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19 Results  for Everything (Includes Articles)

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1
Discovery of Highly Potent and Selective Small Molecule ADAMTS‑5 Inhibitors That Inhibit Human Cartilage Degradation via Encoded Library Technology (ELT)
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Article
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Discovery of Highly Potent and Selective Small Molecule ADAMTS5 Inhibitors That Inhibit Human Cartilage Degradation via Encoded Library Technology (ELT)

Deng, Hongfeng ; O’Keefe, Heather ; Davie, Christopher P ; Lind, Kenneth E ; Acharya, Raksha A ; Franklin, G. Joseph ; Larkin, Jonathan ; Matico, Rosalie ; Neeb, Michael ; Thompson, Monique M ; Lohr, Thomas ; Gross, Jeffrey W ; Centrella, Paolo A ; O’Donovan, Gary K ; Bedard, Katie L. (Sargent) ; van Vloten, Kurt ; Mataruse, Sibongile ; Skinner, Steven R ; Belyanskaya, Svetlana L ; Carpenter, Tiffany Y ; Shearer, Todd W ; Clark, Matthew A ; Cuozzo, John W ; Arico-Muendel, Christopher C ; Morgan, Barry A

Journal of medicinal chemistry, 2012-08-23, Vol.55 (16), p.7061-7079 [Peer Reviewed Journal]

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2
Current and emerging therapeutic strategies for preventing inflammation and aggrecanase-mediated cartilage destruction in arthritis
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Current and emerging therapeutic strategies for preventing inflammation and aggrecanase-mediated cartilage destruction in arthritis

Dancevic, Carolyn M ; McCulloch, Daniel R

Arthritis research & therapy, 2014, Vol.16 (5), p.429 [Peer Reviewed Journal]

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3
Prioritizing multiple therapeutic targets in parallel using automated DNA-encoded library screening
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Prioritizing multiple therapeutic targets in parallel using automated DNA-encoded library screening

Machutta, Carl A ; Kollmann, Christopher S ; Lind, Kenneth E ; Bai, Xiaopeng ; Chan, Pan F ; Huang, Jianzhong ; Ballell, Lluis ; Belyanskaya, Svetlana ; Besra, Gurdyal S ; Barros-Aguirre, David ; Bates, Robert H ; Centrella, Paolo A ; Chang, Sandy S ; Chai, Jing ; Choudhry, Anthony E ; Coffin, Aaron ; Davie, Christopher P ; Deng, Hongfeng ; Deng, Jianghe ; Ding, Yun ; Dodson, Jason W ; Fosbenner, David T ; Gao, Enoch N ; Graham, Taylor L ; Graybill, Todd L ; Ingraham, Karen ; Johnson, Walter P ; King, Bryan W ; Kwiatkowski, Christopher R ; Lelièvre, Joël ; Li, Yue ; Liu, Xiaorong ; Lu, Quinn ; Lehr, Ruth ; Mendoza-Losana, Alfonso ; Martin, John ; McCloskey, Lynn ; McCormick, Patti ; O’Keefe, Heather P ; O’Keeffe, Thomas ; Pao, Christina ; Phelps, Christopher B ; Qi, Hongwei ; Rafferty, Keith ; Scavello, Genaro S ; Steiginga, Matt S ; Sundersingh, Flora S ; Sweitzer, Sharon M ; Szewczuk, Lawrence M ; Taylor, Amy ; Toh, May Fern ; Wang, Juan ; Wang, Minghui ; Wilkins, Devan J ; Xia, Bing ; Yao, Gang ; Zhang, Jean ; Zhou, Jingye ; Donahue, Christine P ; Messer, Jeffrey A ; Holmes, David ; Arico-Muendel, Christopher C ; Pope, Andrew J ; Gross, Jeffrey W ; Evindar, Ghotas

Nature communications, 2017, Vol.8 (1), p.16081 [Peer Reviewed Journal]

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4
Encoded Library Synthesis Using Chemical Ligation and the Discovery of sEH Inhibitors from a 334-Million Member Library
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Encoded Library Synthesis Using Chemical Ligation and the Discovery of sEH Inhibitors from a 334-Million Member Library

Litovchick, Alexander ; Dumelin, Christoph E ; Habeshian, Sevan ; Gikunju, Diana ; Guié, Marie-Aude ; Centrella, Paolo ; Zhang, Ying ; Sigel, Eric A ; Cuozzo, John W ; Keefe, Anthony D ; Clark, Matthew A

Scientific reports, 2015, Vol.5 (1), p.10916 [Peer Reviewed Journal]

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5
Directed Chemical Evolution with an Outsized Genetic Code
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Article
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Directed Chemical Evolution with an Outsized Genetic Code

Krusemark, Casey J ; Tilmans, Nicolas P ; Brown, Patrick O ; Harbury, Pehr B Isalan, Mark

PloS one, 2016, Vol.11 (8), p.e0154765 [Peer Reviewed Journal]

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6
The IL-1[beta]/AP-1/miR-30a/ADAMTS-5 axis regulates cartilage matrix degradation in human osteoarthritis
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Article
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The IL-1[beta]/AP-1/miR-30a/ADAMTS-5 axis regulates cartilage matrix degradation in human osteoarthritis

Quanbo Ji ; Xiaojie Xu ; Qiang Zhang ; Lei Kang ; Yameng Xu ; Ke Zhang ; Ling Li ; Yingchun Liang ; Tian Hong ; Qinong Ye ; Yan Wang

Journal of molecular medicine (Berlin, Germany), 2016-07-01, Vol.94 (7), p.771 [Peer Reviewed Journal]

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7
Tendons – time to revisit inflammation
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Tendons – time to revisit inflammation

Rees, Jonathan D ; Stride, Matthew ; Scott, Alex

British Journal of Sports Medicine, 2014-11, Vol.48 (21), p.1553-1557 [Peer Reviewed Journal]

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8
The role of aggrecan in normal and osteoarthritic cartilage
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Article
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The role of aggrecan in normal and osteoarthritic cartilage

Roughley, Peter J ; Mort, John S

Journal of experimental orthopaedics, 2014, Vol.1 (1), p.1-11 [Peer Reviewed Journal]

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9
Versatile protein recognition by the encoded display of multiple chemical elements on a constant macrocyclic scaffold
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Versatile protein recognition by the encoded display of multiple chemical elements on a constant macrocyclic scaffold

Yizhou Li ; Roberto De Luca ; Samuele Cazzamalli ; Francesca Pretto ; Davor Bajic ; Jörg Scheuermann ; Dario Neri

Nature chemistry, 2018-04-01, Vol.10 (4), p.441-448 [Peer Reviewed Journal]

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10
Design and Construction of a Focused DNA-Encoded Library for Multivalent Chromatin Reader Proteins
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Article
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Design and Construction of a Focused DNA-Encoded Library for Multivalent Chromatin Reader Proteins

Rectenwald, Justin M ; Guduru, Shiva Krishna Reddy ; Dang, Zhao ; Collins, Leonard B ; Liao, Yi-En ; Norris-Drouin, Jacqueline L ; Cholensky, Stephanie H ; Kaufmann, Kyle W ; Hammond, Scott M ; Kireev, Dmitri B ; Frye, Stephen V ; Pearce, Kenneth H

Molecules (Basel, Switzerland), 2020-02-22, Vol.25 (4), p.979 [Peer Reviewed Journal]

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11
Interleukin-1[beta]-mediated suppression of microRNA-27a-3p activity in human cartilage via MAPK and NF-[kappa]B pathways: A potential mechanism of osteoarthritis pathogenesis
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Article
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Interleukin-1[beta]-mediated suppression of microRNA-27a-3p activity in human cartilage via MAPK and NF-[kappa]B pathways: A potential mechanism of osteoarthritis pathogenesis

Li, Xing ; He, Peiheng ; Li, Ziqing ; Wang, Haixing ; Liu, Minghao ; Xiao, Yinbo ; Xu, Dongliang ; Kang, Yan ; Wang, Hua

Molecular medicine reports, 2018-07-01, Vol.18 (1), p.541 [Peer Reviewed Journal]

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12
Theoretical Considerations of the Application of DNA‐Encoded Libraries to Drug Discovery
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Book Chapter
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Theoretical Considerations of the Application of DNA‐Encoded Libraries to Drug Discovery

Wartchow, Charles Goodnow, Robert A

A Handbook for DNA‐Encoded Chemistry, 2014-04-24, p.213-230

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13
Foundations of a DNA‐Encoded Library (DEL)
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Book Chapter
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Foundations of a DNA‐Encoded Library (DEL)

Satz, Alexander Lee Goodnow, Robert A

A Handbook for DNA‐Encoded Chemistry, 2014-04-24, p.99-121

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14
Reported Applications of DNA‐Encoded Library Chemistry
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Book Chapter
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Reported Applications of DNA‐Encoded Library Chemistry

Ottl, Johannes Goodnow, Robert A

A Handbook for DNA‐Encoded Chemistry, 2014-04-24, p.319-347

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15
Exercises in the Synthesis of DNA‐Encoded Libraries
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Book Chapter
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Exercises in the Synthesis of DNA‐Encoded Libraries

Creaser, Steffen P ; Acharya, Raksha A Goodnow, Robert A

A Handbook for DNA‐Encoded Chemistry, 2014-04-24, p.123-151

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16
Arthritis; Researchers at GlaxoSmithKline Publish New Data on Osteoarthritis
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Newspaper Article
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Arthritis; Researchers at GlaxoSmithKline Publish New Data on Osteoarthritis

Life science weekly, 2012-09-11, p.967

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17
A Brief History of DNA‐Encoded Chemistry
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Book Chapter
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A Brief History of DNA‐Encoded Chemistry

Keefe, Anthony D Goodnow, Robert A

A Handbook for DNA‐Encoded Chemistry, 2014-04-24, p.45-66

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18
Leitmolekülsuche mit DNA-codierten Bibliotheken
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Article
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Leitmolekülsuche mit DNA-codierten Bibliotheken

Rudolph, Markus G

BIOspektrum, 2017-03, Vol.23 (2), p.142-145 [Peer Reviewed Journal]

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19
Researchers at GlaxoSmithKline Publish New Data on Osteoarthritis
Material Type:
Journal
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Researchers at GlaxoSmithKline Publish New Data on Osteoarthritis

Health & Medicine Week, 2012-09-14, p.967

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