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26 Results  for Everything (Includes Articles)

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1
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DNA-binding domains of Fos and Jun do not induce DNA curvature: An investigation with solution and gel methods

Sitlani, Ayesha ; Crothers, Donald

Proceedings of the National Academy of Sciences of the United States of America, Feb 17, 1998, Vol.95(4), pp.1404-1409 [Peer Reviewed Journal]

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Fos and Jun do not bend the AP-1 recognition site

Sitlani, Ayesha ; Crothers, Donald

Proceedings of the National Academy of Sciences of the United States of America, Apr 16, 1996, p.3248 [Peer Reviewed Journal]

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3
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Measurement of Fractional Synthetic Rates of Multiple Protein Analytes by Triple Quadrupole Mass Spectrometry

Lee, Anita ; Yates, Nathan ; Ichetovkin, Marina ; Deyanova, Ekaterina ; Southwick, Katie ; Fisher, Timothy ; Wang, Weixun ; Loderstedt, James ; Walker, Nykia ; Zhou, Haihong ; Zhao, Xuemei ; Sparrow, Carl ; Hubbard, Brian ; Rader, Daniel ; Sitlani, Ayesha ; Millar, John ; Hendrickson, Ronald

Clinical Chemistry, Mar 2012, pp.619-27 [Peer Reviewed Journal]

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4
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Identification of a potent synthetic FXR agonist with an unexpected mode of binding and activation

Soisson, Stephen ; Parthasarathy, Gopalakrishnan ; Adams, Alan ; Sahoo, Soumya ; Sitlani, Ayesha ; Sparrow, Carl ; Cui, Jisong ; Becker, Joseph

Proceedings of the National Academy of Sciences of the United States of America, Apr 8, 2008, p.5337 [Peer Reviewed Journal]

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5
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Allosteric effects of dexamethasone and RU486 on glucocorticoid receptor-DNA interactions

Pandit, Shilpa ; Geissler, Wayne ; Harris, Georgianna ; Sitlani, Ayesha

The Journal of biological chemistry, 11 January 2002, Vol.277(2), pp.1538-43 [Peer Reviewed Journal]

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6
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Colorimetric Detection of Glutamine Synthetase-Catalyzed Transferase Activity in Glucocorticoid-Treated Skeletal Muscle Cells

Santoro, Joseph C ; Harris, Georgianna ; Sitlani, Ayesha

Analytical Biochemistry, 01 February 2001, Vol.289(1), pp.18-25 [Peer Reviewed Journal]

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7
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Mechanistic implications for LDL receptor degradation from the PCSK9/LDLR structure at neutral pH

Surdo, Paola Lo ; Bottomley, Matthew J ; Calzetta, Alessandra ; Settembre, Ethan C ; Cirillo, Agostino ; Pandit, Shilpa ; Ni, Yan G ; Hubbard, Brian ; Sitlani, Ayesha ; Carfí, Andrea

EMBO reports, December 2011, Vol.12(12), pp.1300-1305 [Peer Reviewed Journal]

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8
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Immunization against proprotein convertase subtilisin-like/kexin type 9 lowers plasma LDL-cholesterol levels in mice

Fattori, Elena ; Cappelletti, Manuela ; Lo Surdo, Paola ; Calzetta, Alessandra ; Bendtsen, Claus ; Ni, Yan G ; Pandit, Shilpa ; Sitlani, Ayesha ; Mesiti, Giuseppe ; Carfí, Andrea ; Monaci, Paolo

Journal of lipid research, August 2012, Vol.53(8), pp.1654-61 [Peer Reviewed Journal]

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9
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Measurement of fractional synthetic rates of multiple protein analytes by triple quadrupole mass spectrometry

Lee, Anita Y H ; Yates, Nathan A ; Ichetovkin, Marina ; Deyanova, Ekaterina ; Southwick, Katie ; Fisher, Timothy S ; Wang, Weixun ; Loderstedt, James ; Walker, Nykia ; Zhou, Haihong ; Zhao, Xuemei ; Sparrow, Carl P ; Hubbard, Brian K ; Rader, Daniel J ; Sitlani, Ayesha ; Millar, John S ; Hendrickson, Ronald C

Clinical chemistry, March 2012, Vol.58(3), pp.619-27 [Peer Reviewed Journal]

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10
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PCSK9 is not involved in the degradation of LDL receptors and BACE1 in the adult mouse brain

Liu, Mali ; Wu, Guoxin ; Baysarowich, Jennifer ; Kavana, Michael ; Addona, George H ; Bierilo, Kathleen K ; Mudgett, John S ; Pavlovic, Guillaume ; Sitlani, Ayesha ; Renger, John J ; Hubbard, Brian K ; Fisher, Timothy S ; Zerbinatti, Celina V

Journal of lipid research, September 2010, Vol.51(9), pp.2611-8 [Peer Reviewed Journal]

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11
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Effects of pH and low density lipoprotein (LDL) on PCSK9-dependent LDL receptor regulation

Fisher, Timothy S ; Lo Surdo, Paola ; Pandit, Shilpa ; Mattu, Marco ; Santoro, Joseph C ; Wisniewski, Doug ; Cummings, Richard T ; Calzetta, Alessandra ; Cubbon, Rose M ; Fischer, Paul A ; Tarachandani, Anil ; De Francesco, Raffaele ; Wright, Samuel D ; Sparrow, Carl P ; Carfi, Andrea ; Sitlani, Ayesha

The Journal of biological chemistry, 13 July 2007, Vol.282(28), pp.20502-12 [Peer Reviewed Journal]

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12
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Structural and biochemical characterization of the wild type PCSK9-EGF(AB) complex and natural familial hypercholesterolemia mutants

Bottomley, Matthew J ; Cirillo, Agostino ; Orsatti, Laura ; Ruggeri, Lionello ; Fisher, Timothy S ; Santoro, Joseph C ; Cummings, Richard T ; Cubbon, Rose M ; Lo Surdo, Paola ; Calzetta, Alessandra ; Noto, Alessia ; Baysarowich, Jennifer ; Mattu, Marco ; Talamo, Fabio ; De Francesco, Raffaele ; Sparrow, Carl P ; Sitlani, Ayesha ; Carfí, Andrea

The Journal of biological chemistry, 09 January 2009, Vol.284(2), pp.1313-23 [Peer Reviewed Journal]

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13
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Nicotinic acid and DP1 blockade: studies in mouse models of atherosclerosis

Strack, Alison M ; Carballo-Jane, Ester ; Wang, Sheng-Ping ; Xue, Jiyan ; Ping, Xiaoli ; Mcnamara, Lesley Ann ; Thankappan, Anil ; Price, Olga ; Wolff, Michael ; Wu, T J ; Kawka, Douglas ; Mariano, Michele ; Burton, Charlotte ; Chang, Ching H ; Chen, Jing ; Menke, John ; Luell, Silvi ; Zycband, Emanuel I ; Tong, Xinchun ; Raubertas, Richard ; Sparrow, Carl P ; Hubbard, Brian ; Woods, John ; O'Neill, Gary ; Waters, M Gerard ; Sitlani, Ayesha

Journal of lipid research, January 2013, Vol.54(1), pp.177-88 [Peer Reviewed Journal]

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14
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Biochemical characterization of cholesteryl ester transfer protein inhibitors

Ranalletta, Mollie ; Bierilo, Kathleen K ; Chen, Ying ; Milot, Denise ; Chen, Qing ; Tung, Elaine ; Houde, Caroline ; Elowe, Nadine H ; Garcia-Calvo, Margarita ; Porter, Gene ; Eveland, Suzanne ; Frantz-Wattley, Betsy ; Kavana, Mike ; Addona, George ; Sinclair, Peter ; Sparrow, Carl ; O'Neill, Edward A ; Koblan, Ken S ; Sitlani, Ayesha ; Hubbard, Brian ; Fisher, Timothy S

Journal of lipid research, September 2010, Vol.51(9), pp.2739-52 [Peer Reviewed Journal]

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15
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Discovery of betamethasone 17α-carbamates as dissociated glucocorticoid receptor modulators in the rat

Ali, Amjad ; Balkovec, James M ; Greenlee, Mark ; Hammond, Milton L ; Rouen, Greg ; Taylor, Gayle ; Einstein, Monica ; Ge, Lan ; Harris, Georgianna ; Kelly, Terri M ; Mazur, Paul ; Pandit, Shilpa ; Santoro, Joseph ; Sitlani, Ayesha ; Wang, Chuanlin ; Williamson, Joann ; Forrest, Michael J ; Carballo-Jane, Ester ; Luell, Silvi ; Lowitz, Karen ; Visco, Denise

Bioorganic & Medicinal Chemistry, 2008, Vol.16(16), pp.7535-7542 [Peer Reviewed Journal]

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16
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An anti-PCSK9 antibody reduces LDL-cholesterol on top of a statin and suppresses hepatocyte SREBP-regulated genes

Zhang, Liwen ; Mccabe, Timothy ; Condra, Jon H ; Ni, Yan G ; Peterson, Laurence B ; Wang, Weirong ; Strack, Alison M ; Wang, Fubao ; Pandit, Shilpa ; Hammond, Holly ; Wood, Dana ; Lewis, Dale ; Rosa, Ray ; Mendoza, Vivienne ; Cumiskey, Anne Marie ; Johns, Douglas G ; Hansen, Barbara C ; Shen, Xun ; Geoghagen, Neil ; Jensen, Kristian ; Zhu, Lei ; Wietecha, Karol ; Wisniewski, Douglas ; Huang, Lingyi ; Zhao, Jing Zhang ; Ernst, Robin ; Hampton, Richard ; Haytko, Peter ; Ansbro, Frances ; Chilewski, Shannon ; Chin, Jayne ; Mitnaul, Lyndon J ; Pellacani, Andrea ; Sparrow, Carl P ; An, Zhiqiang ; Strohl, William ; Hubbard, Brian ; Plump, Andrew S ; Blom, Daniel ; Sitlani, Ayesha

International journal of biological sciences, 2012, Vol.8(3), pp.310-27 [Peer Reviewed Journal]

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17
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A PCSK9-binding antibody that structurally mimics the EGF(A) domain of LDL-receptor reduces LDL cholesterol in vivo

Ni, Yan G ; Di Marco, Stefania ; Condra, Jon H ; Peterson, Laurence B ; Wang, Weirong ; Wang, Fubao ; Pandit, Shilpa ; Hammond, Holly A ; Rosa, Ray ; Cummings, Richard T ; Wood, Dana D ; Liu, Xiaomei ; Bottomley, Matthew J ; Shen, Xun ; Cubbon, Rose M ; Wang, Sheng-Ping ; Johns, Douglas G ; Volpari, Cinzia ; Hamuro, Lora ; Chin, Jayne ; Huang, Lingyi ; Zhao, Jing Zhang ; Vitelli, Salvatore ; Haytko, Peter ; Wisniewski, Douglas ; Mitnaul, Lyndon J ; Sparrow, Carl P ; Hubbard, Brian ; Carfí, Andrea ; Sitlani, Ayesha

Journal of lipid research, January 2011, Vol.52(1), pp.78-86 [Peer Reviewed Journal]

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18
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A proprotein convertase subtilisin-like/kexin type 9 (PCSK9) C-terminal domain antibody antigen-binding fragment inhibits PCSK9 internalization and restores low density lipoprotein uptake

Ni, Yan G ; Condra, Jon H ; Orsatti, Laura ; Shen, Xun ; Di Marco, Stefania ; Pandit, Shilpa ; Bottomley, Matthew J ; Ruggeri, Lionello ; Cummings, Richard T ; Cubbon, Rose M ; Santoro, Joseph C ; Ehrhardt, Anka ; Lewis, Dale ; Fisher, Timothy S ; Ha, Sookhee ; Njimoluh, Leila ; Wood, Dana D ; Hammond, Holly A ; Wisniewski, Douglas ; Volpari, Cinzia ; Noto, Alessia ; Lo Surdo, Paola ; Hubbard, Brian ; Carfí, Andrea ; Sitlani, Ayesha

The Journal of biological chemistry, 23 April 2010, Vol.285(17), pp.12882-91 [Peer Reviewed Journal]

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19
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Novel N-arylpyrazolo3,2-c-based ligands for the glucocorticoid receptor: receptor binding and in vivo activity

Ali, Amjad ; Thompson, Christopher F ; Balkovec, James M ; Graham, Donald W ; Hammond, Milton L ; Quraishi, Nazia ; Tata, James R ; Einstein, Monica ; Ge, Lan ; Harris, Georgianna ; Kelly, Terri M ; Mazur, Paul ; Pandit, Shilpa ; Santoro, Joseph ; Sitlani, Ayesha ; Wang, Chuanlin ; Williamson, Joanne ; Miller, Douglas K ; Thompson, Chris M ; Zaller, Dennis M ; Forrest, Michael J ; Carballo-Jane, Ester ; Luell, Silvi

Journal of medicinal chemistry, 06 May 2004, Vol.47(10), pp.2441-52 [Peer Reviewed Journal]

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20
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Skeletal muscle: a dual system to measure glucocorticoid-dependent transactivation and transrepression of gene regulation

Carballo-Jane, Ester ; Pandit, Shilpa ; Santoro, Joseph C ; Freund, Concetta ; Luell, Silvi ; Harris, Georgianna ; Forrest, Michael J ; Sitlani, Ayesha

Journal of Steroid Biochemistry and Molecular Biology, 2004, Vol.88(2), pp.191-201 [Peer Reviewed Journal]

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21
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Identification of a potent synthetic FXR agonist with an unexpected mode of binding and activation

Soisson, Stephen M ; Parthasarathy, Gopalakrishnan ; Adams, Alan D ; Sahoo, Soumya ; Sitlani, Ayesha ; Sparrow, Carl ; Cui, Jisong ; Becker, Joseph W

Proceedings of the National Academy of Sciences of the United States of America, 08 April 2008, Vol.105(14), pp.5337-42 [Peer Reviewed Journal]

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22
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Functional analysis of sites within PCSK9 responsible for hypercholesterolemia

Pandit, Shilpa ; Wisniewski, Doug ; Santoro, Joseph C ; Ha, Sookhee ; Ramakrishnan, Vijayalakshmi ; Cubbon, Rose M ; Cummings, Richard T ; Wright, Samuel D ; Sparrow, Carl P ; Sitlani, Ayesha ; Fisher, Timothy S

Journal of lipid research, June 2008, Vol.49(6), pp.1333-43 [Peer Reviewed Journal]

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23
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Selective glucocorticoid receptor nonsteroidal ligands completely antagonize the dexamethasone mediated induction of enzymes involved in gluconeogenesis and glutamine metabolism

Einstein, Monica ; Greenlee, Mark ; Rouen, Greg ; Sitlani, Ayesha ; Santoro, Joe ; Wang, Chuanlin ; Pandit, Shilpa ; Mazur, Paul ; Smalera, Isabella ; Weaver, Alehna Pm ; Zeng, Ying Ying ; Ge, Lan ; Kelly, Theresa ; Paiva, Tony ; Geissler, Wayne ; Mosley, Ralph T ; Williamson, Joanne ; Ali, Amjad ; Balkovec, Jim ; Harris, Georgianna

Journal of Steroid Biochemistry and Molecular Biology, 2004, Vol.92(5), pp.345-356 [Peer Reviewed Journal]

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24
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Novel glucocorticoids containing a 6,5-bicyclic core fused to a pyrazole ring: Synthesis, in vitro profile, molecular modeling studies, and in vivo experiments

Thompson, Christopher F ; Quraishi, Nazia ; Ali, Amjad ; Mosley, Ralph T ; Tata, James R ; Hammond, Milton L ; Balkovec, James M ; Einstein, Monica ; Ge, Lan ; Harris, Georgianna ; Kelly, Terri M ; Mazur, Paul ; Pandit, Shilpa ; Santoro, Joseph ; Sitlani, Ayesha ; Wang, Chuanlin ; Williamson, Joanne ; Miller, Douglas K ; Yamin, Ting-Ting D ; Thompson, Chris M ; O’neill, Edward A ; Zaller, Dennis ; Forrest, Michael J ; Carballo-Jane, Ester ; Luell, Silvi

Bioorganic & Medicinal Chemistry Letters, 2007, Vol.17(12), pp.3354-3361 [Peer Reviewed Journal]

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25
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Novel heterocyclic glucocorticoids: in vitro profile and in vivo efficacy

Thompson, Christopher F ; Quraishi, Nazia ; Ali, Amjad ; Tata, James R ; Hammond, Milton L ; Balkovec, James M ; Einstein, Monica ; Ge, Lan ; Harris, Georgianna ; Kelly, Theresa M ; Mazur, Paul ; Pandit, Shilpa ; Santoro, Joseph ; Sitlani, Ayesha ; Wang, Chuanlin ; Williamson, Joanne ; Miller, Douglas K ; Yamin, Ting-Ting D ; Thompson, Chris M ; O’neill, Edward A ; Zaller, Dennis ; Forrest, Michael J ; Carballo-Jane, Ester ; Luell, Silvi

Bioorganic & Medicinal Chemistry Letters, 2005, Vol.15(8), pp.2163-2167 [Peer Reviewed Journal]

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26
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Novel ketal ligands for the glucocorticoid receptor: in vitro and in vivo activity

Smith, Cameron J ; Ali, Amjad ; Balkovec, James M ; Graham, Donald W ; Hammond, Milton L ; Patel, Gool F ; Rouen, Gregory P ; Smith, Scott K ; Tata, James R ; Einstein, Monica ; Ge, Lan ; Harris, Georgianna S ; Kelly, Theresa M ; Mazur, Paul ; Thompson, Chris M ; Wang, Chuanlin F ; Williamson, Joanne M ; Miller, Douglas K ; Pandit, Shilpa ; Santoro, Joseph C ; Sitlani, Ayesha ; Yamin, Ting-Ting D ; O’neill, Edward A ; Zaller, Dennis M ; Carballo-Jane, Ester ; Forrest, Michael J ; Luell, Silvi

Bioorganic & Medicinal Chemistry Letters, 2005, Vol.15(11), pp.2926-2931 [Peer Reviewed Journal]

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