindgen, Diane ; Bond, Richard ; Mayer-Ezel, Rosemary ; Jakway, James ; Hipkin, R William ; Fossetta, James ; Gonsiorek, Waldemar ; Bian, Hong ; Fan, Xuedong ; Terminelli, Carol ; Fine, Jay ; Lundell, Daniel ; Merritt

Journal of medicinal chemistry, 28 December 2006, Vol.49(26), pp.7603-6 [Peer Reviewed Journal]

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12
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Fluoroalkyl α side chain containing 3,4-diamino-cyclobutenediones as potent and orally bioavailable CXCR2–CXCR1 dual antagonists

Biju, Purakkattle ; Taveras, Arthur G ; Dwyer, Michael P ; Yu, Younong ; Chao, Jianhua ; Hipkin, R. William ; Fan, Xuedong ; Rindgen, Diane ; Fine, Jay ; Lundell, Daniel

Bioorganic & Medicinal Chemistry Letters, 2009, Vol.19(5), pp.1431-1433 [Peer Reviewed Journal]

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13
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3,4-Diamino-1,2,5-thiadiazole as potent and selective CXCR2 antagonists

Biju, Purakkattle ; Taveras, Arthur G ; Yu, Younong ; Zheng, Junying ; Hipkin, R. William ; Fossetta, James ; Fan, Xuedong ; Fine, Jay ; Lundell, Daniel

Bioorganic & Medicinal Chemistry Letters, 2009, Vol.19(5), pp.1434-1437 [Peer Reviewed Journal]

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14
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Research Dataset
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CCDC 621055: Experimental Crystal Structure Determination

Knapp, S. ; Yu, Younong

2007

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15
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Article
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Diaminocyclobutenediones as potent and orally bioavailable CXCR2 receptor antagonists: SAR in the phenolic amide region

Aki, Cynthia ; Chao, Jianping ; Ferreira, Johan A ; Dwyer, Michael P ; Yu, Younong ; Chao, Jianhua ; Merritt, Robert J ; Lai, Gaifa ; Wu, Minglang ; Hipkin, R. William ; Fan, Xuedong ; Gonsiorek, Waldemar ; Fosseta, James ; Rindgen, Diane ; Fine, Jay ; Lundell, Daniel ; Taveras, Arthur G ; Biju, Purakkattle

Bioorganic & Medicinal Chemistry Letters, 01 August 2009, Vol.19(15), pp.4446-4449 [Peer Reviewed Journal]

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16
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Article
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3,4-Diamino-2,5-thiadiazole-1-oxides as potent CXCR2/CXCR1 antagonists

Biju, Purakkattle ; Taveras, Arthur ; Yu, Younong ; Zheng, Junying ; Chao, Jianhua ; Rindgen, Diane ; Jakway, James ; Hipkin, R. William ; Fossetta, James ; Fan, Xuedong ; Fine, Jay ; Qiu, Hongchen ; Merritt, J. Robert ; Baldwin, John J

Bioorganic & Medicinal Chemistry Letters, 2008, Vol.18(1), pp.228-231 [Peer Reviewed Journal]

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17
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C(4)-alkyl substituted furanyl cyclobutenediones as potent, orally bioavailable CXCR2 and CXCR1 receptor antagonists

Chao, Jianhua ; Taveras, Arthur G ; Chao, Jianping ; Aki, Cynthia ; Dwyer, Michael ; Yu, Younong ; Purakkattle, Biju ; Rindgen, Diane ; Jakway, James ; Hipkin, William ; Fosetta, James ; Fan, Xuedong ; Lundell, Daniel ; Fine, Jay ; Minnicozzi, Michael ; Phillips, Jonathan ; Merritt, J. Robert

Bioorganic & Medicinal Chemistry Letters, 2007, Vol.17(13), pp.3778-3783 [Peer Reviewed Journal]

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18
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Synthesis and structure–activity relationships of heteroaryl substituted-3,4-diamino-3-cyclobut-3-ene-1,2-dione CXCR2/CXCR1 receptor antagonists

Yu, Younong ; Dwyer, Michael P ; Chao, Jianping ; Aki, Cynthia ; Chao, Jianhua ; Purakkattle, Biju ; Rindgen, Diane ; Bond, Richard ; Mayer-Ezel, Rosemary ; Jakway, James ; Qiu, Hongchen ; Hipkin, R. William ; Fossetta, James ; Gonsiorek, Waldemar ; Bian, Hong ; Fan, Xuedong ; Terminelli, Carol ; Fine, Jay ; Lundell, Daniel ; Merritt, J. Robert

Bioorganic & Medicinal Chemistry Letters, 2008, Vol.18(4), pp.1318-1322 [Peer Reviewed Journal]

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19
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Discovery of ethyl ketone-based HDACs 1, 2, and 3 selective inhibitors for HIV latency reactivation

Yu, Wensheng ; Liu, Jian ; Yu, Younong ; Zhang, Vivian ; Clausen, Dane ; Kelly, Joseph ; Wolkenberg, Scott ; Beshore, Douglas ; Duffy, Joseph L ; Chung, Christine C ; Myers, Robert W ; Klein, Daniel J ; Fells, James ; Holloway, Kate ; Wu, Jin ; Wu, Guoxin ; Howell, Bonnie J ; Barnard, Richard J.O ; Kozlowski, Joseph

Bioorganic & Medicinal Chemistry Letters, 01 July 2020, Vol.30(13) [Peer Reviewed Journal]

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20
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30
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WIPO PUBLISHES PATENT OF MERCK SHARP & DOHME, JIAN LIU, JOSEPH KOZLOWSKI, RONALD KIM, XIAOLEI GAO, SOBHANA BABU BOGA, YOUNONG YU, HAO WU, SHILAN LIU AND CHUNDAO YANG FOR "AZACARBAZOLE BTK INHIBITORS" (AMERICAN, CHINESE INVENTORS)

US Fed News Service, Including US State News, Oct 16, 2016

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WIPO PUBLISHES PATENT OF MERCK SHARP & DOHME, JIAN LIU, RONALD M. KIM, JOSEPH KOZLOWSKI, DEODIALSINGH GUIADEEN, ARTO D. KRIKORIAN AND YOUNONG YU FOR "BTK INHIBITORS" (AMERICAN INVENTORS)

US Fed News Service, Including US State News, Jun 26, 2015

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WIPO PUBLISHES PATENT OF MERCK SHARP & DOHME, JIAN LIU, JOSEPH KOZLOWSKI, RONALD KIM, XIAOLEI GAO, SOBHANA BABU BOGA, YOUNONG YU, HAO WU, SHILAN LIU AND CHUNDAO YANG FOR "AZACARBAZOLE BTK INHIBITORS" (AMERICAN, CHINESE INVENTORS)

US Fed News Service, Including US State News, Oct 16, 2016

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