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Engineering Glucose Responsiveness Into Insulin

Kaarsholm, Niels C ; Lin, Songnian ; Yan, Lin ; Kelly, Theresa ; Van Heek, Margaret ; Mu, James ; Wu, Margaret ; Dai, Ge ; Cui, Yan ; Zhu, Yonghua ; Carballo-Jane, Ester ; Reddy, Vijay ; Zafian, Peter ; Huo, Pei ; Shi, Shuai ; Antochshuk, Valentyn ; Ogawa, Aimie ; Liu, Franklin ; Souza, Sandra C ; Seghezzi

Diabetes, February 2018, Vol.67(2), pp.299-308 [Peer Reviewed Journal]

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Structural stability and magnetic properties of $$\hbox {Cu}_{m}\hbox {Co}_{n}\hbox {NO}$$ Cu m Co n NO ( $$m+n = 2$$ m + n = 2 –7) clusters

Huo, Pei-Ying ; Zhang, Xiu-Rong ; Zhu, Jun ; Yu, Zhi-Cheng

Bulletin of Materials Science, 2017, Vol.40(6), pp.1087-1096 [Peer Reviewed Journal]

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DFT study of NO and H2O co-adsorption on CumCon(m+n=2∼7) clusters

Huo, Pei-Ying ; Zhang, Xiu-Rong ; Yu, Zhi-Cheng ; Gao, Kun

Journal of Molecular Structure, 15 November 2017, Vol.1148, pp.486-495 [Peer Reviewed Journal]

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Structure stability and electronic properties of PtmIrn (m + n = 2–7) clusters: A DFT study

Gao, Kun ; Zhang, Xiu-Rong ; Yu, Zhi-Cheng ; Huo, Pei-Ying

Computational and Theoretical Chemistry, 15 August 2018, Vol.1138, pp.168-175 [Peer Reviewed Journal]

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Characterization of Argon Glow Discharge Plasma Reduced Pt/Al 2 O 3 Catalyst
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Characterization of Argon Glow Discharge Plasma Reduced Pt/Al 2 O 3 Catalyst

Zhu, Xinli ; Huo, Pei-Pei ; Zhang, Yue-Ping ; Liu, Chang-Jun

Industrial & Engineering Chemistry Research, 12/2006, Vol.45(25), pp.8604-8609 [Peer Reviewed Journal]

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Discovery of N-(4R)-6-(4-chlorophenyl)-7-(2,4-dichlorophenyl)-2,2-dimethyl-3,4-dihydro-2H-pyrano2,3-bpyridin-4-yl-5-methyl-1H-pyrazole-3-carboxamide (MK-5596) as a novel cannabinoid-1 receptor (CB1R) inverse agonist for the treatment of obesity

Yan, Lin ; Huo, Pei ; Debenham, John S ; Madsen-Duggan, Christina B ; Lao, Julie ; Chen, Richard Z ; Xiao, Jing Chen ; Shen, Chun-Pyn ; Stribling, D Sloan ; Shearman, Lauren P ; Strack, Alison M ; Tsou, Nancy ; Ball, Richard G ; Wang, Junying ; Tong, Xinchun ; Bateman, Thomas J ; Reddy, Vijay B G ; Fong, Tung M ; Hale, Jeffrey J

Journal of medicinal chemistry, 27 May 2010, Vol.53(10), pp.4028-37 [Peer Reviewed Journal]

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Erratum. Engineering Glucose Responsiveness Into Insulin. Diabetes 2018;67:299-308

Kaarsholm, Niels C ; Lin, Songnian ; Yan, Lin ; Kelly, Theresa ; Van Heek, Margaret ; Mu, James ; Wu, Margaret ; Dai, Ge ; Cui, Yan ; Zhu, Yonghua ; Carballo-Jane, Ester ; Reddy, Vijay ; Zafian, Peter ; Huo, Pei ; Shi, Shuai ; Antochshuk, Valentyn ; Ogawa, Aimie ; Liu, Franklin ; Souza, Sandra C ; Seghezzi

Diabetes, May 2018, Vol.67(5), pp.1030 [Peer Reviewed Journal]

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A glucose-responsive insulin therapy protects animals against hypoglycemia

Yang, Ruojing ; Wu, Margaret ; Lin, Songnian ; Nargund, Ravi P ; Li, Xinghai ; Kelly, Theresa ; Yan, Lin ; Dai, Ge ; Qian, Ying ; Dallas-Yang, Qing ; Fischer, Paul A ; Cui, Yan ; Shen, Xiaolan ; Huo, Pei ; Feng, Danqing Dennis ; Erion, Mark D ; Kelley, David E ; Mu, James

JCI insight, 11 January 2018, Vol.3(1)

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Dihydro-pyrano[2,3-b]pyridines and tetrahydro-1,8-naphthyridines as CB1 receptor inverse agonists: Synthesis, SAR and biological evaluation

Madsen-Duggan, Christina B ; Debenham, John S ; Walsh, Thomas F ; Yan, Lin ; Huo, Pei ; Wang, Junying ; Tong, Xinchun ; Lao, Julie ; Fong, Tung M ; Xiao, Jing Chen ; Huang, Cathy R.-R.C ; Shen, Chun-Pyn ; Stribling, D.Sloan ; Shearman, Lauren P ; Strack, Alison M ; Goulet, Mark T ; Hale, Jeffrey J

Bioorganic & Medicinal Chemistry Letters, 15 June 2010, Vol.20(12), pp.3750-3754 [Peer Reviewed Journal]

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Characterization of CuO-ZnO Catalyst Prepared by Decomposition of Carbonates Using Dielectric-Barrier Discharge Plasma

Kuai, Ping-yu ; Liu, Chang-jun ; Huo, Pei-pei

Catalysis Letters, 2009, Vol.129(3), pp.493-498 [Peer Reviewed Journal]

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CCDC 760723: Experimental Crystal Structure Determination

Yan, Lin ; Huo, Pei ; Debenham, J.S. ; Madsen-Duggan, C.B. ; Lao, J. ; Chen, R.Z. ; Xiao, Jing Chen ; Shen, Chun-Pyn ; Stribling, D.S. ; Shearman, L.P. ; Strack, A.M. ; Tsou, N. ; Ball, R.G. ; Wang, Junying ; Tong, Xinchun ; Bateman, T.J. ; Reddy, V.B.G. ; Fong, T.M. ; Hale, J.J.

2011

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SAR studies of 3-arylpropionic acids as potent and selective agonists of sphingosine-1-phosphate receptor-1 (S1P 1) with enhanced pharmacokinetic properties

Yan, Lin ; Huo, Pei ; Hale, Jeffrey J ; Mills, Sander G ; Hajdu, Richard ; Keohane, Carol A ; Rosenbach, Mark J ; Milligan, James A ; Shei, Gan-Ju ; Chrebet, Gary ; Bergstrom, James ; Card, Deborah ; Mandala, Suzanne M

Bioorganic & Medicinal Chemistry Letters, 2007, Vol.17(3), pp.828-831 [Peer Reviewed Journal]

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2-Aryl(pyrrolidin-4-yl)acetic acids are potent agonists of sphingosine-1-phosphate (S1P) receptors

Yan, Lin ; Budhu, Richard ; Huo, Pei ; Lynch, Christopher L ; Hale, Jeffrey J ; Mills, Sander G ; Hajdu, Richard ; Keohane, Carol A ; Rosenbach, Mark J ; Milligan, James A ; Shei, Gan-Ju ; Chrebet, Gary ; Bergstrom, James ; Card, Deborah ; Mandala, Suzanne M

Bioorganic & Medicinal Chemistry Letters, 01 July 2006, Vol.16(13), pp.3564-3568 [Peer Reviewed Journal]

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2,5-Disubstituted pyrrolidine carboxylates as potent, orally active sphingosine-1-phosphate (S1P) receptor agonists

Colandrea, Vincent J ; Legiec, Irene E ; Huo, Pei ; Yan, Lin ; Hale, Jeffrey J ; Mills, Sander G ; Bergstrom, James ; Card, Deborah ; Chebret, Gary ; Hajdu, Richard ; Keohane, Carol Ann ; Milligan, James A ; Rosenbach, Mark J ; Shei, Gan-Ju ; Mandala, Suzanne M

Bioorganic & Medicinal Chemistry Letters, 2006, Vol.16(11), pp.2905-2908 [Peer Reviewed Journal]

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Discovery of 3-arylpropionic acids as potent agonists of sphingosine-1-phosphate receptor-1 (S1P 1) with high selectivity against all other known S1P receptor subtypes

Yan, Lin ; Huo, Pei ; Doherty, George ; Toth, Lesile ; Hale, Jeffrey J ; Mills, Sander G ; Hajdu, Richard ; Keohane, Carol A ; Rosenbach, Mark J ; Milligan, James A ; Shei, Gan-Ju ; Chrebet, Gary ; Bergstrom, James ; Card, Deborah ; Quackenbush, Elizabeth ; Wickham, Alexandra ; Mandala, Suzanne M

Bioorganic & Medicinal Chemistry Letters, 2006, Vol.16(14), pp.3679-3683 [Peer Reviewed Journal]

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