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| Result Number | Material Type | Add to My Shelf Action | Record Details and Options |
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| 1 |
Material Type: Article
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Alteration of lymphocyte trafficking by sphingosine-1-phosphate receptor agonistsMandala, Suzanne ; Hajdu, Richard ; Bergstrom, James ; Quackenbush, Elizabeth ; Xie, Jenny ; Milligan, James ; Thornton, Rosemary ; Shei, Gan-Ju ; Card, Deborah ; Keohane, Carolann ; Rosenbach, Mark ; Hale, Jeffrey ; Lynch, Christopher L ; Rupprecht, Kathleen ; Parsons, William ; Rosen, HughScience (New York, N.Y.), 12 April 2002, Vol.296(5566), pp.346-9 [Peer Reviewed Journal]Full text available |
| 2 |
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Reduced immunotoxicity and preservation of antibacterial acitivity in a releasable side-chain carbapenem antibioticRosen, Hugh ; Hajdu, Richard ; Silver, Lynn ; Kropp, HelmutScience, Jan 29, 1999, pp.703-6 [Peer Reviewed Journal]Full text available |
| 3 |
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Discovery of N-Bis(4-methoxyphenyl)methyl-4-hydroxy-2-(pyridazin-3-yl)pyrimidine-5-carboxamide (MK-8617), an Orally Active Pan-Inhibitor of Hypoxia-Inducible Factor Prolyl Hydroxylase 1-3 (HIF PHD1-3) for the Treatment of AnemiaDebenham, John S ; Madsen-Duggan, Christina ; Clements, Matthew J ; Walsh, Thomas F ; Kuethe, Jeffrey T ; Reibarkh, Mikhail ; Salowe, Scott P ; Sonatore, Lisa M ; Hajdu, Richard ; Milligan, James A ; Visco, Denise M ; Zhou, Dan ; Lingham, Russell B ; Stickens, Dominique ; Demartino, Julie A ; Tong, Xinchun ; Wolff, Michael ; Pang, Jianmei ; Miller, Randy R ; Sherer, Edward C ; Hale, Jeffrey JJournal of medicinal chemistry, 22 December 2016, Vol.59(24), pp.11039-11049 [Peer Reviewed Journal]Full text available |
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1,3,8-Triazaspiro4.5decane-2,4-diones as efficacious pan-inhibitors of hypoxia-inducible factor prolyl hydroxylase 1-3 (HIF PHD1-3) for the treatment of anemiaVachal, Petr ; Miao, Shouwu ; Pierce, Joan M ; Guiadeen, Deodial ; Colandrea, Vincent J ; Wyvratt, Matthew J ; Salowe, Scott P ; Sonatore, Lisa M ; Milligan, James A ; Hajdu, Richard ; Gollapudi, Anantha ; Keohane, Carol A ; Lingham, Russell B ; Mandala, Suzanne M ; Demartino, Julie A ; Tong, Xinchun ; Wolff, Michael ; Steinhuebel, Dietrich ; Kieczykowski, Gerard R ; Fleitz, Fred J ; Chapman, Kevin ; Athanasopoulos, John ; Adam, Gregory ; Akyuz, Can D ; Jena, Dhirendra K ; Lusen, Jeffrey W ; Meng, Juncai ; Stein, Benjamin D ; Xia, Lei ; Sherer, Edward C ; Hale, Jeffrey JJournal of medicinal chemistry, 12 April 2012, Vol.55(7), pp.2945-59 [Peer Reviewed Journal]Full text available |
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Mice deficient in sphingosine kinase 1 are rendered lymphopenic by FTY720Allende, Maria L ; Sasaki, Teiji ; Kawai, Hiromichi ; Olivera, Ana ; Mi, Yide ; Van Echten-Deckert, Gerhild ; Hajdu, Richard ; Rosenbach, Mark ; Keohane, Carol Ann ; Mandala, Suzanne ; Spiegel, Sarah ; Proia, Richard LThe Journal of biological chemistry, 10 December 2004, Vol.279(50), pp.52487-92 [Peer Reviewed Journal]Full text available |
| 6 |
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Imipenem cross-reactivity with penicillin in humansSaxon, Andrew ; Adelman, Daniel C ; Patel, Amit ; Hajdu, Richard ; Calandra, Gary BThe Journal of Allergy and Clinical Immunology, 1988, Vol.82(2), pp.213-217 [Peer Reviewed Journal]Full text available |
| 7 |
Material Type: Article
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A rational utilization of high-throughput screening affords selective, orally bioavailable 1-benzyl-3-carboxyazetidine sphingosine-1-phosphate-1 receptor agonistsHale, Jeffrey J ; Lynch, Christopher L ; Neway, William ; Mills, Sander G ; Hajdu, Richard ; Keohane, Carol Ann ; Rosenbach, Mark J ; Milligan, James A ; Shei, Gan-Ju ; Parent, Stephen A ; Chrebet, Gary ; Bergstrom, James ; Card, Deborah ; Ferrer, Marc ; Hodder, Peter ; Strulovici, Berta ; Rosen, Hugh ; Mandala, SuzanneJournal of medicinal chemistry, 30 December 2004, Vol.47(27), pp.6662-5 [Peer Reviewed Journal]Full text available |
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Material Type: Article
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Discovery of MK-4409, a Novel Oxazole FAAH Inhibitor for the Treatment of Inflammatory and Neuropathic PainChobanian, Harry R ; Guo, Yan ; Liu, Ping ; Chioda, Marc D ; Fung, Selena ; Lanza, Thomas J ; Chang, Linda ; Bakshi, Raman K ; Dellureficio, James P ; Hong, Qingmei ; Mclaughlin, Mark ; Belyk, Kevin M ; Krska, Shane W ; Makarewicz, Amanda K ; Martel, Elliot J ; Leone, Joseph F ; Frey, Lisa ; Karanam, Bindhu ; Madeira, Maria ; Alvaro, Raul ; Shuman, Joyce ; Salituro, Gino ; Terebetski, Jenna L ; Jochnowitz, Nina ; Mistry, Shruti ; Mcgowan, Erin ; Hajdu, Richard ; Rosenbach, Mark ; Abbadie, Catherine ; Alexander, Jessica P ; Shiao, Lin-Lin ; Sullivan, Kathleen M ; Nargund, Ravi P ; Wyvratt, Matthew J ; Lin, Linus S ; Devita, Robert JACS medicinal chemistry letters, 12 June 2014, Vol.5(6), pp.717-21 [Peer Reviewed Journal]Full text available |
| 9 |
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Discovery of Triazole CYP11B2 Inhibitors with in Vivo Activity in Rhesus MonkeysHoyt, Scott B ; Petrilli, Whitney ; London, Clare ; Liang, Gui-Bai ; Tata, Jim ; Hu, Qingzhong ; Yin, Lina ; Van Koppen, Chris J ; Hartmann, Rolf W ; Struthers, Mary ; Wisniewski, Tom ; Ren, Ning ; Bopp, Charlene ; Sok, Andrea ; Cai, Tian-Quan ; Stribling, Sloan ; Pai, Lee-Yuh ; Ma, Xiuying ; Metzger, Joe ; Verras, Andreas ; Mcmasters, Daniel ; Chen, Qing ; Tung, Elaine ; Tang, Wei ; Salituro, Gino ; Buist, Nicole ; Clemas, Joe ; Zhou, Gaochao ; Gibson, Jack ; Maxwell, Carrie Ann ; Lassman, Mike ; Mclaughlin, Theresa ; Castro-Perez, Jose ; Szeto, Daphne ; Forrest, Gail ; Hajdu, Richard ; Rosenbach, Mark ; Xiong, YushengACS medicinal chemistry letters, 13 August 2015, Vol.6(8), pp.861-5 [Peer Reviewed Journal]Full text available |
| 10 |
Material Type: Article
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Synthesis, stereochemical determination and biochemical characterization of the enantiomeric phosphate esters of the novel immunosuppressive agent FTY720Hale, Jeffrey J ; Yan, Lin ; Neway, William E ; Hajdu, Richard ; Bergstrom, James D ; Milligan, James A ; Shei, Gan-Ju ; Chrebet, Gary L ; Thornton, Rosemary A ; Card, Deborah ; Rosenbach, Mark ; Hughrosen ; Mandala, SuzanneBioorganic & Medicinal Chemistry, 15 September 2004, Vol.12(18), pp.4803-4807 [Peer Reviewed Journal]Full text available |
| 11 |
Material Type: Article
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Discovery of potent 3,5-diphenyl-1,2,4-oxadiazole sphingosine-1-phosphate-1 (S1P1) receptor agonists with exceptional selectivity against S1P2 and S1P3Li, Zhen ; Chen, Weirong ; Hale, Jeffrey J ; Lynch, Christopher L ; Mills, Sander G ; Hajdu, Richard ; Keohane, Carol Ann ; Rosenbach, Mark J ; Milligan, James A ; Shei, Gan-Ju ; Chrebet, Gary ; Parent, Stephen A ; Bergstrom, James ; Card, Deborah ; Forrest, Michael ; Quackenbush, Elizabeth J ; Wickham, L Alexandra ; Vargas, Hugo ; Evans, Rose M ; Rosen, Hugh ; Mandala, SuzanneJournal of medicinal chemistry, 06 October 2005, Vol.48(20), pp.6169-73 [Peer Reviewed Journal]Full text available |
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Discovery of MK-3168: A PET Tracer for Imaging Brain Fatty Acid Amide HydrolaseLiu, Ping ; Hamill, Terence G ; Chioda, Marc ; Chobanian, Harry ; Fung, Selena ; Guo, Yan ; Chang, Linda ; Bakshi, Raman ; Hong, Qingmei ; Dellureficio, James ; Lin, Linus S ; Abbadie, Catherine ; Alexander, Jessica ; Jin, Hong ; Mandala, Suzanne ; Shiao, Lin-Lin ; Li, Wenping ; Sanabria, Sandra ; Williams, David ; Zeng, Zhizhen ; Hajdu, Richard ; Jochnowitz, Nina ; Rosenbach, Mark ; Karanam, Bindhu ; Madeira, Maria ; Salituro, Gino ; Powell, Joyce ; Xu, Ling ; Terebetski, Jenna L ; Leone, Joseph F ; Miller, Patricia ; Cook, Jacquelynn ; Holahan, Marie ; Joshi, Aniket ; O'Malley, Stacey ; Purcell, Mona ; Posavec, Diane ; Chen, Tsing-Bau ; Riffel, Kerry ; Williams, Mangay ; Hargreaves, Richard ; Sullivan, Kathleen A ; Nargund, Ravi P ; Devita, Robert JACS medicinal chemistry letters, 13 June 2013, Vol.4(6), pp.509-13 [Peer Reviewed Journal]Full text available |
| 13 |
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Discovery of Benzimidazole CYP11B2 Inhibitors with in Vivo Activity in Rhesus MonkeysHoyt, Scott B ; Park, Min K ; London, Clare ; Xiong, Yusheng ; Tata, Jim ; Bennett, D Jonathan ; Cooke, Andrew ; Cai, Jiaqiang ; Carswell, Emma ; Robinson, John ; Maclean, John ; Brown, Lindsay ; Belshaw, Simone ; Clarkson, Thomas R ; Liu, Kun ; Liang, Gui-Bai ; Struthers, Mary ; Cully, Doris ; Wisniewski, Tom ; Ren, Ning ; Bopp, Charlene ; Sok, Andrea ; Cai, Tian-Quan ; Stribling, Sloan ; Pai, Lee-Yuh ; Ma, Xiuying ; Metzger, Joe ; Verras, Andreas ; Mcmasters, Daniel ; Chen, Qing ; Tung, Elaine ; Tang, Wei ; Salituro, Gino ; Buist, Nicole ; Kuethe, Jeff ; Rivera, Nelo ; Clemas, Joe ; Zhou, Gaochao ; Gibson, Jack ; Maxwell, Carrie Ann ; Lassman, Mike ; Mclaughlin, Theresa ; Castro-Perez, Jose ; Szeto, Daphne ; Forrest, Gail ; Hajdu, Richard ; Rosenbach, Mark ; Ali, AmjadACS medicinal chemistry letters, 14 May 2015, Vol.6(5), pp.573-8 [Peer Reviewed Journal]Full text available |
| 14 |
Material Type: Article
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SAR studies of 3-arylpropionic acids as potent and selective agonists of sphingosine-1-phosphate receptor-1 (S1P 1) with enhanced pharmacokinetic propertiesYan, Lin ; Huo, Pei ; Hale, Jeffrey J ; Mills, Sander G ; Hajdu, Richard ; Keohane, Carol A ; Rosenbach, Mark J ; Milligan, James A ; Shei, Gan-Ju ; Chrebet, Gary ; Bergstrom, James ; Card, Deborah ; Mandala, Suzanne MBioorganic & Medicinal Chemistry Letters, 2007, Vol.17(3), pp.828-831 [Peer Reviewed Journal]Full text available |
| 15 |
Material Type: Article
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Highly selective and potent agonists of sphingosine-1-phosphate 1 (S1P 1) receptorVachal, Petr ; Toth, Leslie M ; Hale, Jeffrey J ; Yan, Lin ; Mills, Sander G ; Chrebet, Gary L ; Koehane, Carol A ; Hajdu, Richard ; Milligan, James A ; Rosenbach, Mark J ; Mandala, SuzanneBioorganic & Medicinal Chemistry Letters, 2006, Vol.16(14), pp.3684-3687 [Peer Reviewed Journal]Full text available |
| 16 |
Material Type: Article
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The discovery of 3-(N-alkyl)aminopropylphosphonic acids as potent S1P receptor agonistsHale, Jeffrey J ; Doherty, George ; Toth, Leslie ; Li, Zhen ; Mills, Sander G ; Hajdu, Richard ; Ann Keohane, Carol ; Rosenbach, Mark ; Milligan, James ; Shei, Gan-Ju ; Chrebet, Gary ; Bergstrom, James ; Card, Deborah ; Rosen, Hugh ; Mandala, SuzanneBioorganic & Medicinal Chemistry Letters, 2004, Vol.14(13), pp.3495-3499 [Peer Reviewed Journal]Full text available |
| 17 |
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Lipopeptide antifungal agents: Amine conjugates of the semi-synthetic pneumocandins L-731,373 and L-733,560Zambias, Robert A ; James, Catherine ; Abruzzo, George K ; Bartizal, Kenneth F ; Hajdu, Richard ; Thompson, Randy ; Nollstadt, Karl H ; Marrinan, Jean ; Balkovec, James MBioorganic & Medicinal Chemistry Letters, 1997, Vol.7(15), pp.2021-2026 [Peer Reviewed Journal]Full text available |
| 18 |
Material Type: Article
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2-Aryl(pyrrolidin-4-yl)acetic acids are potent agonists of sphingosine-1-phosphate (S1P) receptorsYan, Lin ; Budhu, Richard ; Huo, Pei ; Lynch, Christopher L ; Hale, Jeffrey J ; Mills, Sander G ; Hajdu, Richard ; Keohane, Carol A ; Rosenbach, Mark J ; Milligan, James A ; Shei, Gan-Ju ; Chrebet, Gary ; Bergstrom, James ; Card, Deborah ; Mandala, Suzanne MBioorganic & Medicinal Chemistry Letters, 01 July 2006, Vol.16(13), pp.3564-3568 [Peer Reviewed Journal]Full text available |
| 19 |
Material Type: Article
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2,5-Disubstituted pyrrolidine carboxylates as potent, orally active sphingosine-1-phosphate (S1P) receptor agonistsColandrea, Vincent J ; Legiec, Irene E ; Huo, Pei ; Yan, Lin ; Hale, Jeffrey J ; Mills, Sander G ; Bergstrom, James ; Card, Deborah ; Chebret, Gary ; Hajdu, Richard ; Keohane, Carol Ann ; Milligan, James A ; Rosenbach, Mark J ; Shei, Gan-Ju ; Mandala, Suzanne MBioorganic & Medicinal Chemistry Letters, 2006, Vol.16(11), pp.2905-2908 [Peer Reviewed Journal]Full text available |
| 20 |
Material Type: Article
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Discovery of 3-arylpropionic acids as potent agonists of sphingosine-1-phosphate receptor-1 (S1P 1) with high selectivity against all other known S1P receptor subtypesYan, Lin ; Huo, Pei ; Doherty, George ; Toth, Lesile ; Hale, Jeffrey J ; Mills, Sander G ; Hajdu, Richard ; Keohane, Carol A ; Rosenbach, Mark J ; Milligan, James A ; Shei, Gan-Ju ; Chrebet, Gary ; Bergstrom, James ; Card, Deborah ; Quackenbush, Elizabeth ; Wickham, Alexandra ; Mandala, Suzanne MBioorganic & Medicinal Chemistry Letters, 2006, Vol.16(14), pp.3679-3683 [Peer Reviewed Journal]Full text available |
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Selecting against S1P 3 enhances the acute cardiovascular tolerability of 3-(N-benzyl)aminopropylphosphonic acid S1P receptor agonistsHale, Jeffrey J ; Doherty, George ; Toth, Leslie ; Mills, Sander G ; Hajdu, Richard ; Ann Keohane, Carol ; Rosenbach, Mark ; Milligan, James ; Shei, Gan-Ju ; Chrebet, Gary ; Bergstrom, James ; Card, Deborah ; Forrest, Michael ; Sun, Shu-Yu ; West, Sarah ; Xie, Huijuan ; Nomura, Naomi ; Rosen, Hugh ; Mandala, SuzanneBioorganic & Medicinal Chemistry Letters, 2004, Vol.14(13), pp.3501-3505 [Peer Reviewed Journal]Full text available |
| 22 |
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Design and synthesis of conformationally constrained 3-(N-alkylamino)propylphosphonic acids as potent agonists of sphingosine-1-phosphate (S1P) receptorsYan, Lin ; Hale, Jeffrey J ; Lynch, Christopher L ; Budhu, Richard ; Gentry, Amy ; Mills, Sander G ; Hajdu, Richard ; Keohane, Carol Ann ; Rosenbach, Mark J ; Milligan, James A ; Shei, Gan-Ju ; Chrebet, Gary ; Bergstrom, James ; Card, Deborah ; Rosen, Hugh ; Mandala, Suzanne MBioorganic & medicinal chemistry letters, 04 October 2004, Vol.14(19), pp.4861-6 [Peer Reviewed Journal]Full text available |
| 23 |
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Potent S1P receptor agonists replicate the pharmacologic actions of the novel immune modulator FTY720Hale, Jeffrey J ; Neway, William ; Mills, Sander G ; Hajdu, Richard ; Ann Keohane, Carol ; Rosenbach, Mark ; Milligan, James ; Shei, Gan-Ju ; Chrebet, Gary ; Bergstrom, James ; Card, Deborah ; Koo, Gloria C ; Koprak, Sam L ; Jackson, Jesse J ; Rosen, Hugh ; Mandala, SuzanneBioorganic & Medicinal Chemistry Letters, 2004, Vol.14(12), pp.3351-3355 [Peer Reviewed Journal]Full text available |
| 24 |
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Design and synthesis of conformationally constrained 3-( N-alkylamino)propylphosphonic acids as potent agonists of sphingosine-1-phosphate (S1P) receptorsYan, Lin ; Hale, Jeffrey J ; Lynch, Christopher L ; Budhu, Richard ; Gentry, Amy ; Mills, Sander G ; Hajdu, Richard ; Keohane, Carol Ann ; Rosenbach, Mark J ; Milligan, James A ; Shei, Gan-Ju ; Chrebet, Gary ; Bergstrom, James ; Card, Deborah ; Rosen, Hugh ; Mandala, Suzanne MBioorganic & Medicinal Chemistry Letters, 2004, Vol.14(19), pp.4861-4866 [Peer Reviewed Journal]Full text available |
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