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Autosomal-Recessive Hearing Impairment Due to Rare Missense Variants within S1PR2

Santos-Cortez, Regie Lyn P ; Faridi, Rabia ; Rehman, Atteeq U ; Lee, Kwanghyuk ; Ansar, Muhammad ; Wang, Xin ; Morell, Robert J ; Isaacson, Rivka ; Belyantseva, Inna A ; Dai, Hang ; Acharya, Anushree ; Qaiser, Tanveer A ; Muhammad, Dost ; Ali, Rana Amjad ; Shams, Sulaiman ; Hassan, Muhammad Jawad ; Shahzad, Shaheen ; Raza, Syed Irfan ; Bashir, Zil-E-Huma ; Smith

American journal of human genetics, 04 February 2016, Vol.98(2), pp.331-8 [Peer Reviewed Journal]

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Prolonging survival of corneal transplantation by selective sphingosine-1-phosphate receptor 1 agonist

Gao, Min ; Liu, Yong ; Xiao, Yang ; Han, Gencheng ; Jia, Liang ; Wang, Liqiang ; Lei, Tian ; Huang, Yifei

PloS one, 2014, Vol.9(9), pp.e105693 [Peer Reviewed Journal]

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Discovery, design and synthesis of novel potent and selective sphingosine-1-phosphate 4 receptor (S1P₄-R) agonists

Guerrero, Miguel ; Urbano, Mariangela ; Zhao, Jian ; Crisp, Melissa ; Chase, Peter ; Hodder, Peter ; Schaeffer, Marie-Therese ; Brown, Steven ; Rosen, Hugh ; Roberts, Edward

Bioorganic & medicinal chemistry letters, 01 January 2012, Vol.22(1), pp.537-42 [Peer Reviewed Journal]

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Reassessment of the pharmacology of Sphingosine-1-phosphate S1P3 receptor ligands using the DiscoveRx PathHunter™ and Ca2+ release functional assays

Riddy, D M ; Stamp, C ; Sykes, D A ; Charlton, S J ; Dowling, M R

British journal of pharmacology, October 2012, Vol.167(4), pp.868-80 [Peer Reviewed Journal]

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Crystal structure of a lipid G protein-coupled receptor

Hanson, Michael A ; Roth, Christopher B ; Jo, Euijung ; Griffith, Mark T ; Scott, Fiona L ; Reinhart, Greg ; Desale, Hans ; Clemons, Bryan ; Cahalan, Stuart M ; Schuerer, Stephan C ; Sanna, M Germana ; Han, Gye Won ; Kuhn, Peter ; Rosen, Hugh ; Stevens, Raymond C

Science (New York, N.Y.), 17 February 2012, Vol.335(6070), pp.851-5 [Peer Reviewed Journal]

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Novel selective allosteric and bitopic ligands for the S1P(3) receptor

Jo, Euijung ; Bhhatarai, Barun ; Repetto, Emanuela ; Guerrero, Miguel ; Riley, Sean ; Brown, Steven J ; Kohno, Yasushi ; Roberts, Edward ; Schürer, Stephan C ; Rosen, Hugh

ACS chemical biology, 21 December 2012, Vol.7(12), pp.1975-83 [Peer Reviewed Journal]

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Therapeutic effects of novel sphingosine-1-phosphate receptor agonist W-061 in murine DSS colitis

Sanada, Yasuaki ; Mizushima, Tsunekazu ; Kai, Yasuyuki ; Nishimura, Junichi ; Hagiya, Hiroshi ; Kurata, Haruto ; Mizuno, Hirotaka ; Uejima, Etsuko ; Ito, Toshinori

PloS one, 2011, Vol.6(9), pp.e23933 [Peer Reviewed Journal]

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Sphingosine-1-Phosphate Receptor 2 Regulates Proinflammatory Cytokine Production and Osteoclastogenesis

Yu, Hong

PloS one, 2016, Vol.11(5), pp.e0156303 [Peer Reviewed Journal]

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Sphingosine-1-phosphate receptor-2 facilitates pulmonary fibrosis through potentiating IL-13 pathway in macrophages

Zhao, Juanjuan ; Okamoto, Yasuo ; Asano, Yuya ; Ishimaru, Kazuhiro ; Aki, Sho ; Yoshioka, Kazuaki ; Takuwa, Noriko ; Wada, Takashi ; Inagaki, Yutaka ; Takahashi, Chiaki ; Nishiuchi, Takumi ; Takuwa, Yoh

PloS one, 2018, Vol.13(5), pp.e0197604 [Peer Reviewed Journal]

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Sphingosine-1-phosphate receptor 3 mediates sphingosine-1-phosphate induced release of weibel-palade bodies from endothelial cells

Van Hooren, Kathinka W E M ; Spijkers, Léon J A ; Van Breevoort, Dorothee ; Fernandez-Borja, Mar ; Bierings, Ruben ; Van Buul, Jaap D ; Alewijnse, Astrid E ; Peters, Stephan L M ; Voorberg, Jan

PloS one, 2014, Vol.9(3), pp.e91346 [Peer Reviewed Journal]

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AKP-11 - A Novel S1P1 Agonist with Favorable Safety Profile Attenuates Experimental Autoimmune Encephalomyelitis in Rat Model of Multiple Sclerosis

Samuvel, Devadoss J ; Saxena, Nishant ; Dhindsa, Jasdeep S ; Singh, Avtar K ; Gill, Gurmit S ; Grobelny, Damian W ; Singh, Inderjit

PloS one, 2015, Vol.10(10), pp.e0141781 [Peer Reviewed Journal]

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Genetic evidence for involvement of neuronally expressed S1P₁ receptor in nociceptor sensitization and inflammatory pain

Mair, Norbert ; Benetti, Camilla ; Andratsch, Manfred ; Leitner, Michael G ; Constantin, Cristina E ; Camprubí-Robles, Maria ; Quarta, Serena ; Biasio, Wolfgang ; Kuner, Rohini ; Gibbins, Ian L ; Kress, Michaela ; Haberberger, Rainer V

PloS one, 17 February 2011, Vol.6(2), pp.e17268 [Peer Reviewed Journal]

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Augmented sphingosine 1 phosphate receptor-1 signaling in cardiac fibroblasts induces cardiac hypertrophy and fibrosis through angiotensin II and interleukin-6

Ohkura, Sei-Ichiro ; Usui, Soichiro ; Takashima, Shin-Ichiro ; Takuwa, Noriko ; Yoshioka, Kazuaki ; Okamoto, Yasuo ; Inagaki, Yutaka ; Sugimoto, Naotoshi ; Kitano, Teppei ; Takamura, Masayuki ; Wada, Takashi ; Kaneko, Shuichi ; Takuwa, Yoh

PloS one, 2017, Vol.12(8), pp.e0182329 [Peer Reviewed Journal]

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ASP4058, a novel agonist for sphingosine 1-phosphate receptors 1 and 5, ameliorates rodent experimental autoimmune encephalomyelitis with a favorable safety profile

Yamamoto, Rie ; Okada, Youhei ; Hirose, Jun ; Koshika, Tadatsura ; Kawato, Yuka ; Maeda, Masashi ; Saito, Rika ; Hattori, Kazuyuki ; Harada, Hironori ; Nagasaka, Yasuhisa ; Morokata, Tatsuaki

PloS one, 2014, Vol.9(10), pp.e110819 [Peer Reviewed Journal]

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15
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Sphingosine-1-phosphate receptor 1 reporter mice reveal receptor activation sites in vivo

Kono, Mari ; Tucker, Ana E ; Tran, Jennifer ; Bergner, Jennifer B ; Turner, Ewa M ; Proia, Richard L

The Journal of clinical investigation, May 2014, Vol.124(5), pp.2076-86 [Peer Reviewed Journal]

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16
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Agonist-dependent effects of mutations in the sphingosine-1-phosphate type 1 receptor

Van Loenen, Pieter B ; De Graaf, Chris ; Verzijl, Dennis ; Leurs, Rob ; Rognan, Didier ; Peters, Stephan L M ; Alewijnse, Astrid E

European journal of pharmacology, 30 September 2011, Vol.667(1-3), pp.105-12 [Peer Reviewed Journal]

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17
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Role of S1P/S1PR3 axis in release of CCL20 from human bronchial epithelial cells

Kawa, Yoshitaka ; Nagano, Tatsuya ; Yoshizaki, Asuka ; Dokuni, Ryota ; Katsurada, Masahiro ; Terashita, Tomomi ; Yasuda, Yuichiro ; Umezawa, Kanoko ; Yamamoto, Masatsugu ; Kamiryo, Hiroshi ; Kobayashi, Kazuyuki ; Nishimura, Yoshihiro

PloS one, 2018, Vol.13(9), pp.e0203211 [Peer Reviewed Journal]

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18
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Impairment of Angiogenic Sphingosine Kinase-1/Sphingosine-1-Phosphate Receptors Pathway in Preeclampsia

Dobierzewska, Aneta ; Palominos, Macarena ; Sanchez, Marianela ; Dyhr, Michael ; Helgert, Katja ; Venegas-Araneda, Pia ; Tong, Stephen ; Illanes, Sebastian E

PloS one, 2016, Vol.11(6), pp.e0157221 [Peer Reviewed Journal]

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19
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Moesin controls clathrin-mediated S1PR1 internalization in T cells

Nomachi, Akira ; Yoshinaga, Masanori ; Liu, Jaron ; Kanchanawong, Pakorn ; Tohyama, Kiyoshi ; Thumkeo, Dean ; Watanabe, Takeshi ; Narumiya, Shuh ; Hirata, Takako

PloS one, 2013, Vol.8(12), pp.e82590 [Peer Reviewed Journal]

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20
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Therapeutic use of a selective S1P1 receptor modulator ponesimod in autoimmune diabetes

You, Sylvaine ; Piali, Luca ; Kuhn, Chantal ; Steiner, Beat ; Sauvaget, Virginia ; Valette, Fabrice ; Clozel, Martine ; Bach, Jean-François ; Chatenoud, Lucienne

PloS one, 2013, Vol.8(10), pp.e77296 [Peer Reviewed Journal]

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21
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Sphingosine 1-phosphate (S1P) induced interleukin-8 (IL-8) release is mediated by S1P receptor 2 and nuclear factor κB in BEAS-2B cells

O'Sullivan, Michael J ; Hirota, Nobuaki ; Martin, James G

PloS one, 2014, Vol.9(4), pp.e95566 [Peer Reviewed Journal]

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22
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Knock out of S1P3 receptor signaling attenuates inflammation and fibrosis in bleomycin-induced lung injury mice model

Murakami, Ken ; Kohno, Masataka ; Kadoya, Masatoshi ; Nagahara, Hidetake ; Fujii, Wataru ; Seno, Takahiro ; Yamamoto, Aihiro ; Oda, Ryo ; Fujiwara, Hiroyoshi ; Kubo, Toshikazu ; Morita, Satoshi ; Nakada, Hiroshi ; Hla, Timothy ; Kawahito, Yutaka

PloS one, 2014, Vol.9(9), pp.e106792 [Peer Reviewed Journal]

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23
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Sphingosine-1-Phosphate Receptor-1 Selective Agonist Enhances Collateral Growth and Protects against Subsequent Stroke

Ichijo, Masahiko ; Ishibashi, Satoru ; Li, Fuying ; Yui, Daishi ; Miki, Kazunori ; Mizusawa, Hidehiro ; Yokota, Takanori

PloS one, 2015, Vol.10(9), pp.e0138029 [Peer Reviewed Journal]

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24
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Sphingosine 1-phosphate attenuates MMP2 and MMP9 in human anaplastic thyroid cancer C643 cells: Importance of S1P2

Asghar, Muhammad Yasir ; Kemppainen, Kati ; Lassila, Taru ; Törnquist, Kid

PloS one, 2018, Vol.13(5), pp.e0196992 [Peer Reviewed Journal]

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25
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S1P1 receptor modulation preserves vascular function in mesenteric and coronary arteries after CPB in the rat independent of depletion of lymphocytes

Samarska, Iryna V ; Bouma, Hjalmar R ; Buikema, Hendrik ; Mungroop, Hubert E ; Houwertjes, Martin C ; Absalom, Anthony R ; Epema, Anne H ; Henning, Robert H

PloS one, 2014, Vol.9(5), pp.e97196 [Peer Reviewed Journal]

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26
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In vitro and in vivo antagonism of a G protein-coupled receptor (S1P3) with a novel blocking monoclonal antibody

Harris, Greg L ; Creason, Michael B ; Brulte, Greg B ; Herr, Deron R

PloS one, 2012, Vol.7(4), pp.e35129 [Peer Reviewed Journal]

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27
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The effect of sphingosine-1-phosphate on colonic smooth muscle contractility: Modulation by TNBS-induced colitis

Al-Jarallah, Aishah ; Oriowo, Mabayoje

PloS one, 2017, Vol.12(5), pp.e0170792 [Peer Reviewed Journal]

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28
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Sphingosine kinase 1 and sphingosine 1-phosphate receptor 3 are functionally upregulated on astrocytes under pro-inflammatory conditions

Fischer, Iris ; Alliod, Chantal ; Martinier, Nicolas ; Newcombe, Jia ; Brana, Corinne ; Pouly, Sandrine

PloS one, 2011, Vol.6(8), pp.e23905 [Peer Reviewed Journal]

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29
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Targeting the SphK1/S1P/S1PR1 Axis That Links Obesity, Chronic Inflammation, and Breast Cancer Metastasis

Nagahashi, Masayuki ; Yamada, Akimitsu ; Katsuta, Eriko ; Aoyagi, Tomoyoshi ; Huang, Wei-Ching ; Terracina, Krista P ; Hait, Nitai C ; Allegood, Jeremy C ; Tsuchida, Junko ; Yuza, Kizuki ; Nakajima, Masato ; Abe, Manabu ; Sakimura, Kenji ; Milstien, Sheldon ; Wakai, Toshifumi ; Spiegel, Sarah ; Takabe, Kazuaki

Cancer research, 01 April 2018, Vol.78(7), pp.1713-1725 [Peer Reviewed Journal]

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30
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A role of the sphingosine-1-phosphate (S1P)-S1P receptor 2 pathway in epithelial defense against cancer (EDAC)

Yamamoto, Sayaka ; Yako, Yuta ; Fujioka, Yoichiro ; Kajita, Mihoko ; Kameyama, Takeshi ; Kon, Shunsuke ; Ishikawa, Susumu ; Ohba, Yusuke ; Ohno, Yusuke ; Kihara, Akio ; Fujita, Yasuyuki

Molecular biology of the cell, 01 February 2016, Vol.27(3), pp.491-9 [Peer Reviewed Journal]

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31
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Discovery, synthesis and SAR analysis of novel selective small molecule S1P4-R agonists based on a (2Z,5Z)-5-((pyrrol-3-yl)methylene)-3-alkyl-2-(alkylimino)thiazolidin-4-one chemotype

Urbano, Mariangela ; Guerrero, Miguel ; Velaparthi, Subash ; Crisp, Melissa ; Chase, Peter ; Hodder, Peter ; Schaeffer, Marie-Therese ; Brown, Steven ; Rosen, Hugh ; Roberts, Edward

Bioorganic & medicinal chemistry letters, 15 November 2011, Vol.21(22), pp.6739-45 [Peer Reviewed Journal]

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32
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Pathophysiological Consequences of a Break in S1P1-Dependent Homeostasis of Vascular Permeability Revealed by S1P1 Competitive Antagonism

Bigaud, Marc ; Dincer, Zuhal ; Bollbuck, Birgit ; Dawson, Janet ; Beckmann, Nicolau ; Beerli, Christian ; Fishli-Cavelti, Gina ; Nahler, Michaela ; Angst, Daniela ; Janser, Philipp ; Otto, Heike ; Rosner, Elisabeth ; Hersperger, Rene ; Bruns, Christian ; Quancard, Jean

PloS one, 2016, Vol.11(12), pp.e0168252 [Peer Reviewed Journal]

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33
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Ozanimod (RPC1063), a selective S1PR1 and S1PR5 modulator, reduces chronic inflammation and alleviates kidney pathology in murine systemic lupus erythematosus

Taylor Meadows, Kristen R ; Steinberg, Marcos W ; Clemons, Bryan ; Stokes, Matthew E ; Opiteck, Gregory J ; Peach, Robert ; Scott, Fiona L

PloS one, 2018, Vol.13(4), pp.e0193236 [Peer Reviewed Journal]

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34
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Sphingosine-1-Phosphate Induces Dose-Dependent Chemotaxis or Fugetaxis of T-ALL Blasts through S1P1 Activation

Messias, Carolina V ; Santana-Van-Vliet, Eliane ; Lemos, Julia P ; Moreira, Otacilio C ; Cotta-De-Almeida, Vinicius ; Savino, Wilson ; Mendes-Da-Cruz, Daniella Arêas

PloS one, 2016, Vol.11(1), pp.e0148137 [Peer Reviewed Journal]

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35
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Berberine reduces fibronectin expression by suppressing the S1P-S1P2 receptor pathway in experimental diabetic nephropathy models

Huang, Kaipeng ; Liu, Weihua ; Lan, Tian ; Xie, Xi ; Peng, Jing ; Huang, Juan ; Wang, Shaogui ; Shen, Xiaoyan ; Liu, Peiqing ; Huang, Heqing

PloS one, 2012, Vol.7(8), pp.e43874 [Peer Reviewed Journal]

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36
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Sphingosine 1-phosphate receptor 1 (S1PR1) agonist CYM5442 inhibits expression of intracellular adhesion molecule 1 (ICAM1) in endothelial cells infected with influenza A viruses

Jiang, Hao ; Shen, Si-Mei ; Yin, Jie ; Zhang, Peng-Peng ; Shi, Yi

PloS one, 2017, Vol.12(4), pp.e0175188 [Peer Reviewed Journal]

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37
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The clinically-tested S1P receptor agonists, FTY720 and BAF312, demonstrate subtype-specific bradycardia (S1P₁) and hypertension (S1P₃) in rat

Fryer, Ryan M ; Muthukumarana, Akalushi ; Harrison, Paul C ; Nodop Mazurek, Suzanne ; Chen, Rong Rhonda ; Harrington, Kyle E ; Dinallo, Roger M ; Horan, Joshua C ; Patnaude, Lori ; Modis, Louise K ; Reinhart, Glenn A

PloS one, 2012, Vol.7(12), pp.e52985 [Peer Reviewed Journal]

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