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20 Results  for Everything (Includes Articles)

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Definitive Metabolite Identification Coupled with Automated Ligand Identification System (ALIS) Technology: A Novel Approach to Uncover Structure-Activity Relationships and Guide Drug Design in a Factor IXa Inhibitor Program

Zhang, Ting ; Liu, Yong ; Yang, Xianshu ; Martin, Gary E ; Yao, Huifang ; Shang, Jackie ; Bugianesi, Randal M ; Ellsworth, Kenneth P ; Sonatore, Lisa M ; Nizner, Peter ; Sherer, Edward C ; Hill, Susan E ; Knemeyer, Ian W ; Geissler, Wayne M ; Dandliker, Peter J ; Helmy, Roy ; Wood, Harold B

Journal of medicinal chemistry, 10 March 2016, Vol.59(5), pp.1818-29 [Peer Reviewed Journal]

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Microscale High-Throughput Experimentation as an Enabling Technology in Drug Discovery: Application in the Discovery of (Piperidinyl)pyridinyl-1H-benzimidazole Diacylglycerol Acyltransferase 1 Inhibitors

Cernak, Tim ; Gesmundo, Nathan J ; Dykstra, Kevin ; Yu, Yang ; Wu, Zhicai ; Shi, Zhi-Cai ; Vachal, Petr ; Sperbeck, Donald ; He, Shuwen ; Murphy, Beth Ann ; Sonatore, Lisa ; Williams, Steven ; Madeira, Maria ; Verras, Andreas ; Reiter, Maud ; Lee, Claire Heechoon ; Cuff, James ; Sherer, Edward C ; Kuethe, Jeffrey ; Goble

Journal of medicinal chemistry, 11 May 2017, Vol.60(9), pp.3594-3605 [Peer Reviewed Journal]

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1,3,8-Triazaspiro4.5decane-2,4-diones as efficacious pan-inhibitors of hypoxia-inducible factor prolyl hydroxylase 1-3 (HIF PHD1-3) for the treatment of anemia

Vachal, Petr ; Miao, Shouwu ; Pierce, Joan M ; Guiadeen, Deodial ; Colandrea, Vincent J ; Wyvratt, Matthew J ; Salowe, Scott P ; Sonatore, Lisa M ; Milligan, James A ; Hajdu, Richard ; Gollapudi, Anantha ; Keohane, Carol A ; Lingham, Russell B ; Mandala, Suzanne M ; Demartino, Julie A ; Tong, Xinchun ; Wolff, Michael ; Steinhuebel, Dietrich ; Kieczykowski, Gerard R ; Fleitz

Journal of medicinal chemistry, 12 April 2012, Vol.55(7), pp.2945-59 [Peer Reviewed Journal]

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Discovery of N-Bis(4-methoxyphenyl)methyl-4-hydroxy-2-(pyridazin-3-yl)pyrimidine-5-carboxamide (MK-8617), an Orally Active Pan-Inhibitor of Hypoxia-Inducible Factor Prolyl Hydroxylase 1-3 (HIF PHD1-3) for the Treatment of Anemia

Debenham, John S ; Madsen-Duggan, Christina ; Clements, Matthew J ; Walsh, Thomas F ; Kuethe, Jeffrey T ; Reibarkh, Mikhail ; Salowe, Scott P ; Sonatore, Lisa M ; Hajdu, Richard ; Milligan, James A ; Visco, Denise M ; Zhou, Dan ; Lingham, Russell B ; Stickens, Dominique ; Demartino, Julie A ; Tong, Xinchun ; Wolff, Michael ; Pang, Jianmei ; Miller, Randy R ; Sherer

Journal of medicinal chemistry, 22 December 2016, Vol.59(24), pp.11039-11049 [Peer Reviewed Journal]

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Pharmacological inhibition of diacylglycerol acyltransferase 1 reduces body weight and modulates gut peptide release—Potential insight into mechanism of action

Liu, Jinqi ; Gorski, Judith N. ; Gold, Stephen J. ; Chen, Dunlu ; Chen, Shirley ; Forrest, Gail ; Itoh, Yoshiki ; Marsh, Donald J. ; Mclaren, David G. ; Shen, Zhu ; Sonatore, Lisa ; Carballo‐Jane, Ester ; Craw, Stephanie ; Guan, Xiaoming ; Karanam, Bindhu ; Sakaki, Junichi ; Szeto, Daphne ; Tong, Xinchun ; Xiao, Jianying ; Yoshimoto, Ryo ; Yu, Hong ; Roddy, Thomas P. ; Balkovec, James ; Pinto, Shirly

Obesity, July 2013, Vol.21(7), pp.1406-1415 [Peer Reviewed Journal]

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The catalytic flexibility of tRNAIle-lysidine synthetase can generate alternative tRNA substrates for isoleucyl-tRNA synthetase

Salowe, Scott P ; Wiltsie, Judyann ; Hawkins, Julio C ; Sonatore, Lisa M

The Journal of biological chemistry, 10 April 2009, Vol.284(15), pp.9656-62 [Peer Reviewed Journal]

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Applying Dataflow Architecture and Visualization Tools to In Vitro Pharmacology Data Automation

Pechter, David ; Xu, Serena ; Kurtz, Marc ; Williams, Steven ; Sonatore, Lisa ; Villafania, Artjohn ; Agrawal, Sony

Journal of Laboratory Automation, December 2016, Vol.21(6), pp.817-823 [Peer Reviewed Journal]

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A peptide-based fluorescence resonance energy transfer assay for Bacillus anthracis lethal factor protease

Cummings, Richard T ; Salowe, Scott P ; Cunningham, Barry R ; Wiltsie, Judyann ; Park, Young Whan ; Sonatore, Lisa M ; Wisniewski, Douglas ; Douglas, Cameron M ; Hermes, Jeffrey D ; Scolnick, Edward M

Proceedings of the National Academy of Sciences of the United States of America, 14 May 2002, Vol.99(10), pp.6603-6 [Peer Reviewed Journal]

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9
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Identification of DGAT2 Inhibitors Using Mass Spectrometry

Song, Xuelei S ; Zhang, Jiaping ; Chen, Xun ; Palyha, Oksana ; Chung, Christine ; Sonatore, Lisa M ; Wilsie, Larissa ; Stout, Steven ; Mclaren, David G ; Taggart, Andrew ; Imbriglio, Jason E ; Pinto, Shirly ; Garcia-Calvo, Margarita ; Addona, George H Wingfield, Jonathan (Editor) ; Wilson, Ian D (Editor)

Journal of Biomolecular Screening, February 2016, Vol.21(2), pp.117-126 [Peer Reviewed Journal]

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Potential mechanism of enhanced postprandial glucagon‐like peptide‐1 release following treatment with a diacylglycerol acyltransferase 1 inhibitor

Liu, Jinqi ; Mclaren, David G. ; Chen, Dunlu ; Kan, Yanqing ; Stout, Steven J. ; Shen, Xiaolan ; Murphy, Beth Ann ; Forrest, Gail ; Karanam, Bindhu ; Sonatore, Lisa ; He, Shuwen ; Roddy, Thomas P. ; Pinto, Shirly

Pharmacology Research & Perspectives, December 2015, Vol.3(6), pp.n/a-n/a [Peer Reviewed Journal]

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11
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Heterocyclic core analogs of a direct thrombin inhibitor

Blizzard, Timothy A ; Singh, Sanjay ; Patil, Basanagoud ; Chidurala, Naresh ; Komanduri, Venukrishnan ; Debnath, Samarpita ; Belyakov, Sergei ; Crespo, Alejandro ; Struck, Alice ; Kurtz, Marc ; Wiltsie, Judyann ; Shen, Xun ; Sonatore, Lisa ; Arocho, Marta ; Lewis, Dale ; Ogletree, Martin ; Biftu, Tesfaye

Bioorganic & medicinal chemistry letters, 15 February 2014, Vol.24(4), pp.1111-5 [Peer Reviewed Journal]

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12
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Rapid development of two factor IXa inhibitors from hit to lead

Parker, Dann L ; Walsh, Shawn ; Li, Bing ; Kim, Esther ; Sharipour, Aurash ; Smith, Cameron ; Chen, Yi-Heng ; Berger, Richard ; Harper, Bart ; Zhang, Ting ; Park, Min ; Shu, Min ; Wu, Jane ; Xu, Jiayi ; Dewnani, Sunita ; Sherer, Edward C ; Hruza, Alan ; Reichert, Paul ; Geissler, Wayne ; Sonatore, Lisa

Bioorganic & Medicinal Chemistry Letters, 01 June 2015, Vol.25(11), pp.2321-2325 [Peer Reviewed Journal]

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13
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Potent DGAT1 Inhibitors in the Benzimidazole Class with a Pyridyl-oxy-cyclohexanecarboxylic Acid Moiety

He, Shuwen ; Hong, Qingmei ; Lai, Zhong ; Wu, Zhicai ; Yu, Yang ; Kim, David W ; Ting, Pauline C ; Kuethe, Jeffrey T ; Yang, Ginger X ; Jian, Tianying ; Liu, Jian ; Guiadeen, Deodial ; Krikorian, Arto D ; Sperbeck, Donald M ; Sonatore, Lisa M ; Wiltsie, Judyann ; Chung, Christine C ; Gibson, Jack T ; Lisnock, Jeanmarie ; Murphy

ACS medicinal chemistry letters, 08 August 2013, Vol.4(8), pp.773-8 [Peer Reviewed Journal]

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14
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Discovery of a Potent and Selective DGAT1 Inhibitor with a Piperidinyl-oxy-cyclohexanecarboxylic Acid Moiety

He, Shuwen ; Hong, Qingmei ; Lai, Zhong ; Yang, David X ; Ting, Pauline C ; Kuethe, Jeffrey T ; Cernak, Timothy A ; Dykstra, Kevin D ; Sperbeck, Donald M ; Wu, Zhicai ; Yu, Yang ; Yang, Ginger X ; Jian, Tianying ; Liu, Jian ; Guiadeen, Deodial ; Krikorian, Arto D ; Sonatore, Lisa M ; Wiltsie, Judyann ; Liu, Jinqi ; Gorski

ACS medicinal chemistry letters, 09 October 2014, Vol.5(10), pp.1082-7 [Peer Reviewed Journal]

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15
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Development of a novel tricyclic class of potent and selective FIXa inhibitors

Meng, Dongfang ; Andre, Patrick ; Bateman, Thomas J ; Berger, Richard ; Chen, Yi-Heng ; Desai, Kunal ; Dewnani, Sunita ; Ellsworth, Kenneth ; Feng, Daming ; Geissler, Wayne M ; Guo, Liangqin ; Hruza, Alan ; Jian, Tianying ; Li, Hong ; Metzger, Joe ; Parker, Dann L ; Reichert, Paul ; Sherer, Edward C ; Smith, Cameron J ; Sonatore, Lisa M

Bioorganic & Medicinal Chemistry Letters, 15 November 2015, Vol.25(22), pp.5437-5443 [Peer Reviewed Journal]

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16
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Development of a novel class of potent and selective FIXa inhibitors

Zhang, Ting ; Andre, Patrick ; Bateman, Thomas J ; Chen, Yi-Heng ; Desai, Kunal ; Ellsworth, Kenneth ; Geissler, Wayne M ; Guo, Liangqin ; Hruza, Alan ; Jian, Tianying ; Meng, Dongfang ; Parker, Dann L ; Qian, Xiaoxia ; Reichert, Paul ; Sherer, Edward C ; Shu, Min ; Smith, Cameron J ; Sonatore, Lisa M ; Tschirret-Guth, Richard ; Nolting, Andrew F

Bioorganic & Medicinal Chemistry Letters, 01 November 2015, Vol.25(21), pp.4945-4949 [Peer Reviewed Journal]

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17
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The Utility of FK506-Binding Protein as a Fusion Partner in Scintillation Proximity Assays: Application to SH2 Domains

Sonatore, Lisa M ; Wisniewski, Doug ; Frank, Lori J ; Cameron, Patricia M ; Hermes, Jeffrey D ; Marcy, Alice I ; Salowe, Scott P

Analytical Biochemistry, 05 September 1996, Vol.240(2), pp.289-297 [Peer Reviewed Journal]

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18
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Disubstituted pyrimidines as Lck inhibitors

Hunt, Julianne A ; Beresis, Richard T ; Goulet, Joung L ; Holmes, Mark A ; Hong, Xinfang J ; Kovacs, Ernest ; Mills, Sander G ; Ruzek, Rowena D ; Wong, Frederick ; Hermes, Jeffrey D ; Park, Young-Whan ; Salowe, Scott P ; Sonatore, Lisa M ; Wu, Lin ; Woods, Andrea ; Zaller, Dennis M ; Sinclair, Peter J

Bioorganic & Medicinal Chemistry Letters, 2009, Vol.19(18), pp.5440-5443 [Peer Reviewed Journal]

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Accelerating the discovery of DGAT1 inhibitors through the application of parallel medicinal chemistry (PMC)

Yu, Yang ; Wu, Zhicai ; Shi, Zhi-Cai ; He, Shuwen ; Lai, Zhong ; Cernak, Timothy A ; Vachal, Petr ; Liu, Min ; Liu, Jian ; Hong, Qingmei ; Jian, Tianying ; Guiadeen, Deodial ; Krikorian, Arto ; Sperbeck, Donald M ; Verras, Andreas ; Sonatore, Lisa M ; Murphy, Beth A ; Wiltsie, Judyann ; Chung, Christine C ; Gorski, Judith N

Bioorganic & Medicinal Chemistry Letters, 01 June 2019, Vol.29(11), pp.1380-1385 [Peer Reviewed Journal]

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Benzimidazole-based DGAT1 inhibitors with a [3.1.0] bicyclohexane carboxylic acid moiety

He, Shuwen ; Lai, Zhong ; Hong, Qingmei ; Shang, Jackie ; Reibarkh, Mikhail ; Kuethe, Jeffrey T ; Liu, Jian ; Guiadeen, Deodial ; Krikorian, Arto D ; Cernak, Timothy A ; Dykstra, Kevin D ; Sperbeck, Donald M ; Wu, Zhicai ; Yu, Yang ; Yang, Ginger X ; Jian, Tianying ; Verras, Andreas ; Sonatore, Lisa M ; Wiltsie, Judyann ; Chung, Christine C

Bioorganic & Medicinal Chemistry Letters, 15 May 2019, Vol.29(10), pp.1182-1186 [Peer Reviewed Journal]

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