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Progression of type 1 diabetes from the prediabetic stage is controlled by interferon-α signaling

Marro, Brett S ; Ware, Brian C ; Zak, Jaroslav ; De La Torre, Juan Carlos ; Rosen, Hugh ; Oldstone, Michael B A

Proceedings of the National Academy of Sciences of the United States of America, 04 April 2017, Vol.114(14), pp.3708-3713 [Peer Reviewed Journal]

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Mapping the innate signaling cascade essential for cytokine storm during influenza virus infection

Teijaro, John R ; Walsh, Kevin B ; Rice, Stephanie ; Rosen, Hugh ; Oldstone, Michael B A

Proceedings of the National Academy of Sciences of the United States of America, 11 March 2014, Vol.111(10), pp.3799-804 [Peer Reviewed Journal]

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Potent and selective inhibitors of glutathione S-transferase omega 1 that impair cancer drug resistance

Tsuboi, Katsunori ; Bachovchin, Daniel A ; Speers, Anna E ; Spicer, Timothy P ; Fernandez-Vega, Virneliz ; Hodder, Peter ; Rosen, Hugh ; Cravatt, Benjamin F

Journal of the American Chemical Society, 19 October 2011, Vol.133(41), pp.16605-16 [Peer Reviewed Journal]

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S1PR1-mediated IFNAR1 degradation modulates plasmacytoid dendritic cell interferon-α autoamplification

Teijaro, John R ; Studer, Sean ; Leaf, Nora ; Kiosses, William B ; Nguyen, Nhan ; Matsuki, Kosuke ; Negishi, Hideo ; Taniguchi, Tadatsugu ; Oldstone, Michael B A ; Rosen, Hugh

Proceedings of the National Academy of Sciences of the United States of America, 02 February 2016, Vol.113(5), pp.1351-6 [Peer Reviewed Journal]

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Suppression of cytokine storm with a sphingosine analog provides protection against pathogenic influenza virus

Walsh, Kevin B ; Teijaro, John R ; Wilker, Peter R ; Jatzek, Anna ; Fremgen, Daniel M ; Das, Subash C ; Watanabe, Tokiko ; Hatta, Masato ; Shinya, Kyoko ; Suresh, Marulasiddappa ; Kawaoka, Yoshihiro ; Rosen, Hugh ; Oldstone, Michael B A

Proceedings of the National Academy of Sciences of the United States of America, 19 July 2011, Vol.108(29), pp.12018-23 [Peer Reviewed Journal]

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Crystal structure of a lipid G protein-coupled receptor

Hanson, Michael A ; Roth, Christopher B ; Jo, Euijung ; Griffith, Mark T ; Scott, Fiona L ; Reinhart, Greg ; Desale, Hans ; Clemons, Bryan ; Cahalan, Stuart M ; Schuerer, Stephan C ; Sanna, M Germana ; Han, Gye Won ; Kuhn, Peter ; Rosen, Hugh ; Stevens, Raymond C

Science (New York, N.Y.), 17 February 2012, Vol.335(6070), pp.851-5 [Peer Reviewed Journal]

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Chemical Proteomic Profiling of Human Methyltransferases

Horning, Benjamin D ; Suciu, Radu M ; Ghadiri, Darian A ; Ulanovskaya, Olesya A ; Matthews, Megan L ; Lum, Kenneth M ; Backus, Keriann M ; Brown, Steven J ; Rosen, Hugh ; Cravatt, Benjamin F

Journal of the American Chemical Society, 12 October 2016, Vol.138(40), pp.13335-13343 [Peer Reviewed Journal]

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A substrate-free activity-based protein profiling screen for the discovery of selective PREPL inhibitors

Lone, Anna Mari ; Bachovchin, Daniel A ; Westwood, David B ; Speers, Anna E ; Spicer, Timothy P ; Fernandez-Vega, Virneliz ; Chase, Peter ; Hodder, Peter S ; Rosen, Hugh ; Cravatt, Benjamin F ; Saghatelian, Alan

Journal of the American Chemical Society, 03 August 2011, Vol.133(30), pp.11665-74 [Peer Reviewed Journal]

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High‐Throughput Screening for Inhibitors of Sialyl‐ and Fucosyltransferases

Rillahan, Cory D. ; Brown, Steven J. ; Register, Amy C. ; Rosen, Hugh ; Paulson, James C.

Angewandte Chemie International Edition, 23 December 2011, Vol.50(52), pp.12534-12537 [Peer Reviewed Journal]

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Reversible inhibitor of p97, DBeQ, impairs both ubiquitin-dependent and autophagic protein clearance pathways

Chou, Tsui-Fen ; Brown, Steve J ; Minond, Dmitriy ; Nordin, Brian E ; Li, Kelin ; Jones, Amanda C ; Chase, Peter ; Porubsky, Patrick R ; Stoltz, Brian M ; Schoenen, Frank J ; Patricelli, Matthew P ; Hodder, Peter ; Rosen, Hugh ; Deshaies, Raymond J

Proceedings of the National Academy of Sciences of the United States of America, 22 March 2011, Vol.108(12), pp.4834-9 [Peer Reviewed Journal]

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Academic cross-fertilization by public screening yields a remarkable class of protein phosphatase methylesterase-1 inhibitors

Bachovchin, Daniel A ; Mohr, Justin T ; Speers, Anna E ; Wang, Chu ; Berlin, Jacob M ; Spicer, Timothy P ; Fernandez-Vega, Virneliz ; Chase, Peter ; Hodder, Peter S ; Schürer, Stephan C ; Nomura, Daniel K ; Rosen, Hugh ; Fu, Gregory C ; Cravatt, Benjamin F

Proceedings of the National Academy of Sciences of the United States of America, 26 April 2011, Vol.108(17), pp.6811-6 [Peer Reviewed Journal]

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Confirming target engagement for reversible inhibitors in vivo by kinetically tuned activity-based probes

Adibekian, Alexander ; Martin, Brent R ; Chang, Jae Won ; Hsu, Ku-Lung ; Tsuboi, Katsunori ; Bachovchin, Daniel A ; Speers, Anna E ; Brown, Steven J ; Spicer, Timothy ; Fernandez-Vega, Virneliz ; Ferguson, Jill ; Hodder, Peter S ; Rosen, Hugh ; Cravatt, Benjamin F

Journal of the American Chemical Society, 27 June 2012, Vol.134(25), pp.10345-8 [Peer Reviewed Journal]

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Discovery and optimization of sulfonyl acrylonitriles as selective, covalent inhibitors of protein phosphatase methylesterase-1

Bachovchin, Daniel A ; Zuhl, Andrea M ; Speers, Anna E ; Wolfe, Monique R ; Weerapana, Eranthie ; Brown, Steven J ; Rosen, Hugh ; Cravatt, Benjamin F

Journal of medicinal chemistry, 28 July 2011, Vol.54(14), pp.5229-36 [Peer Reviewed Journal]

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A benzo[b]thiophene-based selective type 4 S1P receptor agonist

Hur, Wooyoung ; Rosen, Hugh ; Gray, Nathanael S

Bioorganic & Medicinal Chemistry Letters, 01 January 2017, Vol.27(1), pp.1-5 [Peer Reviewed Journal]

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Three phases of CD8 T cell response in the lung following H1N1 influenza infection and sphingosine 1 phosphate agonist therapy

Matheu, Melanie P ; Teijaro, John R ; Walsh, Kevin B ; Greenberg, Milton L ; Marsolais, David ; Parker, Ian ; Rosen, Hugh ; Oldstone, Michael B A ; Cahalan, Michael D

PloS one, 2013, Vol.8(3), pp.e58033 [Peer Reviewed Journal]

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Rapid induction of medullary thymocyte phenotypic maturation and egress inhibition by nanomolar sphingosine 1-phosphate receptor agonist

Rosen, Hugh ; Alfonso, Christopher ; Surh, Charles D ; Mcheyzer-Williams, Michael G

Proceedings of the National Academy of Sciences of the United States of America, 16 September 2003, Vol.100(19), pp.10907-12 [Peer Reviewed Journal]

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17
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Reduced immunotoxicity and preservation of antibacterial acitivity in a releasable side-chain carbapenem antibiotic

Rosen, Hugh ; Hajdu, Richard ; Silver, Lynn ; Kropp, Helmut

Science, Jan 29, 1999, Vol.283(5402), pp.703-6 [Peer Reviewed Journal]

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18
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A sphingosine 1-phosphate receptor 2 selective allosteric agonist

Satsu, Hideo ; Schaeffer, Marie-Therese ; Guerrero, Miguel ; Saldana, Adrian ; Eberhart, Christina ; Hodder, Peter ; Cayanan, Charmagne ; Schürer, Stephan ; Bhhatarai, Barun ; Roberts, Ed ; Rosen, Hugh ; Brown, Steven J

Bioorganic & Medicinal Chemistry, 01 September 2013, Vol.21(17), pp.5373-5382 [Peer Reviewed Journal]

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19
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Sphingosine 1-phosphate receptor 3 and RhoA signaling mediate inflammatory gene expression in astrocytes

Dusaban, Stephanie S ; Chun, Jerold ; Rosen, Hugh ; Purcell, Nicole H ; Brown, Joan Heller

Journal of neuroinflammation, 02 June 2017, Vol.14(1), pp.111 [Peer Reviewed Journal]

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20
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FTY720 (fingolimod) modulates the severity of viral-induced encephalomyelitis and demyelination

Blanc, Caroline ; Rosen, Hugh ; Lane, Thomas

Journal of Neuroinflammation, 2014, Vol.11, p.138 [Peer Reviewed Journal]

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21
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Modulators of the Sphingosine 1-phosphate receptor 1

Urbano, Mariangela ; Guerrero, Miguel ; Rosen, Hugh ; Roberts, Edward

Bioorganic & Medicinal Chemistry Letters, 01 December 2013, Vol.23(23), pp.6377-6389 [Peer Reviewed Journal]

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22
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Antagonists of the kappa opioid receptor

Urbano, Mariangela ; Guerrero, Miguel ; Rosen, Hugh ; Roberts, Edward

Bioorganic & Medicinal Chemistry Letters, 01 May 2014, Vol.24(9), pp.2021-2032 [Peer Reviewed Journal]

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23
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Regulation of immunity by lysosphingolipids and their G protein-coupled receptors

Goetzl, Edward J ; Rosen, Hugh

The Journal of clinical investigation, December 2004, Vol.114(11), pp.1531-7 [Peer Reviewed Journal]

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24
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A fluorescent plate reader assay for ceramide kinase

Don, Anthony S ; Rosen, Hugh

Analytical Biochemistry, 15 April 2008, Vol.375(2), pp.265-271 [Peer Reviewed Journal]

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25
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Host endothelial S1PR1 regulation of vascular permeability modulates tumor growth

Sarkisyan, Gor ; Gay, Laurie J ; Nguyen, Nhan ; Felding, Brunhilde H ; Rosen, Hugh

American journal of physiology. Cell physiology, 01 July 2014, Vol.307(1), pp.C14-24 [Peer Reviewed Journal]

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Sphingosine kinase 2 prevents the nuclear translocation of sphingosine 1-phosphate receptor-2 and tyrosine 416 phosphorylated c-Src and increases estrogen receptor negative MDA-MB-231 breast cancer cell growth: The role of sphingosine 1-phosphate receptor-4

Ohotski, Jan ; Rosen, Hugh ; Bittman, Robert ; Pyne, Susan ; Pyne, Nigel J

Cellular Signalling, May 2014, Vol.26(5), pp.1040-1047 [Peer Reviewed Journal]

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27
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S1P signaling: new therapies and opportunities

Gonzalez-Cabrera, Pedro J ; Brown, Steve ; Studer, Sean M ; Rosen, Hugh

F1000prime reports, 2014, Vol.6, pp.109 [Peer Reviewed Journal]

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28
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SAR analysis of novel non-peptidic NPBWR1 (GPR7) antagonists

Guerrero, Miguel ; Urbano, Mariangela ; Schaeffer, Marie-Therese ; Brown, Steven ; Rosen, Hugh ; Roberts, Edward

Bioorganic & Medicinal Chemistry Letters, 01 February 2013, Vol.23(3), pp.614-619 [Peer Reviewed Journal]

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Modulation of chemokines and allergic airway inflammation by selective local sphingosine-1-phosphate receptor 1 agonism in lungs

Marsolais, David ; Yagi, Saiko ; Kago, Tomoyuki ; Leaf, Nora ; Rosen, Hugh

Molecular pharmacology, January 2011, Vol.79(1), pp.61-8 [Peer Reviewed Journal]

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30
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Host endothelial S1PR^sub 1^ regulation of vascular permeability modulates tumor growth

Sarkisyan, Gor ; Gay, Laurie ; Nguyen, Nhan ; Felding, Brunhilde ; Rosen, Hugh

American Journal of Physiology, Jul 1, 2014, Vol.307(1), p.C14 [Peer Reviewed Journal]

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31
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Dissecting influenza virus pathogenesis uncovers a novel chemical approach to combat the infection

Oldstone, Michael B.A ; Teijaro, John R ; Walsh, Kevin B ; Rosen, Hugh

Virology, 05 January 2013, Vol.435(1), pp.92-101 [Peer Reviewed Journal]

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The function of follicular helper T cells is regulated by the strength of T cell antigen receptor binding

Fazilleau, Nicolas ; Mcheyzer-Williams, Louise ; Rosen, Hugh ; Mcheyzer-Williams, Michael

Nature Immunology, Apr 2011, Vol.12(4), pp.362-363 [Peer Reviewed Journal]

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33
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Real-time differential labeling of blood, interstitium, and lymphatic and single-field analysis of vasculature dynamics in vivo

Sarkisyan, Gor ; Cahalan, Stuart M ; Gonzalez-Cabrera, Pedro J ; Leaf, Nora B ; Rosen, Hugh

American journal of physiology. Cell physiology, 15 May 2012, Vol.302(10), pp.C1460-8 [Peer Reviewed Journal]

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A High-Throughput Cell-Based Gaussia Luciferase Reporter Assay for Identifying Modulators of Fibulin-3 Secretion

Hulleman, John D ; Brown, Steven J ; Rosen, Hugh ; Kelly, Jeffery W

Journal of Biomolecular Screening, July 2013, Vol.18(6), pp.647-658 [Peer Reviewed Journal]

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A critical role for the sphingosine analog AAL-R in dampening the cytokine response during influenza virus infection

Marsolais, David ; Hahm, Bumsuk ; Walsh, Kevin B ; Edelmann, Kurt H ; Mcgavern, Dorian ; Hatta, Yasuko ; Kawaoka, Yoshihiro ; Rosen, Hugh ; Oldstone, Michael B A

Proceedings of the National Academy of Sciences of the United States of America, 03 February 2009, Vol.106(5), pp.1560-5 [Peer Reviewed Journal]

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FTY720 (fingolimod) modulates the severity of viral-induced encephalomyelitis and demyelination

Blanc, Caroline A ; Rosen, Hugh ; Lane, Thomas E

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