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1
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Discovery of a potent class I selective ketone histone deacetylase inhibitor with antitumor activity in vivo and optimized pharmacokinetic properties

Kinzel, Olaf ; Llauger-Bufi, Laura ; Pescatore, Giovanna ; Rowley, Michael ; Schultz-Fademrecht, Carsten ; Monteagudo, Edith ; Fonsi, Massimiliano ; Gonzalez Paz, Odalys ; Fiore, Fabrizio ; Steinkühler, Christian ; Jones, Philip

Journal of medicinal chemistry, 11 June 2009, Vol.52(11), pp.3453-6 [Peer Reviewed Journal]

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2
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An efficient liquid chromatography-high resolution mass spectrometry approach for the optimization of the metabolic stability of therapeutic peptides

Esposito, Simone ; Mele, Riccardo ; Ingenito, Raffaele ; Bianchi, Elisabetta ; Bonelli, Fabio ; Monteagudo, Edith ; Orsatti, Laura

Analytical and Bioanalytical Chemistry, 2017, Vol.409(10), pp.2685-2696 [Peer Reviewed Journal]

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3
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Fosmetpantotenate (RE-024), a phosphopantothenate replacement therapy for pantothenate kinase-associated neurodegeneration: Mechanism of action and efficacy in nonclinical models

Elbaum, Daniel ; Beconi, Maria G ; Monteagudo, Edith ; Di Marco, Annalise ; Quinton, Maria S ; Lyons, Kathryn A ; Vaino, Andrew ; Harper, Steven

PloS one, 2018, Vol.13(3), pp.e0192028 [Peer Reviewed Journal]

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4
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Synthesis and antiviral properties of novel 7-heterocyclic substituted 7-deaza-adenine nucleoside inhibitors of Hepatitis C NS5B polymerase

Di Francesco, M. Emilia ; Avolio, Salvatore ; Pompei, Marco ; Pesci, Silvia ; Monteagudo, Edith ; Pucci, Vincenzo ; Giuliano, Claudio ; Fiore, Fabrizio ; Rowley, Michael ; Summa, Vincenzo

Bioorganic & Medicinal Chemistry, 01 August 2012, Vol.20(15), pp.4801-4811 [Peer Reviewed Journal]

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5
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PEGylation of Neuromedin U yields a promising candidate for the treatment of obesity and diabetes

Ingallinella, Paolo ; Peier, Andrea M ; Pocai, Alessandro ; Marco, Annalise Di ; Desai, Kunal ; Zytko, Karolina ; Qian, Ying ; Du, Xiaobing ; Cellucci, Antonella ; Monteagudo, Edith ; Laufer, Ralph ; Bianchi, Elisabetta ; Marsh, Donald J ; Pessi, Antonello

Bioorganic & Medicinal Chemistry, 01 August 2012, Vol.20(15), pp.4751-4759 [Peer Reviewed Journal]

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6
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Conformations of laulimalide in DMSO-d6

Thepchatri, Pahk ; Cicero, Daniel O ; Monteagudo, Edith ; Ghosh, Arun K ; Cornett, Ben ; Weeks, Eric R ; Snyder, James P

Journal of the American Chemical Society, 21 September 2005, Vol.127(37), pp.12838-46 [Peer Reviewed Journal]

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7
The Conformations of Discodermolide in DMSO
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The Conformations of Discodermolide in DMSO

Monteagudo, Edith ; Cicero, Daniel O. ; Cornett, Ben ; Myles, David C. ; Snyder, James P.

Journal of the American Chemical Society, 07/2001, Vol.123(28), pp.6929-6930 [Peer Reviewed Journal]

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8
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Discovery and Characterization of Novel Anti-schistosomal Properties of the Anti-anginal Drug, Perhexiline and Its Impact on Schistosoma mansoni Male and Female Reproductive Systems

Guidi, Alessandra ; Lalli, Cristiana ; Perlas, Emerald ; Bolasco, Giulia ; Nibbio, Martina ; Monteagudo, Edith ; Bresciani, Alberto ; Ruberti, Giovina Greenberg, Robert M (editor)

PLoS Neglected Tropical Diseases, 2016, Vol.10(8) [Peer Reviewed Journal]

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9
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Use of ‘dilute-and-shoot’ liquid chromatography-high resolution mass spectrometry in preclinical research: application to a DMPK study of perhexiline in mouse plasma

Esposito, Simone ; Bracacel, Elena ; Nibbio, Martina ; Speziale, Roberto ; Orsatti, Laura ; Veneziano, Maria ; Monteagudo, Edith ; Bonelli, Fabio

Journal of Pharmaceutical and Biomedical Analysis, 25 January 2016, Vol.118, pp.70-80 [Peer Reviewed Journal]

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10
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A liquid chromatography high-resolution mass spectrometry in vitro assay to assess metabolism at the injection site of subcutaneously administered therapeutic peptides

Esposito, Simone ; de Leonibus, Maria Lucia ; Ingenito, Raffaele ; Bianchi, Elisabetta ; Orsatti, Laura ; Monteagudo, Edith

Journal of Pharmaceutical and Biomedical Analysis, 10 September 2018, Vol.159, pp.449-458 [Peer Reviewed Journal]

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11
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MK-5172, a selective inhibitor of hepatitis C virus NS3/4a protease with broad activity across genotypes and resistant variants

Summa, Vincenzo ; Ludmerer, Steven W ; Mccauley, John A ; Fandozzi, Christine ; Burlein, Christine ; Claudio, Giuliano ; Coleman, Paul J ; Dimuzio, Jillian M ; Ferrara, Marco ; Di Filippo, Marcello ; Gates, Adam T ; Graham, Donald J ; Harper, Steven ; Hazuda, Daria J ; Huang, Qian ; Mchale, Carolyn ; Monteagudo, Edith ; Pucci, Vincenzo ; Rowley, Michael ; Rudd

Antimicrobial agents and chemotherapy, August 2012, Vol.56(8), pp.4161-7 [Peer Reviewed Journal]

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12
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ApoA-I mimetic peptides promote pre-β HDL formation in vivo causing remodeling of HDL and triglyceride accumulation at higher dose

Carballo-Jane, Ester ; Chen, Zhu ; O’neill, Edward ; Wang, Jun ; Burton, Charlotte ; Chang, Ching H ; Chen, Xun ; Eveland, Suzanne ; Frantz-Wattley, Betsy ; Gagen, Karen ; Hubbard, Brian ; Ichetovkin, Marina ; Luell, Silvi ; Meurer, Roger ; Song, Xuelei ; Strack, Alison ; Langella, Annunziata ; Cianetti, Simona ; Rech, Francesca

Bioorganic & Medicinal Chemistry, 2010, Vol.18(24), pp.8669-8678 [Peer Reviewed Journal]

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13
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Turbulent Flow Chromatography TFC-tandem mass spectrometry supporting in vitro/ vivo studies of NCEs in high throughput fashion

Verdirame, Maria ; Veneziano, Maria ; Alfieri, Anna ; Di Marco, Annalise ; Monteagudo, Edith ; Bonelli, Fabio

Journal of Pharmaceutical and Biomedical Analysis, 2010, Vol.51(4), pp.834-841 [Peer Reviewed Journal]

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14
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Determination of acetyl coenzyme A in human whole blood by ultra-performance liquid chromatography-mass spectrometry

Speziale, Roberto ; Montesano, Camilla ; De Leonibus, Maria Lucia ; Bonelli, Fabio ; Fezzardi, Paola ; Beconi, Maria G ; Monteagudo, Edith ; Elbaum, Daniel ; Orsatti, Laura

Journal of Chromatography B, 15 April 2018, Vol.1083, pp.57-62 [Peer Reviewed Journal]

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15
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2′- C-Methyluridine phosphoramidite: a new building block for the preparation of RNA analogues carrying the 2′-hydroxyl group

Gallo, Mariana ; Monteagudo, Edith ; Cicero, Daniel O ; Torres, Héctor N ; Iribarren, Adolfo M

Tetrahedron, 2001, Vol.57(27), pp.5707-5713 [Peer Reviewed Journal]

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16
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The synthesis of tetrahydropyridopyrimidones as a new scaffold for HIV-1 integrase inhibitors

Kinzel, Olaf D ; Monteagudo, Edith ; Muraglia, Ester ; Orvieto, Federica ; Pescatore, Giovanna ; Ferreira, Maria Del Rosario Rico ; Rowley, Michael ; Summa, Vincenzo

Tetrahedron Letters, 2007, Vol.48(37), pp.6552-6555 [Peer Reviewed Journal]

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17
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Development of substituted 6-[4-fluoro-3-(piperazin-1-ylcarbonyl)benzyl]-4,5-dimethylpyridazin-3(2 H)-ones as potent poly(ADP–ribose) polymerase-1 (PARP-1) inhibitors active in BRCA deficient cells

Ferrigno, Federica ; Branca, Danila ; Kinzel, Olaf ; Lillini, Samuele ; Llauger Bufi, Laura ; Monteagudo, Edith ; Muraglia, Ester ; Rowley, Michael ; Schultz-Fademrecht, Carsten ; Toniatti, Carlo ; Torrisi, Caterina ; Jones, Philip

Bioorganic & Medicinal Chemistry Letters, 2010, Vol.20(3), pp.1100-1105 [Peer Reviewed Journal]

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18
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N-(2-alkylaminoethyl)-4-(1,2,4-oxadiazol-5-yl)piperazine-1-carboxamides as highly potent smoothened antagonists

Muraglia, Ester ; Ontoria, Jesus M ; Branca, Danila ; Dessole, Gabriella ; Bresciani, Alberto ; Fonsi, Massimiliano ; Giuliano, Claudio ; Llauger Bufi, Laura ; Monteagudo, Edith ; Palumbi, Maria Cecilia ; Torrisi, Caterina ; Rowley, Michael ; Steinkühler, Christian ; Jones, Philip

Bioorganic & Medicinal Chemistry Letters, 15 September 2011, Vol.21(18), pp.5283-5288 [Peer Reviewed Journal]

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19
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A single-run liquid chromatography mass spectrometry method to quantify neuroactive kynurenine pathway metabolites in rat plasma

Orsatti, Laura ; Speziale, Roberto ; Orsale, Maria Vittoria ; Caretti, Fulvia ; Veneziano, Maria ; Zini, Matteo ; Monteagudo, Edith ; Lyons, Kathryn ; Beconi, Maria ; Chan, Kelvin ; Herbst, Todd ; Toledo-Sherman, Leticia ; Munoz-Sanjuan, Ignacio ; Bonelli, Fabio ; Dominguez, Celia

Journal of Pharmaceutical and Biomedical Analysis, 25 March 2015, Vol.107, pp.426-431 [Peer Reviewed Journal]

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20
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Novel macrocyclic inhibitors of hepatitis C NS3/4A protease featuring a 2-amino-1,3-thiazole as a P4 carbamate replacement

Di Francesco, M Emilia ; Dessole, Gabriella ; Nizi, Emanuela ; Pace, Paola ; Koch, Uwe ; Fiore, Fabrizio ; Pesci, Silvia ; Di Muzio, Jillian ; Monteagudo, Edith ; Rowley, Michael ; Summa, Vincenzo

Journal of medicinal chemistry, 26 November 2009, Vol.52(22), pp.7014-28 [Peer Reviewed Journal]

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21
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A novel series of potent and selective ketone histone deacetylase inhibitors with antitumor activity in vivo

Jones, Philip ; Altamura, Sergio ; De Francesco, Raffaele ; Paz, Odalys Gonzalez ; Kinzel, Olaf ; Mesiti, Giuseppe ; Monteagudo, Edith ; Pescatore, Giovanna ; Rowley, Michael ; Verdirame, Maria ; Steinkühler, Christian

Journal of medicinal chemistry, 24 April 2008, Vol.51(8), pp.2350-3 [Peer Reviewed Journal]

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22
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Stereospecific synthesis of 1-alkylimidazole derivatives via mitsunobu reactions

Botta, Maurizio ; Summa, Vincenzo ; Trapassi, Gianna ; Monteagudo, Edith ; Corelli, Federico

Tetrahedron: Asymmetry, 1994, Vol.5(2), pp.181-184 [Peer Reviewed Journal]

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23
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Biosynthesis of withanolides in Acnistus breviflorus. Incorporation of labelled 24-methylenecholesterol

Monteagudo, Edith S ; Burton, Gerardo ; Gros, Eduardo G

Phytochemistry, 1994, Vol.35(4), pp.927-929 [Peer Reviewed Journal]

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24
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4,5-dihydroxypyrimidine carboxamides and N-alkyl-5-hydroxypyrimidinone carboxamides are potent, selective HIV integrase inhibitors with good pharmacokinetic profiles in preclinical species

Summa, Vincenzo ; Petrocchi, Alessia ; Matassa, Victor G ; Gardelli, Cristina ; Muraglia, Ester ; Rowley, Michael ; Paz, Odalys Gonzalez ; Laufer, Ralph ; Monteagudo, Edith ; Pace, Paola

Journal of medicinal chemistry, 16 November 2006, Vol.49(23), pp.6646-9 [Peer Reviewed Journal]

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25
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NMR-Spectroscopic, computational and mass-spectrometric investigations on the cis/ trans analogues of 2,3,4-trihydronaphthalene-1-one

Cartoni, Antonella ; Madami, Andrea ; Palomba, Daniela ; Marras, Marco ; Berettoni, Marco ; Olivieri, Lauso ; Ettorre, Alessandro ; Cipollone, Amalia ; Animati, Fabio ; Maggi, Carlo Alberto ; Monteagudo, Edith

Tetrahedron, 2003, Vol.59(8), pp.1309-1316 [Peer Reviewed Journal]

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26
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DPP-IV-resistant, long-acting oxyntomodulin derivatives

Santoprete, Alessia ; Capitò, Elena ; Carrington, Paul E ; Pocai, Alessandro ; Finotto, Marco ; Langella, Annunziata ; Ingallinella, Paolo ; Zytko, Karolina ; Bufali, Simone ; Cianetti, Simona ; Veneziano, Maria ; Bonelli, Fabio ; Zhu, Lan ; Monteagudo, Edith ; Marsh, Donald J ; Sinharoy, Ranabir ; Bianchi, Elisabetta ; Pessi, Antonello

Journal of peptide science : an official publication of the European Peptide Society, April 2011, Vol.17(4), pp.270-80 [Peer Reviewed Journal]

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27
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Identification of MK-5710 ((8 aS)-8 a-methyl-1,3-dioxo-2-[(1 S,2 R)-2-phenylcyclo- propyl]- N-(1-phenyl-1 H-pyrazol-5-yl)hexahydro-imidazo[1,5- a]pyrazine-7(1 H)-carboxamide), a potent smoothened antagonist for use in Hedgehog pathway dependent malignancies, Part 2

Kinzel, Olaf ; Alfieri, Anna ; Altamura, Sergio ; Brunetti, Mirko ; Bufali, Simone ; Colaceci, Fabrizio ; Ferrigno, Federica ; Filocamo, Gessica ; Fonsi, Massimiliano ; Gallinari, Paola ; Malancona, Savina ; Hernando, Jose Ignacio Martin ; Monteagudo, Edith ; Orsale, Maria Vittoria ; Palumbi, Maria Cecilia ; Pucci, Vincenzo ; Rowley, Michael ; Sasso, Romina ; Scarpelli, Rita ; Steinkühler, Christian

Bioorganic & Medicinal Chemistry Letters, 2011, Vol.21(15), pp.4429-4435 [Peer Reviewed Journal]

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28
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Discovery of a Selective Series of Inhibitors of Plasmodium falciparum HDACs

Ontoria, Jesus M ; Paonessa, Giacomo ; Ponzi, Simona ; Ferrigno, Federica ; Nizi, Emanuela ; Biancofiore, Ilaria ; Malancona, Savina ; Graziani, Rita ; Roberts, David ; Willis, Paul ; Bresciani, Alberto ; Gennari, Nadia ; Cecchetti, Ottavia ; Monteagudo, Edith ; Orsale, Maria V ; Veneziano, Maria ; Di Marco, Annalise ; Cellucci, Antonella ; Laufer, Ralph ; Altamura

ACS medicinal chemistry letters, 12 May 2016, Vol.7(5), pp.454-9 [Peer Reviewed Journal]

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29
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Development of a neuromedin U–human serum albumin conjugate as a long‐acting candidate for the treatment of obesity and diabetes. Comparison with the PEGylated peptide

Neuner, Philippe ; Peier, Andrea M. ; Talamo, Fabio ; Ingallinella, Paolo ; Lahm, Armin ; Barbato, Gaetano ; Di Marco, Annalise ; Desai, Kunal ; Zytko, Karolina ; Qian, Ying ; Du, Xiaobing ; Ricci, Davide ; Monteagudo, Edith ; Laufer, Ralph ; Pocai, Alessandro ; Bianchi, Elisabetta ; Marsh, Donald J. ; Pessi, Antonello

Journal of Peptide Science, January 2014, Vol.20(1), pp.7-19 [Peer Reviewed Journal]

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30
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Discovery of 2-{4-(3S)-piperidin-3-ylphenyl}-2H-indazole-7-carboxamide (MK-4827): a novel oral poly(ADP-ribose)polymerase (PARP) inhibitor efficacious in BRCA-1 and -2 mutant tumors

Jones, Philip ; Altamura, Sergio ; Boueres, Julia ; Ferrigno, Federica ; Fonsi, Massimiliano ; Giomini, Claudia ; Lamartina, Stefania ; Monteagudo, Edith ; Ontoria, Jesus M ; Orsale, Maria Vittoria ; Palumbi, Maria Cecilia ; Pesci, Silvia ; Roscilli, Giuseppe ; Scarpelli, Rita ; Schultz-Fademrecht, Carsten ; Toniatti, Carlo ; Rowley, Michael

Journal of medicinal chemistry, 26 November 2009, Vol.52(22), pp.7170-85 [Peer Reviewed Journal]

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31
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Design and synthesis of bicyclic pyrimidinones as potent and orally bioavailable HIV-1 integrase inhibitors

Muraglia, Ester ; Kinzel, Olaf ; Gardelli, Cristina ; Crescenzi, Benedetta ; Donghi, Monica ; Ferrara, Marco ; Nizi, Emanuela ; Orvieto, Federica ; Pescatore, Giovanna ; Laufer, Ralph ; Gonzalez-Paz, Odalys ; Di Marco, Annalise ; Fiore, Fabrizio ; Monteagudo, Edith ; Fonsi, Massimiliano ; Felock, Peter J ; Rowley, Michael ; Summa, Vincenzo

Journal of medicinal chemistry, 28 February 2008, Vol.51(4), pp.861-74 [Peer Reviewed Journal]

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32
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A spiranic withanolide from Jaborosa odonelliana

Monteagudo, Edith S ; Oberti, Juan C ; Gros, Eduardo G ; Burton, Gerardo

Phytochemistry, 1990, Vol.29(3), pp.933-935 [Peer Reviewed Journal]

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33
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High-Throughput Microsomal Stability Assay for Screening New Chemical Entities in Drug Discovery

Fonsi, Massimiliano ; Orsale, Maria V ; Monteagudo, Edith

Journal of Biomolecular Screening, October 2008, Vol.13(9), pp.862-869 [Peer Reviewed Journal]

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34
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High sensitivity determination of valproic acid in mouse plasma using semi‐automated sample preparation and liquid chromatography with tandem mass spectrometric detection

Pucci, Vincenzo ; Monteagudo, Edith ; Bonelli, Fabio

Rapid Communications in Mass Spectrometry, 30 December 2005, Vol.19(24), pp.3713-3718 [Peer Reviewed Journal]

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35
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14β,17β-dihydroxywithanolides from Jaborosa bergii

Monteagudo, Edith S ; Burton, Gerardo ; Gonzalez, Claudia M ; Oberti, Juan C ; Gros, Eduardo G

Phytochemistry, 1988, Vol.27(12), pp.3925-3928 [Peer Reviewed Journal]

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36
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A 19-hydroxywithanolide from Jaborosa leucotricha

Monteagudo, Edith S ; Burton, Gerardo ; Gros, Eduardo G ; Gonzalez, Claudia M ; Oberti, Juan C

Phytochemistry, 1989, Vol.28(9), pp.2514-2515 [Peer Reviewed Journal]

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