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Differential Bone Marrow Homing Capacity of VLA-4 and CD38 High Expressing Chronic Lymphocytic Leukemia Cells (Homing of High-Risk CLL Cells)

Brachtl, Gabriele ; Sahakyan, Karine ; Denk, Ursula ; Girbl, Tamara ; Alinger, Beate ; Hofbauer, Sebastian W ; Neureiter, Daniel ; Hofbauer, Josefina Piñón ; Egle, Alexander ; Greil, Richard ; Hartmann, Tanja Nicole Bunting, Kevin D. (Editor)

PLoS ONE, 2011, Vol.6(8), p.e23758 [Peer Reviewed Journal]

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Regulation of VLA-4 in lupus monocytes objectives

Rahami, Homaira

Annals of the Rheumatic Diseases, Mar 2011, Vol.70, p.A94 [Peer Reviewed Journal]

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Ibrutinib Inhibits VLA-4-Dependent Adhesion in CLL-Letter

Zucchetto, Antonella ; Tissino, Erika ; Hartmann, Tanja Nicole ; Chigaev, Alexandre ; Del Poeta, Giovanni ; Colombatti, Alfonso ; Gattei, Valter

Clinical cancer research : an official journal of the American Association for Cancer Research, 01 July 2016, Vol.22(13), pp.3410-1 [Peer Reviewed Journal]

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Ibrutinib Inhibits VLA-4-Dependent Adhesion in CLL-Reply

Herman, Sarah E M ; Wiestner, Adrian

Clinical cancer research : an official journal of the American Association for Cancer Research, 01 July 2016, Vol.22(13), pp.3412 [Peer Reviewed Journal]

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Long-Term Decrease in VLA-4 Expression and Functional Impairment of Dendritic Cells during Natalizumab Therapy in Patients with Multiple Sclerosis (Dendritic Cell Impairment by Natalizumab)

de Andrés, Clara ; Teijeiro, Roseta ; Alonso, Bárbara ; Sánchez-Madrid, Francisco ; Martínez, M. Luisa ; de Villoria, Juan Guzmán ; Fernández-Cruz, Eduardo ; Sánchez-Ramón, Silvia Nataf, Serge (Editor)

PLoS ONE, 2012, Vol.7(4), p.e34103 [Peer Reviewed Journal]

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Identification of trans-4-[1-[[7-fluoro-2-(1-methyl-3-indolyl)-6-benzoxazolyl]acetyl]-(4S)-fluoro-(2S)-pyrrolidinylmethoxy]cyclohexanecarboxylic acid as a potent, orally active VLA-4 antagonist

Setoguchi, Masaki ; Iimura, Shin ; Sugimoto, Yuuichi ; Yoneda, Yoshiyuki ; Chiba, Jun ; Watanabe, Toshiyuki ; Muro, Fumihito ; Iigo, Yutaka ; Takayama, Gensuke ; Yokoyama, Mika ; Taira, Tomoe ; Aonuma, Misato ; Takashi, Tohru ; Nakayama, Atsushi ; Machinaga, Nobuo

Bioorganic & Medicinal Chemistry, 01 February 2012, Vol.20(3), pp.1201-1212 [Peer Reviewed Journal]

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7
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The interaction affinity between vascular cell adhesion molecule-1 (VCAM-1) and very late antigen-4 (VLA-4) analyzed by quantitative FRET

Sandeep Chakraborty ; Shih-Yang Hu ; Shu-Han Wu ; Artashes Karmenyan ; Arthur Chiou

PLoS ONE, 01 January 2015, Vol.10(3), p.e0121399 [Peer Reviewed Journal]

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A novel, potent, and orally active VLA-4 antagonist with good aqueous solubility: trans-4-[1-[[2-(5-Fluoro-2-methylphenylamino)-7-fluoro-6-benzoxazolyl]acetyl]-(5S)-[methoxy(methyl)amino]methyl-(2S)-pyrrolidinylmethoxy]cyclohexanecarboxylic acid

Setoguchi, Masaki ; Iimura, Shin ; Sugimoto, Yuuichi ; Yoneda, Yoshiyuki ; Chiba, Jun ; Watanabe, Toshiyuki ; Muro, Fumihito ; Iigo, Yutaka ; Takayama, Gensuke ; Yokoyama, Mika ; Taira, Tomoe ; Aonuma, Misato ; Takashi, Tohru ; Nakayama, Atsushi ; Machinaga, Nobuo

Bioorganic & Medicinal Chemistry, 01 January 2013, Vol.21(1), pp.42-61 [Peer Reviewed Journal]

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Pharmacodynamic consequences of administration of VLA-4 antagonist CDP323 to multiple sclerosis subjects: a randomized, double-blind phase 1/2 study

Christian Wolf ; Jagdev Sidhu ; Christian Otoul ; Dexter L Morris ; Jennifer Cnops ; Jorg Taubel ; Barbara Bennett

PLoS ONE, 01 January 2013, Vol.8(3), p.e58438 [Peer Reviewed Journal]

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PHD–2 KNOCKOUT PROMOTES PLAQUE PROGRESSION VIA HIFla AND INCREASES THE EXPRESSION OF MAC–1, PSGL–1 AND VLA4 ON MONOCYTES AND GRANULOCYTES IN MICE

Pfluecke, Christian ; Christoph, Marian ; Ibrahim, Karim ; Mensch, Matthias ; Barthel, Peggy ; Franke, Kristin ; Wielockx, Ben ; Strasser, Ruth H ; Wunderlich, Carsten ; Poitz, David M

Journal of the American College of Cardiology, 12 March 2013, Vol.61(10), pp.E1829-E1829 [Peer Reviewed Journal]

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11
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Treatment with Ibrutinib Inhibits BTK- and VLA-4-Dependent Adhesion of Chronic Lymphocytic Leukemia Cells In Vivo

Herman, Sarah E M ; Mustafa, Rashida Z ; Jones, Jade ; Wong, Deanna H ; Farooqui, Mohammed ; Wiestner, Adrian

Clinical cancer research : an official journal of the American Association for Cancer Research, 15 October 2015, Vol.21(20), pp.4642-51 [Peer Reviewed Journal]

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12
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Early treatment with anti-VLA-4 mAb can prevent the infiltration and/or development of pathogenic CD11b+CD4+ T cells in the CNS during progressive EAE

John E Mindur ; Naoko Ito ; Suhayl Dhib-Jalbut ; Kouichi Ito

PLoS ONE, 01 January 2014, Vol.9(6), p.e99068 [Peer Reviewed Journal]

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13
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Arylsulfonamide pyrimidines as VLA-4 antagonists

Xu, Ying-Zi ; Konradi, Andrei W ; Bard, Frederique ; Dappen, Michael ; Dofiles, Lilibeth ; Dreyer, Mark ; Gallager, Ian ; Garrido, Caroline ; Krimm, Mike ; Liao, Zhenmei ; Messersmith, Elizabeth ; Mutter, Linda ; Pleiss, Michael A ; Samant, Bhushan ; Semko, Christopher M ; Smith, Jennifer ; Stappenbeck, Frank ; Stupi, Brian ; Vandervert, Chris ; Welch, Brent ; Wipke, Brian ; Yednock, Ted

Bioorganic & Medicinal Chemistry Letters, 15 May 2013, Vol.23(10), pp.3070-3074 [Peer Reviewed Journal]

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14
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Discovery of a potent, orally bioavailable pyrimidine VLA-4 antagonist effective in a sheep asthma model

Semko, Christopher M ; Chen, Linda ; Dressen, Darren B ; Dreyer, Mark L ; Dunn, Whitney ; Farouz, Francine S ; Freedman, Stephen B ; Holsztynska, Elizabeth J ; Jefferies, Michael ; Konradi, Andrei W ; Liao, Anna ; Lugar, Judevin ; Mutter, Linda ; Pleiss, Michael A ; Quinn, Kevin P ; Thompson, Thomas ; Thorsett, Eugene D ; Vandevert, Christopher ; Xu, Ying-Zi ; Yednock, Ted A

Bioorganic & Medicinal Chemistry Letters, 2011, Vol.21(6), pp.1741-1743 [Peer Reviewed Journal]

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15
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The link between VLA-4 and JC virus reactivation

Monaco, Maria Chiara G ; Major, Eugene O

Expert Review of Clinical Immunology, 01 January 2012, Vol.8(1), pp.63-72 [Peer Reviewed Journal]

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16
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B‐cell very late antigen‐4 deficiency reduces leukocyte recruitment and susceptibility to central nervous system autoimmunity

Lehmann‐Horn, Klaus ; Sagan, Sharon A. ; Bernard, Claude C. A. ; Sobel, Raymond A. ; Zamvil, Scott S.

Annals of Neurology, May 2015, Vol.77(5), pp.902-908 [Peer Reviewed Journal]

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17
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Synthesis and evaluation of 4,5-dihydro-5-methylisoxazolin-5-carboxamide derivatives as VLA-4 antagonists

Soni, Ajay ; Rehman, Abdul ; Naik, Keshav ; Dastidar, Sunanda ; Alam, M.S ; Ray, Abhijit ; Chaira, Tridib ; Shah, Vanya ; Palle, Venkata P ; Cliffe, Ian A ; Sattigeri, Viswajanani J

Bioorganic & Medicinal Chemistry Letters, 01 March 2013, Vol.23(5), pp.1482-1485 [Peer Reviewed Journal]

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18
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Long-Term Effects of In Vivo Administration of An Anti-VLA-4 Antibody (natalizumab) on Mobilization of Committed and Primitive Hematopoietic Progenitor Cells In Humans

Domenech, Jorge ; Goustille, Julien ; Pallix, Maud ; Bekhechi, Zakia ; Ducrocq, Elfi ; Degenne, Michel ; Herault, Olivier ; Thibault, Gilles ; Guennoc, Anne-Marie ; Binet, Christian Cambefort, Jeanne (Editor)

Blood, 19 November 2010, Vol.116(21), pp.931-931 [Peer Reviewed Journal]

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19
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Solid-phase synthesis of 2,3-diphenylpropionic acid library as VLA-4 antagonists

Hoshina, Yoichiro ; Ikegami, Satoru ; Fujimoto, Kyoko ; Okuyama, Akihiko ; Harada, Tatsuhiro ; James, Susan ; Griffiths, Peter G ; Wu, Zemin ; Lilly, Michael ; Bray, Andrew M

Tetrahedron Letters, 2005, Vol.46(52), pp.9035-9038 [Peer Reviewed Journal]

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20
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Investigation of the teratogenic potential of VLA-4 antagonist derivatives in rats

Sakurai, Ken ; Matsuoka, Toshiki ; Suzuki, Chiharu ; Kinoshita, Junzo ; Takayama, Gensuke ; Shimomura, Kazuhiro

Reproductive Toxicology, November 2014, Vol.49, pp.162-170 [Peer Reviewed Journal]

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21
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The inhibition of the integrin VLA-4 in MV3 melanoma cell binding by non-anticoagulant heparin derivatives

Schlesinger, Martin ; Schmitz, Patrick ; Zeisig, Reiner ; Naggi, Annamaria ; Torri, Giangiacomo ; Casu, Benito ; Bendas, Gerd

Thrombosis Research, May 2012, Vol.129(5), pp.603-610 [Peer Reviewed Journal]

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22
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High CXCR4 and low VLA-4 expression predicts poor survival in adults with acute lymphoblastic leukemia

Ko, Sun-Young ; Park, Chan-Jeoung ; Park, Sang-Hyuk ; Cho, Young-Uk ; Jang, Seongsoo ; Seo, Eul-Ju ; Kim, Nayoung ; Kim, Dae-Young ; Koh, Kyung Nam ; Im, Ho Joon ; Seo, Jong-Jin ; Chi, Hyun-Sook

Leukemia Research, January 2014, Vol.38(1), pp.65-70 [Peer Reviewed Journal]

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23
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Physical Characterization of TRK-720 Hydrate, the Very Late Antigen-4 (VLA-4) Inhibitor, as a Solid Form for Inhalation: Preparation of the Hydrate by Solvent Exchange among Its Solvates and Mechanistical Considerations

Shiraki, Motohiro

Journal of Pharmaceutical Sciences, September 2010, Vol.99(9), pp.3986-4004 [Peer Reviewed Journal]

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24
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Simultaneous Inhibition of CXCR4 and VLA-4 Exhibits Combinatorial Effect in Overcoming Stroma-Mediated Chemotherapy Resistance in Mantle Cell Lymphoma Cells

Kim, Yu-Ri ; Eom, Ki-Seong

Immune network, December 2014, Vol.14(6), pp.296-306 [Peer Reviewed Journal]

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25
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The role of VLA-4 binding for experimental melanoma metastasis and its inhibition by heparin

Schlesinger, Martin ; Roblek, Marko ; Ortmann, Katrin ; Naggi, Annamaria ; Torri, Giangiacomo ; Borsig, Lubor ; Bendas, Gerd

Thrombosis Research, May 2014, Vol.133(5), pp.855-862 [Peer Reviewed Journal]

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26
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G9a Correlates with VLA-4 Integrin and Influences the Migration of Childhood Acute Lymphoblastic Leukemia Cells

Madrazo, Elena ; Ruano, David ; Abad, Lorea ; Alonso-Gómez, Estefanía ; Sánchez-Valdepeñas, Carmen ; González-Murillo, África ; Ramírez, Manuel ; Redondo-Muñoz, Javier

Cancers, Sep 2018, Vol.10(9) [Peer Reviewed Journal]

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27
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Combined VLA-4-Targeted Radionuclide Therapy and Immunotherapy in a Mouse Model of Melanoma

Choi, Jaeyeon ; Beaino, Wissam ; Fecek, Ronald ; Fabian, Kellsye ; Laymon, Charles ; Kurland, Brenda ; Storkus, Walter ; Anderson, Carolyn

The Journal of Nuclear Medicine, Dec 1, 2018, Vol.59(12), p.1843 [Peer Reviewed Journal]

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28
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The truncated RUNX1/ETO activates VLA-4-dependent adhesion and migration of hematopoietic progenitor cells

Ponnusamy, Kanagaraju ; Chen-Wichmann, Linping ; Kuvardina, Olga N ; Lausen, Jörn ; Henschler, Reinhard ; Wichmann, Christian

Haematologica, December 2014, Vol.99(12), pp.e253-6 [Peer Reviewed Journal]

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29
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In vitro VLA-4 blockade results in an impaired NK cell-mediated immune surveillance against melanoma

Gandoglia, Ilaria ; Ivaldi, Federico ; Carrega, Paolo ; Armentani, Eric ; Ferlazzo, Guido ; Mancardi, Gianluigi ; Kerlero de Rosbo, Nicole ; Uccelli, Antonio ; Laroni, Alice

Immunology Letters, January 2017, Vol.181, pp.109-115 [Peer Reviewed Journal]

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30
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Fibronectin and VLA-4 in haematopoietic stem cell–microenvironment interactions

David A. Williams ; Maribel Rios ; Carmella Stephens ; Vikram P. Patel

Nature, 1991, Vol.352(6334), p.438 [Peer Reviewed Journal]

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31
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Functional and clinical relevance of VLA-4 (CD49d/CD29) in ibrutinib-treated chronic lymphocytic leukemia

Tissino, Erika ; Benedetti, Dania ; Herman, Sarah E.M ; Ten Hacken, Elisa ; Ahn, Inhye E ; Chaffee, Kari G ; Rossi, Francesca Maria ; Dal Bo, Michele ; Bulian, Pietro ; Bomben, Riccardo ; Bayer, Elisabeth ; Härzschel, Andrea ; Gutjahr, Julia Christine ; Postorino, Massimiliano ; Santinelli, Enrico ; Ayed, Ayed ; Zaja, Francesco ; Chiarenza, Annalisa ; Pozzato, Gabriele ; Chigaev, Alexandre ; Sklar, Larry A ; Burger, Jan A ; Ferrajoli, Alessandra ; Shanafelt, Tait D ; Wiestner, Adrian ; Del Poeta, Giovanni ; Hartmann, Tanja Nicole ; Gattei, Valter ; Zucchetto, Antonella

The Journal of Experimental Medicine, 2018, Vol.215(2), p.681-697 [Peer Reviewed Journal]

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32
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Mobilization of hematopoietic stem and progenitor cells using inhibitors of CXCR4 and VLA-4

M P Rettig ; G Ansstas ; J F Dipersio

Leukemia, 2011, Vol.26(1), p.34 [Peer Reviewed Journal]

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33
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Preliminary evaluation of 18F-labeled LLP2A-trifluoroborate conjugates as VLA-4 (α4β1 integrin) specific radiotracers for PET imaging of melanoma

Roxin, Áron ; Zhang, Chengcheng ; Huh, Sungjoon ; Lepage, Mathieu L ; Zhang, Zhengxing ; Lin, Kuo-Shyan ; Bénard, François ; Perrin, David M

Nuclear Medicine and Biology, June 2018, Vol.61, pp.11-20 [Peer Reviewed Journal]

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34
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Therapeutic uses of anti-α4-integrin (anti-VLA-4) antibodies in multiple sclerosis

Schwab, Nicholas ; Schneider - Hohendorf, Tilman ; Wiendl, Heinz

International Immunology, 2015, Vol. 27(1), pp.47-53 [Peer Reviewed Journal]

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35
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Discovery of very late antigen-4 (VLA-4, alpha4beta1 integrin) allosteric antagonists

Chigaev, Alexandre ; Wu, Yang ; Williams, D Bart ; Smagley, Yelena ; Sklar, Larry A

The Journal of biological chemistry, 18 February 2011, Vol.286(7), pp.5455-63 [Peer Reviewed Journal]

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36
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Evaluation of (68)Ga- and (177)Lu-DOTA-PEG4-LLP2A for VLA-4-Targeted PET Imaging and Treatment of Metastatic Melanoma

Beaino, Wissam ; Nedrow, Jessie R ; Anderson, Carolyn J

Molecular pharmaceutics, 01 June 2015, Vol.12(6), pp.1929-38 [Peer Reviewed Journal]

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