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Effects of BI 655064, an antagonistic anti-CD40 antibody, on clinical and biomarker variables in patients with active rheumatoid arthritis: a randomised, double-blind, placebo-controlled, phase IIa study

Visvanathan, Sudha ; Daniluk, Stefan ; Ptaszyński, Rafał ; Müller-Ladner, Ulf ; Ramanujam, Meera ; Rosenstock, Bernd ; Eleftheraki, Anastasia G ; Vinisko, Richard ; Petříková, Alena ; Kellner, Herbert ; Dokoupilova, Eva ; Kwiatkowska, Brygida ; Alten, Rieke ; Schwabe

Annals of the rheumatic diseases, June 2019, Vol.78(6), pp.754-760 [Peer Reviewed Journal]

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House dust mite models: Will they translate clinically as a superior model of asthma?

Phillips, Jonathan E ; Peng, Ruoqi ; Harris, Paul ; Burns, Lisa ; Renteria, Lorena ; Lundblad, Lennart K.A ; Fine, Jay S ; Bauer, Carla M.T ; Stevenson, Christopher S

The Journal of Allergy and Clinical Immunology, July 2013, Vol.132(1), pp.242-244 [Peer Reviewed Journal]

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Bleomycin induces molecular changes directly relevant to idiopathic pulmonary fibrosis: a model for "active" disease

Peng, Ruoqi ; Sridhar, Sriram ; Tyagi, Gaurav ; Phillips, Jonathan E ; Garrido, Rosario ; Harris, Paul ; Burns, Lisa ; Renteria, Lorena ; Woods, John ; Chen, Leena ; Allard, John ; Ravindran, Palanikumar ; Bitter, Hans ; Liang, Zhenmin ; Hogaboam, Cory M ; Kitson, Chris ; Budd, David C ; Fine, Jay S ; Bauer, Carla M T ; Stevenson, Christopher S

PloS one, 2013, Vol.8(4), pp.e59348 [Peer Reviewed Journal]

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Systemic Biomarkers of Neutrophilic Inflammation, Tissue Injury and Repair in COPD Patients with Differing Levels of Disease Severity

Cockayne, Debra A ; Cheng, Donavan T ; Waschki, Benjamin ; Sridhar, Sriram ; Ravindran, Palanikumar ; Hilton, Holly ; Kourteva, Galina ; Bitter, Hans ; Pillai, Sreekumar G ; Visvanathan, Sudha ; Müller, Kai-Christian ; Holz, Olaf ; Magnussen, Helgo ; Watz, Henrik ; Fine, Jay S Thatcher, Thomas H. (editor)

PLoS ONE, 2012, Vol.7(6) [Peer Reviewed Journal]

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5
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Btk inhibition suppresses agonist-induced human macrophage activation and inflammatory gene expression in RA synovial tissue explants

Hartkamp, Linda M ; Fine, Jay S ; Van Es, Inge E ; Tang, Man Wai ; Smith, Michael ; Woods, John ; Narula, Satwant ; Demartino, Julie ; Tak, Paul P ; Reedquist, Kris A

Annals of the rheumatic diseases, August 2015, Vol.74(8), pp.1603-11 [Peer Reviewed Journal]

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6
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Inflammatory Signals shift from adipose to liver during high fat feeding and influence the development of steatohepatitis in mice

Greenfeder Scott ; Fine Jay S ; Cui Long ; Kinsley David ; Rojas-Triana Alberto ; Jackson James V ; Chen Shu-Cheng ; Stanton Michaela C ; Bober Loretta A ; Jenh Chung-Her

Journal of Inflammation, 01 March 2011, Vol.8(1), p.8 [Peer Reviewed Journal]

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7
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Intraflagellar Transport Gene Expression Associated with Short Cilia in Smoking and COPD

Hessel, Justina ; Heldrich, Jonna ; Fuller, Jennifer ; Staudt, Michelle ; Radisch, Sharon ; Hollmann, Charleen ; Ben-Gary, Harvey ; Kaner, Robert ; Salit, Jacqueline ; Yee-Levin, Jenny ; Sridhar, Sriram ; Pillai, Sreekumar ; Hilton, Holly ; Wolff, Gerhard ; Bitter, Hans ; Visvanathan, Sudha ; Fine, Jay ; Stevenson, Christopher ; Crystal, Ronald ; Tilley

PLoS One, Jan 2014, Vol.9(1), p.e85453 [Peer Reviewed Journal]

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Persistence of smoking-induced dysregulation of miRNA expression in the small airway epithelium despite smoking cessation

Wang, Guoqing ; Wang, Rui ; Strulovici-Barel, Yael ; Salit, Jacqueline ; Staudt, Michelle R ; Ahmed, Joumana ; Tilley, Ann E ; Yee-Levin, Jenny ; Hollmann, Charleen ; Harvey, Ben-Gary ; Kaner, Robert J ; Mezey, Jason G ; Sridhar, Sriram ; Pillai, Sreekumar G ; Hilton, Holly ; Wolff, Gerhard ; Bitter, Hans ; Visvanathan, Sudha ; Fine, Jay S ; Stevenson

PloS one, 2015, Vol.10(4), pp.e0120824 [Peer Reviewed Journal]

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Bleomycin induced lung fibrosis increases work of breathing in the mouse

Phillips, Jonathan E ; Peng, Ruoqi ; Burns, Lisa ; Harris, Paul ; Garrido, Rosario ; Tyagi, Gaurav ; Fine, Jay S ; Stevenson, Christopher S

Pulmonary Pharmacology & Therapeutics, August 2012, Vol.25(4), pp.281-285 [Peer Reviewed Journal]

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10
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Ambient Pollution-related Reprogramming of the Human Small Airway Epithelial Transcriptome

O'Beirne, Sarah L ; Shenoy, Sushila A ; Salit, Jacqueline ; Strulovici-Barel, Yael ; Kaner, Robert J ; Visvanathan, Sudha ; Fine, Jay S ; Mezey, Jason G ; Crystal, Ronald G

American journal of respiratory and critical care medicine, 01 December 2018, Vol.198(11), pp.1413-1422 [Peer Reviewed Journal]

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11
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HOPE-BAL: Improved Molecular Diagnostics by Application of a Novel Technique for Fixation and Paraffin Embedding

Marwitz, Sebastian ; Abdullah, Mahdi ; Vock, Christina ; Fine, Jay S ; Visvanathan, Sudha ; Gaede, Karoline I ; Hauber, Hans-Peter ; Zabel, Peter ; Goldmann, Torsten

Journal of Histochemistry & Cytochemistry, June 2011, Vol.59(6), pp.601-614 [Peer Reviewed Journal]

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12
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Rise in dermal CD11c + dendritic cells associates with early-stage development of psoriatic lesions

Teunissen, Marcel ; Zheng, Ling ; Groot, Marjan ; Rie, Menno ; Fine, Jay ; Chen, Shu-Cheng

Archives of Dermatological Research, 2012, Vol.304(6), pp.443-449 [Peer Reviewed Journal]

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13
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Systemic biomarkers of neutrophilic inflammation, tissue injury and repair in COPD patients with differing levels of desease severity

Cockayne, Debra A. ; Cheng, Donovan T. ; Waschki, Benjamin ; Sridhar, Sriram ; Ravindran, Palanikumar ; Hilton, Holly ; Kourteva, Galina ; Bitter, Hans ; Pillai, Sreekumar G. ; Visvanathan, Sudha ; Müller, Kai - Christian ; Holz, Olaf ; Magnussen, Helgo ; Watz, Henrik ; Fine, Jay S.

PLoS one. Online journal, Vol.7 (2012), No.6, Art. e38629, 12 pp.

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14
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Pharmacological targeting reveals distinct roles for CXCR2/CXCR1 and CCR2 in a mouse model of arthritis

Min, Soo-Hong ; Wang, Yuanfan ; Gonsiorek, Waldemar ; Anilkumar, Gopinadhan ; Kozlowski, Joseph ; Lundell, Daniel ; Fine, Jay S ; Grant, Ethan P

Biochemical and Biophysical Research Communications, 01 January 2010, Vol.391(1), pp.1080-1086 [Peer Reviewed Journal]

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15
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Conditional expression of murine Flt3 ligand leads to expansion of multiple dendritic cell subsets in peripheral blood and tissues of transgenic mice

Manfra, Denise J ; Chen, Shu-Cheng ; Jensen, Kristian K ; Fine, Jay S ; Wiekowski, Maria T ; Lira, Sergio A

Journal of immunology (Baltimore, Md. : 1950), 15 March 2003, Vol.170(6), pp.2843-52 [Peer Reviewed Journal]

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16
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Kinetic Assessment and Therapeutic Modulation of Metabolic and Inflammatory Profiles in Mice on a High-Fat and Cholesterol Diet

Engstrom, Laura W ; Bober, Loretta ; Chen, Shu-Cheng ; Fine, Jay S ; Li, Ying ; Stanton, Michaela C ; Kinsley, David ; Cui, Long ; Jackson, James V ; Rojas-Triana, Alberto ; Lundell, Daniel ; Laverty, Maureen ; Gustafson, Eric L ; Jenh, Chung-Her ; Kowalski, Timothy J ; Manfra, Denise J Ko, Joshua K

PPAR Research, 2010, Vol.2010, 13 pages [Peer Reviewed Journal]

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17
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A selective and potent CXCR3 antagonist SCH 546738 attenuates the development of autoimmune diseases and delays graft rejection

Jenh Chung-Her ; Cox Mary Ann ; Cui Long ; Reich Eva-Pia ; Sullivan Lee ; Chen Shu-Cheng ; Kinsley David ; Qian Shiguang ; Kim Seong Heon ; Rosenblum Stuart ; Kozlowski Joseph ; Fine Jay S ; Zavodny Paul J ; Lundell Daniel

BMC Immunology, 01 January 2012, Vol.13(1), p.2 [Peer Reviewed Journal]

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18
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A selective and potent CXCR3 antagonist SCH 546738 attenuates the development of autoimmune diseases and delays graft rejection

Jenh, Chung-Her ; Cox, Mary Ann ; Cui, Long ; Reich, Eva-Pia ; Sullivan, Lee ; Chen, Shu-Cheng ; Kinsley, David ; Qian, Shiguang ; Kim, Seong Heon ; Rosenblum, Stuart ; Kozlowski, Joseph ; Fine, Jay ; Zavodny, Paul ; Lundell, Daniel

BMC Immunology, 2012, Vol.13, p.2 [Peer Reviewed Journal]

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19
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Highly selective inhibition of Bruton's tyrosine kinase attenuates skin and brain disease in murine lupus

Chalmers, Samantha A ; Wen, Jing ; Doerner, Jessica ; Stock, Ariel ; Cuda, Carla M ; Makinde, Hadijat M ; Perlman, Harris ; Bosanac, Todd ; Webb, Deborah ; Nabozny, Gerald ; Fine, Jay S ; Klein, Elliott ; Ramanujam, Meera ; Putterman, Chaim

Arthritis research & therapy, 25 January 2018, Vol.20(1), pp.10 [Peer Reviewed Journal]

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20
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Therapeutic Blockade of Immune Complex-Mediated Glomerulonephritis by Highly Selective Inhibition of Bruton's Tyrosine Kinase

Chalmers, Samantha ; Doerner, Jessica ; Bosanac, Todd ; Khalil, Sara ; Smith, Dustin ; Harcken, Christian ; Dimock, Janice ; Der, Evan ; Herlitz, Leal ; Webb, Deborah ; Seccareccia, Elise ; Feng, Di ; Fine, Jay ; Ramanujam, Meera ; Klein, Elliott ; Putterman, Chaim

Scientific Reports (Nature Publisher Group), May 2016, Vol.6, p.26164 [Peer Reviewed Journal]

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21
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Persistence of circulating endothelial microparticles in COPD despite smoking cessation

Strulovici-Barel, Yael ; Staudt, Michelle R ; Krause, Anja ; Gordon, Cynthia ; Tilley, Ann E ; Harvey, Ben-Gary ; Kaner, Robert J ; Hollmann, Charleen ; Mezey, Jason G ; Bitter, Hans ; Pillai, Sreekumar G ; Hilton, Holly ; Wolff, Gerhard ; Stevenson, Christopher S ; Visvanathan, Sudha ; Fine, Jay S ; Crystal, Ronald G

Thorax, Dec 2016, Vol.71(12), p.1137 [Peer Reviewed Journal]

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22
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RN486, a selective Bruton's tyrosine kinase inhibitor, abrogates immune hypersensitivity responses and arthritis in rodents

Xu, Daigen ; Kim, Yong ; Postelnek, Jennifer ; Vu, Minh Diem ; Hu, Dong-Qing ; Liao, Cheng ; Bradshaw, Mike ; Hsu, Jonathan ; Zhang, Jun ; Pashine, Achal ; Srinivasan, Dinesh ; Woods, John ; Levin, Anita ; O'Mahony, Alison ; Owens, Timothy D ; Lou, Yan ; Hill, Ronald J ; Narula, Satwant ; Demartino

The Journal of pharmacology and experimental therapeutics, April 2012, Vol.341(1), pp.90-103 [Peer Reviewed Journal]

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23
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Generation and functional characterization of anti-human and anti-mouse IL-36R antagonist monoclonal antibodies

Ganesan, Rajkumar ; Raymond, Ernest L ; Mennerich, Detlev ; Woska, Joseph R ; Caviness, Gary ; Grimaldi, Christine ; Ahlberg, Jennifer ; Perez, Rocio ; Roberts, Simon ; Yang, Danlin ; Jerath, Kavita ; Truncali, Kristopher ; Frego, Lee ; Sepulveda, Eliud ; Gupta, Priyanka ; Brown, Su-Ellen ; Howell, Michael D ; Canada, Keith A ; Kroe-Barrett, Rachel ; Fine, Jay S

mAbs, 03 October 2017, Vol.9(7), pp.1143-1154 [Peer Reviewed Journal]

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24
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BTK inhibition ameliorates kidney disease in spontaneous lupus nephritis

Chalmers, Samantha A ; Glynn, Elizabeth ; Garcia, Sayra J ; Panzenbeck, Mark ; Pelletier, Josephine ; Dimock, Janice ; Seccareccia, Elise ; Bosanac, Todd ; Khalil, Sara ; Harcken, Christian ; Webb, Deborah ; Nabozny, Gerald ; Fine, Jay S ; Souza, Donald ; Klein, Elliott ; Herlitz, Leal ; Ramanujam, Meera ; Putterman, Chaim

Clinical Immunology, December 2018, Vol.197, pp.205-218 [Peer Reviewed Journal]

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25
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Protamine sulfate precipitation: A new assay for the Ah receptor

Denison, Michael S ; Fine, Jay ; Wilkinson, Christopher F

Analytical Biochemistry, 1984, Vol.142(1), pp.28-36 [Peer Reviewed Journal]

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26
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Drug-induced Hemolytic Anemia and Thrombocytopenia Associated with Alterations of Cell Membrane Lipids and Acanthocyte Formation

Poulet, Frederique M ; Penraat, Kelley ; Collins, Nathaniel ; Evans, Ellen ; Thackaberry, Evan ; Manfra, Denise ; Engstrom, Laura ; Geissler, Richard ; Geraci-Erck, Maria ; Frugone, Carlos ; Abutarif, Malaz ; Fine, Jay S ; Peterson, Brianna L ; Cummings, Brian S ; Johnson, Robert C

Toxicologic Pathology, October 2010, Vol.38(6), pp.907-922 [Peer Reviewed Journal]

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27
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Cloning and pharmacological characterization of CXCR1 and CXCR2 from Macaca fascicularis

Hipkin, R William ; Deno, Gregory ; Fine, Jay ; Sun, Yongliang ; Wilburn, Brian ; Fan, Xuedong ; Gonsiorek, Waldemar ; Wiekowski, Maria T

The Journal of pharmacology and experimental therapeutics, July 2004, Vol.310(1), pp.291-300 [Peer Reviewed Journal]

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28
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Chronic treatment with the gamma-secretase inhibitor LY-411,575 inhibits beta-amyloid peptide production and alters lymphopoiesis and intestinal cell differentiation

Wong, Gwendolyn T ; Manfra, Denise ; Poulet, Frederique M ; Zhang, Qi ; Josien, Hubert ; Bara, Thomas ; Engstrom, Laura ; Pinzon-Ortiz, Maria ; Fine, Jay S ; Lee, Hu-Jung J ; Zhang, Lili ; Higgins, Guy A ; Parker, Eric M

The Journal of biological chemistry, 26 March 2004, Vol.279(13), pp.12876-82 [Peer Reviewed Journal]

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29
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Psoriatic skin molecular and histopathologic profiles after treatment with risankizumab versus ustekinumab

Visvanathan, Sudha ; Baum, Patrick ; Vinisko, Richard ; Schmid, Ramona ; Flack, Mary ; Lalovic, Bojan ; Kleiner, Oliver ; Fuentes-Duculan, Judilyn ; Garcet, Sandra ; Davis, Justin W ; Grebe, Kristie M ; Fine, Jay S ; Padula, Steven J ; Krueger, James G

The Journal of Allergy and Clinical Immunology, June 2019, Vol.143(6), pp.2158-2169 [Peer Reviewed Journal]

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30
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Characterization of peripheral human cannabinoid receptor (hCB2) expression and pharmacology using a novel radioligand, 35SSch225336

Gonsiorek, Waldemar ; Hesk, David ; Chen, Shu-Cheng ; Kinsley, David ; Fine, Jay S ; Jackson, James V ; Bober, Loretta A ; Deno, Gregory ; Bian, Hong ; Fossetta, James ; Lunn, Charles A ; Kozlowski, Joseph A ; Lavey, Brian ; Piwinski, John ; Narula, Satwant K ; Lundell, Daniel J ; Hipkin, R William

The Journal of biological chemistry, 22 September 2006, Vol.281(38), pp.28143-51 [Peer Reviewed Journal]

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31
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Single-cell analysis of Crohn's disease lesions identifies a pathogenic cellular module associated with resistance to anti TNF therapy

Boschetti, Gilles ; Chang, Christie ; Ungaro, Ryan ; Giri, Mamta ; Nayar, Shikha ; Greenstein, Alexander ; Dubinsky, Marla ; Walker, Laura ; Leader, Andrew ; Fine, Jay ; Whitehurst, Charles ; Mbow, Lamine ; Kugathasan, Subra ; Denson, Lee ; Hyams, Jeffrey ; Friedman, Joshua ; Desai, Prerak ; Ko, Mabel ; Laface, Ilaria ; Akturk Kenigsberg, Ephraim (pacrepositoryorg)

BioRxiv, Dec 20, 2018

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32
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Discovery of 2-hydroxy-N,N-dimethyl-3-{2-(R)-1-(5- methylfuran-2-yl)propylamino-3,4-dioxocyclobut-1-enylamino}benzamide (SCH 527123): a potent, orally bioavailable CXCR2/CXCR1 receptor antagonist

Dwyer, Michael P ; Yu, Younong ; Chao, Jianping ; Aki, Cynthia ; Chao, Jianhua ; Biju, Purakkattle ; Girijavallabhan, Viyyoor ; Rindgen, Diane ; Bond, Richard ; Mayer-Ezel, Rosemary ; Jakway, James ; Hipkin, R William ; Fossetta, James ; Gonsiorek, Waldemar ; Bian, Hong ; Fan, Xuedong ; Terminelli, Carol ; Fine, Jay ; Lundell, Daniel ; Merritt

Journal of medicinal chemistry, 28 December 2006, Vol.49(26), pp.7603-6 [Peer Reviewed Journal]

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33
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CCR2 and CXCR4 regulate peripheral blood monocyte pharmacodynamics and link to efficacy in experimental autoimmune encephalomyelitis

Kozlowski Joseph ; Rosenblum Stuart ; Anilkumar Gopinadhan ; Min Soo-Hong ; Gonsiorek Waldemar ; Cui Long ; Wang Yuanfan ; Lundell Daniel ; Fine Jay S ; Grant Ethan P

Journal of Inflammation, 01 November 2009, Vol.6(1), p.32 [Peer Reviewed Journal]

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34
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A novel, orally active CXCR1/2 receptor antagonist, Sch527123, inhibits neutrophil recruitment, mucus production, and goblet cell hyperplasia in animal models of pulmonary inflammation

Chapman, Richard W ; Minnicozzi, Michael ; Celly, Chander S ; Phillips, Jonathan E ; Kung, Ted T ; Hipkin, R William ; Fan, Xuedong ; Rindgen, Diane ; Deno, Gregory ; Bond, Richard ; Gonsiorek, Waldemar ; Billah, Motasim M ; Fine, Jay S ; Hey, John A

The Journal of pharmacology and experimental therapeutics, August 2007, Vol.322(2), pp.486-93 [Peer Reviewed Journal]

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35
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A novel cannabinoid peripheral cannabinoid receptor-selective inverse agonist blocks leukocyte recruitment in vivo

Lunn, Charles A ; Fine, Jay S ; Rojas-Triana, Alberto ; Jackson, James V ; Fan, Xuedong ; Kung, Ted T ; Gonsiorek, Waldemar ; Schwarz, Martin A ; Lavey, Brian ; Kozlowski, Joseph A ; Narula, Satwant K ; Lundell, Daniel J ; Hipkin, R William ; Bober, Loretta A

The Journal of pharmacology and experimental therapeutics, February 2006, Vol.316(2), pp.780-8 [Peer Reviewed Journal]

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36
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Fluoroalkyl α side chain containing 3,4-diamino-cyclobutenediones as potent and orally bioavailable CXCR2–CXCR1 dual antagonists

Biju, Purakkattle ; Taveras, Arthur G ; Dwyer, Michael P ; Yu, Younong ; Chao, Jianhua ; Hipkin, R. William ; Fan, Xuedong ; Rindgen, Diane ; Fine, Jay ; Lundell, Daniel

Bioorganic & Medicinal Chemistry Letters, 2009, Vol.19(5), pp.1431-1433 [Peer Reviewed Journal]

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3,4-Diamino-1,2,5-thiadiazole as potent and selective CXCR2 antagonists

Biju, Purakkattle ; Taveras, Arthur G ; Yu, Younong ; Zheng, Junying ; Hipkin, R. William ; Fossetta, James ; Fan, Xuedong ; Fine, Jay ; Lundell, Daniel

Bioorganic & Medicinal Chemistry Letters, 2009, Vol.19(5), pp.1434-1437 [Peer Reviewed Journal]

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