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Computational study of CCR5 antagonist with support vector machines and three dimensional quantitative structure activity relationship methods

Chen, Yue ; Li, Zeng ; Chen, Hai-Feng

Chemical biology & drug design, March 2010, Vol.75(3), pp.295-309 [Peer Reviewed Journal]

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Stochastic model of in-vivo X4 emergence during HIV infection: implications for the CCR5 inhibitor maraviroc

Savkovic, Borislav ; Symonds, Geoff ; Murray, John M

PloS one, 2012, Vol.7(7), pp.e38755 [Peer Reviewed Journal]

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The chemokine receptor CCR5, a therapeutic target for HIV/AIDS antagonists, is critical for recovery in a mouse model of Japanese encephalitis

Larena, Maximilian ; Regner, Matthias ; Lobigs, Mario

PloS one, 2012, Vol.7(9), pp.e44834 [Peer Reviewed Journal]

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Inhibition of dual/mixed tropic HIV-1 isolates by CCR5-inhibitors in primary lymphocytes and macrophages

Surdo, Matteo ; Balestra, Emanuela ; Saccomandi, Patrizia ; Di Santo, Fabiola ; Montano, Marco ; Di Carlo, Domenico ; Sarmati, Loredana ; Aquaro, Stefano ; Andreoni, Massimo ; Svicher, Valentina ; Perno, Carlo Federico ; Ceccherini-Silberstein, Francesca

PloS one, 2013, Vol.8(7), pp.e68076 [Peer Reviewed Journal]

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Design, synthesis and biological evaluation of novel piperazine derivatives as CCR5 antagonists

Liu, Tao ; Weng, Zhiyong ; Dong, Xiaowu ; Chen, Linjie ; Ma, Ling ; Cen, Shan ; Zhou, Naiming ; Hu, Yongzhou

PloS one, 2013, Vol.8(1), pp.e53636 [Peer Reviewed Journal]

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In vitro downregulation of matrix metalloproteinase-9 in rat glial cells by CCR5 antagonist maraviroc: therapeutic implication for HIV brain infection

Gramegna, Pasqua ; Latronico, Tiziana ; Branà, Maria Teresa ; Di Bari, Gaetano ; Mengoni, Fabio ; Belvisi, Valeria ; Mascellino, Maria T ; Lichtner, Miriam ; Vullo, Vincenzo ; Mastroianni, Claudio M ; Liuzzi, Grazia M

PloS one, 2011, Vol.6(12), pp.e28499 [Peer Reviewed Journal]

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Antifibrotic Effects of the Dual CCR2/CCR5 Antagonist Cenicriviroc in Animal Models of Liver and Kidney Fibrosis

Lefebvre, Eric ; Moyle, Graeme ; Reshef, Ran ; Richman, Lee P ; Thompson, Melanie ; Hong, Feng ; Chou, Hsin-L ; Hashiguchi, Taishi ; Plato, Craig ; Poulin, Dominic ; Richards, Toni ; Yoneyama, Hiroyuki ; Jenkins, Helen ; Wolfgang, Grushenka ; Friedman, Scott L

PloS one, 2016, Vol.11(6), pp.e0158156 [Peer Reviewed Journal]

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Resistance to the CCR5 inhibitor 5P12-RANTES requires a difficult evolution from CCR5 to CXCR4 coreceptor use

Nedellec, Rebecca ; Coetzer, Mia ; Lederman, Michael M ; Offord, Robin E ; Hartley, Oliver ; Mosier, Donald E

PloS one, 2011, Vol.6(7), pp.e22020 [Peer Reviewed Journal]

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Intensification of antiretroviral therapy with a CCR5 antagonist in patients with chronic HIV-1 infection: effect on T cells latently infected

Gutiérrez, Carolina ; Díaz, Laura ; Vallejo, Alejandro ; Hernández-Novoa, Beatriz ; Abad, María ; Madrid, Nadia ; Dahl, Viktor ; Rubio, Rafael ; Moreno, Ana M ; Dronda, Fernando ; Casado, José Luis ; Navas, Enrique ; Pérez-Elías

PloS one, 2011, Vol.6(12), pp.e27864 [Peer Reviewed Journal]

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Cenicriviroc, a Novel CCR5 (R5) and CCR2 Antagonist, Shows In Vitro Activity against R5 Tropic HIV-2 Clinical Isolates

Visseaux, Benoit ; Charpentier, Charlotte ; Collin, Gilles ; Bertine, Mélanie ; Peytavin, Gilles ; Damond, Florence ; Matheron, Sophie ; Lefebvre, Eric ; Brun-Vézinet, Françoise ; Descamps, Diane

PloS one, 2015, Vol.10(8), pp.e0134904 [Peer Reviewed Journal]

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11
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A genotypic test for HIV-1 tropism combining Sanger sequencing with ultradeep sequencing predicts virologic response in treatment-experienced patients

Kagan, Ron M ; Johnson, Erik P ; Siaw, Martin ; Biswas, Pinaki ; Chapman, Douglass S ; Su, Zhaohui ; Platt, Jamie L ; Pesano, Rick L

PloS one, 2012, Vol.7(9), pp.e46334 [Peer Reviewed Journal]

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12
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A topical microbicide gel formulation of CCR5 antagonist maraviroc prevents HIV-1 vaginal transmission in humanized RAG-hu mice

Neff, C Preston ; Kurisu, Theresa ; Ndolo, Thomas ; Fox, Kami ; Akkina, Ramesh

PloS one, 2011, Vol.6(6), pp.e20209 [Peer Reviewed Journal]

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Levels of soluble endothelial protein C receptor are associated with CD4+ changes in Maraviroc-treated HIV-infected patients

Nozza, Silvia ; Pogliaghi, Manuela ; Chiappetta, Stefania ; Spagnuolo, Vincenzo ; Fontana, Gessica ; Razzari, Cristina ; Tambussi, Giuseppe ; Faioni, Elena Maria

PloS one, 2012, Vol.7(6), pp.e37032 [Peer Reviewed Journal]

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14
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Studies on the structure-activity relationship of 1,3,3,4-tetra-substituted pyrrolidine embodied CCR5 receptor antagonists. Part 1: Tuning the N-substituents

Ben, Li ; Jones, Eric Dale ; Zhou, Enkun ; Li, Chen ; Baylis, Dean Cameron ; Yu, Shanghai ; Wang, Miao ; He, Xing ; Coates, Jonathan Alan Victor ; Rhodes, David Ian ; Pei, Gang ; Deadman, John Joseph ; Xie, Xin ; Ma, Dawei

Bioorganic & medicinal chemistry letters, 15 July 2010, Vol.20(14), pp.4012-4 [Peer Reviewed Journal]

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15
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Structural and molecular interactions of CCR5 inhibitors with CCR5

Maeda, Kenji ; Das, Debananda ; Ogata-Aoki, Hiromi ; Nakata, Hirotomo ; Miyakawa, Toshikazu ; Tojo, Yasushi ; Norman, Rachael ; Takaoka, Yoshikazu ; Ding, Jianping ; Arnold, Gail F ; Arnold, Eddy ; Mitsuya, Hiroaki

The Journal of biological chemistry, 05 May 2006, Vol.281(18), pp.12688-98 [Peer Reviewed Journal]

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16
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Structural determinants of the anti-HIV activity of a CCR5 antagonist derived from Toxoplasma gondii

Yarovinsky, Felix ; Andersen, John F ; King, Lisa R ; Caspar, Patricia ; Aliberti, Julio ; Golding, Hana ; Sher, Alan

The Journal of biological chemistry, 17 December 2004, Vol.279(51), pp.53635-42 [Peer Reviewed Journal]

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17
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Efficient synthesis and identification of novel propane-1,3-diamino bridged CCR5 antagonists with variation on the basic center carrier

Fan, Xing ; Zhang, Hu-Shan ; Chen, Li ; Long, Ya-Qiu

European journal of medicinal chemistry, July 2010, Vol.45(7), pp.2827-40 [Peer Reviewed Journal]

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18
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Synthesis, SAR and evaluation of 1,4'-bipiperidinyl-4-yl-imidazolidin-2-one derivatives as novel CCR5 antagonists

Rotstein, David M ; Gabriel, Stephen D ; Manser, Nicole ; Filonova, Lubov ; Padilla, Fernando ; Sankuratri, Surya ; Ji, Changhua ; Derosier, Andre ; Dioszegi, Marianna ; Heilek, Gabrielle ; Jekle, Andreas ; Weller, Paul ; Berry, Pamela

Bioorganic & medicinal chemistry letters, 01 June 2010, Vol.20(11), pp.3219-22 [Peer Reviewed Journal]

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19
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The potential role of anibamine, a natural product CCR5 antagonist, and its analogues as leads toward development of anti-ovarian cancer agents

Zhang, Yan ; Arnatt, Christopher K ; Zhang, Feng ; Wang, Jiannan ; Haney, Kendra M ; Fang, Xianjun

Bioorganic & medicinal chemistry letters, 01 August 2012, Vol.22(15), pp.5093-7 [Peer Reviewed Journal]

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20
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HIV's response to a CCR5 inhibitor: I'd rather tighten than switch!

Farber, Joshua M ; Berger, Edward A

Proceedings of the National Academy of Sciences of the United States of America, 19 February 2002, Vol.99(4), pp.1749-51 [Peer Reviewed Journal]

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21
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HIV-1 escape from a small molecule, CCR5-specific entry inhibitor does not involve CXCR4 use

Trkola, Alexandra ; Kuhmann, Shawn E ; Strizki, Julie M ; Maxwell, Elizabeth ; Ketas, Tom ; Morgan, Tom ; Pugach, Pavel ; Xu, Serena ; Wojcik, Lisa ; Tagat, Jayaram ; Palani, Anandan ; Shapiro, Sherry ; Clader, John W ; Mccombie, Stuart ; Reyes, Gregory R ; Baroudy, Bahige M ; Moore, John P

Proceedings of the National Academy of Sciences of the United States of America, 08 January 2002, Vol.99(1), pp.395-400 [Peer Reviewed Journal]

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22
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Stable reduction of CCR5 by RNAi through hematopoietic stem cell transplant in non-human primates

An, Dong Sung ; Donahue, Robert E ; Kamata, Masakazu ; Poon, Betty ; Metzger, Mark ; Mao, Si-Hua ; Bonifacino, Aylin ; Krouse, Allen E ; Darlix, Jean-Luc ; Baltimore, David ; Qin, F Xiao-Feng ; Chen, Irvin S Y

Proceedings of the National Academy of Sciences of the United States of America, 07 August 2007, Vol.104(32), pp.13110-5 [Peer Reviewed Journal]

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23
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Lymphocyte adhesion to CCR5 ligands is reduced by anti-CCR5 gene delivery

Marusich, Elena ; Louboutin, Jean-Pierre ; Chekmasova, Alena A ; Strayer, David S

Journal of the neurological sciences, 15 September 2011, Vol.308(1-2), pp.25-7 [Peer Reviewed Journal]

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24
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Discovery of a novel series of cyclic urea as potent CCR5 antagonists

Duan, Maosheng ; Kazmierski, Wieslaw M ; Tallant, Matt ; Jun, Jung Ho ; Edelstein, Mark ; Ferris, Rob ; Todd, Dan ; Wheelan, Pat ; Xiong, Zhiping

Bioorganic & medicinal chemistry letters, 01 November 2011, Vol.21(21), pp.6381-5 [Peer Reviewed Journal]

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25
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Spirodiketopiperazine-based CCR5 antagonist: discovery of an antiretroviral drug candidate

Nishizawa, Rena ; Nishiyama, Toshihiko ; Hisaichi, Katsuya ; Minamoto, Chiaki ; Matsunaga, Naoki ; Takaoka, Yoshikazu ; Nakai, Hisao ; Jenkinson, Stephen ; Kazmierski, Wieslaw M ; Tada, Hideaki ; Sagawa, Kenji ; Shibayama, Shiro ; Fukushima, Daikichi ; Maeda, Kenji ; Mitsuya, Hiroaki

Bioorganic & medicinal chemistry letters, 15 February 2011, Vol.21(4), pp.1141-5 [Peer Reviewed Journal]

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26
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Discovery of novel pyridyl carboxamides as potent CCR5 antagonists and optimization of their pharmacokinetic profile in rats

Duan, Maosheng ; Kazmierski, Wieslaw M ; Chong, Pek Y ; Deanda, Felix ; Edelstein, Mark ; Ferris, Rob ; Peckham, Jennifer ; Wheelan, Pat ; Xiong, Zhiping ; Zhang, Huichang ; Nishizawa, Rena ; Takaoka, Yoshikazu

Bioorganic & medicinal chemistry letters, 01 November 2011, Vol.21(21), pp.6470-5 [Peer Reviewed Journal]

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27
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Discovery of 4-4-({(3R)-1-butyl-3-(R)-cyclohexyl(hydroxy)methyl-2,5-dioxo-1,4,9-triazaspiro5.5undec-9-yl}methyl)phenoxybenzoic acid hydrochloride: a highly potent orally available CCR5 selective antagonist

Nishizawa, Rena ; Nishiyama, Toshihiko ; Hisaichi, Katsuya ; Minamoto, Chiaki ; Murota, Masayuki ; Takaoka, Yoshikazu ; Nakai, Hisao ; Tada, Hideaki ; Sagawa, Kenji ; Shibayama, Shiro ; Fukushima, Daikichi ; Maeda, Kenji ; Mitsuya, Hiroaki

Bioorganic & medicinal chemistry, 01 July 2011, Vol.19(13), pp.4028-42 [Peer Reviewed Journal]

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28
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Structure-Based Design of 1-Heteroaryl-1,3-propanediamine Derivatives as a Novel Series of CC-Chemokine Receptor 5 Antagonists

Peng, Panfeng ; Chen, Huan ; Zhu, Ya ; Wang, Zhilong ; Li, Jian ; Luo, Rong-Hua ; Wang, Jiang ; Chen, Liang ; Yang, Liu-Meng ; Jiang, Hualiang ; Xie, Xin ; Wu, Beili ; Zheng, Yong-Tang ; Liu, Hong

Journal of medicinal chemistry, 08 November 2018, Vol.61(21), pp.9621-9636 [Peer Reviewed Journal]

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29
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Could CCR5 be a potential target against infections?

Blanco, José R ; Ochoa-Callejero, Laura

Expert review of anti-infective therapy, April 2012, Vol.10(4), pp.411-4 [Peer Reviewed Journal]

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30
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HIV-1 entry inhibition by small-molecule CCR5 antagonists: a combined molecular modeling and mutant study using a high-throughput assay

Labrecque, Jean ; Metz, Markus ; Lau, Gloria ; Darkes, Marilyn C ; Wong, Rebecca S Y ; Bogucki, David ; Carpenter, Bryon ; Chen, Gang ; Li, Tongshuang ; Nan, Susan ; Schols, Dominique ; Bridger, Gary J ; Fricker, Simon P ; Skerlj, Renato T

Virology, 10 May 2011, Vol.413(2), pp.231-43 [Peer Reviewed Journal]

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31
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Synthesis and evaluation of 2-phenyl-1,4-butanediamine-based CCR5 antagonists for the treatment of HIV-1

Tallant, Matthew D ; Duan, Maosheng ; Freeman, George A ; Ferris, Robert G ; Edelstein, Mark P ; Kazmierski, Wieslaw M ; Wheelan, Pat J

Bioorganic & medicinal chemistry letters, 01 March 2011, Vol.21(5), pp.1394-8 [Peer Reviewed Journal]

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32
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Regio- and stereoselective syntheses of the natural product CCR5 antagonist anibamine and its three olefin isomers

Zhang, Feng ; Zaidi, Saheem ; Haney, Kendra M ; Kellogg, Glen E ; Zhang, Yan

The Journal of organic chemistry, 07 October 2011, Vol.76(19), pp.7945-52 [Peer Reviewed Journal]

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33
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Evaluation of amide replacements in CCR5 antagonists as a means to increase intrinsic permeability. Part 2: SAR optimization and pharmacokinetic profile of a homologous azacyle series

Wanner, Jutta ; Chen, Lijing ; Lemoine, Rémy C ; Kondru, Rama ; Jekle, Andreas ; Heilek, Gabrielle ; Derosier, André ; Ji, Changhua ; Berry, Pamela W ; Rotstein, David M

Bioorganic & medicinal chemistry letters, 15 November 2010, Vol.20(22), pp.6802-7 [Peer Reviewed Journal]

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34
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Evaluation of a 4-aminopiperidine replacement in several series of CCR5 antagonists

Lemoine, Rémy C ; Petersen, Ann C ; Setti, Lina ; Chen, Lijing ; Wanner, Jutta ; Jekle, Andreas ; Heilek, Gabrielle ; Derosier, André ; Ji, Changhua ; Rotstein, David M

Bioorganic & medicinal chemistry letters, 15 March 2010, Vol.20(6), pp.1830-3 [Peer Reviewed Journal]

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35
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Exploration of a new series of CCR5 antagonists: multi-dimensional optimization of a sub-series containing N-substituted pyrazoles

Lemoine, Rémy C ; Petersen, Ann C ; Setti, Lina ; Jekle, Andreas ; Heilek, Gabrielle ; Derosier, André ; Ji, Changhua ; Berry, Pamela ; Rotstein, David M

Bioorganic & medicinal chemistry letters, 15 August 2010, Vol.20(16), pp.4753-6 [Peer Reviewed Journal]

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36
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Spirodiketopiperazine-based CCR5 antagonists: Improvement of their pharmacokinetic profiles

Nishizawa, Rena ; Nishiyama, Toshihiko ; Hisaichi, Katsuya ; Hirai, Keisuke ; Habashita, Hiromu ; Takaoka, Yoshikazu ; Tada, Hideaki ; Sagawa, Kenji ; Shibayama, Shiro ; Maeda, Kenji ; Mitsuya, Hiroaki ; Nakai, Hisao ; Fukushima, Daikichi ; Toda, Masaaki

Bioorganic & medicinal chemistry letters, 15 January 2010, Vol.20(2), pp.763-6 [Peer Reviewed Journal]

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37
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Studies on the structure-activity relationship of 1,3,3,4-tetra-substituted pyrrolidine embodied CCR5 receptor antagonists. Part 2: Discovery of highly potent anti-HIV agents

Li, Ben ; Jones, Eric Dale ; Zhou, Enkun ; Chen, Li ; Baylis, Dean Cameron ; Yu, Shanghai ; Wang, Miao ; He, Xing ; Coates, Jonathan Alan Victor ; Rhodes, David Ian ; Pei, Gang ; Deadman, John Joseph ; Xie, Xin ; Ma, Dawei

Bioorganic & medicinal chemistry letters, 01 September 2010, Vol.20(17), pp.5334-6 [Peer Reviewed Journal]

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