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Ibrutinib Inhibits VLA-4-Dependent Adhesion in CLL-Reply

Herman, Sarah E M ; Wiestner, Adrian

Clinical cancer research : an official journal of the American Association for Cancer Research, 01 July 2016, Vol.22(13), pp.3412 [Peer Reviewed Journal]

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Very late antigen-4 (α(4)β(1) Integrin) targeted PET imaging of multiple myeloma

Soodgupta, Deepti ; Hurchla, Michelle A ; Jiang, Majiong ; Zheleznyak, Alexander ; Weilbaecher, Katherine N ; Anderson, Carolyn J ; Tomasson, Michael H ; Shokeen, Monica

PloS one, 2013, Vol.8(2), pp.e55841 [Peer Reviewed Journal]

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3
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Modeling the molecular basis for α4β1 integrin antagonism

Hutt, Oliver E ; Saubern, Simon ; Winkler, David A

Bioorganic & medicinal chemistry, 01 October 2011, Vol.19(19), pp.5903-11 [Peer Reviewed Journal]

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The interaction affinity between vascular cell adhesion molecule-1 (VCAM-1) and very late antigen-4 (VLA-4) analyzed by quantitative FRET

Chakraborty, Sandeep ; Hu, Shih-Yang ; Wu, Shu-Han ; Karmenyan, Artashes ; Chiou, Arthur

PloS one, 2015, Vol.10(3), pp.e0121399 [Peer Reviewed Journal]

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5
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Pharmacodynamic consequences of administration of VLA-4 antagonist CDP323 to multiple sclerosis subjects: a randomized, double-blind phase 1/2 study

Wolf, Christian ; Sidhu, Jagdev ; Otoul, Christian ; Morris, Dexter L ; Cnops, Jennifer ; Taubel, Jorg ; Bennett, Barbara

PloS one, 2013, Vol.8(3), pp.e58438 [Peer Reviewed Journal]

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6
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The binding of monomeric C-reactive protein (mCRP) to Integrins αvβ3 and α4β1 is related to its pro-inflammatory action

Fujita, Masaaki ; Takada, Yoko K ; Izumiya, Yoshihiro ; Takada, Yoshikazu

PloS one, 2014, Vol.9(4), pp.e93738 [Peer Reviewed Journal]

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Ibrutinib Inhibits VLA-4-Dependent Adhesion in CLL-Letter

Zucchetto, Antonella ; Tissino, Erika ; Hartmann, Tanja Nicole ; Chigaev, Alexandre ; Del Poeta, Giovanni ; Colombatti, Alfonso ; Gattei, Valter

Clinical cancer research : an official journal of the American Association for Cancer Research, 01 July 2016, Vol.22(13), pp.3410-1 [Peer Reviewed Journal]

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Alpha4beta1 integrin affinity changes govern cell adhesion

Chigaev, Alexandre ; Zwartz, Gordon ; Graves, Steven W ; Dwyer, Denise C ; Tsuji, Hisashi ; Foutz, Terry D ; Edwards, Bruce S ; Prossnitz, Eric R ; Larson, Richard S ; Sklar, Larry A

The Journal of biological chemistry, 03 October 2003, Vol.278(40), pp.38174-82 [Peer Reviewed Journal]

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9
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Regulation of cell adhesion by affinity and conformational unbending of alpha4beta1 integrin

Chigaev, Alexandre ; Waller, Anna ; Zwartz, Gordon J ; Buranda, Tione ; Sklar, Larry A

Journal of immunology (Baltimore, Md. : 1950), 01 June 2007, Vol.178(11), pp.6828-39 [Peer Reviewed Journal]

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10
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Early treatment with anti-VLA-4 mAb can prevent the infiltration and/or development of pathogenic CD11b+CD4+ T cells in the CNS during progressive EAE

Mindur, John E ; Ito, Naoko ; Dhib-Jalbut, Suhayl ; Ito, Kouichi

PloS one, 2014, Vol.9(6), pp.e99068 [Peer Reviewed Journal]

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11
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Tetraspanins CD81 and CD82 facilitate α4β1-mediated adhesion of human erythroblasts to vascular cell adhesion molecule-1

Spring, Frances A ; Griffiths, Rebecca E ; Mankelow, Tosti J ; Agnew, Christopher ; Parsons, Stephen F ; Chasis, Joel A ; Anstee, David J

PloS one, 2013, Vol.8(5), pp.e62654 [Peer Reviewed Journal]

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12
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Tie2 Signaling Enhances Mast Cell Progenitor Adhesion to Vascular Cell Adhesion Molecule-1 (VCAM-1) through α4β1 Integrin

Kanemaru, Kazumasa ; Noguchi, Emiko ; Tokunaga, Takahiro ; Nagai, Kei ; Hiroyama, Takashi ; Nakamura, Yukio ; Tahara-Hanaoka, Satoko ; Shibuya, Akira

PloS one, 2015, Vol.10(12), pp.e0144436 [Peer Reviewed Journal]

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13
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PI3-kinase γ promotes Rap1a-mediated activation of myeloid cell integrin α4β1, leading to tumor inflammation and growth

Schmid, Michael C ; Franco, Irene ; Kang, Sang Won ; Hirsch, Emilio ; Quilliam, Lawrence A ; Varner, Judith A

PloS one, 2013, Vol.8(4), pp.e60226 [Peer Reviewed Journal]

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14
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Differential bone marrow homing capacity of VLA-4 and CD38 high expressing chronic lymphocytic leukemia cells

Brachtl, Gabriele ; Sahakyan, Karine ; Denk, Ursula ; Girbl, Tamara ; Alinger, Beate ; Hofbauer, Sebastian W ; Neureiter, Daniel ; Hofbauer, Josefina Piñón ; Egle, Alexander ; Greil, Richard ; Hartmann, Tanja Nicole

PloS one, 2011, Vol.6(8), pp.e23758 [Peer Reviewed Journal]

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15
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Directing mesenchymal stem cells to bone to augment bone formation and increase bone mass

Guan, Min ; Yao, Wei ; Liu, Ruiwu ; Lam, Kit ; Nolta, Jan ; Jia, Junjing ; Panganiban, Brian ; Meng, Liping ; Zhou, Ping ; Shahnazari, Mohammad ; Ritchie, Robert ; Lane, Nancy

Nature Medicine, Mar 2012, pp.456-62 [Peer Reviewed Journal]

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16
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Aberrant regulation of the integrin very late antigen-4 in systemic lupus erythematosus

Rahimi, H ; Maurer, K ; Song, L ; Akhter, E ; Petri, M ; Sullivan, K E

Lupus, March 2013, Vol.22(3), pp.297-306 [Peer Reviewed Journal]

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17
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Synthesis and biological activity of N-substituted aminocarbonyl-1,3-dioxolanes as VLA-4 antagonists

Rehman, Abdul ; Soni, Ajay ; Naik, Keshav ; Nair, Sreeji ; Palle, Venkata P ; Dastidar, Sunanda ; Ray, Abhijit ; Alam, M S ; Salman, Mohammad ; Cliffe, Ian A ; Sattigeri, Viswajanani

Bioorganic & medicinal chemistry letters, 15 September 2010, Vol.20(18), pp.5514-20 [Peer Reviewed Journal]

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18
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Differential resolution of inflammation and recovery after renal ischemia-reperfusion injury in Brown Norway compared with Sprague Dawley rats

Sáenz-Morales, David ; Conde, Elisa ; Blanco-Sánchez, Ignacio ; Ponte, Belen ; Aguado-Fraile, Elia ; De Las Casas, Gonzalo ; García-Martos, Maria ; Alegre, Laura ; Escribese, Maria ; Molina, Ana ; Santiuste, Carmen ; Liaño, Fernando ; García-Bermejo, Maria-Laura

Kidney International, May 2010, pp.781-93 [Peer Reviewed Journal]

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19
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A Novel Association of Polymorphism in the Gene Encoding the VLA-4 4 Subunit with Increased Risk of Alzheimer's Disease

Durmanova, Vladimira ; Parnicka, Zuzana ; Javor, Juraj ; Minarik, Gabriel ; Vrazda, Lubomir ; Vaseckova, Barbora ; Gmitterova, Karin ; Kralova, Maria ; Pecenak, Jan ; Filipcik, Peter ; Shawkatova, Ivana

Mediators of inflammation, 2018, Vol.2018, pp.7623823 [Peer Reviewed Journal]

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20
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Targeted blockade in lethal West Nile virus encephalitis indicates a crucial role for very late antigen (VLA)-4-dependent recruitment of nitric oxide-producing macrophages

Getts, Daniel ; Terry, Rachael ; Getts, Meghann Teague ; Müller, Marcus ; Rana, Sabita ; Deffrasnes, Celine ; Ashhurst, Thomas Myles ; Radford, Jane ; Hofer, Markus ; Thomas, Shane ; Campbell, Iain ; King, Nicholas

Journal of Neuroinflammation, 2012, Vol.9, p.246 [Peer Reviewed Journal]

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21
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Actin polymerization stabilizes α4β1 integrin anchors that mediate monocyte adhesion

Rullo, Jacob ; Becker, Henry ; Hyduk, Sharon J ; Wong, Janice C ; Digby, Genevieve ; Arora, Pamma D ; Cano, Adrianet Puig ; Hartwig, John ; Mcculloch, Christopher A ; Cybulsky, Myron I

The Journal of cell biology, 02 April 2012, Vol.197(1), pp.115-29 [Peer Reviewed Journal]

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22
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Synthesis and evaluation of 4,5-dihydro-5-methylisoxazolin-5-carboxamide derivatives as VLA-4 antagonists

Soni, Ajay ; Rehman, Abdul ; Naik, Keshav ; Dastidar, Sunanda ; Alam, M S ; Ray, Abhijit ; Chaira, Tridib ; Shah, Vanya ; Palle, Venkata P ; Cliffe, Ian A ; Sattigeri, Viswajanani J

Bioorganic & medicinal chemistry letters, 01 March 2013, Vol.23(5), pp.1482-5 [Peer Reviewed Journal]

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23
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Orally available and efficacious α4β1/α4β7 integrin inhibitors

Xu, Ying-Zi ; Smith, Jenifer L ; Semko, Christopher M ; Rossiter, Kassandra I ; Fukuda, Juri Y ; Dappen, Michael S ; Quincy, David A ; Konradi, Andrei W ; Mao, Wenxian ; Welch, Brent ; Dreyer, Mark L ; Samant, Bhushan ; Zhang, Hongbin ; Lugar, Judevin ; Liao, Zhenmei ; Henschel, Carrol ; Petersen, Eric ; Vandevert, Christopher ; Shoemaker, Mark ; Wehner, Nancy ; Mutter, Linda ; Shopp, George ; Krimm, Michael ; Chen, Linda ; Wipke, Brian ; Dofiles, Lilibeth ; Gallager, Ian ; Sauer, John-Michael ; Messersmith, Elizabeth K ; Pleiss, Michael A ; Bard, Frederique ; Yednock, Ted A

Bioorganic & medicinal chemistry letters, 01 August 2013, Vol.23(15), pp.4370-3 [Peer Reviewed Journal]

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24
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Long-term decrease in VLA-4 expression and functional impairment of dendritic cells during natalizumab therapy in patients with multiple sclerosis

De Andrés, Clara ; Teijeiro, Roseta ; Alonso, Bárbara ; Sánchez-Madrid, Francisco ; Martínez, M Luisa ; Guzmán De Villoria, Juan ; Fernández-Cruz, Eduardo ; Sánchez-Ramón, Silvia

PloS one, 2012, Vol.7(4), pp.e34103 [Peer Reviewed Journal]

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25
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Elongated membrane tethers, individually anchored by high affinity α4β1/VCAM-1 complexes, are the quantal units of monocyte arrests

Chu, Calvin ; Celik, Emrah ; Rico, Felix ; Moy, Vincent T Aix-Marseille Université, U1006 (Editor)

PLoS ONE, 17 May 2013, Vol.8(5), p.e64187 [Peer Reviewed Journal]

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26
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Treatment with Ibrutinib Inhibits BTK- and VLA-4-Dependent Adhesion of Chronic Lymphocytic Leukemia Cells In Vivo

Herman, Sarah E M ; Mustafa, Rashida Z ; Jones, Jade ; Wong, Deanna H ; Farooqui, Mohammed ; Wiestner, Adrian

Clinical cancer research : an official journal of the American Association for Cancer Research, 15 October 2015, Vol.21(20), pp.4642-51 [Peer Reviewed Journal]

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27
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VLA-4 integrin concentrates at the peripheral supramolecular activation complex of the immune synapse and drives T helper 1 responses

Mittelbrunn, María ; Molina, Ana ; Escribese, María M ; Yáñez-Mó, María ; Escudero, Ester ; Ursa, Angeles ; Tejedor, Reyes ; Mampaso, Francisco ; Sánchez-Madrid, Francisco

Proceedings of the National Academy of Sciences of the United States of America, 27 July 2004, Vol.101(30), pp.11058-63 [Peer Reviewed Journal]

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28
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CD14 is a ligand for the integrin alpha4beta1

Humphries, Jonathan D ; Humphries, Martin J

FEBS letters, 20 February 2007, Vol.581(4), pp.757-63 [Peer Reviewed Journal]

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29
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The solution structure of EMILIN1 globular C1q domain reveals a disordered insertion necessary for interaction with the alpha4beta1 integrin

Verdone, Giuliana ; Doliana, Roberto ; Corazza, Alessandra ; Colebrooke, Simon A ; Spessotto, Paola ; Bot, Simonetta ; Bucciotti, Francesco ; Capuano, Alessandra ; Silvestri, Alessandra ; Viglino, Paolo ; Campbell, Iain D ; Colombatti, Alfonso ; Esposito, Gennaro

The Journal of biological chemistry, 04 July 2008, Vol.283(27), pp.18947-56 [Peer Reviewed Journal]

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30
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Identification of N-acyl 4-(5-pyrimidine-2,4-dionyl)phenylalanine derivatives and their orally active prodrug esters as dual-acting alpha4-beta1 and alpha4-beta7 receptor antagonists

Sidduri, Achyutharao ; Tilley, Jefferson W ; Lou, Jianping ; Tare, Nadine ; Cavallo, Gary ; Frank, Karl ; Pamidimukkala, Anjula ; Choi, Duk Soon ; Gerber, Louise ; Railkar, Aruna ; Renzetti, Louis

Bioorganic & medicinal chemistry letters, 15 February 2013, Vol.23(4), pp.1026-31 [Peer Reviewed Journal]

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31
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Enhanced Integrin α4β1-Mediated Adhesion Contributes to a Mobilization Defect of Endothelial Progenitor Cells in Diabetes

Abplanalp, Wesley T ; Conklin, Daniel J ; Cantor, Joseph M ; Ginsberg, Mark H ; Wysoczynski, Marcin ; Bhatnagar, Aruni ; O'Toole, Timothy E

Diabetes, November 2016, Vol.65(11), pp.3505-3515 [Peer Reviewed Journal]

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32
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Nanoscale Tuning of VCAM-1 Determines VLA-4-Dependent Melanoma Cell Plasticity on RGD Motifs

Amschler, Katharina ; Kossmann, Eugen ; Erpenbeck, Luise ; Kruss, Sebastian ; Schill, Tillmann ; Schön, Margarete ; Möckel, Sigrid M C ; Spatz, Joachim P ; Schön, Michael P

Molecular cancer research : MCR, March 2018, Vol.16(3), pp.528-542 [Peer Reviewed Journal]

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33
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The inhibition of the integrin VLA-4 in MV3 melanoma cell binding by non-anticoagulant heparin derivatives

Schlesinger, Martin ; Schmitz, Patrick ; Zeisig, Reiner ; Naggi, Annamaria ; Torri, Giangiacomo ; Casu, Benito ; Bendas, Gerd

Thrombosis research, May 2012, Vol.129(5), pp.603-10 [Peer Reviewed Journal]

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34
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Dependence of acute myeloid leukemia on adhesion within the bone marrow microenvironment

Becker, Pamela S

TheScientificWorldJournal, 2012, Vol.2012, pp.856467 [Peer Reviewed Journal]

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35
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Gamma-delta T lymphocytes coordinate eosinophil influx during allergic responses

Maria Das Graças Muller De Oliveira Henriques ; Carmen Epenido

Frontiers in Pharmacology, 01 December 2012, Vol.3 [Peer Reviewed Journal]

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36
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Discovery of potential integrin VLA-4 antagonists using pharmacophore modeling, virtual screening and molecular docking studies

Thangapandian, Sundarapandian ; John, Shalini ; Sakkiah, Sugunadevi ; Lee, Keun Woo

Chemical biology & drug design, August 2011, Vol.78(2), pp.289-300 [Peer Reviewed Journal]

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37
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Proteomic analysis of α4β1 integrin adhesion complexes reveals α-subunit-dependent protein recruitment

Byron, Adam ; Humphries, Jonathan D ; Craig, Sue E ; Knight, David ; Humphries, Martin J

Proteomics, July 2012, Vol.12(13), pp.2107-14 [Peer Reviewed Journal]

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