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40 Results  for Everything (Includes Articles)

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1
Material Type:
Review
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Novel treatment approaches and future perspectives in follicular lymphoma

Sutamtewagul, Grerk ; Link, Brian K

Therapeutic Advances in Hematology, January 2019, Vol.10 [Peer Reviewed Journal]

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2
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Article
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β2‐microglobulin normalization within 6 months of ibrutinib‐based treatment is associated with superior progression‐free survival in patients with chronic lymphocytic leukemia

Thompson, Philip A. ; O' Brien, Susan M. ; Xiao, Lianchun ; Wang, Xuemei ; Burger, Jan A. ; Jain, Nitin ; Ferrajoli, Alessandra ; Estrov, Zeev ; Keating, Michael J. ; Wierda, William G.

Cancer, 15 February 2016, Vol.122(4), pp.565-573 [Peer Reviewed Journal]

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3
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Article
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The mTOR kinase inhibitor everolimus synergistically enhances the anti‐tumor effect of the Bruton's tyrosine kinase (BTK) inhibitor PLS‐123 on Mantle cell lymphoma

Li, Jiao ; Wang, Xiaogan ; Xie, Yan ; Ying, Zhitao ; Liu, Weiping ; Ping, Lingyan ; Zhang, Chen ; Pan, Zhengying ; Ding, Ning ; Song, Yuqin ; Zhu, Jun

International Journal of Cancer, 01 January 2018, Vol.142(1), pp.202-213 [Peer Reviewed Journal]

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4
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Article
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Development of the Bruton's tyrosine kinase inhibitor ibrutinib for B cell malignancies

Gayko, Urte ; Fung, Mann ; Clow, Fong ; Sun, Steven ; Faust, Elizabeth ; Price, Samiyeh ; James, Danelle ; Doyle, Margaret ; Bari, Samina ; Zhuang, Sen Hong

Annals of the New York Academy of Sciences, November 2015, Vol.13581(1), pp.82-94 [Peer Reviewed Journal]

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5
Material Type:
Article
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Discovery of potent, highly selective covalent irreversible BTK inhibitors from a fragment hit

Qiu, Hui ; Liu-Bujalski, Lesley ; Caldwell, Richard D ; Follis, Ariele Viacava ; Gardberg, Anna ; Goutopoulos, Andreas ; Grenningloh, Roland ; Head, Jared ; Johnson, Theresa ; Jones, Reinaldo ; Mochalkin, Igor ; Morandi, Federica ; Neagu, Constantin ; Sherer, Brian

Bioorganic & Medicinal Chemistry Letters, 15 September 2018, Vol.28(17), pp.2939-2944 [Peer Reviewed Journal]

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6
Material Type:
Article
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Discovery of Novel Bruton's Tyrosine Kinase (BTK) Inhibitors Bearing a ,9-Diphenyl-9-purin-2-amine Scaffold

Ge, Yang ; Jin, Yue ; Wang, Changyuan ; Zhang, Jianbin ; Tang, Zeyao ; Peng, Jinyong ; Liu, Kexin ; Li, Yanxia ; Zhou, Youwen ; Ma, Xiaodong

ACS medicinal chemistry letters, 08 December 2016, Vol.7(12), pp.1050-1055 [Peer Reviewed Journal]

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7
Material Type:
Article
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New agents in follicular lymphoma

Cheson, Bruce D

Best Practice & Research Clinical Haematology, 2011, Vol.24(2), pp.305-312 [Peer Reviewed Journal]

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8
Material Type:
Article
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Evaluation of 230 patients with relapsed/refractory deletion 17p chronic lymphocytic leukaemia treated with ibrutinib from 3 clinical trials

Jones, Jeffrey ; Mato, Anthony ; Coutre, Steven ; Byrd, John C. ; Furman, Richard R. ; Hillmen, Peter ; Osterborg, Anders ; Tam, Constantine ; Stilgenbauer, Stephan ; Wierda, William G. ; Heerema, Nyla A. ; Eckert, Karl ; Clow, Fong ; Zhou, Cathy ; Chu, Alvina D. ; James, Danelle F. ; O' Brien, Susan M.

British Journal of Haematology, August 2018, Vol.182(4), pp.504-512 [Peer Reviewed Journal]

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9
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Article
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Discovery of a novel series of pyridine and pyrimidine carboxamides as potent and selective covalent inhibitors of Btk

Caldwell, Richard ; Liu-Bujalski, Lesley ; Qiu, Hui ; Mochalkin, Igor ; Jones, Reinaldo ; Neagu, Constantin ; Goutopoulos, Andreas ; Grenningloh, Roland ; Johnson, Theresa ; Sherer, Brian ; Gardberg, Anna ; Follis, Ariele Viacava ; Morandi, Federica ; Head, Jared

Bioorganic & Medicinal Chemistry Letters, 15 November 2018, Vol.28(21), pp.3419-3424 [Peer Reviewed Journal]

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10
Material Type:
Article
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HM71224, a novel Bruton's tyrosine kinase inhibitor, suppresses B cell and monocyte activation and ameliorates arthritis in a mouse model: a potential drug for rheumatoid arthritis

Park, Jin Kyun ; Byun, Joo-Yun ; Park, Ji Ah ; Kim, Yu-Yon ; Lee, Ye Ji ; Oh, Jeong In ; Jang, Sun Young ; Kim, Young Hoon ; Song, Yeong Wook ; Son, Jeewoong ; Suh, Kwee Hyun ; Lee, Young-Mi ; Lee, Eun Bong

Arthritis research & therapy, 18 April 2016, Vol.18, pp.91 [Peer Reviewed Journal]

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11
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Article
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Three Newly Approved Drugs for Chronic Lymphocytic Leukemia: Incorporating Ibrutinib, Idelalisib, and Obinutuzumab into Clinical Practice

Sanford, David S ; Wierda, William G ; Burger, Jan A ; Keating, Michael J ; O'Brien, Susan M

Clinical Lymphoma Myeloma and Leukemia, July 2015, Vol.15(7), pp.385-391 [Peer Reviewed Journal]

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12
Material Type:
Article
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Effective virtual screening strategy focusing on the identification of novel Bruton's tyrosine kinase inhibitors

Xiao, Jianhu ; Zhang, Shengping ; Luo, Minghao ; Zou, Yi ; Zhang, Yihua ; Lai, Yisheng

Journal of Molecular Graphics and Modelling, July 2015, Vol.60, pp.142-154 [Peer Reviewed Journal]

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13
Material Type:
Article
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Optimization of the efflux ratio and permeability of covalent irreversible BTK inhibitors

Qiu, Hui ; Liu-Bujalski, Lesley ; Caldwell, Richard D ; Viacava Follis, Ariele ; Gardberg, Anna ; Goutopoulos, Andreas ; Grenningloh, Roland ; Head, Jared ; Johnson, Theresa ; Jones, Christopher C.V ; Jones, Reinaldo ; Mochalkin, Igor ; Morandi, Federica ; Neagu, Constantin ; Potnick, Justin ; Sherer, Brian

Bioorganic & Medicinal Chemistry Letters, 01 November 2018, Vol.28(20), pp.3307-3311 [Peer Reviewed Journal]

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14
Material Type:
Article
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Design and Synthesis of Novel Pyrazolo[3,4‐d]pyrimidin‐1‐yl piperidine Derivatives as Bruton's Tyrosine Kinase Inhibitors

Park, Hyebin ; Park, Chi Hoon ; Kang, Seung‐Tae ; Jeon, Jeong Hee ; Archary, Raghavendra ; Lee, Joo‐Youn ; Kim, Pilho ; Jung, Heejung ; Yun, Chang‐Soo ; Hwang, Jong Yeon ; Ryu, Do Hyun ; Cho, Sung Yun

Bulletin of the Korean Chemical Society, February 2017, Vol.38(2), pp.278-281 [Peer Reviewed Journal]

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15
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Article
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Discovery of 3-morpholino-imidazole[1,5-a]pyrazine BTK inhibitors for rheumatoid arthritis

Boga, Sobhana Babu ; Alhassan, Abdul-Basit ; Liu, Jian ; Guiadeen, Deodial ; Krikorian, Arto ; Gao, Xiaolei ; Wang, James ; Yu, Younong ; Anand, Rajan ; Liu, Shilan ; Yang, Chundao ; Wu, Hao ; Cai, Jiaqiang ; Zhu, Hugh ; Desai, Jagdish ; Maloney, Kevin ; Gao, Ying-Duo ; Fischmann, Thierry O ; Presland, Jeremy ; Mansueto, My

Bioorganic & Medicinal Chemistry Letters, 15 August 2017, Vol.27(16), pp.3939-3943 [Peer Reviewed Journal]

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16
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Article
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Homogeneous BTK Occupancy Assay for Pharmacodynamic Assessment of Tirabrutinib (GS-4059/ONO-4059) Target Engagement

Yu, Helen ; Truong, Hoa ; Mitchell, Scott A ; Liclican, Albert ; Gosink, John J ; Li, Wanying ; Lin, Julie ; Feng, Joy Y ; Jürgensmeier, Juliane M ; Billin, Andrew ; Xu, Ren ; Patterson, Scott ; Pagratis, Nikos

SLAS Discovery, October 2018, Vol.23(9), pp.919-929 [Peer Reviewed Journal]

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17
Material Type:
Article
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Treatment Response of Cutaneous Mantle Cell Lymphoma to Ibrutinib and Radiotherapy

Mancebo, Silvia E ; Smith, Jeffrey R ; Intlekofer, Andrew M ; Zelenetz, Andrew D ; Myskowski, Patricia L

Clinical Lymphoma Myeloma and Leukemia, June 2015, Vol.15(6), pp.e113-e115 [Peer Reviewed Journal]

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18
Material Type:
Article
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Design and Synthesis of Novel 3‐(2‐Aminopyridin‐3‐yl)‐1,2,4‐Triazolo[4,3‐b]Pyridazine Derivatives as a Reversible Bruton's Tyrosine Kinase Inhibitors

Park, Chi Hoon ; Kim, Dukwoon ; Jung, Hyeonseok ; Jeon, Jeong Hee ; Achary, Raghavendra ; Lee, Joo‐Youn ; Kim, Pilho ; Jung, Heejung ; Hwang, Jong Yeon ; Ryu, Do Hyun ; Du Ha, Jae ; Cho, Sung Yun

Bulletin of the Korean Chemical Society, July 2018, Vol.39(7), pp.853-857 [Peer Reviewed Journal]

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19
Material Type:
Article
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Discovery of novel BTK inhibitors with carboxylic acids

Gao, Xiaolei ; Wang, James ; Liu, Jian ; Guiadeen, Deodial ; Krikorian, Arto ; Boga, Sobhana Babu ; Alhassan, Abdul-Basit ; Selyutin, Oleg ; Yu, Wensheng ; Yu, Younong ; Anand, Rajan ; Liu, Shilan ; Yang, Chundao ; Wu, Hao ; Cai, Jiaqiang ; Cooper, Alan ; Zhu, Hugh ; Maloney, Kevin ; Gao, Ying-Duo ; Fischmann, Thierry O

Bioorganic & Medicinal Chemistry Letters, 15 March 2017, Vol.27(6), pp.1471-1477 [Peer Reviewed Journal]

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20
Material Type:
Article
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The effect of Bruton's tyrosine kinase (BTK) inhibitors on collagen‐induced platelet aggregation, BTK, and tyrosine kinase expressed in hepatocellular carcinoma (TEC

Chen, Jun ; Kinoshita, Taisei ; Gururaja, Tarikere ; Sukbuntherng, Juthamas ; James, Danelle ; Lu, Daniel ; Whang, Jennifer ; Versele, Matthias ; Chang, Betty Y.

European Journal of Haematology, November 2018, Vol.101(5), pp.604-612 [Peer Reviewed Journal]

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21
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Article
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Pitfalls of Combining Novel Agents in Lymphoma

Rodgers, Thomas ; Barr, Paul

Current Treatment Options in Oncology, 2018, Vol.19(7), pp.1-14 [Peer Reviewed Journal]

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22
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Article
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A head-to-head Phase III study comparing zanubrutinib versus ibrutinib in patients with Waldenström macroglobulinemia

Tam, Constantine S ; Leblond, Veronique ; Novotny, William ; Owen, Roger G ; Tedeschi, Alessandra ; Atwal, Siminder ; Cohen, Aileen ; Huang, Jane ; Buske, Christian

Future oncology (London, England), September 2018, Vol.14(22), pp.2229-2237 [Peer Reviewed Journal]

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23
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Article
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Selective BTK inhibition improves bendamustine therapy response and normalizes immune effector functions in chronic lymphocytic leukemia

Lee‐Vergés, Eriong ; Hanna, Bola S. ; Yazdanparast, Haniyeh ; Rodríguez, Vanina ; Rodríguez, Marta Leonor ; Giró, Ariadna ; Vidal‐Crespo, Anna ; Rosich, Laia ; Amador, Virginia ; Aymerich, Marta ; Villamor, Neus ; Delgado, Julio ; Lichter, Peter ; Pérez‐Galán, Patricia ; López‐Guerra, Mònica ; Campo, Elías ; Seiffert, Martina ; Colomer, Dolors

International Journal of Cancer, 01 June 2019, Vol.144(11), pp.2762-2773 [Peer Reviewed Journal]

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24
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Article
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Liquid chromatography-tandem mass spectrometric assay for the simultaneous determination of the irreversible BTK inhibitor ibrutinib and its dihydrodiol-metabolite in plasma and its application in mouse pharmacokinetic studies

Rood, Johannes J M ; Van Hoppe, Stephanie ; Schinkel, Alfred H ; Schellens, Jan H M ; Beijnen, Jos H ; Sparidans, Rolf W

Journal of pharmaceutical and biomedical analysis, 25 January 2016, Vol.118, pp.123-131 [Peer Reviewed Journal]

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25
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Article
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Complete remission with ibrutinib after allogeneic stem cell transplant for central nervous system relapse of mantle cell lymphoma: A case report and literature review

Rich, Jessica D. ; Clark, Stephen M. ; Fedoriw, Yuri ; Jewells, Valerie ; Wood, William ; Dittus, Christopher

Clinical Case Reports, October 2019, Vol.7(10), pp.1957-1961 [Peer Reviewed Journal]

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26
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Article
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Clinical activity of ibrutinib in classical Hodgkin lymphoma relapsing after allogeneic stem cell transplantation is independent of tumor BTK expression

Badar, Talha ; Astle, John ; Kakar, Imran K ; Zellner, Katie ; Hari, Parameswaran N ; Hamadani, Mehdi

British journal of haematology, 16 May 2020 [Peer Reviewed Journal]

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27
Material Type:
Article
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Discovery and structure-activity relationship of novel diphenylthiazole derivatives as BTK inhibitor with potent activity against B cell lymphoma cell lines

Guo, Xiaofeng ; Yang, Dongyan ; Fan, Zhijin ; Zhang, Nailou ; Zhao, Bin ; Huang, Chun ; Wang, Fangjie ; Ma, Rongji ; Meng, Meng ; Deng, Youcai

European Journal of Medicinal Chemistry, 15 September 2019, Vol.178, pp.767-781 [Peer Reviewed Journal]

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28
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Article
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Changes in clinical stage identify patients with CLL and different outcome within iwCLL partial response: RESONATE study

Moreno, Carol ; Delgado, Julio ; Byrd, John C. ; Zvagelsky, William L. ; Suzuki, Samuel ; Hsu, Emily ; James, Danelle F. ; Montserrat, Emili

British Journal of Haematology, April 2019, Vol.185(1), pp.148-150 [Peer Reviewed Journal]

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29
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Article
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Clinical Experience With Ibrutinib Alone or in Combination With Either Cytarabine or Azacitidine in Patients With Acute Myeloid Leukemia

Cortes, Jorge E ; Jonas, Brian A ; Graef, Thorsten ; Luan, Ying ; Stein, Anthony S

Clinical Lymphoma, Myeloma and Leukemia, August 2019, Vol.19(8), pp.509-515.e1 [Peer Reviewed Journal]

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30
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Article
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Combination of Enzastaurin and Ibrutinib synergistically induces anti-tumor effects in diffuse large B cell lymphoma

He, Yizi ; Li, Jiao ; Ding, Ning ; Wang, Xiaogan ; Deng, Lijuan ; Xie, Yan ; Ying, Zhitao ; Liu, Weiping ; Ping, Lingyan ; Zhang, Chen ; Song, Yuqin ; Zhu, Jun

Journal of experimental & clinical cancer research : CR, 18 February 2019, Vol.38(1), pp.86 [Peer Reviewed Journal]

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31
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Article
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The Development and Applications of a Dual Optical Imaging System for Studying Glioma Stem Cells

Tai, Po-An ; Liu, Yen-Lin ; Wen, Ya-Ting ; Lin, Chien-Min ; Huynh, Thanh-Tuan ; Hsiao, Michael ; Wu, Alexander T. H ; Wei, Li

Molecular Imaging, 04 September 2019, Vol.18 [Peer Reviewed Journal]

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32
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Article
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The STELLAR trial protocol: a prospective multicentre trial for Richter’s syndrome consisting of a randomised trial investigation CHOP-R with or without acalabrutinib for newly diagnosed RS and a single-arm platform study for evaluation of novel agents in relapsed disease

Appleby, Niamh ; Eyre, Toby ; Cabes, Maite ; Jackson, Aimee ; Boucher, Rebecca ; Yates, Francesca ; Fox, Sonia ; Rawstron, Andrew ; Hillmen, Peter ; Schuh, Anna

BMC Cancer, 2019, Vol.19 [Peer Reviewed Journal]

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33
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Article
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Molecular Drug Discovery of Single Ginsenoside Compounds as a Potent Bruton’s Tyrosine Kinase Inhibitor

Lee, Woong ; Baek-Soo, Han ; Doo, Eun ; Jeong-Hwan, Kim

International Journal of Molecular Sciences, 2020, Vol.21(9), p.3065 [Peer Reviewed Journal]

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34
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Article
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Biochemical characterization of tirabrutinib and other irreversible inhibitors of Bruton's tyrosine kinase reveals differences in on - and off - target inhibition

Liclican, Albert ; Serafini, Loredana ; Xing, Weimei ; Czerwieniec, Gregg ; Steiner, Bart ; Wang, Ting ; Brendza, Katherine M ; Lutz, Justin D ; Keegan, Kathleen S ; Ray, Adrian S ; Schultz, Brian E ; Sakowicz, Roman ; Feng, Joy Y

BBA - General Subjects, April 2020, Vol.1864(4) [Peer Reviewed Journal]

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35
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Article
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A potent seven-membered cyclic BTK (Bruton's tyrosine Kinase) chiral inhibitor conceived by structure-based drug design to lock its bioactive conformation

Lopez-Tapia, Francisco ; Lou, Yan ; Brotherton-Pleiss, Christine ; Kuglstatter, Andreas ; So, Sung-Sau ; Kondru, Rama

Bioorganic & Medicinal Chemistry Letters, 01 May 2019, Vol.29(9), pp.1074-1078 [Peer Reviewed Journal]

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36